L-Dopa- and dopamine-(R)-α-lipoic acid conjugates as multifunctional codrugs with antioxidant properties

Journal of Medicinal Chemistry

Volumn 49, Issue 4, 2006, Pages 1486-1493

  Di Stefano, Antonio ^a   Sozio, Piera ^a   Cocco, Alessandra ^a   Iannitelli, Antonio ^a   Santucci, Eleonora ^b   Costa, Mara ^b   Pecci, Laura ^b   Nasuti, Cinzia ^c   Cantalamessa, Franco ^c   Pinnen, Francesco ^a  

^a UNIVERSITY OF CHIETI   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c UNIVERSITY OF CAMERINO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2 (ACETYLOXY) 4 [2 [[5 (1,2 DITHIOLAN 3 YL)PENTANOYL]AMINO]ETHYL]PHENYL ACETATE; AMINE OXIDASE (FLAVIN CONTAINING); BENSERAZIDE; BUFFER; DOPAMINE; GLUTATHIONE PEROXIDASE; LEVODOPA; METHYL N [5 (1,2 DITHIOLAN 3 YL)PENTANOYL] 3 HYDROXYTYROSINATE; METHYL O ACETYL 3 (ACETYLOXY) N [5 (1,2 DITHIOLAN 3 YL)PENTANOYL]TYROSINATE; N [2 (3,4 DIHYDROXYPHENYL)ETHYL] 5 (1,2 DITHIOLAN 3 YL)PENTAMIDE; SUPEROXIDE DISMUTASE; THIOCTIC ACID; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANTIOXIDANT ACTIVITY; AQUEOUS SOLUTION; ARTICLE; CONTROLLED STUDY; DOPAMINERGIC SYSTEM; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG CONJUGATION; DRUG FORMULATION; DRUG POTENCY; DRUG STABILITY; DRUG SYNTHESIS; ENZYME ACTIVITY; HUMAN; IRON CHELATION; LOCOMOTION; MALE; NONHUMAN; OXIDATION; PARKINSON DISEASE; PHYSICAL CHEMISTRY; RAT; SUSTAINED RELEASE PREPARATION;

ANIMALS; ANTIOXIDANTS; BIOLOGICAL MARKERS; DOPAMINE; DOPAMINE AGONISTS; DRUG STABILITY; FREE RADICAL SCAVENGERS; GLUTATHIONE PEROXIDASE; HUMANS; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; IRON CHELATING AGENTS; KINETICS; LEVODOPA; MALE; MOTOR ACTIVITY; OXIDATIVE STRESS; RATS; RATS, WISTAR; SOLUBILITY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SUPEROXIDE DISMUTASE; THIOCTIC ACID;

EID: 33144480459     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm051145p     Document Type: Article

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