TA-270 [4-Hydroxy-1-methyl-3-octyloxy-7-sinapinoylamino-2(1H)-quinolinone], an Anti-Asthmatic Agent, Inhibits Leukotriene Production Induced by IgE Receptor Stimulation in RBL-2H3 Cells

Journal of Pharmacology and Experimental Therapeutics

Volumn 307, Issue 2, 2003, Pages 583-588

  Ishiwara, Mitsuteru ^a,b   Aoki, Yasuo ^b   Takagaki, Hidetsugu ^b   Ui, Michio ^c   Okajima, Fumikazu ^a  

^a GUNMA UNIVERSITY   (Japan)

^b DIC CORPORATION   (Japan)

^c TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXY 1 METHYL 3 OCTYLOXY 7 SINAPINOYLAMINO 2(1H) QUINOLINE; ANTIASTHMATIC AGENT; ANTIGEN; ARACHIDONATE 5 LIPOXYGENASE; ARACHIDONIC ACID; IMMUNOGLOBULIN E RECEPTOR; INOSITOL PHOSPHATE; LEUKOTRIENE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOLIPASE A2; PHOSPHOLIPASE C; PROSTAGLANDIN SYNTHASE; TA 270; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARACHIDONIC ACID METABOLISM; ARTICLE; ASTHMA; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG ACTIVITY; DRUG MECHANISM; DRUG RECEPTOR BINDING; ENZYME ACTIVATION; ENZYME INHIBITION; GUINEA PIG; IMMUNOPHARMACOLOGY; IN VIVO STUDY; MAST CELL; MEDIATOR RELEASE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANTI-ASTHMATIC AGENTS; ARACHIDONATE 5-LIPOXYGENASE; BETA-N-ACETYLHEXOSAMINIDASE; CALCIMYCIN; CELLS, CULTURED; CINNAMATES; EOSINOPHILS; HUMANS; IONOPHORES; LEUKOTRIENES; MAST CELLS; NEUTROPHILS; QUINOLONES; RECEPTORS, IGE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0142148166     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.103.055145     Document Type: Article

References (30)

1. Aoki Y, Ishiwara M, Koda A, and Takagaki H (2000) Inhibitory effect of a novel quinolinone derivative, TA-270, on asthmatic inflammatory responses in sensitized guinea pigs. Eur J Pharmacol 409:325-330.
2. Arakida Y, Ohga K, Suwa K, Okada Y, Morio H, Yokota M, Miyata K, Yamada T, and Honda K (2000) Effect of YM158, a dual lipid mediator antagonist, on immediate and late asthmatic responses and on airway hyper-responsiveness in guinea pigs. Jpn J Pharmacol 82:287-294.
3. 4 on ionophore A23187 challenge. J Allergy Clin Immunol 74:310-315.
4. Coffey M and Peters-Golden M (2003) Extending the understanding of leukotrienes in asthma. Curr Opin Allergy Clin Immunol 3:57-63.
5. Dahlen SE, Hedqvist P, Hammarstrom S, and Samuelsson B (1980) Leukotrienes are potent constrictors of human bronchi. Nature (Lond) 288:484-486.
6. Dixon RA, Diehl RE, Opas E, Rands E, Vickers PJ, Evans JF, Gillard JW, and Miller DK (1990) Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis. Nature (Lond) 343:282-284.
7. Drazen JM, Israel E, and O'Byrne PM (1999) Treatment of asthma with drugs modifying the leukotriene pathway. N Engl J Med 340:197-206.
8. Durham SR, Craddock CF, Cookson WO, and Benson MK (1988) Increase in airway hyperresponsiveness to histamine precede allergen-induced late asthmatic responses. J Allergy Clin Immunol 82:595-598.
9. 4 release by human eosinophils with the new 5-lipoxygenase inhibitor 6-hydroxy-2(4-sulfamoylbenzylamino)-4,5,7-trimethylbenzothiazole hydrochloride. Arzneim Forsch 45:1002-1004.
10. Gordon JR and Galli SJ (1990) Mast cells as a source of both preformed and immunologically inducible TNF-/cachectin. Nature (Lond) 346:274-276.
11. Haeggstrom JZ and Wetterholm A (2002) Enzymes and receptors in the leukotriene cascade. Cell Mol Life Sci 59:742-753.
12. Hansel TT, De Vries IJ, Iff T, Rihs S, Wandzilak M, Betz S, Blaser K, and Walker C (1991) An improved immunomagnetic procedure for the isolation of highly purified human blood eosinophils. J Immunol Methods 145:105-110.
13. Hide I, Toriu N, Nuibe T, Inoue A, Hide M, Yamamoto S, and Nakata Y (1997) Suppression of TNF-alpha secretion by azelastine in a rat mast (RBL-2H3) cell line: evidence for differential regulation of TNF-alpha release, transcription and degranulation. J Immunol 159:2932-2940.
14. Holgate ST and Kay AB (1985) Mast cells, mediators and asthma. Clin Allergy 15:221-234.
15. Kay AB (1992) "Helper"(CD4+)T cell and eosinophils in allergy and asthma. Am Rev Respir Dis 145:22-26.
16. Kikuchi M, Hashimura Y, Tsuzurahara K, Nagasawa M, Inoue H, Taniguchi T, and Uchida T (1994) 4-acylaminophenol derivatives as novel lipoxygenase inhibitors: synthesis and inhibitory effect on 5-lipoxygenase and leukotriene B4 production. Biol Pharm Bull 17:1038-1046.
17. Kinet J-P (1989) The high-affinity receptor for IgE. Curr Opin Immunol 2:499-505.
18. Kon J, Sato K, Watanabe T, Tomura H, Kuwabara A, Kimura T, Tamama K, Ishizuka T, Murata N, Kanda T, et al. (1999) Comparison of intrinsic activities of the putative sphingosine 1-phosphate receptor subtypes to regulate several signaling pathways in their cDNA-transfected Chinese hamster ovary cells. J Biol Chem 274:23940-23947.
19. Krawiec ME and Wenzel SE (2001) Leukotriene inhibitors and non-steroidal therapies in the treatment of asthma. Expert Opin Pharmacother 2:47-65.
20. 2 generation after activation of rat and human mast cells with anti-IgE. J Immunol 129:1627-1631.
21. 4, increase the release of mucus from human airways in vitro. Am Rev Respir Dis 126:449-451.
22. Metcalfe DD, Baram D, and Mekori YA (1997) Mast cells. Physiol Rev 77:1033-1079.
23. Miller DK, Gillard JW, Vickers PJ, Sadowski S, Leveille C, Mancini JA, Charleson P, Dixon RA, Ford-Hutchinson AW, Fortin R, et al. (1990) Identification and isolation of a membrane protein necessary for leukotriene production. Nature (Lond) 343:278-281.
24. Nakagawa N, Obata T, Kobayashi T, Okada Y, Nambu F, Terawaki T, Furuya T, Muryobayashi K, Sawada M, and Aishita H (1993) Effect of a peptide leukotriene receptor antagonist, ONO-1078, on guinea-pig models of asthma. Eur J Pharmacol 235:211-219.
25. O'Byrne PM, Dolovich J, and Hargreave FE (1986) Late asthmatic response. Am Rev Respir Dis 136:740-751.
26. Okajima F and Ui M (1984) ADP-ribosylation of the specific membrane protein by islet-activating protein, pertussis toxin, associated with inhibition of a chemotactic peptide-induced arachidonate release in neutrophils. J Biol Chem 259:13863-13871.
27. 4 on the microvasculature of guinea-pig skin. Prostaglandins 21:315-321.
28. Reid GK, Kargman S, Vickers PJ, Mancini JA, Leveille C, Ethier D, Miller DK, Gillard JW, Dixon RA, and Evans JF (1990) Correlation between expression of 5-lipoxygenase-activating protein, 5-lipoxygenase and cellular leukotriene synthesis. J Biol Chem 265:19818-19823.
29. Sato K, Tomura H, Igarashi Y, Ui M, and Okajima F (1999) Possible involvement of cell surface receptors in sphingosine 1-phosphate-induced activation of extracellular signal-regulated kinase in C6 glioma cells. Mol Pharmacol 55:126-133.
30. 4 administration in the guinea pig. Am J Respir Crit Care Med 154:850-857.