Design, synthesis and in vitro evaluation of potent, novel, small molecule inhibitors of plasminogen activator inhibitor-1

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 7, 2002, Pages 1063-1066

  Folkes, Adrian ^a   Brown, S David ^b   Canne, Lynne E ^b   Chan, Jocelyn ^b   Engelhardt, Erin ^b   Epshteyn, Sergey ^b   Faint, Richard ^a   Golec, Julian ^a   Hanel, Art ^b   Kearney, Patrick ^b   Leahy, James W ^b   Mac, Morrison ^b   Matthews, David ^b   Prisbylla, Michael P ^b   Sanderson, Jason ^a   Simon, Reyna J ^b   Tesfai, Zerom ^b   Vicker, Nigel ^a   Wang, Shouming ^a   Webb, Robert R ^b   Charlton, Peter ^a   more..

^a Cantab Pharmaceuticals Ltd   (United Kingdom)

^b MetaXen   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; PLASMINOGEN ACTIVATOR INHIBITOR 1; PLASMINOGEN ACTIVATOR INHIBITOR 1 BLOCKING AGENT; QUINOLONE DERIVATIVE; TETRAMIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG DESIGN; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; IN VITRO STUDY; STRUCTURE ACTIVITY RELATION;

CHROMOGENIC COMPOUNDS; DRUG DESIGN; DRUG EVALUATION; HYDROXYQUINOLINES; MOLECULAR STRUCTURE; PLASMINOGEN ACTIVATOR INHIBITOR 1; PYRROLIDINONES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 18344392241     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00078-1     Document Type: Article

References (20)