Synthesis and reactivity of laquinimod, a quinoline-3-carboxamide: Intramolecular transfer of the enol proton to a nitrogen atom as a plausible mechanism for ketene formation

Journal of Organic Chemistry

Volumn 71, Issue 4, 2006, Pages 1658-1667

  Jansson, Karl ^a   Fristedt, Tomas ^a   Olsson, Arne ^a   Svensson, Bo ^a   Jönsson, Stig ^a  

^a Active Biotech Research AB   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

INTRAMOLECULAR HYDROGEN BONDING; MECHANISTIC MODEL; MULTIPLE SCLEROSIS;

CONFORMATIONS; DRUG PRODUCTS; HYDROGEN BONDS; METHANOL; PHOTONS; PROTONS; SOLVENTS;

NITROGEN COMPOUNDS;

ALCOHOL; CARBONYL DERIVATIVE; ESTER; ETHYLANILINE; KETENE DERIVATIVE; LAQUINIMOD; METHANOL; NITROGEN; PROTON; QUINOLINE 3 CARBOXAMIDE; SOLVENT; UNCLASSIFIED DRUG;

AMINOLYSIS; ARTICLE; CHEMICAL REACTION; DRUG SYNTHESIS; HYDROGEN BOND; MODEL; MULTIPLE SCLEROSIS; PROTON TRANSPORT; QUANTUM YIELD; SOLVOLYSIS; SPECTROSCOPY; STEREOCHEMISTRY;

ETHYLENES; HYDROGEN BONDING; KETONES; KINETICS; MULTIPLE SCLEROSIS; NITROGEN; PROTONS; QUINOLONES; SOLVENTS;

EID: 33644554781     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo052368q     Document Type: Article

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