Design, synthesis, and biological evaluation of prazosin-related derivatives as multipotent compounds

Journal of Medicinal Chemistry

Volumn 48, Issue 1, 2005, Pages 28-31

  Antonello, Alessandra ^a   Hrelia, Patrizia ^a   Leonardi, Amedeo ^b   Marucci, Gabriella ^c   Rosini, Michela ^a   Tarozzi, Andrea ^a   Tumiatti, Vincenzo ^a   Melchiorre, Carlo ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b Recordati SpA   (Italy)

^c UNIVERSITY OF CAMERINO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENERGIC RECEPTOR BLOCKING AGENT; PRAZOSIN; QUINAZOLINE DERIVATIVE; REACTIVE OXYGEN METABOLITE;

ADRENERGIC RECEPTOR BLOCKING; ANTIOXIDANT ACTIVITY; ARTICLE; BINDING AFFINITY; CELL PROLIFERATION; CONTROLLED STUDY; DRUG DESIGN; DRUG EFFICACY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; OXIDATIVE STRESS; PROSTATE CARCINOMA;

ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; ANTIOXIDANTS; BIOCHEMISTRY; CARCINOMA; CHO CELLS; CRICETINAE; CRICETULUS; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; HUMANS; MALE; PRAZOSIN; PROSTATIC NEOPLASMS; RATS; REACTIVE OXYGEN SPECIES; RECEPTORS, ADRENERGIC, ALPHA-1; STRUCTURE-ACTIVITY RELATIONSHIP; THIOCTIC ACID; TUMOR CELLS, CULTURED; VAS DEFERENS;

EID: 12144265607     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm049153d     Document Type: Article

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