Synthesis of N-Pyridinyl(methyl)-1,2-dihydro-4-hydroxy-2-oxoquinoline-3-carboxamides and analogues and their anti-inflammatory activity in mice and rats

Journal of Pharmacy and Pharmacology

Volumn 53, Issue 3, 2001, Pages 417-423

  Collin, X ^a   Robert, J M ^a   Duflos, M ^a   Wielgosz, G ^a   Le Baut, G ^a   Robin Dubigeon, C ^a   Grimaud, N ^a   Lang, F ^a   Petit, J Y ^a  

^a UNIVERSITÉ DE NANTES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE; ANTIINFLAMMATORY AGENT; BROMINE DERIVATIVE; CARBOXYLIC ACID DERIVATIVE; CARRAGEENAN; IBUPROFEN; IMINE; N PYRIDINYL(METHYL) 1,2 DIHYDRO 4 HYDROXY 2 OXOQUINOLINE 3 CARBOXAMIDE DERIVATIVE; PENTAFLUOROBENZALDIMINE DERIVATIVE; PENTAFLUOROBENZOYLACETAMIDE; PENTAFLUOROCINNAMAMIDE DERIVATIVE; PHORBOL 13 ACETATE 12 MYRISTATE; ROQUINIMEX; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; EAR; EDEMA; INHIBITION KINETICS; MALE; MOUSE; NONHUMAN; PAW EDEMA; RAT; SCREENING TEST;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CARRAGEENAN; EAR, EXTERNAL; EDEMA; FOOT; MALE; MICE; PYRIDINES; QUINOLONES; RATS; RATS, WISTAR; TETRADECANOYLPHORBOL ACETATE;

EID: 0035090159     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357011775505     Document Type: Article

References (15)

1. Roquinimex (Linomide)
2. Cytokine expression in chronic inflammatory disease
3. Agents that block TNF-α synthesis or activity
4. Modulation of mouse ear edema by cyclooxygenase and lipooxygenase inhibitors and other pharmacologic agents
5. 4-Hydroxy-3-quinolinecarbox-amides with antiarthritic and analgesic activities
6. Synthesis and potent tumor necrosis factor-α production inhibitory activity of N-pyridinylphthalimides and derivatives
7. N-pyridinyl(alkyl)polyhalogenobenzamides acting as TNF-α production inhibitors
8. 3 receptor antagonists. 4-Hydroxy-3-quinolinecarboxylic acid derivatives
9. Synthèse et approche immunopharmacologique de dérivés de la 1,2-dihydroquinoléine-2-one
10. New anti-inflammatory compounds that inhibit tumor necrosis factor production: Probable interaction with protein kinase C activation
11. The synthesis of emetine and related compounds. The utility of bi-functional catalysts in amine-ester interactions
12. Non-carboxylic anti-inflammatory compounds. III. N-(4,6-dimethyl-pyridin-2-yl)arylcarboxamides and aryl-thiocarboxamides acting as brain oedema inhibitors
13. Thalidomide selectively inhibits tumor necrosis factor-α production by stimulated human monocytes
14. An anti-inflammatory benzamide derivative inhibits the protein kinase C (PKC)-dependent pathway of Erk2 phosphorylation in murine macrophages
15. Carrageenin-induced edema in hind paw of rat as an assay for anti-inflammatory drugs