Hydrodynamic liver gene transfer mechanism involves transient sinusoidal blood stasis and massive hepatocyte endocytic vesicles

Gene Therapy

Volumn 12, Issue 11, 2005, Pages 927-935

  Crespo, A ^a   Peydro A ^b   Dasi F ^a   Benet, M ^a   Calvete, J J ^c   Revert, F ^a   Alino S F ^a  

^a UNIVERSITY OF VALENCIA   (Spain)

^b UNIVERSITY OF VALENCIA   (Spain)

^c INSTITUTO DE BIOMEDICINA DE VALENCIA   (Spain)

Author keywords

Alpha 1 antitrypsin; Fluid endocytosis; Gene delivery; Genomic DNA; Liver; Nonviral vector

Indexed keywords

ALPHA 1 ANTITRYPSIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL STRUCTURE; CELL VACUOLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG MECHANISM; DRUG TOLERABILITY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE DOSAGE; GENE IDENTIFICATION; GENE TRANSFER; HEMODYNAMICS; HEMOSTASIS; HEPATIC VEIN; HYDRODYNAMICS; INJECTION; INTRACELLULAR FLUID; LIVER BLOOD FLOW; LIVER CELL; LIVER DISEASE; LIVER SINUSOID; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEOMICS; TRANSGENE; TRANSMISSION ELECTRON MICROSCOPY; VENOUS PRESSURE;

ALPHA 1-ANTITRYPSIN; ANIMALS; CYTOPLASMIC VESICLES; ENDOCYTOSIS; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HEPATOCYTES; HUMANS; LIVER CIRCULATION; MICE; MICE, INBRED C57BL; MICROSCOPY, ELECTRON; MOLECULAR SEQUENCE DATA; PORTAL VEIN; VENA CAVA, INFERIOR; VENOUS PRESSURE;

EID: 20744458578     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3302469     Document Type: Article

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