Hepatocyte growth factor is a preferred in vitro substrate for human hepsin, a membrane-anchored serine protease implicated in prostate and ovarian cancers

Biochemical Journal

Volumn 390, Issue 1, 2005, Pages 125-136

  Herter, Sylvia ^a,c   Piper, Derek E ^a   Aaron, Wade ^a   Gabriele, Timothy ^a   Cutler, Gene ^a   Cao, Ping ^a   Bhatt, Ami S ^b   Choe, Youngchool ^b   Craik, Charles S ^b   Walker, Nigel ^a   Meininger, David ^a   Hoey, Timothy ^a   Austin, Richard J ^a,c  

^a AMGEN INC   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c GENENTECH INC   (United States)

Author keywords

c Met receptor activation; Hepatocyte growth factor (HGF); Hepsin; Positional scanning synthetic combinatorial library (PS SCL); Proteolytic cascade; Substrate specificity

Indexed keywords

BIOLOGICAL MEMBRANES; MACROMOLECULES; POLYPEPTIDES; SUBSTRATES;

C-MET RECEPTOR ACTIVATION; HEPSIN; PROTEOLYTIC CASCADE; SUBSTRATE SPECIFICITY;

ENZYMES;

7 AMINO 4 METHYLCOUMARIN; ARGININE; CHLOROMETHYL KETONE; COUMARIN DERIVATIVE; KETONE DERIVATIVE; LIVER PROTEIN; LYSINE; PROLINE; PROTEIN HEPSIN; SCATTER FACTOR; SERINE PROTEINASE; TETRAPEPTIDE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; COMBINATORIAL LIBRARY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MACROMOLECULE; OVARY CANCER; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; X RAY CRYSTALLOGRAPHY;

BINDING SITES; CELL LINE, TUMOR; ENZYME ACTIVATION; FEMALE; GENE EXPRESSION; HEPATOCYTE GROWTH FACTOR; HUMANS; MALE; OVARIAN NEOPLASMS; PROSTATIC NEOPLASMS; PROTEIN CONFORMATION; SERINE ENDOPEPTIDASES; SUBSTRATE SPECIFICITY; UP-REGULATION;

EID: 21244448682     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20041955     Document Type: Article

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