Impact on farnesyltransferase inhibition of 4-chlorophenyl moiety replacement in the Zarnestra® series

European Journal of Medicinal Chemistry

Volumn 42, Issue 5, 2007, Pages 702-714

  Angibaud, Patrick ^a   Mevellec, Laurence ^a   Meyer, Christophe ^a   Bourdrez, Xavier ^a   Lezouret, Patricia ^a   Pilatte, Isabelle ^a   Poncelet, Virginie ^a   Roux, Bruno ^a   Merillon, Sophie ^a   End, David W ^b   Van Dun, Jacky ^c   Wouters, Walter ^c   Venet, Marc ^a  

^a JOHNSON AND JOHNSON   (United States)

^b Johnson and Johnson Pharmaceutical Research and Development LLC   (United States)

^c JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

Author keywords

Anticancer agents; Farnesyltransferase inhibition; R115777; Tipifarnib; Zarnestra

Indexed keywords

2,2,2 TRICHLORO N [2 (3 CHLOROBENZOYL) 4 [(5 CHLORO 2 THIENYL)CARBONYL]PHENYL] ACETAMIDE; 4 (3 CHLOROPHENYL) N,2 DIMETHOXY N METHYL 6 QUINAZOLINECARBOXAMIDE; 4 [[5 [[5 (3 CHLOROPHENYL)TETRAZOLO[1,5 A]QUINOLIN 7 YL]HYDROXYMETHYL] 1H IMIDAZOL 1 YL]METHYL] BENZONITRILE; 5 (3 CHLOROPHENYL) ALPHA (1 METHYL 1H IMIDAZOL 5 YL) TETRAZOLO[1,5 A]QUINAZOLINE 7 METHANOL; 5 (3 CHLOROPHENYL) ALPHA [1 [(4 CHLOROPHENYL)METHYL] 1H IMIDAZOL 5 YL] TETRAZOLO[1,5 A]QUINOLINE 7 METHANOL; 7 [CHLORO (5 CHLORO 2 THIENYL)(1 METHYL 1H IMIDAZOL 5 YL] 5 (3 CHLOROPHENYL) TETRAZOLO [1,5 A]QUINAZOLINE; 7 [CHLORO(1 METHYL 1H IMIDAZOL 5 YL)METHYL] 5 (3 CHLOROPHENYL) TETRAZOLO[1,5 A]QUINAZOLINE; [2 CHLORO 4 (3 CHLOROPHENYL) 6 QUINAZOLINYL](5 CHLORO 2 THIENYL) METHANONE; [3 (3 CHLOROPHENYL) 1,2 BENZISOXAZOL 5 YL] (5 CHLORO 2 THIENYL) METHANOL; [3 (3 CHLOROPHENYL) 1,2 BENZISOXAZOL 5 YL](5 CHLORO 2 THIENYL) METHANONE; IMIDAZOLE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; QUINOLINE DERIVATIVE; TIPIFARNIB; UNCLASSIFIED DRUG;

ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; PROTEIN MOTIF; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; ENZYME INHIBITORS; FARNESYLTRANSTRANSFERASE; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; QUINOLONES;

EID: 34248177357     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2006.12.007     Document Type: Article

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