Synthesis and cytotoxic activity of substituted Luotonin A derivatives

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 23, 2004, Pages 5757-5761

  Dallavalle, Sabrina ^a   Merlini, Lucio ^a   Beretta, Giovanni Luca ^b   Tinelli, Stella ^b   Zunino, Franco ^b  

^a UNIVERSITY OF MILAN   (Italy)

^b Istituto Nazionale per lo Studio   (Italy)

Author keywords

Antitumor agents; Cytotoxic alkaloid; Topoisomerase I

Indexed keywords

10 CHLOROLUOTONIN A; 2,3 DIMETHOXYLUOTONIN A; 2,3 METHYLENEDIOXYLUOTONIN A; 7 ETHYL 10 HYDROXYCAMPTOTHECIN; 7 METHOXYLUOTONIN A; 7 METHYLLUOTONIN A; 9 CHLOROLUOTONIN A; 9 HYDROXYLUOTONIN A; 9 IMINO 4A,5,13A,14 TETRAHYDROQUINO[2',3':3,4]PYRROLO[2,1 B]QUINAZOLIN 11(13H) ONE; 9 NITROLUOTONIN A; ANTINEOPLASTIC AGENT; DNA TOPOISOMERASE INHIBITOR; LUOTONIN A; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; LUNG CANCER; SUBSTITUTION REACTION;

CELL LINE, TUMOR; DNA TOPOISOMERASES, TYPE I; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HUMANS; PYRROLES; QUINONES;

EID: 7044241040     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.09.039     Document Type: Article

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