Quantitative structure-antitumor activity relationships of camptothecin analogues: Cluster analysis and genetic algorithm-based studies

Journal of Medicinal Chemistry

Volumn 44, Issue 20, 2001, Pages 3254-3263

  Fan, Y ^a,b   Shi, L M ^a,c   Kohn, K W ^a   Pommier, Y ^a   Weinstein, J N ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b PFIZER INC   (United States)

^c Chipscreen Biosciences Ltd   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CAMPTOTHECIN DERIVATIVE; DNA TOPOISOMERASE INHIBITOR;

ALGORITHM; ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING SITE; CANCER CELL CULTURE; CANCER INHIBITION; CHEMICAL STRUCTURE; CLUSTER ANALYSIS; CORRELATION FUNCTION; DATA BASE; GENETIC ANALYSIS; LIGAND BINDING; NONLINEAR SYSTEM; PRINCIPAL COMPONENT ANALYSIS; QUANTITATIVE STRUCTURE ACTIVITY RELATION; VALIDATION PROCESS; X RAY CRYSTALLOGRAPHY;

ALGORITHMS; ANTINEOPLASTIC AGENTS; CAMPTOTHECIN; CLUSTER ANALYSIS; DATABASES, FACTUAL; DNA TOPOISOMERASES, TYPE I; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; REGRESSION ANALYSIS; TUMOR CELLS, CULTURED;

EID: 0035960060     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0005151     Document Type: Article

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