Emerging therapeutic approaches multi-targeting receptor tyrosine kinases and G protein-coupled receptors in cardiovascular disease

Cardiovascular and Hematological Agents in Medicinal Chemistry

Volumn 5, Issue 2, 2007, Pages 133-145

  Flordellis, C ^a   Papathanasopoulos, P ^a   Lymperopoulos, A ^a   Matsoukas, J ^b   Paris, H ^c  

^a UNIVERSITY OF PATRAS   (Greece)

^b UNIVERSITY OF PATRAS   (Greece)

^c CHU RANGUEIL   (France)

Author keywords

Designed multiple ligands; GPCRs; Multi targeted ligands; Promiscuous drugs; RTKs; Selectively non selective drugs

Indexed keywords

4 (4 FLUORO 2 METHYL 5 INDOLYLOXY) 6 METHOXY 7 [3 (1 PYRROLIDINYL)PROPOXY]QUINAZOLINE; 6 [4 (4 ETHYL 1 PIPERAZINYLMETHYL)PHENYL] 4 (ALPHA METHYLBENZYLAMINO) 7H PYRROLO[2,3 D]PYRIMIDINE; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; BEVACIZUMAB; BM 567; BM 573; CANDESARTAN; DALTROBAN; ENDOTHELIN A RECEPTOR ANTAGONIST; ERLOTINIB; IRBESARTAN; ISBOGREL; LOSARTAN; MRS 1740; MRS 1741; N ISOXAZOLYL BIPHENYLSULFONAMIDE; PIOGLITAZONE; PTK 787 ZK 222584; RIDOGREL; ROSIGLITAZONE; SAMIXOGREL; SORAFENIB; SULOTROBAN; SUNITINIB; TELMISARTAN; THROMBOXANE RECEPTOR BLOCKING AGENT; TORASEMIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VALSARTAN; VANDETANIB; VATALANIB;

ANGIOGENESIS; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTHRALGIA; ASTHENIA; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CLINICAL TRIAL; COLORECTAL CANCER; CORONARY ARTERY ATHEROSCLEROSIS; CORONARY ARTERY THROMBOSIS; DIABETES MELLITUS; DIZZINESS; DRUG DOSE ESCALATION; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; DYSLIPIDEMIA; EDEMA; ESSENTIAL HYPERTENSION; FLUID RETENTION; GENE TARGETING; GLYCEMIC CONTROL; HAIR DISCOLORATION; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HUMAN; HYPERTENSION; ISCHEMIC HEART DISEASE; KIDNEY CARCINOMA; KIDNEY FAILURE; LEG ISCHEMIA; LETHARGY; NAIL DISEASE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; OVARY CARCINOMA; PANCREAS CANCER; PARKINSON DISEASE; PROTEIN TARGETING; QT PROLONGATION; RECOMMENDED DRUG DOSE; REVIEW; SIDE EFFECT; SKIN TOXICITY; STROKE; STRUCTURE ACTIVITY RELATION; THROMBOSIS; UNSPECIFIED SIDE EFFECT; VASOCONSTRICTION; WEIGHT GAIN;

CARDIOVASCULAR DISEASES; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; HUMANS; NEOVASCULARIZATION, PATHOLOGIC; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, G-PROTEIN-COUPLED;

EID: 34247581359     PISSN: 18715257     EISSN: None     Source Type: Journal    
DOI: 10.2174/187152507780363188     Document Type: Review

References (118)

1. Morphy, R.; Kay, C.; Rankovic, Z. Drug Discov. Today, 2004, 9, 641.
2. Flordellis, C.S.; Manolis, A.S.; Paris, H.; Karabinis, A. Curr. Top. Med. Chem., 2006, in press.
3. Wermuth, C.G. Drug Discov. Today, 2004, 9, 826.
4. Hopkins, A.L.; Mason, J.S.; Overington, J.P. Curr. Opin. Struct. Biol., 2006, 16, 127.
5. Thatcher, N.; Chang, A.; Parikh, P.; Rodrigues Pereira, J.; Ciuleanu, T.; von Pawel, J.; Thongprasert, S.; Tan, E.H.; Pemberton, K.; Archer, V.; Carroll, K. Lancet, 2005, 366, 1527.
6. Tamura, K.; Fukuoka, M. Exp. Opin. Pharmacother., 2005, 6, 985.
7. Karin, M. Proc. Am. Thorac. Soc., 2005, 2, 386.
8. Kleinschmidt-DeMasters, B.K.; Tyler, K.L. N. Engl. J. Med., 2005, 353, 369.
9. Langer-Gould, A.; Atlas, S.W.; Green, A.J.; Bollen, A.W.; Pelletier, D. N. Engl. J. Med., 2005, 353, 375.
10. Van Assche, G.; Van Ranst, M.; Sciot, R.; Dubois, B.; Vermeire, S.; Noman, M.; Verbeeck, J.; Geboes, K.; Robberecht, W.; Rutgeerts, P. N. Engl. J. Med., 2005, 353, 362.
11. Hartwell, L.H.; Hopfield, J.J.; Leibler, S.; Murray, A.W. Nature, 1999, 402, C47.
12. Newman, M.E. Phys. Rev. E Stat. Nonlin. Soft Matter Phys., 2004, 70, 056131.
13. Barabasi, A.L.; Oltvai, Z.N. Nat. Rev. Genet., 2004, 5, 101.
14. Fishman, M.C.; Porter, J.A. Nature, 2005, 437, 491.
15. O'Brien, P.J.; Herschlag, D. Chem. Biol., 1999, 6, R91.
16. Gu, Z.; Steinmetz, L.M.; Gu, X.; Scharfe, C.; Davis, R.W.; Li, W.H. Nature, 2003, 421, 63.
17. Kaelin, W.G., Jr. Nat. Rev. Cancer, 2005, 5, 689.
18. Roth, B.L.; Sheffler, D.J.; Kroeze, W.K. Nat. Rev. Drug Discov., 2004, 3, 353.
19. Keith, C.T.;. Borisy, A.A.; Stockwell, B.R. Nat. Rev. Drug Discov., 2005, 4, 71.
20. Mencher, S.K.; Wang, L.G. BMC Clin. Pharmacol., 2005, 5, 3.
21. Agoston, V.; Csermely, P.; Pongor, S. Phys. Rev. E Stat. Nonlin. Soft Matter Phys., 3005, 71, 051909.
22. Csermely, P.; Agoston, V.; Pongor, S. Trends Pharmacol. Sci., 2005, 26, 178.
23. Csermely, P. Trends Biochem. Sci., 2004, 29, 331.
24. Wellen, K.E.; Hotamisligil, G.S. J. Clin. Invest., 2005, 115, 1111.
25. Wilson, P.W.; Kannel, W.B.; Silbershatz, H.; D'Agostino, R.B. Arch. Intern. Med., 1999, 159, 1104.
26. Lewington, S.; Clarke, R.; Qizilbash, N.; Peto, R.; Collins, R. Lancet, 2002, 360, 1903.
27. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. JAMA, 2001, 285, 2486.
28. Whitworth, J.A. J. Hypertens., 2003, 21, 1983.
29. Daviglus, M.L.; Lloyd-Jones, D.M.; Pirzada, A. Am. J. Cardiovasc. Drugs, 2006, 6, 87.
30. Wald, N.J.; Law, M.R. BMJ, 2003, 326, 1419.
31. Morphy, R.; Rankovic, Z. J. Med. Chem., 2005, 48, 6523.
32. Borisy, A.A.; Elliott, P.J.; Hurst, N.W.; Lee, M.S.; Lehar, J.; Price, E.R.; Serbedzija, G.; Zimmermann, G.R.; Foley, M.A.; Stockwell, B.R.; Keith, C.T. Proc. Natl. Acad. Sci. USA, 2003, 100, 7977.
33. McGovern, S.L.; Shoichet, B.K. J. Med. Chem., 2003, 46, 1478.
34. Seidler, J.; McGovern, S.L.; Doman, T.N.; Shoichet, B.K. J. Med. Chem., 2003, 46, 4477.
35. Buijsman, R.C.; Basten, J.E.; van Dinther, T.G.; van der Marel, G.A.; van Boeckel, C.A.; van Boom, J.H. Bioorg. Med. Chem. Lett., 1999, 9, 2013.
36. Stephenson, V.C.; Heyding, R.A.; Weaver, D.F. FEBS Lett., 2005, 579, 1338.
37. Walsh, T.F.; Fitch, K.J.; Williams, D.L., Jr.; Murphy, K.L.; Nolan, N.A.; Pettibone, D.J.; Chan, R.S.L.; O'Malley, S.S.; Clineschmidt, B.V.; Veber, D.F.; Greenlee, W.J. Bioorganic Med. Chem. Lett., 1996, 5, 1155.
38. Burnier, M. Exp. Opin. Investig. Drugs, 2001, 10, 1957.
39. Moreau, P.; Dao, H.H. Exp. Opin. Investig. Drugs, 2001, 10, 1937.
40. Liu, J.L.; Pliquett, R.U.; Brewer, E.; Cornish, K.G.; Shen, Y.T.; Zucker, I.H. Am. J. Physiol. Regul. Integr. Comp. Physiol., 2001, 280, R1906.
41. Flordellis, C.S.; Goumenos, D.; Kourounis, G.; Tsementzis, S.A.; Paris, H.; Vlachojiannis, J. Curr. Top. Med. Chem., 2004, 4, 487.
42. Ruiz-Ortega, M.; Lorenzo, O.; Ruperez, M.; Esteban, V.; Suzuki, Y.; Mezzano, S.; Plaza, J.J.; Egido, J. Hypertension, 2001, 38, 1382.
43. Caughey, G.E.; Cleland, L.G.; Penglis, P.S.; Gamble, J.R.; James, M.J. J. Immunol., 2001, 167, 2831.
44. Kowala, M.C.; Murugesan, N.; Tellew, J.; Carlson, K.; Monshizadegan, H.; Ryan, C.; Gu, Z.; Kane, B.; Fadnis, L.; Baska, R.A.; Beyer, S.; Arthur, S.; Dickinson, K.; Zhang, D.; Perrone, M.; Ferrer, P.; Giancarli, M.; Baumann, J.; Bird, E.; Panchal, B.; Yang, Y.; Trippodo, N.; Barrish, J.; Macor, J.E. J. Pharmacol. Exp. Ther., 2004, 309, 275.
45. Murugesan, N.; Gu, Z.; Fadnis, L.; Tellew, J.E.; Baska, R.A.; Yang, Y.; Beyer, S.M.; Monshizadegan, H.; Dickinson, K.E.; Valentine, M.T.; Humphreys, W.G.; Lan, S.J.; Ewing, W.R.; Carlson, K.E.; Kowala, M.C.; Zahler, R.; Macor, J.E. J. Med. Chem., 2005, 48, 171.
46. Moussa, O.; Yordy, J.S.; Abol-Enein, H.; Sinha, D.; Bissada, N.K.; Halushka, P.V.; Ghoneim, M.A.; Watson, D.K. Cancer Res., 2005, 65, 11581.
47. Nie, D.; Che, M.; Zacharek, A.; Qiao, Y.; Li, L.; Li, X.; Lamberti, M.; Tang, K.; Cai, Y.; Guo, Y.; Grignon, D.; Honn, K.V. Am. J. Pathol., 2004, 164, 429.
48. Dogne, J.M.; de Leval, X.; Delarge, J.; David, J.L.; Masereel, B. Curr. Med. Chem., 2000, 7, 609.
49. Carty, E.; Rampton, D.S.; Schneider, H.; Rutgeerts, P.; Wright, J.P. Aliment. Pharmacol. Ther., 2001, 15, 1323.
50. FitzGerald, G.A. Nat. Rev. Drug Discov., 2003, 2, 879.
51. Pratico, D.; Dogne, J.M. Circulation, 2005, 112, 1073.
52. Soyka, R.; Guth, B.D.; Weisenberger, H.M.; Luger, P.; Muller, T.H. J. Med. Chem., 1999, 42, 1235.
53. Golino, P.; Rosolowsky, M.; Yao, S.K.; McNatt, J.; De Clerck, F.; Buja, L.M.; Willerson, J.T. J. Clin. Invest., 1990, 86, 1095.
54. Vandeplassche, G.; Hermans, C.; Somers, Y.; Van de Werf, F.; de Clerck, F. J. Am. Coll. Cardiol., 1993, 21, 1269.
55. Van de Werf, F.; fortheRAPTInvestigators. Circulation, 1994, 89, 588.
56. Carty, E.; Macey, M.; McCartney, S.A.; Rampton, D.S. Aliment. Pharmacol. Ther., 2000, 14, 807.
57. Jurasz, P.; Alonso-Escolano, D.; Radomski, M.W. Br. J. Pharmacol., 2004, 143, 819.
58. de Leval, X.J.; Dassesse, T.; Dogne, J.M.; Waltregny, D.; Bellahcene, A.; Benoit, V.; Pirotte, B.; Castronovo, V. J. Pharmacol. Exp. Ther., 2006.
59. Nie, D.; Lamberti, M.; Zacharek, A.; Li, L.; Szekeres, K.; Tang, K.; Chen, Y.; Honn, K.V. Biochem. Biophys. Res. Commun., 2000, 267, 245.
60. Miggin, S.M.; Kinsella, B.T. Mol. Pharmacol., 2002, 61, 817.
61. Bombardier, C.; Laine, L.; Reicin, A.; Shapiro, D.; Burgos-Vargas, R.; Davis, B.; Day, R.; Ferraz, M.B.; Hawkey, C.J.; Hochberg, M.C.; Kvien, T.K.; Schnitzer, T.J. N. Engl. J. Med., 2000, 343, 1520.
62. Bresalier, R.S.; Sandler, R.S.; Quan, H.; Bolognese, J.A.; Oxenius, B.; Horgan, K.; Lines, C.; Riddell, R.; Morton, D.; Lanas, A.; Konstam, M.A.; Baron, J.A. N. Engl. J. Med., 2005, 352, 1092.
63. Kurtz, T.W.; Pravenec, M. J. Hypertens., 2004, 22, 2253.
64. Schupp, M.; Janke, J.; Clasen, R.; Unger, T.; Kintscher, U. Circulation, 2004, 109, 2054.
65. Benson, S.C.; Pershadsingh, H.A.; Ho, C.I.; Chittiboyina, A.; Desai, P.; Pravenec, M.; Qi, N.; Wang, J.; Avery, M.A.; Kurtz, T.W. Hypertension, 2004, 43, 993.
66. Burnier, M.; Maillard, M. Blood Press. Suppl., 2001, 1, 6.
67. Berger, J.; Moller, D.E. Annu. Rev. Med., 2002, 53, 409.
68. Strazzullo, P.; Galletti, F. Curr. Opin. Nephrol. Hypertens., 2004, 13, 325.
69. Yamagishi, S.; Takeuchi, M. Med. Hypotheses, 2005, 64, 476.
70. Teo, K.K.; Mitchell, L.B.; Pogue, J.; Bosch, J.; Dagenais, G.; Yusuf, S. Circulation, 2004, 110, 1413.
71. Zimmermann, M.; Unger, T. Exp. Opin. Pharmacother., 2004, 5, 1201.
72. Mubagwa, K.; Flameng, W. Cardiovasc. Res., 2001, 52, 25.
73. Kloner, R.A.; Rezkalla, S.H. J. Am. Coll. Cardiol., 2004, 44, 276.
74. Shneyvays, V.; Leshem, D.; Zinman, T.; Mamedova, L.K.; Jacobson, K.A.; Shainberg, A. Am. J. Physiol. Heart Circ. Physiol., 2005, 288, H2792.
75. Ralevic, V.; Burnstock, G. Pharmacol. Rev., 1998, 50, 413.
76. Sato, T.; Sasaki, N.; O'Rourke, B.; Marban, E. Circulation, 2000, 102, 800.
77. Jacobson, K.A.; Xie, R.; Young, L.; Chang, L.; Liang, B.T. J. Biol. Chem., 2000, 275, 30272.
78. Garlid, K.D. Basic Res. Cardiol., 2000, 95, 275.
79. Oldenburg, O.; Cohen, M.V.; Yellon, D.M.; Downey, J.M. Cardiovasc. Res., 2002, 55, 429.
80. Shneyvays, V.; Mamedova, L.; Zinman, T.; Jacobson, K.; Shainberg, A. J. Mol. Cell Cardiol., 2001, 33, 1249.
81. Shneyvays, V.; Zinman, T.; Shainberg, A. Cell Calcium, 2004, 36, 387.
82. Folkman, J. Nat. Med., 1995, 1, 27.
83. Balasubramanian, L.; Evens, A.M. Curr. Opin. Oncol., 2006, 18, 354.
84. Zania, P.; Kritikou, S.; Flordellis, C.S.; Maragoudakis, M.E.; Tsopanoglou, N.E. J. Pharmacol. Exp. Ther., 2006, 318, 246.
85. Zakarija, A.; Soff, G. Curr. Opin. Oncol., 2005, 17, 578.
86. Zukowska, Z.; Grant, D.S.; Lee, E.W. Trends Cardiovasc. Med., 2003, 13, 86.
87. Carmeliet, P.; Jain, R.K. Nature, 2000, 407, 249.
88. Shiojima, I.; Sato, K.; Izumiya, Y.; Schiekofer, S.; Ito, M.; Liao, R.; Colucci, W.S.; Walsh, K. J. Clin. Invest., 2005, 115, 2108.
89. Zukowska, Z. Pharmacol. Rep., 2005, 57(Suppl.), 229.
90. Zukowska, Z.; Pons, J.; Lee, E.W.; Li, L. Can. J. Physiol. Pharmacol., 2003, 81, 89.
91. Kitlinska, J.; Abe, K.; Kuo, L.; Pons, J.; Yu, M.; Li, L.; Tilan, J.; Everhart, L.; Lee, E.W.; Zukowska, Z.; Toretsky, J.A. Cancer Res., 2005, 65, 1719.
92. Kallio, J.; Pesonen, U.; Kaipio, K.; Karvonen, M.K.; Jaakkola, U.; Heinonen, O.J.; Uusitupa, M.I.; Koulu, M. FASEB J., 2001, 15, 1242.
93. Li, L.; Jonsson-Rylander, A.C.; Abe, K.; Zukowska, Z. Arterioscler. Thromb. Vasc. Biol., 2005, 25, 2075.
94. Iaccarino, G.; Ciccarelli, M.; Sorriento, D.; Galasso, G.; Campanile, A.; Santulli, G.; Cipolletta, E.; Cerullo, V.; Cimini, V.; Altobelli, G.G.; Piscione, F.; Priante, O.; Pastore, L.; Chiariello, M.; Salvatore, F.; Koch, W.J.; Trimarco, B. Circ. Res., 2005, 97, 1182.
95. Pons, J.; Kitlinska, J.; Ji, H.; Lee, E.W.; Zukowska, Z. Can. J. Physiol. Pharmacol., 2003, 81, 177.
96. Papaconstantinou, M.E.; Carrell, C.J.; Pineda, A.O.; Bobofchak, K.M.; Mathews, F.S.; Flordellis, C.S.; Maragoudakis, M.E.; Tsopanoglou, N.E.; Di Cera, E. J. Biol. Chem., 2005, 280, 29393.
97. D'Adamo, D.R.; Anderson, S.E.; Albritton, K.; Yamada, J.; Riedel, E.; Scheu, K.; Schwartz, G.K.; Chen, H.; Maki, R.G. J. Clin. Oncol., 2005, 23, 7135.
98. Bozec, A.; Fischel, J.L.; Milano, G. Curr. Opin. Oncol., 2006, 18, 330.
99. Maione, P.; Gridelli, C.; Troiani, T.; Ciardiello, F. Oncologist, 2006, 11, 274.
100. Siu, L.L.; Awada, A.; Takimoto, C.H.; Piccart, M.; Schwartz, B.; Giannaris, T.; Lathia, C.; Petrenciuc, O.; Moore, M.J. Clin. Cancer Res., 2006, 12, 144.
101. Denduluri, N.; Tan, A.R.; Walshe, J.; Berman, A.; Yang, S.X.; Chow, C.K.; Swain, S.M. Clin. Breast Cancer, 2005, 6, 460.
102. Thaker, P.H.; Yazici, S.; Nilsson, M.B.; Yokoi, K.; Tsan, R.Z.; He, J.; Kim, S.J.; Fidler, I.J.; Sood, A.K. Clin. Cancer Res., 2005, 11, 4923.
103. Younes, M.N.; Yazici, Y.D.; Kim, S.; Jasser, S.A.; El-Naggar, A.K.; Myers, J.N. Clin. Cancer Res., 2006, 12, 3425.
104. Arteaga, C.L. Clin. Cancer Res., 2003, 9, 1231.
105. Beeram, M.; Patnaik, A.; Rowinsky, E.K. J. Clin. Oncol., 2005, 23, 6771.
106. Ratain, M.J.; Eisen, T.; Stadler, W.M.; Flaherty, K.T.; Kaye, S.B.; Rosner, G.L.; Gore, M.; Desai, A.A.; Patnaik, A.; Xiong, H.Q.; Rowinsky, E.; Abbruzzese, J.L.; Xia, C.; Simantov, R.; Schwartz, B.; O'Dwyer, P.J. J. Clin. Oncol., 2006, 24, 2505.
107. Atkins, M.; Jones, C.A.; Kirkpatrick, P. Nat. Rev. Drug Discov., 2006, 5, 279.
108. Motzer, R.J.; Michaelson, M.D.; Redman, B.G.; Hudes, G.R.; Wilding, G.; Figlin, R.A.; Ginsberg, M.S.; Kim, S.T.; Baum, C.M.; DePrimo, S.E.; Li, J.Z.; Bello, C.L.; Theuer, C.P.; George, D.J.; Rini, B.I. J. Clin. Oncol., 2006, 24, 16.
109. Carlomagno, F.; Anaganti, S.; Guida, T.; Salvatore, G.; Troncone, G.; Wilhelm, S.M.; Santoro, M. J. Natl. Cancer Inst., 2006, 98, 326.
110. Mross, K.; Drevs, J.; Muller, M.; Medinger, M.; Marme, D.; Hennig, J.; Morgan, B.; Lebwohl, D.; Masson, E.; Ho, Y.Y.; Gunther, C.; Laurent, D.; Unger, C. Eur. J. Cancer, 2005, 41, 1291.
111. Morabito, A.; De Maio, E.; Di Maio, M.; Normanno, N.; Perrone, F. Oncologist, 2006, 11, 753.
112. Berman, D.M.; Karhadkar, S.S.; Maitra, A.; Montes De Oca, R.; Gerstenblith, M.R.; Briggs, K.; Parker, A.R.; Shimada, Y.; Eshleman, J.R.; Watkins, D.N.; Beachy, P.A. Nature, 2003, 425, 846.
113. Karkoulias, G.; Mastrogianni, O.; Lymperopoulos, A.; Paris, H.; Flordellis, C. Cell Signal., 2006, 18, 729.
114. Breitwieser, G.E. Circ. Res., 2004, 94, 17.
115. Bulenger, S.; Marullo, S.; Bouvier, M. Trends Pharmacol. Sci., 2005, 26, 131.
116. Kroeger, K.M.; Pfleger, K.D.; Eidne, K.A. Front. Neuroendocrinol., 2003, 24, 254.
117. Ma, B.; Shatsky, M.; Wolfson, H.J.; Nussinov, R. Protein Sci., 2002, 11, 184.
118. Espinoza-Fonseca, L.M. Bioorg. Med. Chem., 2006, 14, 896.