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Volumn 5, Issue 11, 1995, Pages 1155-1158

Potent dual antagonists of endothelin and angiotensin II receptors derived from α-phenoxyphenylacetic acids (Part III)

Author keywords

[No Author keywords available]

Indexed keywords

2 PHENOXY 2 PHENYLACETIC ACID DERIVATIVE; ANGIOTENSIN 2 RECEPTOR; ANGIOTENSIN II ANTAGONIST; ENDOTHELIN RECEPTOR; ENDOTHELIN RECEPTOR ANTAGONIST; IMIDAZO[4,5 B]PYRIDINE DERIVATIVE; L 746072; UNCLASSIFIED DRUG;

EID: 18244424424     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0960-894X(95)00186-W     Document Type: Article
Times cited : (40)

References (22)
  • 16
    • 84921207383 scopus 로고    scopus 로고
    • Walsh, T.F.; Fitch, K.J.; Chang, R.S.L.; Faust, K.A.; Chen, T.-B.; Kivlighn, S.D.; Zingaro, G.J.; Lotti, V.J.; Siegl, P.K.S.; Patchett, A.A.; Greenlee, W.J. Bioorg. Med. Chem. Lett. preceding communication.
  • 19
    • 84921207381 scopus 로고    scopus 로고
    • 1H-NMR and FAB-mass spectra were recorded for all new compounds.
  • 21
    • 84921207380 scopus 로고    scopus 로고
    • 3OD, ppm): δ 0.79 (t, J=7.60 Hz, 3H), 1.17 (d, J=7.20 Hz, 6H), 1.21 (t, J=7.60 Hz, 3H), 1.45–1.53 (m, 2H), 2.41–2.49 (m, 1H), 2.53–2.64 (m, 1H), 2.59 (s, 3H), 2.61 (s, 3H), 2.82 (q, J=7.60 Hz, 2H), 5.23 (s, 1H), 5.41 (s, 2H), 5.91 (br s, 2H), 6.57 (d, J=8.40 Hz, 1H), 6.72–6.76 (m, 2H), 6.91 (d, J=2.40 Hz, 1H), 6.59–6.97 (m, 2H), 7.02 (s, 1H), 7.15 (d, J=8.20 Hz, 2H), 7.63 (d, J=8.20 Hz, 2H). FAB-MS: m/e 683 (M+1).
  • 22
    • 84921207379 scopus 로고    scopus 로고
    • 2) receptors as described in: Chang, R.S.L.; Siegl, P.K.S.; Clineschmidt, B.V.; Mantlo, N.B.; Chakravarty, P.K.; Greenlee, W.J.; Patchett, A.A.; Lotti, V.J. J. Pharmacol. Exp. Ther.1992, 262, 133 with the exception that the 0.2% BSA component was ommited.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.