Regulation of extracellular signal-regulated kinase cascades by α- and β-isoforms of the human thromboxane A2 receptor

Molecular Pharmacology

Volumn 61, Issue 4, 2002, Pages 817-831

  Miggin, Sinead M ^a   Kinsella, B Therese ^a  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; 7 [3 [(4 PHENYLSEMICARBAZIDO)METHYL] 7 OXABICYCLO[2.2.1]HEPT 2 YL] 5 HEPTENOIC ACID; BETA GALACTOSIDASE; EPIDERMAL GROWTH FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; NUCLEOTIDE; PROTEIN KINASE B; PROTEIN KINASE C; THROMBOXANE A2 RECEPTOR;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; ENZYME REGULATION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOPRECIPITATION; MITOGENESIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL;

1-PHOSPHATIDYLINOSITOL 3-KINASE; 15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; CELLS, CULTURED; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; INDOLES; ISOQUINOLINES; MALEIMIDES; MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN ISOFORMS; PROTO-ONCOGENE PROTEINS A-RAF; PROTO-ONCOGENE PROTEINS C-RAF; RAP GTP-BINDING PROTEINS; RECEPTORS, THROMBOXANE; SULFONAMIDES; TRANSFECTION;

EID: 0036203142     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.61.4.817     Document Type: Article

References (40)

1. The RAF family: An expanding network of posttranslational controls and protein-protein interactions
2. Transmodulation of epidermal growth factor receptor function by cyclic AMP-dependent protein kinase
3. Endothelin-1 and fibroblast growth factors stimulate the mitogen-activate protein kinase signalling cascade in cardiac myocytes
4. Purification and properties of extracellular signal-regulated kinase 1, an insulin-stimulated microtubule-associated protein 2 kinase
5. ras-directed activation of extracellular signal-regulated kinase 2 and phosphorylation of mSos nucleotide exchange factor
6. The small GTP-binding proteins rac-1 and cdc-42 regulate the activity of the JNK/SAPK signalling pathway
7. Thromboxane/prostaglandin endoperoxide-induced hypertrophy of rat vascular smooth muscle cells is signalled by protein kinase C-dependent increases in transforming growth factor-β
8. 2-adrenergic receptor to different G proteins by protein kinase A
9. Cellular survival: A play in three Akts
10. cAMP and βγ subunits of heterotrimeric G-proteins stimulate the mitogen-activated protein kinase pathway in COS-7 cells
11. Cyclic AMP activates the mitogen-activated protein kinase cascade in PC12 cells
12. The thromboxane A2 receptor activates mitogen-activated protein kinase via protein kinase C-dependent Gi coupling and Src-dependent phosphorylation of the epidermal growth factor receptor
13. 2
14. 2 induces cell signalling but requires platelet-derived growth factor to act as a mitogen
15. Isotype-specific functions of raf kinases
16. Activation of thromboxane and prostacyclin receptors elicits opposing effects on vascular smooth muscle cell growth and mitogen-activated protein kinase signalling cascades
17. 2 signalling in humans: A 'tail' of two receptors
18. Posttranslational modification of Ha-ras by farnesyl versus geranylgeranyl isoprenoids is determined by the COOH-terminal amino acid
19. Cellular expression of the carboxyl terminus of a protein-coupled receptor kinase attenuates Gβγ-mediated signalling
20. Protein kinase A dependent phosphorylation of serine 357 of the mouse prostacyclin receptor regulated its coupling to Gs-, Gi- and to Gq-coupled effector signalling
21. Gβγ stimulates phosphoinositide 3-kinase-γ by direct interaction with two domains of the catalytic p110 subunit
22. Phosphoinositide 3-kinase γ is a mediator of Gβγ-dependent jun kinase activation
23. Selective inhibition of protein kinase C isozymes by the indolocarbazole Go 6976
24. 2 receptor (TP) alpha and beta isoforms
25. 2 receptor mediated activation of the mitogen activated protein kinase cascades in human uterine smooth muscle cells
26. 2 mimetic I-BOP in A7r5 cells
27. 2-stimulated mitogenesis of coronary artery smooth muscle cells involves activation of mitogen-activated protein kinase and S6 kinase
28. Prostanoid receptors: Structures, properties, and functions
29. Pharmacological inhibition of protein kinases in intact cells: Antagonism of beta adrenergic receptor ligand binding by H-89 reveals limitations of usefulness
30. 2-adrenergic receptor activates extracellular signal regulated kinases (ERKs) via the small G-protein rap1 and the serine/threonine kinase B-raf
31. 2 receptor or PKC
32. Regulation of the ERK subgroup of MAP kinase cascades through G protein-coupled receptors
33. A phosphatidylinositol 3-kinase-dependent pathway that differentially regulates c-raf and a-raf
34. Phosphoinositide 3-kinases: A conserved family of signal transducers
35. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)
36. 2 receptor alpha and beta isoforms
37. 2 receptor (TP) is a target for prostacyclin mediated desensitization
38. 1 and IP receptors
39. Direct association of Grb2 with the p85 subunit of phosphatidylinositol 3-kinase
40. Structure and function of phosphoinositide 3-kinases