메뉴 건너뛰기




Volumn 18, Issue 4, 2006, Pages 354-359

Targeting angiogenesis for the treatment of sarcoma

Author keywords

Anti angiogenesis; Sarcoma; Treatment; Vascular endothelial growth factor

Indexed keywords

2,4 DIMETHYL 5 (2 OXO 1H INDOL 3 YLMETHYLENE) 3 PYRROLEPROPIONIC ACID; 4 DEDIMETHYLAMINOSANCYCLINE; AE 941; ALITRETINOIN; ALPHA INTERFERON; ANGIOGENESIS INHIBITOR; ANGIOSTATIN; ANTHRACYCLINE; ANTIAMEBIC AGENT; ANTINEOPLASTIC AGENT; BEVACIZUMAB; CILENGITIDE; COMBRETASTATIN; DOXORUBICIN; ENDOSTATIN; FUMAGILLIN; FUMAGILLOL CHLOROACETYLCARBAMATE; IM 862; IMATINIB; MARIMASTAT; NEUTRALIZING ANTIBODY; OXIGENE; PRINOMASTAT; PROTEIN TYROSINE KINASE INHIBITOR; RAZOXANE; REBIMASTAT; RETINOIC ACID; SEMAXANIB; SORAFENIB; SQUALAMINE; SUNITINIB; THALIDOMIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASCULOTROPIN ANTIBODY; VATALANIB; VINCA ALKALOID; ZK 22584;

EID: 33748092028     PISSN: 10408746     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.cco.0000228741.64541.ca     Document Type: Review
Times cited : (38)

References (63)
  • 1
    • 7544227802 scopus 로고    scopus 로고
    • Soft tissue sarcoma in children and adolescents: Experiences of the cooperative Soft Tissue Sarcoma Group Studies (CWS-81-96)
    • Brecht IB, Treuner J. Soft tissue sarcoma in children and adolescents: experiences of the cooperative Soft Tissue Sarcoma Group Studies (CWS-81-96) [in German]. Handchir Mikrochir Plast Chir 2004; 36:275-281.
    • (2004) Handchir Mikrochir Plast Chir , vol.36 , pp. 275-281
    • Brecht, I.B.1    Treuner, J.2
  • 3
    • 0017704418 scopus 로고
    • Dose response evaluation of adriamycin in human neoplasia
    • O'Bryan RM, Baker LH, Gottlieb JE, et al. Dose response evaluation of adriamycin in human neoplasia. Cancer 1977; 39:1940-1948.
    • (1977) Cancer , vol.39 , pp. 1940-1948
    • O'Bryan, R.M.1    Baker, L.H.2    Gottlieb, J.E.3
  • 4
    • 0024513428 scopus 로고
    • Response to ifosfamide and mesna: 124 Previously treated patients with metastatic or unresectable sarcoma
    • Antman KH, Ryan L, Elias A, et al. Response to ifosfamide and mesna: 124 previously treated patients with metastatic or unresectable sarcoma. J Clin Oncol 1989; 7:126-131.
    • (1989) J Clin Oncol , vol.7 , pp. 126-131
    • Antman, K.H.1    Ryan, L.2    Elias, A.3
  • 5
    • 0027280571 scopus 로고
    • An intergroup phase III randomized study of doxorubicin and dacarbazine with or without ifosfamide and mesna in advanced soft tissue and bone sarcomas
    • Antman K, Crowley J, Balcerzak SP, et al. An intergroup phase III randomized study of doxorubicin and dacarbazine with or without ifosfamide and mesna in advanced soft tissue and bone sarcomas. J Clin Oncol 1993; 11:1276-1285.
    • (1993) J Clin Oncol , vol.11 , pp. 1276-1285
    • Antman, K.1    Crowley, J.2    Balcerzak, S.P.3
  • 6
    • 0031865087 scopus 로고    scopus 로고
    • Results of two consecutive trials of dose-intensive chemotherapy with doxorubicin and ifosfamide in patients with sarcomas
    • Patel SR, et al. Results of two consecutive trials of dose-intensive chemotherapy with doxorubicin and ifosfamide in patients with sarcomas. Am J Clin Oncol 1998; 21:317-321.
    • (1998) Am J Clin Oncol , vol.21 , pp. 317-321
    • Patel, S.R.1
  • 7
    • 0027256397 scopus 로고
    • Randomized comparison of doxorubicin alone versus ifosfamide plus doxorubicin or mitomycin, doxorubicin, and cisplatin against advanced soft tissue sarcomas
    • Edmonson JH, Ryan LM, Blum RH, et al. Randomized comparison of doxorubicin alone versus ifosfamide plus doxorubicin or mitomycin, doxorubicin, and cisplatin against advanced soft tissue sarcomas. J Clin Oncol 1993; 11:1269-1275.
    • (1993) J Clin Oncol , vol.11 , pp. 1269-1275
    • Edmonson, J.H.1    Ryan, L.M.2    Blum, R.H.3
  • 8
    • 18144448739 scopus 로고    scopus 로고
    • Randomized phase II study of docetaxel versus doxorubicin in first- and second-line chemotherapy for locally advanced or metastatic soft tissue sarcomas in adults: A study of the European organization for research and treatment of cancer soft tissue and bone sarcoma group
    • Verweij J, Lee SM, Ruka W, et al. Randomized phase II study of docetaxel versus doxorubicin in first- and second-line chemotherapy for locally advanced or metastatic soft tissue sarcomas in adults: a study of the European organization for research and treatment of cancer soft tissue and bone sarcoma group. J Clin Oncol 2000; 18:2081-2086.
    • (2000) J Clin Oncol , vol.18 , pp. 2081-2086
    • Verweij, J.1    Lee, S.M.2    Ruka, W.3
  • 9
    • 0036984640 scopus 로고    scopus 로고
    • Role of angiogenesis in tumor growth and metastasis
    • Folkman J. Role of angiogenesis in tumor growth and metastasis. Semin Oncol 2002; 29:15.
    • (2002) Semin Oncol , vol.29 , pp. 15
    • Folkman, J.1
  • 10
    • 0031454617 scopus 로고    scopus 로고
    • Endostatin: An endogenous inhibitor of angiogenesis and tumor growth
    • O'Reilly MS, Boehm T, Shing Y, et al. Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Cell 1997; 88:277-285.
    • (1997) Cell , vol.88 , pp. 277-285
    • O'Reilly, M.S.1    Boehm, T.2    Shing, Y.3
  • 11
    • 1642307340 scopus 로고    scopus 로고
    • Endostatin's antiangiogenic signaling network
    • Abdollahi A, Hahnfeldt P, Maercker C, et al. Endostatin's antiangiogenic signaling network. Mol Cell 2004; 13:649-663.
    • (2004) Mol Cell , vol.13 , pp. 649-663
    • Abdollahi, A.1    Hahnfeldt, P.2    Maercker, C.3
  • 12
    • 0026708632 scopus 로고
    • The vascular endothelial growth factor proteins: Identification of biologically relevant regions by neutralizing monoclonal antibodies
    • Kim KJ, Li B, Houck K, et al. The vascular endothelial growth factor proteins: identification of biologically relevant regions by neutralizing monoclonal antibodies. Growth Factors 1992; 7:53-64.
    • (1992) Growth Factors , vol.7 , pp. 53-64
    • Kim, K.J.1    Li, B.2    Houck, K.3
  • 13
    • 0037143764 scopus 로고    scopus 로고
    • VEGF-Trap: A VEGF blocker with potent antitumor effects
    • Holash J, Davis S, Papadopoulos N, et al. VEGF-Trap: a VEGF blocker with potent antitumor effects. Proc Natl Acad Sci U S A 2002; 99:11393-11398.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 11393-11398
    • Holash, J.1    Davis, S.2    Papadopoulos, N.3
  • 14
    • 2942689227 scopus 로고    scopus 로고
    • Effective inhibition of Rta expression and lytic replication of Kaposi's sarcoma-associated herpesvirus by human RNase P
    • Zhu J, Trang P, Kim K, et al. Effective inhibition of Rta expression and lytic replication of Kaposi's sarcoma-associated herpesvirus by human RNase P. Proc Natl Acad Sci U S A 2004; 101:9073-9078.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 9073-9078
    • Zhu, J.1    Trang, P.2    Kim, K.3
  • 15
    • 33644843339 scopus 로고    scopus 로고
    • SU11248, a multi-targeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, demonstrated antitumor activity in patients with metastatic renal cell carcinoma
    • Motzer RJ, Michaelson MD, Redman BG, et al. SU11248, a multi-targeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, demonstrated antitumor activity in patients with metastatic renal cell carcinoma. J Clin Oncol 2005; 24:1-8. SU11248, a tyrosine kinase inhibitor of VEGF and PDGF, demonstrated clinical activity as a second-line agent in renal cell carcinoma.
    • (2005) J Clin Oncol , vol.24 , pp. 1-8
    • Motzer, R.J.1    Michaelson, M.D.2    Redman, B.G.3
  • 16
    • 24344448690 scopus 로고    scopus 로고
    • Expression and activity of vascular endothelial growth factor and metalloproteinases in alveolar and embryonal rhabdomyosarcoma cell lines
    • Onisto M, Slongo ML, Gregnanin L, et al. Expression and activity of vascular endothelial growth factor and metalloproteinases in alveolar and embryonal rhabdomyosarcoma cell lines. Int J Oncol 2005; 27:791-798.
    • (2005) Int J Oncol , vol.27 , pp. 791-798
    • Onisto, M.1    Slongo, M.L.2    Gregnanin, L.3
  • 17
    • 28544444282 scopus 로고    scopus 로고
    • Vascular endothelial growth factor acts in an autocrine manner in rhabdomyosarcoma cell lines and can be inhibited with all-trans-retinoic acid
    • Gee MF, Tsuchida R, Eichler-Jonsson C, et al. Vascular endothelial growth factor acts in an autocrine manner in rhabdomyosarcoma cell lines and can be inhibited with all-trans-retinoic acid. Oncogene 2005; 24:8025-8037. The study presents preclinical data in rhabdomyosarcoma cell lines indicating that autocrine VEGF signaling likely influences its growth and inhibition of VEGF may be effective treatment for rhabdomyosarcoma.
    • (2005) Oncogene , vol.24 , pp. 8025-8037
    • Gee, M.F.1    Tsuchida, R.2    Eichler-Jonsson, C.3
  • 18
    • 23344435454 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor and its receptor, KDR/Flk-1, in soft tissue sarcomas
    • Pakos EE, Goussia AC, Tsekeris PG, et al. Expression of vascular endothelial growth factor and its receptor, KDR/Flk-1, in soft tissue sarcomas. Anticancer Res 2005; 25:3591-3596.
    • (2005) Anticancer Res , vol.25 , pp. 3591-3596
    • Pakos, E.E.1    Goussia, A.C.2    Tsekeris, P.G.3
  • 19
    • 29244443976 scopus 로고    scopus 로고
    • Microvessel density does not predict outcome in high grade soft tissue sarcoma
    • West CC, Brown NJ, Mangham DC, et al. Microvessel density does not predict outcome in high grade soft tissue sarcoma. Eur J Surg Oncol 2005; 31:1198-2105.
    • (2005) Eur J Surg Oncol , vol.31 , pp. 1198-2105
    • West, C.C.1    Brown, N.J.2    Mangham, D.C.3
  • 20
    • 18344390219 scopus 로고    scopus 로고
    • Increased pre-therapeutic serum vascular endothelial growth factor in patients with early clinical relapse of osteosarcoma
    • Kaya M, Wada T, Kawaguchi S, et al. Increased pre-therapeutic serum vascular endothelial growth factor in patients with early clinical relapse of osteosarcoma. Br J Cancer 2002; 86:864-869.
    • (2002) Br J Cancer , vol.86 , pp. 864-869
    • Kaya, M.1    Wada, T.2    Kawaguchi, S.3
  • 21
    • 18844467502 scopus 로고    scopus 로고
    • Vascular endothelial growth factor expression in untreated osteosarcoma is predictive of pulmonary metastasis and poor prognosis
    • Kaya M, Wada T, Akatsuka T, et al. Vascular endothelial growth factor expression in untreated osteosarcoma is predictive of pulmonary metastasis and poor prognosis. Clin Cancer Res 2000; 6:572-577.
    • (2000) Clin Cancer Res , vol.6 , pp. 572-577
    • Kaya, M.1    Wada, T.2    Akatsuka, T.3
  • 22
    • 11144245499 scopus 로고    scopus 로고
    • Prognostic relevance of increased angiogenesis in osteosarcoma
    • Kreuter M, Bieker R, Bielack SS, et al. Prognostic relevance of increased angiogenesis in osteosarcoma. Clin Cancer Res 2004; 10:8531-8537.
    • (2004) Clin Cancer Res , vol.10 , pp. 8531-8537
    • Kreuter, M.1    Bieker, R.2    Bielack, S.S.3
  • 23
    • 16844366948 scopus 로고    scopus 로고
    • Vascular endothelial growth factor: A therapeutic target for tumors of the Ewing's sarcoma family
    • Dalal S, Berry AM, Cullinane CJ, et al. Vascular endothelial growth factor: a therapeutic target for tumors of the Ewing's sarcoma family. Clin Cancer Res 2005; 11:2364-2378.
    • (2005) Clin Cancer Res , vol.11 , pp. 2364-2378
    • Dalal, S.1    Berry, A.M.2    Cullinane, C.J.3
  • 24
    • 17644403503 scopus 로고    scopus 로고
    • A small interfering RNA targeting vascular endothelial growth factor inhibits Ewing's sarcoma growth in a xenograft mouse model
    • Guan H, Zhou Z, Wang H, et al. A small interfering RNA targeting vascular endothelial growth factor inhibits Ewing's sarcoma growth in a xenograft mouse model. Clin Cancer Res 2005; 11:2662-2669.
    • (2005) Clin Cancer Res , vol.11 , pp. 2662-2669
    • Guan, H.1    Zhou, Z.2    Wang, H.3
  • 25
    • 4444286921 scopus 로고    scopus 로고
    • Circulating angiogenic factor levels correlate with extent of disease and risk of recurrence in patients with soft tissue sarcoma
    • Yoon SS, Segal NH, Olshen AB, et al. Circulating angiogenic factor levels correlate with extent of disease and risk of recurrence in patients with soft tissue sarcoma. Ann Oncol 2004; 15:1261-1266.
    • (2004) Ann Oncol , vol.15 , pp. 1261-1266
    • Yoon, S.S.1    Segal, N.H.2    Olshen, A.B.3
  • 26
    • 84864966774 scopus 로고    scopus 로고
    • Bethesda: National Cancer Institute
    • National Cancer Institute. Understanding cancer series: angiogenesis. Bethesda: National Cancer Institute; 2006. http://www.cancer.gov/cancertopics/ understandingcancer/angiogenesis. [Accessed 25 January 2006]. National Cancer Institute website that includes a comprehensive review of molecules in the angiogenesis pathway with discussion of early clinical studies.
    • (2006) Understanding Cancer Series: Angiogenesis
  • 27
    • 14544305077 scopus 로고    scopus 로고
    • Combination of antiangiogenic therapy with other anticancer therapies: Results, challenges, and open questions
    • Gasparini G, Longo R, Fanelli M, Teicher BA. Combination of antiangiogenic therapy with other anticancer therapies: results, challenges, and open questions. J Clin Oncol 2005; 23:1295-1311. Excellent review of anti-angiogenic agents in translational and early-phase clinical studies.
    • (2005) J Clin Oncol , vol.23 , pp. 1295-1311
    • Gasparini, G.1    Longo, R.2    Fanelli, M.3    Teicher, B.A.4
  • 28
    • 0033593014 scopus 로고    scopus 로고
    • Thrombospondin-2: A potent endogenous inhibitor of tumor growth and angiogenesis
    • Streit M, Riccardi L, Velasco P, et al. Thrombospondin-2: a potent endogenous inhibitor of tumor growth and angiogenesis. Proc Natl Acad Sci U S A 1999; 96:14888-14893.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 14888-14893
    • Streit, M.1    Riccardi, L.2    Velasco, P.3
  • 29
    • 0033638716 scopus 로고    scopus 로고
    • Soluble vascular endothelial growth factor levels in patients with primary colorectal carcinoma
    • The Danish RANX05 Colorectal Cancer Study Group
    • Werther K, Christensen IJ, Brunner N, Nielsen HJ. Soluble vascular endothelial growth factor levels in patients with primary colorectal carcinoma. The Danish RANX05 Colorectal Cancer Study Group. Eur J Surg Oncol 2000; 26:657-662.
    • (2000) Eur J Surg Oncol , vol.26 , pp. 657-662
    • Werther, K.1    Christensen, I.J.2    Brunner, N.3    Nielsen, H.J.4
  • 30
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz H, Fehrenbacher L, Novotny W, et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004; 350:2335-2342. Pivotal phase III study in metastatic colorectal cancer with bevacizumab added to fluouracil-based combination chemotherapy that resulted in a statistically signifi-cant survival benefit.
    • (2004) N Engl J Med , vol.350 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3
  • 31
    • 20044364346 scopus 로고    scopus 로고
    • Randomized phase III trial of capecitabine compared with bevacizumab plus capecitabine in patients with previously treated metastatic breast cancer
    • Miller KD, Chap LI, Holmes FA, et al. Randomized phase III trial of capecitabine compared with bevacizumab plus capecitabine in patients with previously treated metastatic breast cancer. J Clin Oncol 2005; 23:792-799.
    • (2005) J Clin Oncol , vol.23 , pp. 792-799
    • Miller, K.D.1    Chap, L.I.2    Holmes, F.A.3
  • 32
    • 30944452354 scopus 로고    scopus 로고
    • Treatment of metastatic renal cell carcinoma with a combination of bevacizumab and erlotinib
    • Hainsworth JD, Sosman JA, Spigel DR, et al. Treatment of metastatic renal cell carcinoma with a combination of bevacizumab and erlotinib. J Clin Oncol 2005; 23:7889-7896.
    • (2005) J Clin Oncol , vol.23 , pp. 7889-7896
    • Hainsworth, J.D.1    Sosman, J.A.2    Spigel, D.R.3
  • 33
    • 22144471081 scopus 로고    scopus 로고
    • Randomized phase II/III Trial of paclitaxel (P) plus carboplatin (C) with or without bevacizumab (NSC #704865) in patients with advanced non-squamous non-small cell lung cancer (NSCLC): An Eastern Cooperative Oncology Group (ECOG) Trial - E4599
    • Sandler AB, Gray R, Brahmer J, et al. Randomized phase II/III Trial of paclitaxel (P) plus carboplatin (C) with or without bevacizumab (NSC #704865) in patients with advanced non-squamous non-small cell lung cancer (NSCLC): an Eastern Cooperative Oncology Group (ECOG) Trial - E4599 [abstract]. J Clin Oncol 2005; 16S:LBA4.
    • (2005) J Clin Oncol , vol.16 S
    • Sandler, A.B.1    Gray, R.2    Brahmer, J.3
  • 34
    • 27244450145 scopus 로고    scopus 로고
    • Phase II study of doxorubicin and bevacizumab for patients with metastatic soft-tissue sarcomas
    • D'Adamo DR, Anderson SE, Albritton K. Phase II study of doxorubicin and bevacizumab for patients with metastatic soft-tissue sarcomas. J Clin Oncol 2005; 23:7135-7142. Anthracycline-naïve patients with advanced soft tissue sarcoma received doxorubicin and bevacizumab with 12% partial response and 65% stable disease (lasting 4 cycles), although with increased incidence of cardiotoxicity despite routine use of dexrazoxane (6/17 patients with grade 2 or more cardiotoxicity).
    • (2005) J Clin Oncol , vol.23 , pp. 7135-7142
    • D'Adamo, D.R.1    Anderson, S.E.2    Albritton, K.3
  • 35
    • 0032748385 scopus 로고    scopus 로고
    • Antitumor activity of thalidomide in refractory multiple myeloma
    • Singhal S, Mehta J, Desikan R, et al. Antitumor activity of thalidomide in refractory multiple myeloma. N Engl J Med 1999; 341:1565-1571.
    • (1999) N Engl J Med , vol.341 , pp. 1565-1571
    • Singhal, S.1    Mehta, J.2    Desikan, R.3
  • 36
    • 0037710726 scopus 로고    scopus 로고
    • Therapy of AIDS-associated Kaposi's sarcoma: Targeting pathogenetic mechanisms
    • Krown SE. Therapy of AIDS-associated Kaposi's sarcoma: targeting pathogenetic mechanisms. Hematol Oncol Clin North Am 2003; 17:763-783.
    • (2003) Hematol Oncol Clin North Am , vol.17 , pp. 763-783
    • Krown, S.E.1
  • 38
    • 2942711726 scopus 로고    scopus 로고
    • Thalidomide: Current role in the treatment of non-plasma cell malignancies
    • Kumar S, Witzig TE, Rajkumar SV. Thalidomide: current role in the treatment of non-plasma cell malignancies. J Clin Oncol 2004; 22:2477-2488.
    • (2004) J Clin Oncol , vol.22 , pp. 2477-2488
    • Kumar, S.1    Witzig, T.E.2    Rajkumar, S.V.3
  • 39
    • 23944495120 scopus 로고    scopus 로고
    • Thalidomide downregulates angiogenic genes in bone marrow endothelial cells of patients with active multiple myeloma
    • Vacca A, Scavelli C, Montefusco V, et al. Thalidomide downregulates angiogenic genes in bone marrow endothelial cells of patients with active multiple myeloma. J Clin Oncol 2005; 23:5334-5346. A recent report reviewing the mechanism of thalidomide in multiple myeloma, with attention to its role in altering the function of angiogenic genes.
    • (2005) J Clin Oncol , vol.23 , pp. 5334-5346
    • Vacca, A.1    Scavelli, C.2    Montefusco, V.3
  • 40
    • 29144436646 scopus 로고    scopus 로고
    • Phase II trial of thalidomide for advanced and recurrent gynecologic sarcoma: A brief communication from the New York Phase II consortium
    • Yi-Shin Kuo D, Timmins P, Blank SV, et al. Phase II trial of thalidomide for advanced and recurrent gynecologic sarcoma: a brief communication from the New York Phase II consortium. Gynecol Oncol 2006; 100:160-165.
    • (2006) Gynecol Oncol , vol.100 , pp. 160-165
    • Yi-Shin Kuo, D.1    Timmins, P.2    Blank, S.V.3
  • 41
    • 0031675320 scopus 로고    scopus 로고
    • Activity of thalidomide in AIDS-related Kaposi's sarcoma and correlation with HHV8 titre
    • Fife K, Howard MR, Gracie F, et al. Activity of thalidomide in AIDS-related Kaposi's sarcoma and correlation with HHV8 titre. Int J STD AIDS 1998; 9:751-755.
    • (1998) Int J STD AIDS , vol.9 , pp. 751-755
    • Fife, K.1    Howard, M.R.2    Gracie, F.3
  • 42
    • 0033916672 scopus 로고    scopus 로고
    • Activity of thalidomide in AIDS-related Kaposi's sarcoma
    • Little RF, Wyvill KM, Pluda JM, et al. Activity of thalidomide in AIDS-related Kaposi's sarcoma. J Clin Oncol 2000; 18:2593-2602.
    • (2000) J Clin Oncol , vol.18 , pp. 2593-2602
    • Little, R.F.1    Wyvill, K.M.2    Pluda, J.M.3
  • 43
    • 0037319957 scopus 로고    scopus 로고
    • 9-Cis-retinoic acid capsules in the treatment of AIDS-related Kaposi sarcoma: Results of a phase 2 multicenter clinical trial
    • Aboulafia DM, Norris D, Henry D, et al. 9-Cis-retinoic acid capsules in the treatment of AIDS-related Kaposi sarcoma: results of a phase 2 multicenter clinical trial. Arch Dermatol 2003; 139:178-186.
    • (2003) Arch Dermatol , vol.139 , pp. 178-186
    • Aboulafia, D.M.1    Norris, D.2    Henry, D.3
  • 44
    • 0037083808 scopus 로고    scopus 로고
    • Antitumor activity of oral 9-cis-retinoic acid in HIV-associated Kaposi's sarcoma
    • Miles SA, Dezube BJ, Lee JY, et al. Antitumor activity of oral 9-cis-retinoic acid in HIV-associated Kaposi's sarcoma. AIDS 2002; 16:421-429.
    • (2002) AIDS , vol.16 , pp. 421-429
    • Miles, S.A.1    Dezube, B.J.2    Lee, J.Y.3
  • 45
    • 0037114717 scopus 로고    scopus 로고
    • A multicenter phase II study of the intravenous administration of liposomal tretinoin in patients with acquired immunodeficiency syndrome-associated Kaposi's sarcoma
    • Bernstein ZP, Chanan-Khan A, Miller KC, et al. A multicenter phase II study of the intravenous administration of liposomal tretinoin in patients with acquired immunodeficiency syndrome-associated Kaposi's sarcoma. Cancer 2002; 95:2555-2561.
    • (2002) Cancer , vol.95 , pp. 2555-2561
    • Bernstein, Z.P.1    Chanan-Khan, A.2    Miller, K.C.3
  • 46
    • 33644840580 scopus 로고    scopus 로고
    • Targeted therapy for metastatic renal cell carcinoma
    • Patel PH, Chaganti RS, Motzer RJ. Targeted therapy for metastatic renal cell carcinoma. Br J Cancer 2006; 94:614-619.
    • (2006) Br J Cancer , vol.94 , pp. 614-619
    • Patel, P.H.1    Chaganti, R.S.2    Motzer, R.J.3
  • 47
    • 33748062718 scopus 로고    scopus 로고
    • FDA approves new treatment for gastrointestinal and kidney cancer
    • FDA News. FDA approves new treatment for gastrointestinal and kidney cancer. http://www.fda.gov/bbs/topics/news/2006/NEW01302.html. [Accessed 25 February 2006].
    • FDA News
  • 48
    • 28044467635 scopus 로고    scopus 로고
    • Phase 3, multicenter, randomized, double-blind, placebo-controlled trial of SU11248 in patients (pts) following failure of imatinib for metastatic GIST
    • Demetri GD, van Oosterom AT, Blackstein M, et al. Phase 3, multicenter, randomized, double-blind, placebo-controlled trial of SU11248 in patients (pts) following failure of imatinib for metastatic GIST [abstract]. J Clin Oncol 2005; 16S:4000. An American Society of Clinical Oncology presentation of the multi-targeted inhibitor VEGF receptor and PDGF receptor, SI11248 (sunitinib), with clinical activity following failure of imatinib resulting in accelerated approval of the drug by the Food and Drugs Administration. Median time-to-tumor progression for patients treated with sunitinib (sutent) was 27 weeks compared to 6 weeks for patients who were not treated.
    • (2005) J Clin Oncol , vol.16 S , pp. 4000
    • Demetri, G.D.1    Van Oosterom, A.T.2    Blackstein, M.3
  • 49
    • 33748069191 scopus 로고    scopus 로고
    • FDA approves new treatment for advanced kidney cancer
    • FDA News. FDA approves new treatment for advanced kidney cancer. http://www.fda.gov/bbs/topics/NEWS/2005/NEW01282.html. [Accessed 25 February 2006].
    • FDA News
  • 50
    • 23844455555 scopus 로고    scopus 로고
    • Final findings from a phase II, placebo-controlled, randomized discontinuation trial (RDT) of sorafenib (BAY 43-9006) in patients with advanced renal cell carcinoma (RCC)
    • abstr 4544
    • Ratain MJ, Eisen T, Stadler WM, et al. Final findings from a phase II, placebo-controlled, randomized discontinuation trial (RDT) of sorafenib (BAY 43-9006) in patients with advanced renal cell carcinoma (RCC). J Clin Oncol 2005; 23:388 (abstr 4544). In a randomized phase III comparison against placebo in relapsed advanced renal cell carcinoma patients, sorafenib doubled median progression free survival (24 versus 12 weeks).
    • (2005) J Clin Oncol , vol.23 , pp. 388
    • Ratain, M.J.1    Eisen, T.2    Stadler, W.M.3
  • 51
    • 27244457769 scopus 로고    scopus 로고
    • Raf: A strategic target for therapeutic development against cancer
    • Beeram M, Patnaik A, Rowinsky EK. Raf: a strategic target for therapeutic development against cancer. J Clin Oncol 2005; 23:6771-6790. A review that discusses the structure and diverse functions of Raf, the rationale for targeting Raf, and the current status of small molecules.
    • (2005) J Clin Oncol , vol.23 , pp. 6771-6790
    • Beeram, M.1    Patnaik, A.2    Rowinsky, E.K.3
  • 52
    • 4444250452 scopus 로고    scopus 로고
    • Phase II study of the antiangiogenic agent SU5416 in patients with advanced soft tissue sarcomas
    • Heymach JV, Desai J, Manola J, et al. Phase II study of the antiangiogenic agent SU5416 in patients with advanced soft tissue sarcomas. Clin Cancer Res 2004; 10:5732-5740.
    • (2004) Clin Cancer Res , vol.10 , pp. 5732-5740
    • Heymach, J.V.1    Desai, J.2    Manola, J.3
  • 53
    • 0038327794 scopus 로고    scopus 로고
    • Efficacy and toxicity of the angiogenesis inhibitor SU5416 as a single agent in patients with advanced renal cell carcinoma, melanoma, and soft tissue sarcoma
    • Kuenen BC, Tabernero J, Baselga J, et al. Efficacy and toxicity of the angiogenesis inhibitor SU5416 as a single agent in patients with advanced renal cell carcinoma, melanoma, and soft tissue sarcoma. Clin Cancer Res 2003; 9:1648-1655.
    • (2003) Clin Cancer Res , vol.9 , pp. 1648-1655
    • Kuenen, B.C.1    Tabernero, J.2    Baselga, J.3
  • 54
    • 1642459321 scopus 로고    scopus 로고
    • The effect of human tissue factor pathway inhibitor-2 on the growth and metastasis of fibrosarcoma tumors in athymic mice
    • Chand HS, Du X, Ma D, et al. The effect of human tissue factor pathway inhibitor-2 on the growth and metastasis of fibrosarcoma tumors in athymic mice. Blood 2004; 103:1069-1077.
    • (2004) Blood , vol.103 , pp. 1069-1077
    • Chand, H.S.1    Du, X.2    Ma, D.3
  • 55
    • 0034544536 scopus 로고    scopus 로고
    • Antiangiogenic effects of latent antithrombin through perturbed cell-matrix interactions and apoptosis of endothelial cells
    • Larsson H, Sjoblom T, Dixelius J, et al. Antiangiogenic effects of latent antithrombin through perturbed cell-matrix interactions and apoptosis of endothelial cells. Cancer Res 2000; 60:6723-6729.
    • (2000) Cancer Res , vol.60 , pp. 6723-6729
    • Larsson, H.1    Sjoblom, T.2    Dixelius, J.3
  • 56
    • 30144442299 scopus 로고    scopus 로고
    • Up-to-date epidemiological data and better treatment for Kaposi's sarcoma
    • Alamartine E. Up-to-date epidemiological data and better treatment for Kaposi's sarcoma. Transplantation 2005; 80:1656-1657.
    • (2005) Transplantation , vol.80 , pp. 1656-1657
    • Alamartine, E.1
  • 57
    • 1442339463 scopus 로고    scopus 로고
    • Highly active antiretroviral therapy in AIDS-associated Kaposi's sarcoma: Implications for the design of therapeutic trials in patients with advanced, symptomatic Kaposi's sarcoma
    • Krown SE. Highly active antiretroviral therapy in AIDS-associated Kaposi's sarcoma: implications for the design of therapeutic trials in patients with advanced, symptomatic Kaposi's sarcoma. J Clin Oncol 2004; 22:399-402. This commentary discusses the anti-tumor effects of highly active anti-retroviral therapy from agents under study for treatment of Kaposi's sarcoma.
    • (2004) J Clin Oncol , vol.22 , pp. 399-402
    • Krown, S.E.1
  • 58
    • 0033957239 scopus 로고    scopus 로고
    • Results of a randomized study of IM862 nasal solution in the treatment of AIDS-related Kaposi's sarcoma
    • Tulpule A, Scadden DT, Espina BM, et al. Results of a randomized study of IM862 nasal solution in the treatment of AIDS-related Kaposi's sarcoma. J Clin Oncol 2000; 18:716-723.
    • (2000) J Clin Oncol , vol.18 , pp. 716-723
    • Tulpule, A.1    Scadden, D.T.2    Espina, B.M.3
  • 59
    • 14644445181 scopus 로고    scopus 로고
    • Angiogenesis inhibitor IM862 is ineffective against AIDS-Kaposi's sarcoma in a phase III trial, but demonstrates sustained, potent effect of highly active antiretroviral therapy: From the AIDS Malignancy Consortium and IM862 Study Team
    • Noy A, Scadden DT, Lee J, et al. Angiogenesis inhibitor IM862 is ineffective against AIDS-Kaposi's sarcoma in a phase III trial, but demonstrates sustained, potent effect of highly active antiretroviral therapy: from the AIDS Malignancy Consortium and IM862 Study Team. J Clin Oncol 2005; 23:990-998. Despite apparent activity of IM862 in phase I and II clinical studies, there was no clinical activity seen in a blinded, placebo-controlled randomized phase III clinical study. This study underscores the importance of phase III clinical studies.
    • (2005) J Clin Oncol , vol.23 , pp. 990-998
    • Noy, A.1    Scadden, D.T.2    Lee, J.3
  • 60
    • 20044393819 scopus 로고    scopus 로고
    • Imatinib-induced regression of AIDS-related Kaposi's sarcoma
    • Koon HB, Bubley GJ, Pantanowitz L, et al. Imatinib-induced regression of AIDS-related Kaposi's sarcoma. J Clin Oncol 2005; 23:982-989.
    • (2005) J Clin Oncol , vol.23 , pp. 982-989
    • Koon, H.B.1    Bubley, G.J.2    Pantanowitz, L.3
  • 61
    • 0036137547 scopus 로고    scopus 로고
    • Matrix metalloproteinase inhibitor COL-3 in the treatment of AIDS-related Kaposi's sarcoma: A phase I AIDS malignancy consortium study
    • Cianfrocca M, Cooley TP, Lee JY, et al. Matrix metalloproteinase inhibitor COL-3 in the treatment of AIDS-related Kaposi's sarcoma: a phase I AIDS malignancy consortium study. J Clin Oncol 2002; 20:153-159.
    • (2002) J Clin Oncol , vol.20 , pp. 153-159
    • Cianfrocca, M.1    Cooley, T.P.2    Lee, J.Y.3
  • 62
    • 0036085271 scopus 로고    scopus 로고
    • Treatment of Kaposi's sarcoma with human chorionic gonadotropin
    • Simonart T, Van Vooren JP, Meuris S. Treatment of Kaposi's sarcoma with human chorionic gonadotropin. Dermatology 2002; 204:330-333.
    • (2002) Dermatology , vol.204 , pp. 330-333
    • Simonart, T.1    Van Vooren, J.P.2    Meuris, S.3
  • 63
    • 0031897809 scopus 로고    scopus 로고
    • Fumagillin analog in the treatment of Kaposi's sarcoma: A phase I AIDS Clinical Trial Group study
    • Dezube BJ, Von Roenn JH, Holden-Wiltse J, et al. Fumagillin analog in the treatment of Kaposi's sarcoma: a phase I AIDS Clinical Trial Group study. J Clin Oncol 1998; 16:1444-1449.
    • (1998) J Clin Oncol , vol.16 , pp. 1444-1449
    • Dezube, B.J.1    Von Roenn, J.H.2    Holden-Wiltse, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.