메뉴 건너뛰기




Volumn 32, Issue 2, 2007, Pages 123-136

Plerixafor hydrochloride. Chemokine CXCR4 (SDF-1) antagonist stem cell-mobilizing agent

Author keywords

[No Author keywords available]

Indexed keywords

1,1' [1,4 PHENYLENEBIS(METHYLENE)]BIS(1,4,8,11 TETRAAZACYCLOTETRADECANE); BUSULFAN; CARBOPLATIN; CHEMOKINE RECEPTOR CXCR4 ANTAGONIST; CISPLATIN; CYCLOPHOSPHAMIDE; CYTARABINE; ETOPOSIDE; FLUDARABINE; GRANULOCYTE COLONY STIMULATING FACTOR; IFOSFAMIDE; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MEPREDNISONE; MOZOBIL; PLERIXAFOR HYDROCHLORIDE; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; RITUXIMAB; SDZ SID 791; THYMOCYTE ANTIBODY; UNCLASSIFIED DRUG;

EID: 34247530304     PISSN: 03778282     EISSN: None     Source Type: Journal    
DOI: 10.1358/dof.2007.032.02.1071897     Document Type: Review
Times cited : (10)

References (106)
  • 1
    • 0040401412 scopus 로고
    • Dinickel and dicopper complexes with N,N-linked bis(cyclam) ligands. An ideal system for the investigation of electrostatic effects on the redox behavior of pairs of metal ions
    • Ciampolini, M., Fabbrizzi, L., Perotti, A., Poggi, A., Seghi, B., Zanobini, F. Dinickel and dicopper complexes with N,N-linked bis(cyclam) ligands. An ideal system for the investigation of electrostatic effects on the redox behavior of pairs of metal ions. Inorg Chem 1987, 26(21): 3527-33.
    • (1987) Inorg Chem , vol.26 , Issue.21 , pp. 3527-3533
    • Ciampolini, M.1    Fabbrizzi, L.2    Perotti, A.3    Poggi, A.4    Seghi, B.5    Zanobini, F.6
  • 2
    • 0029067663 scopus 로고
    • Synthesis and structure-activity relationships of phenylenebis(methylene)-linked bis-tetraazamacrocycles that inhibit HIV replication. Effects of macrocyclic ring size and substituents on the aromatic linker
    • Bridger, G.J., Skerlj, R.T., Thornton, D. et al. Synthesis and structure-activity relationships of phenylenebis(methylene)-linked bis-tetraazamacrocycles that inhibit HIV replication. Effects of macrocyclic ring size and substituents on the aromatic linker. J Med Chem 1995, 38(2): 366-78.
    • (1995) J Med Chem , vol.38 , Issue.2 , pp. 366-378
    • Bridger, G.J.1    Skerlj, R.T.2    Thornton, D.3
  • 3
    • 0002592568 scopus 로고    scopus 로고
    • New facile and convenient synthesis of bispolyazamacrocyles using Boc protection. Determination of geometric parameters of dinuclear copper(II) complexes using ESR spectroscopy and molecular mechanics calculations
    • Brandes, S., Gros, C., Denat, F., Pullumbi, P., Guilard, R. New facile and convenient synthesis of bispolyazamacrocyles using Boc protection. Determination of geometric parameters of dinuclear copper(II) complexes using ESR spectroscopy and molecular mechanics calculations. Bull Soc Chim Fr 1996, 133(1): 65-73.
    • (1996) Bull Soc Chim Fr , vol.133 , Issue.1 , pp. 65-73
    • Brandes, S.1    Gros, C.2    Denat, F.3    Pullumbi, P.4    Guilard, R.5
  • 4
    • 0032959833 scopus 로고    scopus 로고
    • New bicyclam-AZT conjugates: Design, synthesis, anti-HIV evaluation, and their interction with CXCR-4 coreceptor
    • Dessolin, J., Galea, P., Vlieghe, P., Chermann, J.-C., Kraus, J.-L. New bicyclam-AZT conjugates: Design, synthesis, anti-HIV evaluation, and their interction with CXCR-4 coreceptor. J Med Chem 1999, 42(2): 229-41.
    • (1999) J Med Chem , vol.42 , Issue.2 , pp. 229-241
    • Dessolin, J.1    Galea, P.2    Vlieghe, P.3    Chermann, J.-C.4    Kraus, J.-L.5
  • 5
    • 34247540163 scopus 로고    scopus 로고
    • Giandomenico, C.M, Yang, W, AnorMED, Inc, Process for preparation of N-1 protected N ring nitrogen containing cyclic polyamines and products thereof. WO 0226721
    • Giandomenico, C.M., Yang, W. (AnorMED, Inc.). Process for preparation of N-1 protected N ring nitrogen containing cyclic polyamines and products thereof. WO 0226721.
  • 6
    • 0037450906 scopus 로고    scopus 로고
    • Facile N-1 protection of cyclam, cyclen and 1,4,7-triazacyclonanene
    • Yan, W., Giandomenico, C.M., Sartori, M., Moore, D.A. Facile N-1 protection of cyclam, cyclen and 1,4,7-triazacyclonanene. Tetrahedron Lett 2003, 44: 2481-3.
    • (2003) Tetrahedron Lett , vol.44 , pp. 2481-2483
    • Yan, W.1    Giandomenico, C.M.2    Sartori, M.3    Moore, D.A.4
  • 7
    • 34247488532 scopus 로고    scopus 로고
    • Prashad, M, Kapa, P, Johnson Matthey plc, Process for preparing 1,1′-[1,4-phenylenebis-methylene, bis-1,4,8,11- tetraazacyclotetradecane. WO 9634860
    • Prashad, M., Kapa, P. (Johnson Matthey plc). Process for preparing 1,1′-[1,4-phenylenebis-(methylene)]-bis-1,4,8,11- tetraazacyclotetradecane. WO 9634860.
  • 8
    • 34247470942 scopus 로고    scopus 로고
    • Xu, D, Kapa, P, Repic, O, Blacklock, T.J, Johnson Matthey plc, Process for preparing 1,1′-[1,4-phenylenebis-methylene, bis-1,4,8,11- tetraazacyclotetradecane. WO 9630349
    • Xu, D., Kapa, P., Repic, O., Blacklock, T.J. (Johnson Matthey plc). Process for preparing 1,1′-[1,4-phenylenebis-(methylene)]-bis-1,4,8,11- tetraazacyclotetradecane. WO 9630349.
  • 9
    • 0030598007 scopus 로고    scopus 로고
    • An expeditious synthesis of a biscyclam with an aromatic linker
    • Xu, D., Mattner, P.G., Prasad, K., Repic, O., Blacklock, T.J. An expeditious synthesis of a biscyclam with an aromatic linker. Tetrahedron Lett 1996, 37(30): 5301-4.
    • (1996) Tetrahedron Lett , vol.37 , Issue.30 , pp. 5301-5304
    • Xu, D.1    Mattner, P.G.2    Prasad, K.3    Repic, O.4    Blacklock, T.J.5
  • 10
    • 0042074662 scopus 로고    scopus 로고
    • Achmatowicz, M., Hegedus, L.S. Direct synthesis of 1,1′-[1,4-phenylenebis(methylene)]-bis-1,4,8,11-tetraazacyclotetradecane octahydrochloride (AMD 3100) without the use of protecting groups. J Org Chem 2003, 68(16): 6435-6.
    • Achmatowicz, M., Hegedus, L.S. Direct synthesis of 1,1′-[1,4-phenylenebis(methylene)]-bis-1,4,8,11-tetraazacyclotetradecane octahydrochloride (AMD 3100) without the use of protecting groups. J Org Chem 2003, 68(16): 6435-6.
  • 12
    • 34247509900 scopus 로고    scopus 로고
    • Handel, H, Yaouanc, J.-J, Zegzouti, A.F. et al, Centre National de la Recherche Scientifique [CNRS, Process for the preparation of monofunctionalized cyclic tetramines. US 5047527
    • Handel, H., Yaouanc, J.-J., Zegzouti, A.F. et al. (Centre National de la Recherche Scientifique [CNRS]). Process for the preparation of monofunctionalized cyclic tetramines. US 5047527.
  • 14
    • 0031822843 scopus 로고    scopus 로고
    • Efficient one-pot synthesis of JM3100
    • Guillaume, D., Marshall, G.R. Efficient one-pot synthesis of JM3100. Synth Commun 1998, 28(15): 2903-6.
    • (1998) Synth Commun , vol.28 , Issue.15 , pp. 2903-2906
    • Guillaume, D.1    Marshall, G.R.2
  • 15
    • 0036803279 scopus 로고    scopus 로고
    • Chemokines, chemokine receptors and small-molecule antagonists: Recent developments
    • Onuffer, J.J., Horuk, R. Chemokines, chemokine receptors and small-molecule antagonists: Recent developments. Trends Pharmacol Sci 2002, 23(10): 459-67.
    • (2002) Trends Pharmacol Sci , vol.23 , Issue.10 , pp. 459-467
    • Onuffer, J.J.1    Horuk, R.2
  • 16
    • 33344464945 scopus 로고    scopus 로고
    • CXCR4: A key receptor in the crosstalk between tumor cells and their microenvironment
    • Burger, J.A., Kipps, T.J. CXCR4: A key receptor in the crosstalk between tumor cells and their microenvironment. Blood 2006, 107(5): 1761-7.
    • (2006) Blood , vol.107 , Issue.5 , pp. 1761-1767
    • Burger, J.A.1    Kipps, T.J.2
  • 17
    • 0031026475 scopus 로고    scopus 로고
    • The chemokine SDF-1 is a chemoattractant for human CD34+ hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34+ progenitors to peripheral blood
    • Aiuti, A., Webb, I.J., Bleul, C., Springer, T., Gutierrez-Ramos, J.C. The chemokine SDF-1 is a chemoattractant for human CD34+ hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34+ progenitors to peripheral blood. J Exp Med 1997, 185: 111-20.
    • (1997) J Exp Med , vol.185 , pp. 111-120
    • Aiuti, A.1    Webb, I.J.2    Bleul, C.3    Springer, T.4    Gutierrez-Ramos, J.C.5
  • 18
    • 0033524834 scopus 로고    scopus 로고
    • Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4
    • Peled, A., Petit, I., Kollet, O. et al. Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4. Science 1999, 283: 845-8.
    • (1999) Science , vol.283 , pp. 845-848
    • Peled, A.1    Petit, I.2    Kollet, O.3
  • 20
    • 0029080968 scopus 로고
    • Broad inter-individual variations in circulating progenitor cell numbers induced by granulocyte colony-stimulating factor therapy
    • Roberts, A.W., DeLuca, E., Begley, C.G., Basser, R., Grigg, A.P., Metcalf, D. Broad inter-individual variations in circulating progenitor cell numbers induced by granulocyte colony-stimulating factor therapy. Stem Cells 1995, 13: 512-6.
    • (1995) Stem Cells , vol.13 , pp. 512-516
    • Roberts, A.W.1    DeLuca, E.2    Begley, C.G.3    Basser, R.4    Grigg, A.P.5    Metcalf, D.6
  • 21
    • 23444445718 scopus 로고    scopus 로고
    • Antiviral drug discovery and development: Where chemistry meets with biomedicine
    • De Clercq, E. Antiviral drug discovery and development: Where chemistry meets with biomedicine. Antiviral Res 2005, 67(2): 56-75.
    • (2005) Antiviral Res , vol.67 , Issue.2 , pp. 56-75
    • De Clercq, E.1
  • 22
    • 0029086827 scopus 로고
    • Quantitative structural activity relationship study of bis-tetraazacyclic compounds. A novel series of HIV-1 and HIV-2 inhibitors
    • Joao, H.C., De, V.K., Pauwels, R., De, C.E., Henson, G.W., Bridger, G.J. Quantitative structural activity relationship study of bis-tetraazacyclic compounds. A novel series of HIV-1 and HIV-2 inhibitors. J Med Chem 1995, 38(19): 3865-73.
    • (1995) J Med Chem , vol.38 , Issue.19 , pp. 3865-3873
    • Joao, H.C.1    De, V.K.2    Pauwels, R.3    De, C.E.4    Henson, G.W.5    Bridger, G.J.6
  • 23
    • 34247550500 scopus 로고
    • Structure-activity relationships in the anti-HIV activity of bis-azamacrocycles: Highly potent inhibitors of HIV replication with a unique mechanism of action
    • March 13-17, San Diego, Abst MEDI-23
    • Bridger, G.J., Skerji, R.T., Padmanabhan, S. et al. Structure-activity relationships in the anti-HIV activity of bis-azamacrocycles: Highly potent inhibitors of HIV replication with a unique mechanism of action. 207th ACS Natl Meet (March 13-17, San Diego) 1994, Abst MEDI-23.
    • (1994) 207th ACS Natl Meet
    • Bridger, G.J.1    Skerji, R.T.2    Padmanabhan, S.3
  • 24
    • 34247513216 scopus 로고
    • Synthesis and anti-HIV activity of aromatic linked bis-azamacrocycles
    • March 13-17, San Diego, Abst MEDI-24
    • Skerli, R.T., Bridger, G.J., Padmanabhan, S. et al. Synthesis and anti-HIV activity of aromatic linked bis-azamacrocycles. 207th ACS Natl Meet (March 13-17, San Diego) 1994, Abst MEDI-24.
    • (1994) 207th ACS Natl Meet
    • Skerli, R.T.1    Bridger, G.J.2    Padmanabhan, S.3
  • 25
    • 34247540608 scopus 로고
    • Highly selective and potent inhibition of human immunodeficiency virus (HIV) by the novel bicyclam derivative JM3100
    • Abst 3
    • De Clercq, E., Yamamoto, N., Pauwels, R. et al. Highly selective and potent inhibition of human immunodeficiency virus (HIV) by the novel bicyclam derivative JM3100. Antivir Res 1993, 20(Suppl. 1): Abst 3.
    • (1993) Antivir Res , vol.20 , Issue.SUPPL. 1
    • De Clercq, E.1    Yamamoto, N.2    Pauwels, R.3
  • 26
    • 33748352845 scopus 로고
    • SDZ SID 791 (JM 3100): A mechanistically unique anti-HIV agent with potent antiviral activity in vitro and in vivo
    • ICAAC, Oct 4-7, Orlando, Abst F158
    • Datema, R., Abrams, M., Bridger, G. et al. SDZ SID 791 (JM 3100): A mechanistically unique anti-HIV agent with potent antiviral activity in vitro and in vivo. 34th Intersci Conf Antimicrob Agents Chemother (ICAAC) (Oct 4-7, Orlando) 1994, Abst F158.
    • (1994) 34th Intersci Conf Antimicrob Agents Chemother
    • Datema, R.1    Abrams, M.2    Bridger, G.3
  • 27
    • 34247548975 scopus 로고
    • SDZ SID 791 (JM 3100): A mechanistically unique anti-HIV agent with potent antiviral activity in vitro and in vivo
    • Aug 7-12, Yokohama, Abst 113A
    • Datema, R. SDZ SID 791 (JM 3100): A mechanistically unique anti-HIV agent with potent antiviral activity in vitro and in vivo. 10th Int Conf AIDS (Aug 7-12, Yokohama) 1994, Abst 113A.
    • (1994) 10th Int Conf AIDS
    • Datema, R.1
  • 28
    • 0037063329 scopus 로고    scopus 로고
    • Chemokine receptor inhibition by AMD3100 is strictly confined to CXCR4
    • Hatse, S., Princen, K., Bridger, G., De Clercq, E., Schols, D. Chemokine receptor inhibition by AMD3100 is strictly confined to CXCR4. FEBS Lett 2002, 527(1-3): 255-62.
    • (2002) FEBS Lett , vol.527 , Issue.1-3 , pp. 255-262
    • Hatse, S.1    Princen, K.2    Bridger, G.3    De Clercq, E.4    Schols, D.5
  • 29
    • 0035957911 scopus 로고    scopus 로고
    • Molecular interactions of cyclam and bicyclam non-peptide antagonists with the CXCR4 chemokine receptor
    • Gerlach, L.O., Skerlj, R.T., Bridger, G.J., Schwartz, T.W. Molecular interactions of cyclam and bicyclam non-peptide antagonists with the CXCR4 chemokine receptor. J Biol Chem 2001, 276(17): 14153-60.
    • (2001) J Biol Chem , vol.276 , Issue.17 , pp. 14153-14160
    • Gerlach, L.O.1    Skerlj, R.T.2    Bridger, G.J.3    Schwartz, T.W.4
  • 30
    • 0031891516 scopus 로고    scopus 로고
    • AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor
    • Donzella, G.A., Schols, D., Lin, S.W. et al. AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor. Nat Med 1998, 4: 72-7.
    • (1998) Nat Med , vol.4 , pp. 72-77
    • Donzella, G.A.1    Schols, D.2    Lin, S.W.3
  • 31
    • 4644227515 scopus 로고    scopus 로고
    • Safety, pharmacokinetics, and antiviral activity of AMD3100, a selective CXCR4 receptor inhibitor, in HIV-1 infection
    • Hendrix, C.W., Collier, A.C., Lederman, M.M. et al. Safety, pharmacokinetics, and antiviral activity of AMD3100, a selective CXCR4 receptor inhibitor, in HIV-1 infection. J Acquir Immune Defic Syndr 2004, 37(2): 1253-62.
    • (2004) J Acquir Immune Defic Syndr , vol.37 , Issue.2 , pp. 1253-1262
    • Hendrix, C.W.1    Collier, A.C.2    Lederman, M.M.3
  • 32
    • 0001609181 scopus 로고    scopus 로고
    • Interference of the SDF-1/CXCR4 axis in mice with AMD3100 induces rapid high level mobilization of hematopoietic progenitor cells, and AMD3100 acts synergistically with G-CSF and MIP-1α to mobilize progenitors
    • Abst 3371
    • Broxmeyer, H.E., Hangoc, G., Cooper, S., Bridger, G. Interference of the SDF-1/CXCR4 axis in mice with AMD3100 induces rapid high level mobilization of hematopoietic progenitor cells, and AMD3100 acts synergistically with G-CSF and MIP-1α to mobilize progenitors. Blood 2001, 98(11, Part 1): Abst 3371.
    • (2001) Blood , vol.98 , Issue.11 and PART 1
    • Broxmeyer, H.E.1    Hangoc, G.2    Cooper, S.3    Bridger, G.4
  • 33
    • 1642535388 scopus 로고    scopus 로고
    • Molecular mechanism of AMD3100 antagonism in the CXCR4 receptor: Transfer of binding site to the CXCR3 receptor
    • Rosenkilde, M.M., Gerlach, L.O., Jakobsen, J.S., Skerlj, R.T., Bridger, G.J., Schwartz, T.W. Molecular mechanism of AMD3100 antagonism in the CXCR4 receptor: Transfer of binding site to the CXCR3 receptor. J Biol Chem 2004, 279(4): 3033-41.
    • (2004) J Biol Chem , vol.279 , Issue.4 , pp. 3033-3041
    • Rosenkilde, M.M.1    Gerlach, L.O.2    Jakobsen, J.S.3    Skerlj, R.T.4    Bridger, G.J.5    Schwartz, T.W.6
  • 34
    • 20944440068 scopus 로고    scopus 로고
    • Rapid mobilization of murine and human hematopoietic stem and progenitor cells with AMD3100, a CXCR4 antagonist
    • Broxmeyer, H.E., Orschell, C.M., Clapp, D.W. et al. Rapid mobilization of murine and human hematopoietic stem and progenitor cells with AMD3100, a CXCR4 antagonist. J Exp Med 2005, 201(8): 1307-18.
    • (2005) J Exp Med , vol.201 , Issue.8 , pp. 1307-1318
    • Broxmeyer, H.E.1    Orschell, C.M.2    Clapp, D.W.3
  • 35
    • 34247543678 scopus 로고    scopus 로고
    • AMD3100, an antagonist of CXCR4, is a potent myeloid progenitor cell mobilizing agent in mouse strains differing in response to G-CSF-induced mobilization, and synergizes with G-CSF in these mice to enhance mobilization
    • Abst 34
    • Broxmeyer, H.E., Cooper, S., Hangoc, G., Bridger, G. AMD3100, an antagonist of CXCR4, is a potent myeloid progenitor cell mobilizing agent in mouse strains differing in response to G-CSF-induced mobilization, and synergizes with G-CSF in these mice to enhance mobilization. Exp Hematol 2002, 30(6, Suppl. 1): Abst 34.
    • (2002) Exp Hematol , vol.30 , Issue.6 and SUPPL. 1
    • Broxmeyer, H.E.1    Cooper, S.2    Hangoc, G.3    Bridger, G.4
  • 36
    • 0242325230 scopus 로고    scopus 로고
    • AMD3100, an antagonist of CXCR4 and mobilizer of myeloid progenitor cells, is a potent mobilizer of competitive repopulating long term marrow self-renewing stem cells in mice
    • Abst 2397
    • Broxmeyer, H.E., Hangoc, G., Cooper, S., Li, X., Bridger, G., Clapp, D.W. AMD3100, an antagonist of CXCR4 and mobilizer of myeloid progenitor cells, is a potent mobilizer of competitive repopulating long term marrow self-renewing stem cells in mice. Blood 2002, 100(11, Part 1): Abst 2397.
    • (2002) Blood , vol.100 , Issue.11 and PART 1
    • Broxmeyer, H.E.1    Hangoc, G.2    Cooper, S.3    Li, X.4    Bridger, G.5    Clapp, D.W.6
  • 37
    • 85112382120 scopus 로고    scopus 로고
    • The CXCR4 antagonist AMD3100 does not prevent homing and engraftment of murine syngeneic bone marrow stem cells
    • Abst 5074
    • van Os, R., Schols, D., Struyf, S., De Clercq, E., Willemze, R., Fibbe, W.E. The CXCR4 antagonist AMD3100 does not prevent homing and engraftment of murine syngeneic bone marrow stem cells. Blood 2000, 96(11, Part 2): Abst 5074.
    • (2000) Blood , vol.96 , Issue.11 and PART 2
    • van Os, R.1    Schols, D.2    Struyf, S.3    De Clercq, E.4    Willemze, R.5    Fibbe, W.E.6
  • 39
    • 27944510941 scopus 로고    scopus 로고
    • AMD3100-mobilized murine hematopoietic stem cells and T-lymphocytes have identical capacity to induce multilineage stem cell engraftment, donor T-cell chimerism and GVHD in mice compared with G-CSF mobilized cells
    • Abst 3495
    • Devine, S.M., Liu, F., Holt, M., Link, D., DiPersio, J.F. AMD3100-mobilized murine hematopoietic stem cells and T-lymphocytes have identical capacity to induce multilineage stem cell engraftment, donor T-cell chimerism and GVHD in mice compared with G-CSF mobilized cells. Blood 2003, 102(11, Part 1): Abst 3495.
    • (2003) Blood , vol.102 , Issue.11 and PART 1
    • Devine, S.M.1    Liu, F.2    Holt, M.3    Link, D.4    DiPersio, J.F.5
  • 40
    • 34247479786 scopus 로고    scopus 로고
    • Evaluation of the phenotype and GVHD-inducing potential of splenic T cells isolated from G-CSF, AMD3100, or G-CSF and AMD3100 pretreated allogeneic donors
    • Dec 10-13, Atlanta, Abst 5224
    • Rettig, M., Holt, M., Liu, F., Ritchey, J., Link, D., Bridger, G., DiPersio, J. Evaluation of the phenotype and GVHD-inducing potential of splenic T cells isolated from G-CSF, AMD3100, or G-CSF and AMD3100 pretreated allogeneic donors. Blood [47th Annu Meet Am Soc Hematol (Dec 10-13, Atlanta) 2005] 2005, 106(11): Abst 5224.
    • (2005) Blood [47th Annu Meet Am Soc Hematol , vol.106 , Issue.11
    • Rettig, M.1    Holt, M.2    Liu, F.3    Ritchey, J.4    Link, D.5    Bridger, G.6    DiPersio, J.7
  • 41
    • 34247473636 scopus 로고    scopus 로고
    • Allograft cell content and GVHD differ in murine recipients of AMD3100 versus G-CSF mobilized peripheral blood stem cells
    • Dec 10-13, Atlanta, Abst 3108
    • Lundqvist, A., Hamoui, N., Andersson, J. et al. Allograft cell content and GVHD differ in murine recipients of AMD3100 versus G-CSF mobilized peripheral blood stem cells. Blood [47th Annu Meet Am Soc Hematol (Dec 10-13, Atlanta) 2005] 2005, 106(11): Abst 3108.
    • (2005) Blood [47th Annu Meet Am Soc Hematol , vol.106 , Issue.11
    • Lundqvist, A.1    Hamoui, N.2    Andersson, J.3
  • 42
    • 34247544764 scopus 로고    scopus 로고
    • Kinetics of hematopoietic progenitor cell mobilization with cyclophosphamide or cyclophosphamide plus AMD3100 using a mouse model
    • Dec 10-13, Atlanta, Abst 5217
    • Gai, B.Q., Holt, M.S., Nervi, B., Rettig, M.P., Ritchey, J.K., Bridger, G., DiPersio, J.F. Kinetics of hematopoietic progenitor cell mobilization with cyclophosphamide or cyclophosphamide plus AMD3100 using a mouse model. Blood [47th Annu Meet Am Soc Hematol (Dec 10-13, Atlanta) 2005] 2005, 106(11): Abst 5217.
    • (2005) Blood [47th Annu Meet Am Soc Hematol , vol.106 , Issue.11
    • Gai, B.Q.1    Holt, M.S.2    Nervi, B.3    Rettig, M.P.4    Ritchey, J.K.5    Bridger, G.6    DiPersio, J.F.7
  • 43
    • 28444443372 scopus 로고    scopus 로고
    • Durable engraftment of AMD3100-mobilized autologous and allogeneic peripheral-blood mononuclear cells in a canine transplantation model
    • Burroughs, L., Mielcarek, M., Little, M.T. et al. Durable engraftment of AMD3100-mobilized autologous and allogeneic peripheral-blood mononuclear cells in a canine transplantation model. Blood 2005, 106(12): 4002-8.
    • (2005) Blood , vol.106 , Issue.12 , pp. 4002-4008
    • Burroughs, L.1    Mielcarek, M.2    Little, M.T.3
  • 44
    • 33646398840 scopus 로고    scopus 로고
    • AMD3100 mobilizes hematopoietic stem cells with long-term repopulating capacity in nonhuman primates
    • Larochelle, A., Krouse, A., Metzger, M. et al. AMD3100 mobilizes hematopoietic stem cells with long-term repopulating capacity in nonhuman primates. Blood 2006, 107(9): 3772-8.
    • (2006) Blood , vol.107 , Issue.9 , pp. 3772-3778
    • Larochelle, A.1    Krouse, A.2    Metzger, M.3
  • 45
    • 24744441090 scopus 로고    scopus 로고
    • The use of AMD3100 mobilized peripheral blood stem cell CD34+ targets for retroviral transduction results in high-level in vivo marking in rhesus macaques
    • Abst 5315
    • Larochelle, A., Krouse, A., Orlic, D., Donahue, R., Dunbar, C., Hematti, P. The use of AMD3100 mobilized peripheral blood stem cell CD34+ targets for retroviral transduction results in high-level in vivo marking in rhesus macaques. Blood 2003, 102(11, Part 2): Abst 5315.
    • (2003) Blood , vol.102 , Issue.11 and PART 2
    • Larochelle, A.1    Krouse, A.2    Orlic, D.3    Donahue, R.4    Dunbar, C.5    Hematti, P.6
  • 46
    • 34247480233 scopus 로고    scopus 로고
    • Proulx, C., El-Helou, V., Gosselin, H., Clement, R., Calderone, A. Antagonism of the stromal cell-derived factor 1-alpha receptor CXCR4 reduced scar size and improved ventricular function in myocardial infarcted rats. Circulation [Am Heart Assoc Sci Sess (Nov 13-16, Dallas) 2005] 2005, 112(17, Suppl. 2): Abst 849.
    • Proulx, C., El-Helou, V., Gosselin, H., Clement, R., Calderone, A. Antagonism of the stromal cell-derived factor 1-alpha receptor CXCR4 reduced scar size and improved ventricular function in myocardial infarcted rats. Circulation [Am Heart Assoc Sci Sess (Nov 13-16, Dallas) 2005] 2005, 112(17, Suppl. 2): Abst 849.
  • 47
    • 33748637393 scopus 로고    scopus 로고
    • AMD3100, a CXCR4 antagonist, augments mobilization and incorporation of bone marrow-derived endothelial progenitor cells into sites of myocardial neovascularization
    • Abst 752
    • Iwakura, A., Luedemann, C., Kusano, K., Takenaka, H., Eaton, E. AMD3100, a CXCR4 antagonist, augments mobilization and incorporation of bone marrow-derived endothelial progenitor cells into sites of myocardial neovascularization. Circulation 2003, 108(17, Suppl. 4): Abst 752.
    • (2003) Circulation , vol.108 , Issue.17 and SUPPL. 4
    • Iwakura, A.1    Luedemann, C.2    Kusano, K.3    Takenaka, H.4    Eaton, E.5
  • 48
    • 23844447551 scopus 로고    scopus 로고
    • AMD-3100, a CXCR4 antagonist, augments incorporation of bone marrow-derived endothelial progenitor cells into sites of myocardial neovascularization
    • Abst 1127
    • Iwakura, A., Yamaguchi, J., Luedemann, C., Asahara, T., Losordo, D., Bridger, G. AMD-3100, a CXCR4 antagonist, augments incorporation of bone marrow-derived endothelial progenitor cells into sites of myocardial neovascularization. Blood 2002, 100(11, Part 1): Abst 1127.
    • (2002) Blood , vol.100 , Issue.11 and PART 1
    • Iwakura, A.1    Yamaguchi, J.2    Luedemann, C.3    Asahara, T.4    Losordo, D.5    Bridger, G.6
  • 49
    • 28444439716 scopus 로고    scopus 로고
    • Contrast in the mobilization of hematopoietic versus endothelial progenitors by AMD3100 in a rhesus macaque infarction model
    • Abst 4332
    • Hu, J., Andersson, S., Orlic, D., Dunbar, C. Contrast in the mobilization of hematopoietic versus endothelial progenitors by AMD3100 in a rhesus macaque infarction model. Blood 2003, 102(11, Part 2): Abst 4332.
    • (2003) Blood , vol.102 , Issue.11 and PART 2
    • Hu, J.1    Andersson, S.2    Orlic, D.3    Dunbar, C.4
  • 50
    • 34247546848 scopus 로고    scopus 로고
    • The role of the CXCR4 inhibitor AMD3100 in multiple myeloma (MM)
    • Dec 10-13, Atlanta, Abst 2492
    • Ghobrial, I.M., Melhem, M., Singha, U. et al. The role of the CXCR4 inhibitor AMD3100 in multiple myeloma (MM). Blood [47th Annu Meet Am Soc Hematol (Dec 10-13, Atlanta) 2005] 2005, 106(11): Abst 2492.
    • (2005) Blood [47th Annu Meet Am Soc Hematol , vol.106 , Issue.11
    • Ghobrial, I.M.1    Melhem, M.2    Singha, U.3
  • 51
    • 0043085011 scopus 로고    scopus 로고
    • In vitro preclinical activity of the novel AMD3100 CXCR4 antagonist in lymphoma models
    • Abst 2276
    • Paul, S., Mancuso, P., Rabascio, C. et al. In vitro preclinical activity of the novel AMD3100 CXCR4 antagonist in lymphoma models. Blood 2002, 100(11, Part 1): Abst 2276.
    • (2002) Blood , vol.100 , Issue.11 and PART 1
    • Paul, S.1    Mancuso, P.2    Rabascio, C.3
  • 52
    • 34247482076 scopus 로고    scopus 로고
    • The CXCR4 antagonist, AMD3100, inhibits AML transmigratory activity but does not alter blast proliferation or survival
    • Abst 2881
    • Liesveld, J.L., Lancet, J.E., Rosell, K.E., Bechelli, J., Abboud, C.N., Phillips, G.L. The CXCR4 antagonist, AMD3100, inhibits AML transmigratory activity but does not alter blast proliferation or survival. Blood 2004, 104(11, Part 1): Abst 2881.
    • (2004) Blood , vol.104 , Issue.11 and PART 1
    • Liesveld, J.L.1    Lancet, J.E.2    Rosell, K.E.3    Bechelli, J.4    Abboud, C.N.5    Phillips, G.L.6
  • 53
    • 0038103869 scopus 로고    scopus 로고
    • Effects of inhibitors of the chemokine receptor CXCR4 on acute lymphoblastic leukemia cells in vitro
    • Juarez, J., Bradstock, K.F., Gottlieb, D.J., Bendall, L.J. Effects of inhibitors of the chemokine receptor CXCR4 on acute lymphoblastic leukemia cells in vitro. Leukemia 2003, 17(7): 1294-300.
    • (2003) Leukemia , vol.17 , Issue.7 , pp. 1294-1300
    • Juarez, J.1    Bradstock, K.F.2    Gottlieb, D.J.3    Bendall, L.J.4
  • 54
    • 34247523014 scopus 로고    scopus 로고
    • The SDF-1/CXCR4 pathway is involved in the homing of chronic lymphocytic leukemia B cells and in their survival after migration into bone marrow stromal layers: Inhibition by the CXCR4 antagonist (AMD3100)
    • Abst 72
    • Lagneaux, L., Delforge, A., Dejeneffe, M., Schols, D., Bron, D. The SDF-1/CXCR4 pathway is involved in the homing of chronic lymphocytic leukemia B cells and in their survival after migration into bone marrow stromal layers: Inhibition by the CXCR4 antagonist (AMD3100). Exp Hematol 2002, 30(6, Suppl. 1): Abst 72.
    • (2002) Exp Hematol , vol.30 , Issue.6 and SUPPL. 1
    • Lagneaux, L.1    Delforge, A.2    Dejeneffe, M.3    Schols, D.4    Bron, D.5
  • 55
    • 0344823964 scopus 로고    scopus 로고
    • A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors
    • Rubin, J.B., Kung, A.L., Klein, R.S. et al. A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors. Proc Natl Acad Sci USA 2003, 100(23): 13513-8.
    • (2003) Proc Natl Acad Sci USA , vol.100 , Issue.23 , pp. 13513-13518
    • Rubin, J.B.1    Kung, A.L.2    Klein, R.S.3
  • 56
    • 34247529192 scopus 로고    scopus 로고
    • Systemic delivery of a small molecule inhibitor of CXCR4 blocks the growth of intracranial xenografts of glioblastoma multiforme and medulloblastoma
    • Abst ET-41
    • Rubin, J.B., Kung, A.L., Klein, R.S. et al. Systemic delivery of a small molecule inhibitor of CXCR4 blocks the growth of intracranial xenografts of glioblastoma multiforme and medulloblastoma. Neuro-Oncol 2003, 5(4): Abst ET-41.
    • (2003) Neuro-Oncol , vol.5 , Issue.4
    • Rubin, J.B.1    Kung, A.L.2    Klein, R.S.3
  • 57
    • 2342563895 scopus 로고    scopus 로고
    • Systemic delivery of a small molecule inhibitor of CXCR4 blocks the growth of intracranial xenografts of glioblastoma mutliforme
    • 2nd ed, Abst R2772
    • Rubin, J.B., Kung, A.L., Klein, R.S. et al. Systemic delivery of a small molecule inhibitor of CXCR4 blocks the growth of intracranial xenografts of glioblastoma mutliforme. Proc Am Assoc Cancer Res (AACR) 2003, 44(2nd ed): Abst R2772.
    • (2003) Proc Am Assoc Cancer Res (AACR) , vol.44
    • Rubin, J.B.1    Kung, A.L.2    Klein, R.S.3
  • 58
    • 34247525306 scopus 로고    scopus 로고
    • Blocking CXCR4, the receptor for SDF-1, in mice with ischemic acute renal failure (ARF) improves renal function and survival
    • Nov 8-13, Philadelphia, Abst F-PO292
    • Toegel, F.E., Hu, Z., Westenfelder, C. Blocking CXCR4, the receptor for SDF-1, in mice with ischemic acute renal failure (ARF) improves renal function and survival. 38th Annu Meet Am Soc Nephrol (ASN) (Nov 8-13, Philadelphia) 2005, Abst F-PO292.
    • (2005) 38th Annu Meet Am Soc Nephrol (ASN)
    • Toegel, F.E.1    Hu, Z.2    Westenfelder, C.3
  • 60
    • 35449006630 scopus 로고    scopus 로고
    • AMD3100 mobilizes acute promyelocyte leukemia cells from the bone marrow into the peripheral blood and sensitizes leukemia cells to chemotherapy
    • Dec 10-13, Atlanta, Abst 246
    • Nervi, B., Holt, M., Rettig, M.P., Bridger, G., Ley, T.J., DiPersio, J.F. AMD3100 mobilizes acute promyelocyte leukemia cells from the bone marrow into the peripheral blood and sensitizes leukemia cells to chemotherapy. Blood [47th Annu Meet Am Soc Hematol (Dec 10-13, Atlanta) 2005] 2005, 106(11): Abst 246.
    • (2005) Blood [47th Annu Meet Am Soc Hematol , vol.106 , Issue.11
    • Nervi, B.1    Holt, M.2    Rettig, M.P.3    Bridger, G.4    Ley, T.J.5    DiPersio, J.F.6
  • 61
    • 0036116174 scopus 로고    scopus 로고
    • AMD3100, a CxCR4 antagonist, attenuates allergic lung inflammation and airway hyperreactivity
    • Lukacs, N.W., Berlin, A., Schols, D., Skerlj, R.T., Bridger, G.J. AMD3100, a CxCR4 antagonist, attenuates allergic lung inflammation and airway hyperreactivity. Am J Pathol 2002, 160(4): 1353-60.
    • (2002) Am J Pathol , vol.160 , Issue.4 , pp. 1353-1360
    • Lukacs, N.W.1    Berlin, A.2    Schols, D.3    Skerlj, R.T.4    Bridger, G.J.5
  • 62
    • 33644677814 scopus 로고    scopus 로고
    • Pro-inflammatory properties of stromal cell-derived factor-1 (CXCL12) in collagen-induced arthritis
    • De Klerck, B., Geboes, L., Hatse, S. et al. Pro-inflammatory properties of stromal cell-derived factor-1 (CXCL12) in collagen-induced arthritis. Arthritis Res Ther 2005, 7(6): R1208-20.
    • (2005) Arthritis Res Ther , vol.7 , Issue.6
    • De Klerck, B.1    Geboes, L.2    Hatse, S.3
  • 63
    • 34247495770 scopus 로고    scopus 로고
    • Pro-inflammatory properties of stromal cell-derived factor-1 (SDF-1, CXCL12) in collagen-induced arthritis, and inhibition by a specific CXCR4 antagonist
    • Nov 3-7, Budapest, Abst
    • De Klerck, B., Hatse, S., Kelchtermans, H. et al. Pro-inflammatory properties of stromal cell-derived factor-1 (SDF-1, CXCL12) in collagen-induced arthritis, and inhibition by a specific CXCR4 antagonist. 4th Int Congr Autoimmun (Nov 3-7, Budapest) 2004, Abst.
    • (2004) 4th Int Congr Autoimmun
    • De Klerck, B.1    Hatse, S.2    Kelchtermans, H.3
  • 64
    • 0035887637 scopus 로고    scopus 로고
    • AMD3100, a potent and specific antagonist of the stromal cell-derived factor-1 chemokine receptor CXCR4, inhibits autoimmune joint inflammation in IFN-γ receptor-deficient mice
    • Matthys, P., Hatse, S., Vermeire, K. et al. AMD3100, a potent and specific antagonist of the stromal cell-derived factor-1 chemokine receptor CXCR4, inhibits autoimmune joint inflammation in IFN-γ receptor-deficient mice. J Immunol 2001, 167(8): 4686-92.
    • (2001) J Immunol , vol.167 , Issue.8 , pp. 4686-4692
    • Matthys, P.1    Hatse, S.2    Vermeire, K.3
  • 65
    • 34247464457 scopus 로고    scopus 로고
    • Chemokine CXCR-4 receptor blocker. AMD-3100: Clinical and pre-clinical studies of pharmacokinetics and safety
    • Jan 31-Feb 4, Chicago, Abst 610
    • Hendrix, C., Flexner, C., MacFarland, R., Giandomenico, C., Schweitzer, Henson, G. Chemokine CXCR-4 receptor blocker. AMD-3100: Clinical and pre-clinical studies of pharmacokinetics and safety. 6th Conf Retroviruses Opportunistic Infect (CROI) (Jan 31-Feb 4, Chicago) 1999, Abst 610.
    • (1999) 6th Conf Retroviruses Opportunistic Infect (CROI)
    • Hendrix, C.1    Flexner, C.2    MacFarland, R.3    Giandomenico, C.4
  • 66
    • 0030051924 scopus 로고    scopus 로고
    • Pharmacokinetics of the anti-HIV bicyclam SID791 (JM3100) in rabbits, as determined by both analytical and bio-assay methods
    • Witvrouw, M., Seifert, J.-M., Henson, G.W., Martellucci, S.A., Desmyter, J., De Clercq, E. Pharmacokinetics of the anti-HIV bicyclam SID791 (JM3100) in rabbits, as determined by both analytical and bio-assay methods. Antivir Chem Chemother 1996, 7(1): 27-30.
    • (1996) Antivir Chem Chemother , vol.7 , Issue.1 , pp. 27-30
    • Witvrouw, M.1    Seifert, J.-M.2    Henson, G.W.3    Martellucci, S.A.4    Desmyter, J.5    De Clercq, E.6
  • 67
    • 0034120373 scopus 로고    scopus 로고
    • Pharmacokinetics and safety of AMD-3100, a novel antagonist of the CXCR-4 chemokine receptor, in human volunteers
    • Hendrix, C.W., Flexner, C., MacFarland, R.T. et al. Pharmacokinetics and safety of AMD-3100, a novel antagonist of the CXCR-4 chemokine receptor, in human volunteers. Antimicrob Agents Chemother 2000, 44(6): 1667-73.
    • (2000) Antimicrob Agents Chemother , vol.44 , Issue.6 , pp. 1667-1673
    • Hendrix, C.W.1    Flexner, C.2    MacFarland, R.T.3
  • 69
    • 34247529194 scopus 로고    scopus 로고
    • A population pharmacokinetic/ pharmacodynamic model for the mobilization of progenitor cells by AMD3100
    • March 2-6, Orlando, Abst PII-160
    • Green, B., Lee, H., Lack, N. et al. A population pharmacokinetic/ pharmacodynamic model for the mobilization of progenitor cells by AMD3100. Clin Pharmacol Ther [Annu Meet Am Soc Clin Pharmacol Ther (ASCPT) (March 2-6, Orlando) 2005] 2005, 77(2): Abst PII-160.
    • (2005) Clin Pharmacol Ther [Annu Meet Am Soc Clin Pharmacol Ther (ASCPT) , vol.77 , Issue.2
    • Green, B.1    Lee, H.2    Lack, N.3
  • 70
    • 34247466223 scopus 로고    scopus 로고
    • Use of an indirect effect model to describe the mobilization of progenitor cells induced by AMD3100
    • June 16-17, Pamplona, Abst P-11
    • Green, B., Lee, H., Lack, N. et al. Use of an indirect effect model to describe the mobilization of progenitor cells induced by AMD3100. 14th Meet Popul Approach Group Eur (June 16-17, Pamplona) 2005, Abst P-11.
    • (2005) 14th Meet Popul Approach Group Eur
    • Green, B.1    Lee, H.2    Lack, N.3
  • 71
    • 27944496347 scopus 로고    scopus 로고
    • A pharmacokinetic/pharmacodynamic profile of the CXCR4 antagonist AMD3100 for the mobilization of hematopoietic progenitor cells
    • Abst 391
    • Lack, N.A., Dale, D.C.;, Calandra, G., MacFarland, R.T., Badel, K., Liles, W.C. A pharmacokinetic/pharmacodynamic profile of the CXCR4 antagonist AMD3100 for the mobilization of hematopoietic progenitor cells. Blood 2003, 102(11, Part 1): Abst 391.
    • (2003) Blood , vol.102 , Issue.11 and PART 1
    • Lack, N.A.1    Dale, D.C.2    Calandra, G.3    MacFarland, R.T.4    Badel, K.5    Liles, W.C.6
  • 72
    • 15244344083 scopus 로고    scopus 로고
    • Optimizing the use of AMD3100, a CXCR-4 antagonist, for mobilization of hematopoietic progenitor cells: Studies on healthy volunteers
    • Abst 123
    • Dale, D.C., Rodger, E., Christensen, J.J., Dehner, C., Badel, K., Calandra, G.B., Liles, W.C. Optimizing the use of AMD3100, a CXCR-4 antagonist, for mobilization of hematopoietic progenitor cells: Studies on healthy volunteers. Blood 2003, 102(11, Part 1):Abst 123.
    • (2003) Blood , vol.102 , Issue.11 and PART 1
    • Dale, D.C.1    Rodger, E.2    Christensen, J.J.3    Dehner, C.4    Badel, K.5    Calandra, G.B.6    Liles, W.C.7
  • 73
    • 79960971604 scopus 로고    scopus 로고
    • Leukocytosis and mobilization of pluripotent hematopoietic progenitor cells in healthy volunteers induced by single dose administration of AMD-3100, a CXCR4 antagonist
    • Abst 3071
    • Liles, W.C., Broxmeyer, H.E., Rodger, E. et al. Leukocytosis and mobilization of pluripotent hematopoietic progenitor cells in healthy volunteers induced by single dose administration of AMD-3100, a CXCR4 antagonist. Blood 2001, 98(11, Part 1): Abst 3071.
    • (2001) Blood , vol.98 , Issue.11 and PART 1
    • Liles, W.C.1    Broxmeyer, H.E.2    Rodger, E.3
  • 74
    • 0141923918 scopus 로고    scopus 로고
    • Mobilization of hematopoietic progenitor cells in healthy volunteers by AMD3100, a CXCR4 antagonist
    • Liles, W.C., Broxmeyer, H.E., Rodger, E. et al. Mobilization of hematopoietic progenitor cells in healthy volunteers by AMD3100, a CXCR4 antagonist. Blood 2003, 102(8): 2728-30.
    • (2003) Blood , vol.102 , Issue.8 , pp. 2728-2730
    • Liles, W.C.1    Broxmeyer, H.E.2    Rodger, E.3
  • 75
    • 0043085838 scopus 로고    scopus 로고
    • Mobilization and collection of CD34+ progenitor cells from normal human volunteers with AMD-3100, a CXCR4 antagonist, and G-CSF
    • Abst 404
    • Liles, W.C., Rodger, E., Broxmeyer, H.E. et al. Mobilization and collection of CD34+ progenitor cells from normal human volunteers with AMD-3100, a CXCR4 antagonist, and G-CSF. Blood 2002, 100(11, Part 1): Abst 404.
    • (2002) Blood , vol.100 , Issue.11 and PART 1
    • Liles, W.C.1    Rodger, E.2    Broxmeyer, H.E.3
  • 76
    • 20144362394 scopus 로고    scopus 로고
    • Augmented mobilization and collection of CD34+ hematopoietic cells from normal human volunteers stimulated with granulocyte-colony-stimulating factor by single-dose administration of AMD3100, a CXCR4 antagonist
    • Liles, W.C., Rodger, E., Broxmeyer, H.E. et al. Augmented mobilization and collection of CD34+ hematopoietic cells from normal human volunteers stimulated with granulocyte-colony-stimulating factor by single-dose administration of AMD3100, a CXCR4 antagonist. Transfusion 2005, 45(3): 295-300.
    • (2005) Transfusion , vol.45 , Issue.3 , pp. 295-300
    • Liles, W.C.1    Rodger, E.2    Broxmeyer, H.E.3
  • 77
    • 1842509856 scopus 로고    scopus 로고
    • Rapid mobilization of CD34+ cells following administration of the CXCR4 antagonist AMD3100 to patients with multiple myeloma and non-Hodgkin's lymphoma
    • Devine, S.M., Flomenberg, N., Vesole, D.H. et al. Rapid mobilization of CD34+ cells following administration of the CXCR4 antagonist AMD3100 to patients with multiple myeloma and non-Hodgkin's lymphoma. J Clin Oncol 2004, 22(6): 1095-102.
    • (2004) J Clin Oncol , vol.22 , Issue.6 , pp. 1095-1102
    • Devine, S.M.1    Flomenberg, N.2    Vesole, D.H.3
  • 78
    • 23944464609 scopus 로고    scopus 로고
    • AMD3100 combined with standard doses of G-CSF leads to rapid, consistent mobilization of hematopoietic progenitor cells in patients with non-Hodgkin's lymphoma (NHL) and multiple myeloma
    • Abst 2847
    • Stiff, P., Micallef, I., McCarthy, P. et al. AMD3100 combined with standard doses of G-CSF leads to rapid, consistent mobilization of hematopoietic progenitor cells in patients with non-Hodgkin's lymphoma (NHL) and multiple myeloma. Blood 2004, 104(11, Part 1): Abst 2847.
    • (2004) Blood , vol.104 , Issue.11 and PART 1
    • Stiff, P.1    Micallef, I.2    McCarthy, P.3
  • 79
    • 8844260479 scopus 로고    scopus 로고
    • AMD3100 + G-CSF hematopoietic progenitor cell (HPC) mobilization is safe, effective, and superior to mobilization with G-CSF alone
    • Abst 124
    • Flomenberg, N., DiPersio, J., Liesveld, J. et al. AMD3100 + G-CSF hematopoietic progenitor cell (HPC) mobilization is safe, effective, and superior to mobilization with G-CSF alone. Blood 2003, 102(11, Part 1): Abst 124.
    • (2003) Blood , vol.102 , Issue.11 and PART 1
    • Flomenberg, N.1    DiPersio, J.2    Liesveld, J.3
  • 80
    • 23944525352 scopus 로고    scopus 로고
    • The use of AMD3100 plus G-CSF for autologous hematopoietic progenitor cell mobilization is superior to G-CSF alone
    • Flomenberg, N., Devine, S.M., DiPersio, J.F. et al. The use of AMD3100 plus G-CSF for autologous hematopoietic progenitor cell mobilization is superior to G-CSF alone. Blood 2005, 106(5): 1867-74.
    • (2005) Blood , vol.106 , Issue.5 , pp. 1867-1874
    • Flomenberg, N.1    Devine, S.M.2    DiPersio, J.F.3
  • 82
    • 34247495769 scopus 로고    scopus 로고
    • The CXCR4-antagonist AMD3100 augments the number of mobilized peripheral blood progenitor cells (PBPC) when added to a G-CSF standard mobilization regime and AMD3100-mobilized PBPC result in rapid hematopoietic reconstitution after autologous transplantation
    • Dec 10-13, Atlanta, Abst 1961
    • Fruehauf, S., Seeger, T., Topaly, J. et al. The CXCR4-antagonist AMD3100 augments the number of mobilized peripheral blood progenitor cells (PBPC) when added to a G-CSF standard mobilization regime and AMD3100-mobilized PBPC result in rapid hematopoietic reconstitution after autologous transplantation. Blood [47th Annu Meet Am Soc Hematol (Dec 10-13, Atlanta) 2005] 2005, 106(11): Abst 1961.
    • (2005) Blood [47th Annu Meet Am Soc Hematol , vol.106 , Issue.11
    • Fruehauf, S.1    Seeger, T.2    Topaly, J.3
  • 83
    • 34247468639 scopus 로고    scopus 로고
    • AMD3100 augments the number of mobilised peripheral blood progenitor cells when added to a G-CSF standard mobilisation regime and AMD3100-mobilised PBPC result in rapid haematopoietic reconstitution after autologous transplantation
    • March 20-23, Prague, Abst O275
    • Fruehauf, S., Seeger, T., Topaly, J. et al. AMD3100 augments the number of mobilised peripheral blood progenitor cells when added to a G-CSF standard mobilisation regime and AMD3100-mobilised PBPC result in rapid haematopoietic reconstitution after autologous transplantation. 31st Annu Meet Eur Group Blood Marrow Transplant (EBMT) (March 20-23, Prague) 2005, Abst O275.
    • (2005) 31st Annu Meet Eur Group Blood Marrow Transplant (EBMT)
    • Fruehauf, S.1    Seeger, T.2    Topaly, J.3
  • 84
    • 34247542744 scopus 로고    scopus 로고
    • CD34+ cells mobilized with the new CXCR4 antagonist AMD3100 + G-CSF show increased anti-apoptotic, cell cycle, DNA repair and cell motility-associated gene expression when compared to G-CSF mobilization alone
    • Dec 10-13, Atlanta, Abst 4264
    • Seeger, T., Maier, P., Li, L., Laufs, S. et al. CD34+ cells mobilized with the new CXCR4 antagonist AMD3100 + G-CSF show increased anti-apoptotic, cell cycle, DNA repair and cell motility-associated gene expression when compared to G-CSF mobilization alone. Blood [47th Annu Meet Am Soc Hematol (Dec 10-13, Atlanta) 2005] 2005, 106(11): Abst 4264.
    • (2005) Blood [47th Annu Meet Am Soc Hematol , vol.106 , Issue.11
    • Seeger, T.1    Maier, P.2    Li, L.3    Laufs, S.4
  • 85
    • 34247467228 scopus 로고    scopus 로고
    • AMD3100 mobilises CD34+ cells with increased anti-apoptotic, cell cycle, DNA repair and cell motility-associated gene expression when compared to G-CSF mobilisation alone
    • March 19-22, Hamburg, Abst P805
    • Fruehauf, S., Seeger, T., Maier, P. et al. AMD3100 mobilises CD34+ cells with increased anti-apoptotic, cell cycle, DNA repair and cell motility-associated gene expression when compared to G-CSF mobilisation alone. Bone Marrow Transplant [32nd Annu Meet Eur Group Blood Marrow Transplant (EBMT) (March 19-22, Hamburg) 2006] 2006, 37(Suppl. 1): Abst P805.
    • (2006) Bone Marrow Transplant [32nd Annu Meet Eur Group Blood Marrow Transplant (EBMT) , vol.37 , Issue.SUPPL. 1
    • Fruehauf, S.1    Seeger, T.2    Maier, P.3
  • 87
    • 34247491792 scopus 로고    scopus 로고
    • Comparison of CXCR-4 and adhesion molecule expression in healthy bone marrow with expression in bone marrow and peripheral blood of patients receiving G-CSF plus AMD3100
    • Dec 10-13, Atlanta, Abst 1974
    • Oelschlaegel, U., Bornhauser, M., Kroschinsky, F., Calandra, G., Ehninger, G., Platzbecker, U. Comparison of CXCR-4 and adhesion molecule expression in healthy bone marrow with expression in bone marrow and peripheral blood of patients receiving G-CSF plus AMD3100. Blood [47th Annu Meet Am Soc Hematol (Dec 10-13, Atlanta) 2005] 2005, 106(11): Abst 1974.
    • (2005) Blood [47th Annu Meet Am Soc Hematol , vol.106 , Issue.11
    • Oelschlaegel, U.1    Bornhauser, M.2    Kroschinsky, F.3    Calandra, G.4    Ehninger, G.5    Platzbecker, U.6
  • 88
    • 27644530537 scopus 로고    scopus 로고
    • Improved mobilization of CD34+ peripheral blood stem cells (PBSC) and dendritic cells (DCs) by AMD-3100 (AMD) in hard to mobilize non-Hodgkin's lymphoma (NHL patients (pts) mobilized with standard dose of G-CSF
    • Abst 2856
    • Gazitt, Y., Freytes, C.O., Akay, C., Besinger, W., Badel, K., Calandra, G. Improved mobilization of CD34+ peripheral blood stem cells (PBSC) and dendritic cells (DCs) by AMD-3100 (AMD) in hard to mobilize non-Hodgkin's lymphoma (NHL patients (pts) mobilized with standard dose of G-CSF. Blood 2004, 104(11, Part 1): Abst 2856.
    • (2004) Blood , vol.104 , Issue.11 and PART 1
    • Gazitt, Y.1    Freytes, C.O.2    Akay, C.3    Besinger, W.4    Badel, K.5    Calandra, G.6
  • 89
    • 34247488089 scopus 로고    scopus 로고
    • AMD3100 + G-CSF improves hematopoietic progenitor cell (HPC) collection in patients with Hodgkin's disease (HD)
    • Dec 10-13, Atlanta, Abst 1979
    • Cashen, A., Devine, S., Vij, R., DiPersio, J. AMD3100 + G-CSF improves hematopoietic progenitor cell (HPC) collection in patients with Hodgkin's disease (HD). Blood [47th Annu Meet Am Soc Hematol (Dec 10-13, Atlanta) 2005] 2005, 106(11): Abst 1979.
    • (2005) Blood [47th Annu Meet Am Soc Hematol , vol.106 , Issue.11
    • Cashen, A.1    Devine, S.2    Vij, R.3    DiPersio, J.4
  • 90
    • 23944491808 scopus 로고    scopus 로고
    • A pilot study evaluating the safety and efficacy of AMD3100 for the mobilization and transplantation of HLA-matched sibling donor hematopoietic stem cells in patients with advanced hematological malignancies
    • Abst 3341
    • Devine, S.M., Bonde, J., Hess, D.A. et al. A pilot study evaluating the safety and efficacy of AMD3100 for the mobilization and transplantation of HLA-matched sibling donor hematopoietic stem cells in patients with advanced hematological malignancies. Blood 2004, 104(11, Part 1): Abst 3341.
    • (2004) Blood , vol.104 , Issue.11 and PART 1
    • Devine, S.M.1    Bonde, J.2    Hess, D.A.3
  • 92
    • 34247489498 scopus 로고    scopus 로고
    • A pilot study evaluating the safety and efficacy of AMD3100 for the mobilization and transplantation of HLA-matched sibling donor hematopoietic stem cells in patients with advanced hematological malignancies
    • ISCT, May 5-6, Vancouver, Abst 212
    • Devine, S.M., Andritsos, L., Edwards, T., Calandra, G., Bridger, G., DiPersio, J.F. A pilot study evaluating the safety and efficacy of AMD3100 for the mobilization and transplantation of HLA-matched sibling donor hematopoietic stem cells in patients with advanced hematological malignancies. 11th Annu Meet Int Soc Cell Ther (ISCT) (May 5-6, Vancouver) 2005, Abst 212.
    • (2005) 11th Annu Meet Int Soc Cell Ther
    • Devine, S.M.1    Andritsos, L.2    Edwards, T.3    Calandra, G.4    Bridger, G.5    DiPersio, J.F.6
  • 93
    • 34247546373 scopus 로고    scopus 로고
    • A pilot study evaluating the safety and efficacy of AMD3100 for the mobilization and transplantation of HLA-matched sibling donor hematopoietic stem cells in patients with advanced hematological malignancies
    • July 30-Aug 2, Glasgow, Abst 344
    • Devine, S.M., Andritsos, L., Edwards, T., Calandra, G., Bridger, G., DiPersio, J.F. A pilot study evaluating the safety and efficacy of AMD3100 for the mobilization and transplantation of HLA-matched sibling donor hematopoietic stem cells in patients with advanced hematological malignancies. Exp Hematol [34th Annu Sci Meet Int Soc Exp Hematol (July 30-Aug 2, Glasgow) 2005] 2005, 33(7, Suppl. 1): Abst 344.
    • (2005) Exp Hematol [34th Annu Sci Meet Int Soc Exp Hematol , vol.33 , Issue.7 SUPPL. 1
    • Devine, S.M.1    Andritsos, L.2    Edwards, T.3    Calandra, G.4    Bridger, G.5    DiPersio, J.F.6
  • 94
    • 33645997837 scopus 로고    scopus 로고
    • A pilot study evaluating the safety and efficacy of AMD3100 for the mobilization and transplantation of HLA-matched sibling donor hematopoietic stem cells in patients with advanced hematological malignancies
    • Dec 10-13, Atlanta, Abst 299
    • Devine, S.M., Andritsos, L., Todt, L. et al. A pilot study evaluating the safety and efficacy of AMD3100 for the mobilization and transplantation of HLA-matched sibling donor hematopoietic stem cells in patients with advanced hematological malignancies. Blood [47th Annu Meet Am Soc Hematol (Dec 10-13, Atlanta) 2005] 2005, 106(11): Abst 299.
    • (2005) Blood [47th Annu Meet Am Soc Hematol , vol.106 , Issue.11
    • Devine, S.M.1    Andritsos, L.2    Todt, L.3
  • 98
    • 34247496069 scopus 로고    scopus 로고
    • Treatment with AMD3100 in multiple myeloma or non-Hodgkin's lymphoma patients to increase the number of peripheral blood stem cells when given with a mobilising regimen of chemotherapy and G-CSF
    • March 20-23, Prague, Abst P503
    • Dugan, M., Akard, L., Thompson, J. et al. Treatment with AMD3100 in multiple myeloma or non-Hodgkin's lymphoma patients to increase the number of peripheral blood stem cells when given with a mobilising regimen of chemotherapy and G-CSF. 31st Annu Meet Eur Group Blood Marrow Transplant (EBMT) (March 20-23, Prague) 2005, Abst P503.
    • (2005) 31st Annu Meet Eur Group Blood Marrow Transplant (EBMT)
    • Dugan, M.1    Akard, L.2    Thompson, J.3
  • 100
    • 34247521619 scopus 로고    scopus 로고
    • Genzyme completes tender offer for outstanding shares of AnorMED. Genzyme Corp. Press Release, November 7, 2006.
    • Genzyme completes tender offer for outstanding shares of AnorMED. Genzyme Corp. Press Release, November 7, 2006.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.