An expeditious synthesis of a biscyclam with an aromatic linker

Tetrahedron Letters

Volumn 37, Issue 30, 1996, Pages 5301-5304

  Xu, Daqiang ^a   Mattner, Paul G ^a   Prasad, Kapa ^a   Repic, Oljan ^a   Blacklock, Thomas J ^a  

^a Sandoz Pharma Ltd   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLAM DERIVATIVE;

ARTICLE; DRUG SYNTHESIS; REACTION ANALYSIS; TECHNIQUE;

EID: 0030598007     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/0040-4039(96)01097-0     Document Type: Article

References (12)

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2. 2. a) Yaouanc, J. J.; Le Bris, N.; Le Gall, G.; Clément, J. C.; Handel, H.; des Abbayes, H. J. Chem. Soc. 1991, 206.
3. b) Patinec, V.; Yaouanc, J. J.; Clément, J.-C.; Handel, H.; des Abbayes, H. Tetrahedron Lett. 1995, 36, 79.
4. c) Bernard, H.; Yaouanc, J. J.; Clément, J.-C.; des Abbayes, H.; Handel, H. Tetrahedron Lett. 1991, 32, 639.
5. d) Filali, A.; Yaouanc, J. J.; Handel, H. Angew. Chem. Int. Ed. Engl. 1991, 30, 560.
6. 3. Xu, D.; Prasad, K.; Repic, O.; Blacklock, T.J. Tetrahedron Lett. 1995, 36, 7357.
7. 4. Satisfactory spectral analysis were obtained for all new compounds described in this communication.
8. 5. a) Krespan, C. G.; King, A. P. J. Org. Chem. 1974, 39, 1315.
9. b) Nordlander, J. E.; Batalane, D. B.; Eberlein, T. H.; Farkas, L. V.; Howe, R. S.; Stevens, R. M.; Tripoulas, N. A. Tetrahedron Lett. 1978, 19, 4987.
10. 6. a) Richman, J. E.; Atkins, T. J. J. Am. Chem. Soc. 1974, 96, 2268.
11. b) Atkins, T. J.; Richman, J. E.; Oettle, W. F. Organic Synthesis Vol VI, 652.
12. 3CN gave 13.83 g of 6 (35% yield).