Efficient one-pot synthesis of JM3100

Synthetic Communications

Volumn 28, Issue 15, 1998, Pages 2903-2906

  Guillaume, Dom ^a   Marshall, Garland R ^a  

^a WASHINGTON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,1' [1,4 PHENYLENEBIS(METHYLENE)]BIS(1,4,8,11 TETRAAZACYCLOTETRADECANE); ANTIVIRUS AGENT; MACROCYCLIC COMPOUND; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; HUMAN IMMUNODEFICIENCY VIRUS; SYNTHESIS;

EID: 0031822843     PISSN: 00397911     EISSN: None     Source Type: Journal    
DOI: 10.1080/00397919808004867     Document Type: Article

References (9)

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2. Bridger, G J.; Skerlj, R.T.; Thornton, D.; Sreenivasan, P.; Martellicci, S.A.; Henson, G.W.; Abrams, M.J.; Yamamoto, N.; De Vreese, K.; Pauwels, R.; De Clerq, E. J. Med. Chem. 1995, 38, 366.
3. Esté, J. A.; De Vreese, K.; Witrouw, M.; Schmit, J.-C.; Vandamme, A.-M.; Anné, J.; Desmyter, J.; Henson, G. W.; Bridger, G.; De Clercq, E. Antiviral Res., 1996, 29, 297.
4. Brandes, S.; Gros, C.; Denat, F.; Pullumbi, P.; Guillard, R. Bull. Soc. Chim. Fr. 1996, 133, 65.
5. Gardinier, I.; Roignant, A.; Oget, N.; Bernard, H.; Yaouanc, J.J.; Handel, H. Tetrahedron Lett. 1996, 37, 7711 and references cited herein.
6. Use of chloroform was found to be necessary and its replacement by methylene chloride led to 1a in low yield (10-18%).
7. Filali, A.; Yaouanc, J.-J.; Handel, H. Angew. Chem. Int. Ed. Engl. 1991, 30, 560.
8. 3, 75 MHz) δ: 43.6, 43.5.
9. Richman, J. E.; Kubale, J. J. J. Am. Chem. Soc. 1983, 105, 749.