Macrophages in rheumatoid arthritis

Histology and Histopathology

Volumn 22, Issue 4-6, 2007, Pages 581-586

  Maruotti, N ^a   Cantatore, F P ^a   Crivellato, E ^b   Vacca, A ^c   Ribatti, Domenico ^c  

^a UNIVERSITY OF FOGGIA   (Italy)

^b UNIVERSITY OF UDINE   (Italy)

^c UNIVERSITY OF BARI MEDICAL SCHOOL   (Italy)

Author keywords

Chemokine; Cytokine; Macrophage; Metalloproteinase; Rheumatoid arthritis

Indexed keywords

ANGIOGENIC PROTEIN; CHEMOKINE; CYTOKINE; GROWTH FACTOR; MACROPHAGE CHEMOTACTIC FACTOR; MACROPHAGE INFLAMMATORY PROTEIN 1; MATRIX METALLOPROTEINASE; METALLOPROTEINASE;

GENE EXPRESSION; GENE SEQUENCE; GENETIC TRANSCRIPTION; HUMAN; INFLAMMATION; MACROPHAGE ACTIVATION; MACROPHAGE FUNCTION; MACROPHAGE MIGRATION INHIBITION; PATHOPHYSIOLOGY; REVIEW; RHEUMATOID ARTHRITIS; ANIMAL; MACROPHAGE; METABOLISM; NEOVASCULARIZATION (PATHOLOGY);

ANIMALS; ARTHRITIS, RHEUMATOID; CHEMOKINES; CYTOKINES; HUMANS; INFLAMMATION; MACROPHAGES; METALLOPROTEASES; NEOVASCULARIZATION, PATHOLOGIC;

EID: 34247494260     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (95)

1. Aarvak T., Chabaud M., Miossec P. and Natvig J.B. (1999). IL-17 is produced by some proinflammatory Th1/Th0 cells but not by Th2 cells. J. Immunol. 162, 1246-1251.
2. Akahoshi T., Wada C., Endo H., Hirota K., Hosaka S. and Takagishi K. (1993). Expression of monocyte chemotactic and activating factor in rheumatoid arthritis. Arthritis Rheum. 36, 762.
3. Aliberti J.C., Machado F.S., Souto J.T., Campanelli A.P., Teixeira M.M., Gazzinelli R.T. and Silva J.S. (1999). b-Chemokines enhance parasite uptake and promote nitric oxide-dependent microbiostatic activity in murine inflammatory macrophages infected with Trypanosoma cruzi. Infect. Immun. 67, 4819-4826.
4. Albina J.E., Henry Jr W.L., Mastrofrancesco B., Martin B.A. and Reichner J.S. (1995). Macrophage activation by culture in an anoxic environment. J. Immunol. 155, 4391-4396.
5. Athanasou N.A. (1995). Synovial macrophages. Ann. Rheum. Dis. 54, 392-394.
6. Allen J.B., Wong H.L,, Costa G.L., Bienkowski M.J. and Wahl S.M. (1993). Suppression of monocyte function and differential regulation of IL-1 and IL-1ra by IL-4 contribute to resolution of experimental arthritis. J. Immunol. 151, 4344-4351.
7. Arend W.P., Malyak M., Guthridge C.J. and Gabay C. (1998). Interleukin-1 receptor antagonist: Role in biology. Annu. Rev. Immunol. 16, 27-55.
8. Badolato R., Ponzi A.N., Millesimo M., Notarangelo L.D. and Musso T. (1997). Interleukin-15 (IL-15) induces IL-8 and monocyte chemotactic protein 1 production in human monocytes. Blood 90, 2804-2809.
9. Bazan J.F., Bacon K.B., Hardiman G., Wang W., Soo K., Rossi D., Greaves D.R., Zlotnik A. and Schall T.J. (1997). A new class of membrane bound chemokine with a CX3C motif. Nature 385, 640.
10. Bessis N., Boissier M.C., Ferrara P., Blankestein T., Fradelizi D. and Fournier C. (1996). Attenuation of collagen-induced arthritis in mice by treatment with vector cells engineered to secrete interleukin-13. Eur. J. Immunol. 26, 2399-2403.
11. Bresnihan B. (1999). Pathogenesis of joint damage in rheumatoid arthritis. J. Rheumatol. 26, 717-719.
12. Burmester G.R., Stuhlmüller B., Keyszer G. and Kinne R.W. (1997). Mononuclear phagocytes and rheumatoid synovitis. Mastermind or workhorse in arthritis? Arthritis Rheum. 40, 5-18.
13. Calandra T., Bernhagen J., Metz C.N., Spiegel L.A., Bacher M., Donnelly T., Cerami A. and Bucala R. (1995). MIF as a glucocorticoid-induced modulator of cytokine production. Nature 377, 68-71.
14. Carlsen H.S., Baekkevold E.S., Morton H.C., Haraldsen G. and Brandtzaeg P. (2004). Monocyte-like and mature macrophages produce CXCL13 (B cell-attracting chemokine 1) in inflammatory lesions with lymphoid neogenesis. Blood 104, 3021-3027.
15. Chae H.J., Park R.K., Chung H.T., Kang J.S., Kim M.S., Choi D.Y., Bang B.G. and Kim H.R. (1997). Nitric oxide is a regulator of bone remodelling. J. Pharm. Pharmacol. 49, 897-902.
16. Chang J.S., Quinn J.M., Demaziere A., Buldstrode C.J., Francis M.J., Duthie R.B. and Athanasou N.A. (1992). Bone resorption by cells isolated from rheumatoid synovium. Ann. Rheum. Dis. 51, 1223-1229.
17. Cook D.N., Beck M.A., Coffman T.M., Kirby S.L., Sheridan J.F., Pragnell I.B. and Smithies O. (1995). Requirement of MIP-lα for an inflammatory response to viral infection. Science 269, 1583-1585.
18. Cunnane G., FitzGerald O., Hummel K.M., Youssef P.P., Gay R.E., Gay S. and Bresnihan B. (2001). Synovial tissue protease gene expression and joint erosions in early rheumatoid arthritis. Arthritis Rheum. 44, 1744-1753.
19. Dayer J.M. and Fenner H. (1992). The role of cytokines and their inhibitors in arthritis. Baillieres Clin. Rheumatol. 8, 485-516.
20. De Gendt C.M., De Clerck L.S., Bridts C.H., Van Osselaer N. and Stevens W.J. (1996). Relationship between interleukin-8 and neutrophil adhesion molecules in rheumatoid arthritis. Rheumatol. Int. 16, 169.
21. Desmouliere A., Redard M., Darby I. and Gabbiani G. (1995). Apoptosis mediates the decrease in cellularity during the transition between granulation tissue and scar. Am. J. Pathol. 146, 56-66.
22. DiGiovine E.S., Nuki G. and Duff G.W. (1988). Tumor necrosis factor in synovial exudates. Ann. Rheum. Dis. 47, 768.
23. Dinarello C.A. (1999). Interleukin-18. Methods 19, 121-132.
24. Donnelly S.C., Haslett C., Reid P.T., Grant I.S., Wallace W.A.H., Metz C.N., Bruce L.J. and Bucala R. (1997). Regulatory role for macrophage migration inhibitory factor in acute respiratory distress syndrome. Nat. Med. 3, 320-323.
25. Duffield J.S., Ware C.F., Ryffel B. and Savill J. (2001a). Suppression by apoptotic cells defines tumor necrosis factor-mediated induction of glomerular mesangial cell apoptosis by activated macrophages. Am. J. Pathol. 159, 1397-1404.
26. Duffield J.S. and Savill J. (2001b). Macrophages ingesting opsonised zymosan induce glomerular mesangial cell apoptosis by hydrogen peroxide and TNFα generation. J. Am. Soc. Nephrol. 12, 589A.
27. Edwards D.R., Murphy G., Reynolds J.J., Whitham S.E., Docherty A.J., Angel P. and Heath J.K. (1987). Transforming growth factor beta modulates the expression of collagenase and metallo-proteinase inhibitor. EMBO J. 6, 1899-1904.
28. Fadok V.A., Bratton D.L., Konowal A., Freed, P.W. Westcott J.Y. and Henson P.M. (1998). Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/ paracrine mechanisms involving TGF-β, PGE2, and PAF. J. Clin. Invest. 101, 890-898.
29. Fava R., Olsen N., Keski-Oja J., Moses H. and Pincus T. (1989). Active and latent form of transforming growth factor B activity in synovial effusions. J. Exp. Med. 169, 291-296.
30. Fava R.A., Olsen N.J., Spencer-Green G., Yeo K.T., Yeo T.K., Berse B., Jackman R.W., Senger D.R., Dvorak H.F. and Brown L.F. (1994). Vascular Permeability Factor/Endothelial Growth Factor (VPF/VEGF): accumulation and expression in human synovial Fluids and rheumatoid synovial tissue. J. Exp. Med. 180, 341-346.
31. Gerber J.S. and Mosser D.M. (2001). Reversing lipopolysaccharide toxicity by ligating the macrophage Fc γ receptors. J. Immunol. 166, 6861-6868.
32. Gibbs D.F., Warner R.L., Weiss S.J., Johnson K.J. and Varani J. (1999). Characterization of matrix metalloproteinases produced by rat alveolar macrophages. Am. J. Respir. Cell. Mol. Biol. 20, 1136-1144.
33. Gracie J.A., Forsey R.J., Chan W.L., Gilmour A., Leung B.P., Greer M.R., Kennedy K., Carter R., Wei X.Q., Xu D., Fiel M., Foulis A.,
34. Liew F.Y. and McInnes I.B. (1999). A proinflammatory role for IL-18 in rheumatoid arthritis. J. Clin. Invest. 104, 1393-1401.
35. Gratchev A., Guillot P., Hakiy N. Politz O., Orfanos C.E., Schledzewski K. and Goerdt S. (2001). Alternatively activated macrophages differentially express fibronectin and its splice variants and the extracellular matrix protein bIG-H3. Scand. J. Immunol. 53, 386-392.
36. Hart P.H., Hunt E.K., Bonder C.S., Watson C.J., Finlay-Jones J.J. (1996). Regulation of surface and soluble TNF receptor expression on human monocytes and synovial fluid macrophages by IL-4 and IL-10. J. Immunol. 157, 3672-3680.
37. + monocyte-lineage cells from the bone marrow of rheumatoid arthritis patients. Arthritis Rheum. 39, 836-843.
38. Isomaki P., Luukkainen R., Toivanen P. and Punnonen J. (1996a). The presence of interleukin-13 in rheumatoid synovium and its antiinflammatory effects on synovial fluid macrophages from patients with rheumatoid arthritis. Arthritis Rheum. 39, 1693-1702.
39. Isomaki P., Luukkainen R., Saario R., Toivanen P. and Punnonen J. (1996b). Interleukin-10 functions as an antiinflammatory cytokine in rheumatoid synovium. Arthritis Rheum. 39, 386-395.
40. Janusz M.J. and Hare M. (1993). Cartilage degradation by cocultures of transformed macrophage and fibroblast cell lines. A model of metallo-proteinase-mediated connective tissue degradation. J. Immunol. 150, 1922-1931.
41. Kinne R.W., Bräuer R., Stuhlmüller B., Palombo-Kinne E. and Burmester G.R. (2000a). Macrophages in rheumatoid arthritis. Arthritis Res. 2, 189-202.
42. Kinne R.W., Stuhlmüller B., Palombo-Kinne E. and Burmester G.R. (2000b). The role of macrophages in the pathogenesis of rheumatoid arthritis. In: Rheumatoid arthritis: The New frontiers in pathogenesis and treatment. Wollheim F., Firestein G.S. and Panayi G.S. (eds). Oxford University Press. Oxford. pp 69-87.
43. Kipari T. and Hughes J. (2002). Macrophage-mediated renal cell death. Kidney Int. 61, 760-761.
44. Klimiuk P.A., Goronzy J.J., Bjornsson J., Beckenbaugh R.D. and Weyand C.M. (1997). Tissue cytokine patterns distinguish variants of rheumatoid synovitis. Am. J. Pathol. 151, 1311-1319.
45. Klimiuk P.A., Sierakowski S., Latosiewicz R., Cylwik B., Skowronski J. and Chwiecko J. (2001). Serum cytokines in different histological variants of rheumatoid arthritis. J. Rheumatol. 28, 1211-1217.
46. Koch A.E., Kunkel S.L., Burrows J.C., Evanoff H.L., Haines G.K., Pope R.M. and Strieter R.M. (1991). Synovial tissue macrophage as a source of the chemotactic cytokine IL-8. J. Immunol. 147, 2187-2195.
47. Koch A.E., Kunkel S.L., Harlow L.A., Johnson B., Evanoff H.L., Haines G.K., Burdick M.D., Pope R.M. and Strieter R.M. (1992). Enhanced production of monocyte chemoattractant protein-1 in rheumatoid arthritis. J. Clin. Invest. 90, 772-779.
48. Koch A.E., Kunkel S.L., Harlow L.A., Mazarakis D.D., Haines G.K., Burdick M.D. and Strieter R.M. (1994). Epithelial neutrophil activating peptide-78: a novel chemotactic cytokine for neutrophils in arthritis. J. Clin. Invest. 94, 1012-1018.
49. Koch A.E., Volin M.V., Woods J.M., Kunkel S.L., Connors M.A., Harlow L.A., Woodruff D.C., Burdick M.D. and Strieter R.M. (2001). Regulation of angiogenesis by the C-X-C chemokines interleukin-8 and epithelial neutrophil activating peptide-78 in the rheumatoid joint. Arthritis Rheum. 44, 31-40.
50. Konttinen Y.T., Li T.F., Mandelin J., Liljestrom M., Sorsa T., Santavirta S. and Virtanen I. (2000). Increased expression of extracellular matrix metalloproteinase inducer in rheumatoid synovium. Arthritis Rheum. 43, 275-280.
51. Lake F.R., Noble P.W., Henson P.M. and Riches D.W. (1994). Functional switching of macrophage responses to tumor necrosis factor α (TNFα) by interferons. Implications for the pleiotropic activities of TNFα. J. Clin. Invest. 93, 1661-1669.
52. Leech M., Metz C., Santos L., Peng T., Holdsworth S.R., Bucala R. and Morand E.F. (1998). Involvement of macrophage migration inhibitory factor in the evolution of rat adjuvant arthritis. Arthritis Rheum. 41, 910-917.
53. Leech M., Metz C., Hall P., Hutchinson P., Gianis K., Smith M., Weedon H., Holdsworth S.R., Bucala R. and Morand E.F. (1999). Macrophage migration inhibitory factor in rheumatoid arthritis: evidence of proinflammatory function and regulation by glucocorticoids. Arthritis Rheum. 42, 1601-1608.
54. McInnes I.B., Al-Mughales J., Field M., Leung B.P., Huang F.P., Dixon R., Sturrock R.D., Wilkinson P.C. and Liew F.Y. (1996a). The role of interleukin-15 in T-cell migration and activation in rheumatoid arthritis. Nature Med. 2, 175-182.
55. McInnes I.B., Leung B.P., Field M., Wei X.Q., Huang F.P., Sturrock R.D., Kinninmonth A., Weidner J., Mumford R. and Liew F.Y. (1996b). Production of nitric oxide in the synovial membrane of rheumatoid and osteoarthritis patients. J. Exp. Med. 184, 1519-1524.
56. McInnes I.B., Leung B.P., Sturrock R.D., Field M. and Liew F.Y. (1997). Interleukin-15 mediates T cell-dependent regulation of tumor necrosis factor-alpha production in rheumatoid arthritis. Nature Med. 3, 189-195.
57. Meszaros A.J., Reichner J.S. and Albina J.E. (2000). Macrophage-induced neutrophil apoptosis. J. Immunol. 165, 435-441.
58. Miesel R., Murphy M.P. and Kröger H. (1996). Enhanced mitochondrial radical production in patients with rheumatoid arthritis correlates with elevated levels of tumor necrosis factor alpha in plasma. Free Radic. Res. 25, 161-169.
59. Mikulowska A., Metz C.N., Bucala R. and Holmdahl R. (1997). Macrophage migration inhibitory factor is involved in the pathogenesis of collagen type II-induced arthritis in mice. J. Immunol. 158, 5514-5517.
60. Miossec P. and van den Berg W. (1997). Thl/Th2 cytokine balance in arthritis. Arthritis Rheum. 40, 2105-2115.
61. Moldovan F., Pelletier J.P., Hambor J., Cloutier J.M. and Martel-Pelletier J. (1997). Collagenase-3 (matrix metalloprotease 13) is preferentially localized in the deep layer of human arthritic cartilage in situ: In vitro mimicking effect by transforming growth factor beta. Arthritis Rheum. 40, 1653-1661.
62. Morand E.F., Leech M., Weedon H., Metz C., Bucala R. and Smith M.D. (2002). Macrophage migration inhibitory factor in rheumatoid arthritis: clinical correlations. Rheumatology (Oxford). 41, 558-562.
63. Morand E.F., Bucala R. and Leech M. (2003). Macrophage migration inhibitory factor. An emerging therapeutic target in rheumatoid arthritis. Arthritis Rheum. 48, 291-299.
64. Mulherin D., Fitzgerald O. and Bresnihan B. (1996). Synovial tissue macrophage populations and articular damage in rheumatoid arthritis. Arthritis Rheum. 39, 115-124.
65. Neidel J., Schulze M. and Lindschau J. (1995). Association between degree of bone-erosion and synovial fluid-levels of tumor necrosis factor alpha in the knee-joints of patients with rheumatoid arthritis. Inflamm. Res. 44, 217-221.
66. Onodera S., Kaneda K., Mizue Y., Koyama Y., Fujinaga M. and Nishihira J. (2000). Macrophage migration inhibitory factor up-regulares expression of matrix metalloproteinases in synovial fibroblasts of rheumatoid arthritis. J. Biol. Chem. 275, 444-450.
67. Onodera S., Nishihira J., Iwabuchi K., Koyama Y., Yoshida K., Tanaka S. and Minami A. (2002). Macrophage migration inhibitory factor upregulates matrix metalloproteinase-9 and -13 in rat osteoblasts: relevance to intracellular signaling pathways. J. Biol. Chem. 277, 7865-7874.
68. Page G., Lebecque S. and Miossec P. (2002). Anatomic localization of immature and mature dendritic cells in an ectopic lymphoid organ: correlation with selective chemokine expression in rheumatoid synovium. J. Immunol. 168, 5333-5341.
69. Park Y.W., Kang Y.M., Butterfield J., Detmar M., Goronzy J.J. and Weyand C.M. (2004). Thrombospondin 2 functions as an endogenous regulator of angiogenesis and inflammation in rheumatoid arthritis. Am. J. Pathol. 165, 2087-2098.
70. Ross J.A. and Auger M.J. (2002). The biology of the macrophage. In: The macrophage. 2nd ed. Burke B. and Lewis C.E. (eds). Oxford University Press. Oxford. pp 1-22.
71. Ruth J.H., Volin M.V., Haines III G.K., Woodruff D.C., Katschke K.J. Jr., Woods J.M., Park C.C., Morel J.C. and Koch A.E. (2001). Fractalkine, a novel chemokine in rheumatoid arthritis and rat adjuvant-induced arthritis. Arthritis Rheum. 44, 1568.
72. Sakurai H., Kohsaka H., Liu M.F., Higashiyama H., Hirata Y., Kanno K., Saito I. and Miyasaka N. (1995). Nitric oxide production and inducible nitric oxide synthase expression in inflammatory arthritis. J. Clin. Invest. 96, 2357-2363.
73. Sampey A.V., Hall P.H., Mitchell R.A., Metz C.N. and Morand E.F. (2001). Regulation of synoviocyte phospholipase A2 and cyclooxygenase 2 by macrophage migration inhibitory factor. Arthritis Rheum. 44, 1273-1280.
74. Santos L.L., Hall P., Metz C.N., Bucala R. and Morand E.F. (2001). Role of macrophage migration inhibitory factor (MIF) in murine antigen induced arthritis: interaction with glucocorticoids. Clin. Exp. Immunol. 123, 309-314.
75. Scott B.B., Weisbrot L.M., Greenwood J.D., Bogoch E.R., Paige C.J. and Keystone E.C. (1997). Rheumatoid arthritis synovial fibroblast and U937 macrophage/monocyte cell line interaction in cartilage degradation. Arthritis Rheum. 40, 490-498.
76. Sebbag M., Parry S.L., Brennan F.M. and Feldmann M. (1997). Cytokine stimulation of T lymphocytes regulares their capacity to induce monocyte production of tumor necrosis factor-alpha, but not interleukin-10: possible relevance to pathophysiology of rheumatoid arthritis. Eur. J. Immunol. 27, 624-632.
77. Strieter R.M., Kunkel S.L. and Shanafelt A.B. (1996). The role of C-X-C chemokines in the regulation of angiogenesis. In: Chemokines in disease. Koch A.E. and Strieter R.M. (eds). RG Landes Company. Austin. pp 195-209.
78. Stuhlmüller B., Ungethüm U., Scholze S., Martinez L., Backhaus M., Kraetsch H.G., Kinne R.W. and Burmester G.M. (2000). Identification of known and novel genes in activated monocytes from patients with rheumatoid arthritis. Arthritis Rheum. 43, 775-790.
79. Szekanecz Z. and Koch A.E. (2001). Chemokines and angiogenesis. Curr. Opin. Rheumatol. 13, 202-208.
80. Szekanecz Z., Strieter R.M., Kunkel S.L. and Koch A.E. (1998). Chemokines in rheumatoid arthritis. Springer Semin. Immunopathol. 20, 115-140.
81. Tak P.P., Smeets T.J., Daha M.R., Kluin P.M., Meijers K.A., Brand R., Meinders A.E. and Breedveld F.C. (1997). Analysis of the synovial cell infiltrate in early rheumatoid synovial tissue in relation to local disease activity. Arthritis Rheum. 40, 217-225.
82. Tauber A.I. and Chernyak L. (1991). Metchnikoff and the origins of immunology: from metaphor to theory. Monographs on the history and philosophy of biology. Oxford University Press. New York.
83. Tetlow L.C., Lees M., Ogata Y., Nagase H. and Woolley D.E. (1993). Differential expression of gelatinase B (MMP-9) and stromelysin-1 (MMP- 3) by rheumatoid synovial cells in vitro and in vivo. Rheumatol. Int. 13, 53-59.
84. Tomita T., Nakase T., Kaneko M., Shi K., Takahi K., Ochi T. and Yoshikawa H. (2002). Expression of extracellular matrix metalloproteinase inducer and enhancement of the production of matrix metalloproteinases in rheumatoid arthritis. Arthritis Rheum. 46, 373-378.
85. Trepicchio W.L. and Dorner A.J. (1998). Interleukin-11. A gp130 cytokine. Ann. N.Y. Acad. Sci. 856, 12-21.
86. Van Furth R. (1992). Production and migration of monocytes and kinetics of macrophages. In: Mononuclear phagocytes. Van Furth R. (ed). Kluwer Academic Publishers. Dordrecht. pp 3-12.
87. Volin M.V., Woods J.M., Amin M.A., Connors M.A., Harlow L.A. and Koch A.E. (2001). Fractalkine: a novel angiogenic chemokine in rheumatoid arthritis. Am. J. Pathol. 159, 1521-1530.
88. Voll R.E., Herrmann, M. Roth E.A., Stach C., Kalden J.R. and Girkontaite I. (1997). Immunosuppressive effects of apoptotic cells. Nature 390, 350-351.
89. Von den Hoff H., de Koning M., van Kampen J. and van der Korst J. (1995). Interleukin-1 reversibly inhibits the synthesis of biglycan and decorin in intact articular cartilage in culture. J. Rheumatol. 22, 1520-1526.
90. Wahl S.M., Allen J.B., Wong H.L., Dougherty S.F. and Euingsworth L.R. (1990). Antagonistic and agonistic effects of transforming growth factor-B and IL-1 in rheumatoid synovium. J. Immunol. 145, 2515-2519.
91. Wahl S.M., Allen J.B., Welch G.R. and Wong H.L. (1992). Transforming growth factor-beta in synovial fluids modulates Fc gamma RII (CD16) expression on mononuclear phagocytes. J. Immunol. 148, 485-490.
92. Wahl S.M., Allen J.B., Weeks B.S., Wong H.L. and Klotman P.E. (1993). Transforming growth factor beta enhances integrin expression and type IV collagenase secretion in human monocytes. Proc. Natl. Acad. Sci. USA 90, 4577-4581.
93. Walz A., Burgener R., Car B., Baggiolini M., Kunkel S.L. and Strieter R.M. (1991). Structure and neutrophil-activating properties of a novel inflammatory peptide (ENA-78) with homology to interleukin 8. J. Exp. Med. 174, 1355.
94. Walz A., Kunkel S.L. and Strieter R.M. (1996). C-X-C chemokines - an overview. In: Chemokines in disease. Koch A.E. and Strieter R.M. (eds). RG Landes Company. Austin. pp 1-25.
95. Zhu P., Ding J., Zhou J., Dong W.J., Fan C.M. and Chen Z.N. (2005). Expression of CD147 on monocytes/macrophages in rheumatoid arthritis: its potential role in monocyte accumulation and matrix metalloproteinase production. Arthritis Res. Ther. 7, R1023-R1033.