Alternatively activated macrophages differentially express fibronectin and its splice variants and the extracellular matrix protein βIG-H3

Scandinavian Journal of Immunology

Volumn 53, Issue 4, 2001, Pages 386-392

  Gratchev, A ^a,b   Guillot, P ^a   Hakiy, N ^a   Politz, O ^a   Orfanos, C E ^a   Schledzewski, K ^a   Goerdt, S ^a,b  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; FIBRONECTIN; GAMMA INTERFERON; INTERLEUKIN 4; NUCLEAR PROTEIN; PROTEIN BETA IG H3; SCLEROPROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; DNA HYBRIDIZATION; GENE OVEREXPRESSION; GENE REPRESSION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; INFLAMMATORY DISEASE; MACROPHAGE; PRIORITY JOURNAL; PROTEIN DETERMINATION; WOUND HEALING;

ALTERNATIVE SPLICING; BASE SEQUENCE; DNA PRIMERS; EXTRACELLULAR MATRIX PROTEINS; FIBRONECTINS; GENE EXPRESSION; HUMANS; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MACROPHAGE ACTIVATION; MACROPHAGES; NEOPLASM PROTEINS; RNA, MESSENGER; TRANSFORMING GROWTH FACTOR BETA;

EID: 0035057051     PISSN: 03009475     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3083.2001.00885.x     Document Type: Article

References (37)

1. Other functions, other genes: Alternative activation of antigen-presenting cells
2. Interleukin 4 potently enhances murine macrophage mannose receptor activity: A marker of alternative immunologic macrophage activation
3. Inducible expression of MS-1 high-molecular-weight protein by endothelial cells of continuous origin and by dendritic cells/macrophages in vivo and in vitro
4. Identification of a novel high molecular weight protein preferentially expressed by sinusoidal endothelial cells in normal human tissues
5. A monoclonal antibody to a novel differentiation antigen on human macrophages associated with the down-regulatory phase of the inflammatory process
6. Identification of a novel surface molecule, RM3/1, that contributes to the adhesion of glucocorticoid-induced human monocytes to endothelial cells
7. Identification of the integral membrane protein RM3/1 on human monocytes as a glucocorticoid-inducible member of the scavenger receptor cysteine-rich family (CD163)
8. Dissection of macrophage differentiation pathways in cutaneous macrophage disorders and in vitro
9. Alternative macrophage activation-associated CC-chemokine-1, a novel structural homologue of macrophage inflammatory protein-1 alpha with a Th2-associated expression pattern
10. Pseudoexons and regulatory elements in the geoomic sequence of the beta-chemokine, alternative activation-associated CC-chemokine (AMAC)-1
11. Antagonistic and additive effects of IL-4 and interferon-gamma on human monocytes and macrophages: Effects on Fc receptors, HLA-D antigens, and superoxide production
12. IL-4 decreases Fc gamma R membrane expression and Fc gamma R-mediated cytotoxic activity of human monocytes
13. Dexamethasone up-regulates mannose receptor activity by increasing mRNA levels
14. Specific inflammatory cytokines regulate the expression of human monocyte 15-lipoxygenase
15. Potential antiinflammatory effects of interleukin 4: Suppression of human monocyte tumor necrosis factor alpha, interleukin 1, and prostaglandin E2
16. Augmentation of glucocorticoid action on human monocytes by interleukin-4
17. Contrasting effects of interferon-gamma and interleukin-4 on the interleukin-6 activity of stimulated human monocytes
18. Alternative versus Classical Activation of Macrophages
19. Phenotypic dynamics of macrophage subpopulations during human experimental gingivitis
20. Differential distribution of intercellular adhesion molecules (ICAM-1, ICAM-2, and ICAM-3) and the MS-1 antigen in normal and diseased human synovia. Their possible pathogenetic and clinical significance in rheumatoid arthritis
21. Immunohistochemical identification of type II alternatively activated dendritic macrophages (RM 3/1+3, MS-1+/-, 25F9-) in psoriatic dermis
22. Detection of differentially expressed genes in primary tumor tissues using representational differences analysis coupled to microarray hybridization
23. The fibronectin gene as a model for splicing and transcription studies
24. Wound repair in the context of extracellular matrix
25. Differences in angiogenic potential of classically vs alternatively activated macrophages
26. Wound macrophages express TGF-alpha and other growth factors in vivo: Analysis by mRNA phenotyping
27. Transforming growth factor type beta: Rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro
28. Fibronectin is produced by human macrophages
29. Human fibroblasts synthesize elevated levels of extracellular matrix proteins in response to interleukin 4
30. Cultured human monocytes secrete fibronectin in response to activation by proinflammatory cytokines
31. Transforming growth factor-beta regulates the splicing pattern of fibronectin messenger RNA precursor
32. Polarized regulation of fibronectin secretion and alternative splicing by transforming growth factor
33. Macrophages and fibroblasts express embryonic fibronectins during cutaneous wound healing
34. cDNA cloning and sequence analysis of beta ig-h3, a novel gene induced in a human adenocarcinoma cell line after treatment with transforming growth factor-beta
35. Beta IG-H3, a novel secretory protein inducible by transforming growth factor-beta, is present in normal skin and promotes the adhesion and spreading of dermal fibroblasts in vitro
36. Effects of cortisone and vitamin A on wound healing