An Episulfide Cation (Thiiranium Ring) Trapped in the Active Site of HAV 3C Proteinase Inactivated by Peptide-based Ketone Inhibitors

Journal of Molecular Biology

Volumn 361, Issue 4, 2006, Pages 673-686

  Yin, Jiang ^a   Cherney, Maia M ^a   Bergmann, Ernst M ^a   Zhang, Jianmin ^a   Huitema, Carly ^b   Pettersson, Hanna ^a   Eltis, Lindsay D ^b   Vederas, John C ^a   James, Michael N G ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

3C proteinase; episulfide; hepatitis A virus; inhibitor design; methylketone

Indexed keywords

ACETONE; CATION; CHYMOTRYPSIN; CYSTEINE; CYSTEINE PROTEINASE INHIBITOR; EPISULFIDE; PAPAIN; SERINE PROTEINASE; SULFIDE; TETRAPEPTIDE; UNCLASSIFIED DRUG;

ARTICLE; CARBOXY TERMINAL SEQUENCE; COMPLEX FORMATION; COVALENT BOND; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME DEGRADATION; ENZYME INACTIVATION; ENZYME SUBSTRATE; HEPATITIS A VIRUS; MOLECULAR MECHANICS; MOLECULAR STABILITY; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN MOTIF; PROTEIN STRUCTURE; QUANTUM YIELD; SARS CORONAVIRUS;

HEPATITIS A VIRUS;

EID: 33746827783     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2006.06.047     Document Type: Article

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