메뉴 건너뛰기




Volumn 19, Issue 3, 2007, Pages 252-258

Therapeutic use of T regulatory cells

Author keywords

Autoimmunity; Foxp3; T regulatory; Therapies

Indexed keywords

ABATACEPT; INTERLEUKIN 1 ANTIBODY; INTERLEUKIN 10; INTERLEUKIN 6; INTERLEUKIN 6 ANTIBODY; MONOCLONAL ANTIBODY CD3; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA ANTIBODY;

EID: 34247160468     PISSN: 10408711     EISSN: None     Source Type: Journal    
DOI: 10.1097/BOR.0b013e3280ad46bb     Document Type: Review
Times cited : (26)

References (87)
  • 1
    • 16844365788 scopus 로고    scopus 로고
    • Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and nonself
    • Sakaguchi S. Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and nonself. Nat Immunol 2005; 6:345-352.
    • (2005) Nat Immunol , vol.6 , pp. 345-352
    • Sakaguchi, S.1
  • 2
    • 16844363097 scopus 로고    scopus 로고
    • A well adapted regulatory contrivance: Regulatory T cell development and the forkhead family transcription factor Foxp3
    • Fontenot JD, Rudensky AY. A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3. Nat Immunol 2005; 6:331-337.
    • (2005) Nat Immunol , vol.6 , pp. 331-337
    • Fontenot, J.D.1    Rudensky, A.Y.2
  • 3
    • 27644433355 scopus 로고    scopus 로고
    • Role of regulatory T cells in human diseases
    • Chatila TA. Role of regulatory T cells in human diseases. J Allergy Clin Immunol 2005; 116:949-959.
    • (2005) J Allergy Clin Immunol , vol.116 , pp. 949-959
    • Chatila, T.A.1
  • 4
    • 4143066714 scopus 로고    scopus 로고
    • Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptors
    • Hsieh CS, Liang Y, Tyznik AJ, et al. Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptors. Immunity 2004; 21:267-277.
    • (2004) Immunity , vol.21 , pp. 267-277
    • Hsieh, C.S.1    Liang, Y.2    Tyznik, A.J.3
  • 5
    • 0035801335 scopus 로고    scopus 로고
    • Cell contact-dependent immunosuppression by CD4+CD25+ regulatory T cells is mediated by cell surface-bound transforming growth factor β
    • Nakamura K, Kitani A, Strober W. Cell contact-dependent immunosuppression by CD4+CD25+ regulatory T cells is mediated by cell surface-bound transforming growth factor β. J Exp Med 2001; 194:629-644.
    • (2001) J Exp Med , vol.194 , pp. 629-644
    • Nakamura, K.1    Kitani, A.2    Strober, W.3
  • 6
    • 5644302161 scopus 로고    scopus 로고
    • Human T regulatory cells can use the perforin pathway to cause autologous target cell death
    • Grossman WJ, Verbsky JW, Barchet W, et al. Human T regulatory cells can use the perforin pathway to cause autologous target cell death. Immunity 2004; 21:589-601.
    • (2004) Immunity , vol.21 , pp. 589-601
    • Grossman, W.J.1    Verbsky, J.W.2    Barchet, W.3
  • 7
    • 3142708571 scopus 로고    scopus 로고
    • Engagement of B7 on effector T cells by regulatory T cells prevents autoimmune disease
    • Paust S, Lu L, McCarty N, Cantor H. Engagement of B7 on effector T cells by regulatory T cells prevents autoimmune disease. Proc Natl Acad Sci U S A 2004; 101:10398-10403.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 10398-10403
    • Paust, S.1    Lu, L.2    McCarty, N.3    Cantor, H.4
  • 8
    • 0141703239 scopus 로고    scopus 로고
    • CD4+CD25+ T regulatory cells control antiislet CD8+ T cells through TGF-beta-TGF-beta receptor interactions in type 1 diabetes
    • Green EA, Gorelik L, McGregor CM, et al. CD4+CD25+ T regulatory cells control antiislet CD8+ T cells through TGF-beta-TGF-beta receptor interactions in type 1 diabetes. Proc Natl Acad Sci U S A 2003; 100:10878-10883.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 10878-10883
    • Green, E.A.1    Gorelik, L.2    McGregor, C.M.3
  • 9
    • 0031647622 scopus 로고    scopus 로고
    • Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: Induction of autoimmune disease by breaking their anergic/suppressive state
    • Takahashi T, Kuniyasu Y, Toda M, et al. Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. Int Immunol 1998; 10:1969-1980.
    • (1998) Int Immunol , vol.10 , pp. 1969-1980
    • Takahashi, T.1    Kuniyasu, Y.2    Toda, M.3
  • 10
    • 0031821875 scopus 로고    scopus 로고
    • CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production
    • Thornton AM, Shevach EM. CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J Exp Med 1998; 188:287-296.
    • (1998) J Exp Med , vol.188 , pp. 287-296
    • Thornton, A.M.1    Shevach, E.M.2
  • 11
    • 0033985780 scopus 로고    scopus 로고
    • Suppressor effector function of CD4+CD25+ immunoregulatory T cells is antigen nonspecific
    • Thornton AM, Shevach EM. Suppressor effector function of CD4+CD25+ immunoregulatory T cells is antigen nonspecific. J Immunol 2000; 164:183-190.
    • (2000) J Immunol , vol.164 , pp. 183-190
    • Thornton, A.M.1    Shevach, E.M.2
  • 12
    • 0033523607 scopus 로고    scopus 로고
    • An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation
    • Asseman C, Mauze S, Leach MW, et al. An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J Exp Med 1999; 190:995-1004.
    • (1999) J Exp Med , vol.190 , pp. 995-1004
    • Asseman, C.1    Mauze, S.2    Leach, M.W.3
  • 13
    • 0034679567 scopus 로고    scopus 로고
    • Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation
    • Read S, Malmstrom V, Powrie F. Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation. J Exp Med 2000; 192:295-302.
    • (2000) J Exp Med , vol.192 , pp. 295-302
    • Read, S.1    Malmstrom, V.2    Powrie, F.3
  • 14
    • 0037364804 scopus 로고    scopus 로고
    • Natural versus adaptive regulatory T cells [Review]
    • Bluestone JA, Abbas AK. Natural versus adaptive regulatory T cells [Review]. Nat Rev Immunol 2003; 3:253-257.
    • (2003) Nat Rev Immunol , vol.3 , pp. 253-257
    • Bluestone, J.A.1    Abbas, A.K.2
  • 15
    • 0030704726 scopus 로고    scopus 로고
    • A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
    • Groux H, O'Garra A, Bigler M, et al. A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 1997; 389:737-742.
    • (1997) Nature , vol.389 , pp. 737-742
    • Groux, H.1    O'Garra, A.2    Bigler, M.3
  • 16
    • 2442450433 scopus 로고    scopus 로고
    • IL-10-secreting regulatory T cells do not express Foxp3 but have comparable regulatory function to naturally occurring CD4+CD25+ regulatory T cells
    • Vieira PL, Christensen JR, Minaee S, et al. IL-10-secreting regulatory T cells do not express Foxp3 but have comparable regulatory function to naturally occurring CD4+CD25+ regulatory T cells. J Immunol 2004; 172:5986-5993.
    • (2004) J Immunol , vol.172 , pp. 5986-5993
    • Vieira, P.L.1    Christensen, J.R.2    Minaee, S.3
  • 18
    • 0028037782 scopus 로고
    • Regulatory T cell clones induced by oral tolerance: Suppression of autoimmune encephalomyelitis
    • Chen Y, Kuchroo VK, Inobe J, et al. Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science 1994; 265:1237-1240.
    • (1994) Science , vol.265 , pp. 1237-1240
    • Chen, Y.1    Kuchroo, V.K.2    Inobe, J.3
  • 19
    • 0348223787 scopus 로고    scopus 로고
    • Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-β induction of transcription factor Foxp3
    • Chen W, Jin W, Hardegen N, et al. Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-β induction of transcription factor Foxp3. J Exp Med 2003; 198:1875-1886.
    • (2003) J Exp Med , vol.198 , pp. 1875-1886
    • Chen, W.1    Jin, W.2    Hardegen, N.3
  • 20
    • 2142645808 scopus 로고    scopus 로고
    • Cutting edge: TGF-β induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7
    • Fantini MC, Becker C, Monteleone G, et al. Cutting edge: TGF-β induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7. J Immunol 2004; 172:5149-5153.
    • (2004) J Immunol , vol.172 , pp. 5149-5153
    • Fantini, M.C.1    Becker, C.2    Monteleone, G.3
  • 21
    • 0346969978 scopus 로고    scopus 로고
    • Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25- T cells
    • Walker M, Kasprowicz DJ, Gersuk VH, et al. Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25- T cells. J Clin Invest 2003; 112:1437-1443.
    • (2003) J Clin Invest , vol.112 , pp. 1437-1443
    • Walker, M.1    Kasprowicz, D.J.2    Gersuk, V.H.3
  • 22
    • 2442425262 scopus 로고    scopus 로고
    • Induction of foxP3+ regulatory T cells in the periphery of T cell receptor transgenic mice tolerized to transplants
    • Cobbold SP, Castejon R, Adams E, et al. Induction of foxP3+ regulatory T cells in the periphery of T cell receptor transgenic mice tolerized to transplants. J Immunol 2004; 172:6003-6010.
    • (2004) J Immunol , vol.172 , pp. 6003-6010
    • Cobbold, S.P.1    Castejon, R.2    Adams, E.3
  • 23
    • 29244435493 scopus 로고    scopus 로고
    • Inducing and expanding regulatory T cell populations by foreign antigen
    • Kretschmer K, Apostolou I, Hawiger D, et al. Inducing and expanding regulatory T cell populations by foreign antigen. Nat Immunol 2005; 6:1219-1227.
    • (2005) Nat Immunol , vol.6 , pp. 1219-1227
    • Kretschmer, K.1    Apostolou, I.2    Hawiger, D.3
  • 24
    • 3543140687 scopus 로고    scopus 로고
    • Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFα therapy
    • Ehrenstein MR, Evans JG, Singh A, et al. Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFα therapy. J Exp Med 2004; 200:277-285.
    • (2004) J Exp Med , vol.200 , pp. 277-285
    • Ehrenstein, M.R.1    Evans, J.G.2    Singh, A.3
  • 25
    • 1842732224 scopus 로고    scopus 로고
    • Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis
    • Viglietta V, Baecher-Allan C, Weiner HL, Hafler DA. Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis. J Exp Med 2004; 199:971-979.
    • (2004) J Exp Med , vol.199 , pp. 971-979
    • Viglietta, V.1    Baecher-Allan, C.2    Weiner, H.L.3    Hafler, D.A.4
  • 26
    • 2442628376 scopus 로고    scopus 로고
    • Defective suppressor function of human CD4+ CD25+ regulatory T cells in autoimmune polyglandular syndrome type II
    • Kriegel MA, Lohmann T, Gabler C, et al. Defective suppressor function of human CD4+ CD25+ regulatory T cells in autoimmune polyglandular syndrome type II. J Exp Med 2004; 199:1285-1291.
    • (2004) J Exp Med , vol.199 , pp. 1285-1291
    • Kriegel, M.A.1    Lohmann, T.2    Gabler, C.3
  • 27
    • 12144249838 scopus 로고    scopus 로고
    • Defective suppressor function in CD4+CD25+ T-cells from patients with type 1 diabetes
    • Lindley S, Dayan CM, Bishop A, et al. Defective suppressor function in CD4+CD25+ T-cells from patients with type 1 diabetes. Diabetes 2005; 54:92-99.
    • (2005) Diabetes , vol.54 , pp. 92-99
    • Lindley, S.1    Dayan, C.M.2    Bishop, A.3
  • 28
    • 10844222790 scopus 로고    scopus 로고
    • Dysfunctional blood and target tissue CD4+CD25high regulatory T cells in psoriasis: Mechanism underlying unrestrained pathogenic effector T cell proliferation
    • Sugiyama H, Gyulai R, Toichi E, et al. Dysfunctional blood and target tissue CD4+CD25high regulatory T cells in psoriasis: mechanism underlying unrestrained pathogenic effector T cell proliferation. J Immunol 2005; 174:164-173.
    • (2005) J Immunol , vol.174 , pp. 164-173
    • Sugiyama, H.1    Gyulai, R.2    Toichi, E.3
  • 29
    • 11244291391 scopus 로고    scopus 로고
    • Functional defect of regulatory CD4+CD25+ T cells in the thymus of patients with autoimmune myasthenia gravis
    • Balandina A, Lecart S, Dartevelle P, et al. Functional defect of regulatory CD4+CD25+ T cells in the thymus of patients with autoimmune myasthenia gravis. Blood 2005; 105:735-741.
    • (2005) Blood , vol.105 , pp. 735-741
    • Balandina, A.1    Lecart, S.2    Dartevelle, P.3
  • 30
    • 27944499757 scopus 로고    scopus 로고
    • Reduced suppressive effect of CD4+CD25high regulatory T cells on the T cell immune response against myelin oligodendrocyte glycoprotein in patients with multiple sclerosis
    • Haas J, Hug A, Viehover A, et al. Reduced suppressive effect of CD4+CD25high regulatory T cells on the T cell immune response against myelin oligodendrocyte glycoprotein in patients with multiple sclerosis. Eur J Immunol 2005; 35:3343-3352.
    • (2005) Eur J Immunol , vol.35 , pp. 3343-3352
    • Haas, J.1    Hug, A.2    Viehover, A.3
  • 31
    • 33344457856 scopus 로고    scopus 로고
    • The immune paradox of sarcoidosis and regulatory T cells
    • Miyara M, Amoura Z, Parizot C, et al. The immune paradox of sarcoidosis and regulatory T cells. J Exp Med 2006; 203:359-370.
    • (2006) J Exp Med , vol.203 , pp. 359-370
    • Miyara, M.1    Amoura, Z.2    Parizot, C.3
  • 32
    • 33746809277 scopus 로고    scopus 로고
    • High donor FOXP3-positive regulatory T-cell (Treg) content is associated with a low risk of GVHD following HLA-matched allogeneic SCT
    • Rezvani K, Mielke S, Ahmadzadeh M, et al. High donor FOXP3-positive regulatory T-cell (Treg) content is associated with a low risk of GVHD following HLA-matched allogeneic SCT. Blood 2006; 108:1291-1297.
    • (2006) Blood , vol.108 , pp. 1291-1297
    • Rezvani, K.1    Mielke, S.2    Ahmadzadeh, M.3
  • 33
    • 32644448124 scopus 로고    scopus 로고
    • Mucosal FOXP3+ regulatory T cells are numerically deficient in acute and chronic GvHD
    • Rieger K, Loddenkemper C, Maul J, et al. Mucosal FOXP3+ regulatory T cells are numerically deficient in acute and chronic GvHD. Blood 2006; 107:1717-1723.
    • (2006) Blood , vol.107 , pp. 1717-1723
    • Rieger, K.1    Loddenkemper, C.2    Maul, J.3
  • 34
    • 0141461418 scopus 로고    scopus 로고
    • CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation
    • Edinger M, Hoffmann P, Ermann J, et al. CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation. Nat Med 2003; 9:1144-1150.
    • (2003) Nat Med , vol.9 , pp. 1144-1150
    • Edinger, M.1    Hoffmann, P.2    Ermann, J.3
  • 35
    • 0037025943 scopus 로고    scopus 로고
    • Donor-type CD4(+)CD25(+) regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation
    • Hoffmann P, Ermann J, Edinger M, et al. Donor-type CD4(+)CD25(+) regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation. J Exp Med 2002; 196:389-399.
    • (2002) J Exp Med , vol.196 , pp. 389-399
    • Hoffmann, P.1    Ermann, J.2    Edinger, M.3
  • 36
    • 32644482551 scopus 로고    scopus 로고
    • R cells in bone marrow transplantation.
    • R cells in bone marrow transplantation.
  • 37
    • 30744458573 scopus 로고    scopus 로고
    • Lymphopenia and interleukin-2 therapy alter homeostasis of CD4+CD25+ regulatory T cells
    • Zhang H, Chua KS, Guimond M, et al. Lymphopenia and interleukin-2 therapy alter homeostasis of CD4+CD25+ regulatory T cells. Nat Med 2005; 11:1238-1243.
    • (2005) Nat Med , vol.11 , pp. 1238-1243
    • Zhang, H.1    Chua, K.S.2    Guimond, M.3
  • 38
    • 33645759979 scopus 로고    scopus 로고
    • Suppression of natural killer cell-mediated bone marrow cell rejection by CD4+CD25+ regulatory T cells
    • can also prevent natural killer cell mediated graft rejection in addition to their effects on graft versus host disease
    • R cells can also prevent natural killer cell mediated graft rejection in addition to their effects on graft versus host disease.
    • R cells
    • Barao, I.1    Hanash, A.M.2    Hallett, W.3
  • 39
    • 28144463375 scopus 로고    scopus 로고
    • Stem cell transplantation in autoimmune diseases: An update
    • Jantunen E, Luosujarvi R. Stem cell transplantation in autoimmune diseases: an update. Ann Med 2005; 37:533-541.
    • (2005) Ann Med , vol.37 , pp. 533-541
    • Jantunen, E.1    Luosujarvi, R.2
  • 40
    • 85117738983 scopus 로고    scopus 로고
    • R cell numbers.
    • R cell numbers.
  • 41
    • 3142519564 scopus 로고    scopus 로고
    • In vitro-expanded human CD4+CD25+ T-regulatory cells can markedly inhibit allogeneic dendritic cell-stimulated MLR cultures
    • Godfrey WR, Ge YG, Spoden DJ, et al. In vitro-expanded human CD4+CD25+ T-regulatory cells can markedly inhibit allogeneic dendritic cell-stimulated MLR cultures. Blood 2004; 104:453-461.
    • (2004) Blood , vol.104 , pp. 453-461
    • Godfrey, W.R.1    Ge, Y.G.2    Spoden, D.J.3
  • 42
    • 33746356813 scopus 로고    scopus 로고
    • Human regulatory T cells and their role in autoimmune disease
    • Baecher-Allan C, Hafler DA. Human regulatory T cells and their role in autoimmune disease. Immunol Rev 2006; 212:203-216.
    • (2006) Immunol Rev , vol.212 , pp. 203-216
    • Baecher-Allan, C.1    Hafler, D.A.2
  • 43
    • 33745817085 scopus 로고    scopus 로고
    • CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells
    • Liu W, Putnam AL, Xu-Yu Z, et al. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J Exp Med 2006; 203:1701-1711.
    • (2006) J Exp Med , vol.203 , pp. 1701-1711
    • Liu, W.1    Putnam, A.L.2    Xu-Yu, Z.3
  • 44
    • 33645778289 scopus 로고    scopus 로고
    • MHC class II expression identifies functionally distinct human regulatory T cells
    • Baecher-Allan C, Wolf E, Hafler DA. MHC class II expression identifies functionally distinct human regulatory T cells. J Immunol 2006; 176:4622-4631.
    • (2006) J Immunol , vol.176 , pp. 4622-4631
    • Baecher-Allan, C.1    Wolf, E.2    Hafler, D.A.3
  • 45
    • 0035806290 scopus 로고    scopus 로고
    • Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood
    • Jonuleit H, Schmitt E, Stassen M, et al. Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood. J Exp Med 2001; 193:1285-1294.
    • (2001) J Exp Med , vol.193 , pp. 1285-1294
    • Jonuleit, H.1    Schmitt, E.2    Stassen, M.3
  • 46
    • 0036144888 scopus 로고    scopus 로고
    • Homeostasis and anergy of CD4+CD25+ suppressor T cells in vivo
    • Gavin MA, Clarke SR, Negrou E, et al. Homeostasis and anergy of CD4+CD25+ suppressor T cells in vivo. Nat Immunol 2002; 3:33-41.
    • (2002) Nat Immunol , vol.3 , pp. 33-41
    • Gavin, M.A.1    Clarke, S.R.2    Negrou, E.3
  • 47
    • 3242801352 scopus 로고    scopus 로고
    • Large-scale in vitro expansion of polyclonal human CD4+CD25high regulatory T cells
    • Hoffmann P, Eder R, Kunz-Schughart LA, et al. Large-scale in vitro expansion of polyclonal human CD4+CD25high regulatory T cells. Blood 2004; 104:895-903.
    • (2004) Blood , vol.104 , pp. 895-903
    • Hoffmann, P.1    Eder, R.2    Kunz-Schughart, L.A.3
  • 48
    • 18144396195 scopus 로고    scopus 로고
    • In vitro expanded human CD4+CD25+ regulatory T cells suppress effector T cell proliferation
    • Earle KE, Tang Q, Zhou X, et al. In vitro expanded human CD4+CD25+ regulatory T cells suppress effector T cell proliferation. Clin Immunol 2005; 115:3-9.
    • (2005) Clin Immunol , vol.115 , pp. 3-9
    • Earle, K.E.1    Tang, Q.2    Zhou, X.3
  • 49
    • 33747889822 scopus 로고    scopus 로고
    • Calcineurin inhibitors, but not rapamycin, reduce percentages of CD4+CD25+FOXP3+ regulatory T cells in renal transplant recipients
    • Segundo DS, Ruiz JC, Izquierdo M, et al. Calcineurin inhibitors, but not rapamycin, reduce percentages of CD4+CD25+FOXP3+ regulatory T cells in renal transplant recipients. Transplantation 2006; 82:550-557.
    • (2006) Transplantation , vol.82 , pp. 550-557
    • Segundo, D.S.1    Ruiz, J.C.2    Izquierdo, M.3
  • 50
    • 33745861719 scopus 로고    scopus 로고
    • Rapamycin-mediated enrichment of T cells with regulatory activity in stimulated CD4+ T cell cultures is not due to the selective expansion of naturally occurring regulatory T cells but to the induction of regulatory functions in conventional CD4+ T cells
    • Valmori D, Tosello V, Souleimanian NE, et al. Rapamycin-mediated enrichment of T cells with regulatory activity in stimulated CD4+ T cell cultures is not due to the selective expansion of naturally occurring regulatory T cells but to the induction of regulatory functions in conventional CD4+ T cells. J Immunol 2006; 177:944-949.
    • (2006) J Immunol , vol.177 , pp. 944-949
    • Valmori, D.1    Tosello, V.2    Souleimanian, N.E.3
  • 51
    • 31544482746 scopus 로고    scopus 로고
    • Rapamycin, and not cyclosporin A, preserves the highly suppressive CD27+ subset of human CD4+CD25+ regulatory T cells
    • Coenen JJ, Koenen HJ, van Rijssen E, et al. Rapamycin, and not cyclosporin A, preserves the highly suppressive CD27+ subset of human CD4+CD25+ regulatory T cells. Blood 2006; 107:1018-1023.
    • (2006) Blood , vol.107 , pp. 1018-1023
    • Coenen, J.J.1    Koenen, H.J.2    van Rijssen, E.3
  • 52
    • 22144475453 scopus 로고    scopus 로고
    • Differential effect of calcineurin inhibitors, anti-CD25 antibodies and rapamycin on the induction of FOXP3 in human T cells
    • Baan CC, van der Mast BJ, Klepper M, et al. Differential effect of calcineurin inhibitors, anti-CD25 antibodies and rapamycin on the induction of FOXP3 in human T cells. Transplantation 2005; 80:110-117.
    • (2005) Transplantation , vol.80 , pp. 110-117
    • Baan, C.C.1    van der Mast, B.J.2    Klepper, M.3
  • 53
    • 20444373376 scopus 로고    scopus 로고
    • Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells
    • Battaglia M, Stabilini A, Roncarolo MG. Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells. Blood 2005; 105:4743-4748.
    • (2005) Blood , vol.105 , pp. 4743-4748
    • Battaglia, M.1    Stabilini, A.2    Roncarolo, M.G.3
  • 54
    • 0042512461 scopus 로고    scopus 로고
    • Direct expansion of functional CD25+ CD4+ regulatory T cells by antigen-processing dendritic cells
    • Yamazaki S, Iyoda T, Tarbell K, et al. Direct expansion of functional CD25+ CD4+ regulatory T cells by antigen-processing dendritic cells. J Exp Med 2003; 198:235-247.
    • (2003) J Exp Med , vol.198 , pp. 235-247
    • Yamazaki, S.1    Iyoda, T.2    Tarbell, K.3
  • 55
    • 0041884743 scopus 로고    scopus 로고
    • Continuous activation of autoreactive CD4+ CD25+ regulatory T cells in the steady state
    • Fisson S, Darrasse-Jeze G, Litvinova E, et al. Continuous activation of autoreactive CD4+ CD25+ regulatory T cells in the steady state. J Exp Med 2001; 198:737-746.
    • (2001) J Exp Med , vol.198 , pp. 737-746
    • Fisson, S.1    Darrasse-Jeze, G.2    Litvinova, E.3
  • 56
    • 0344585521 scopus 로고    scopus 로고
    • Cutting edge: Self-peptides drive the peripheral expansion of CD4+CD25+ regulatory T cells
    • Cozzo C, Larkin J III, Caton AJ. Cutting edge: self-peptides drive the peripheral expansion of CD4+CD25+ regulatory T cells. J Immunol 2003; 171:5678-5682.
    • (2003) J Immunol , vol.171 , pp. 5678-5682
    • Cozzo, C.1    Larkin III, J.2    Caton, A.J.3
  • 57
    • 33645102841 scopus 로고    scopus 로고
    • An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires
    • Hsieh CS, Zheng Y, Liang Y, et al. An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires. Nat Immunol 2006; 7:401-410.
    • (2006) Nat Immunol , vol.7 , pp. 401-410
    • Hsieh, C.S.1    Zheng, Y.2    Liang, Y.3
  • 58
    • 0036196305 scopus 로고    scopus 로고
    • Pancreatic lymph node-derived CD4(+)CD25(+) Treg cells: Highly potent regulators of diabetes that require TRANCE-RANK signals
    • Green EA, Choi Y, Flavell RA. Pancreatic lymph node-derived CD4(+)CD25(+) Treg cells: highly potent regulators of diabetes that require TRANCE-RANK signals. Immunity 2002; 16:183-191.
    • (2002) Immunity , vol.16 , pp. 183-191
    • Green, E.A.1    Choi, Y.2    Flavell, R.A.3
  • 59
    • 2942642383 scopus 로고    scopus 로고
    • In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes
    • Tang Q, Henriksen KJ, Bi M, et al. In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes. J Exp Med 2004; 199:1455-1465.
    • (2004) J Exp Med , vol.199 , pp. 1455-1465
    • Tang, Q.1    Henriksen, K.J.2    Bi, M.3
  • 60
    • 2942692039 scopus 로고    scopus 로고
    • CD25+ CD4+ T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes
    • Tarbell KV, Yamazaki S, Olson K, et al. CD25+ CD4+ T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes. J Exp Med 2004; 199:1467-1477.
    • (2004) J Exp Med , vol.199 , pp. 1467-1477
    • Tarbell, K.V.1    Yamazaki, S.2    Olson, K.3
  • 61
    • 2442618129 scopus 로고    scopus 로고
    • CD4+CD25bright regulatory T cells actively regulate inflammation in the joints of patients with the remitting form of juvenile idiopathic arthritis
    • de Kleer IM,Wedderburn LR, Taams LS, et al. CD4+CD25bright regulatory T cells actively regulate inflammation in the joints of patients with the remitting form of juvenile idiopathic arthritis. J Immunol 2004; 172:6435-6443.
    • (2004) J Immunol , vol.172 , pp. 6435-6443
    • de Kleer, I.M.1    Wedderburn, L.R.2    Taams, L.S.3
  • 62
    • 22344432319 scopus 로고    scopus 로고
    • Coexpression of CD25 and CD27 identifies FoxP3+ regulatory T cells in inflamed synovia
    • Ruprecht CR, Gattorno M, Ferlito F, et al. Coexpression of CD25 and CD27 identifies FoxP3+ regulatory T cells in inflamed synovia. J Exp Med 2005; 201:1793-1803.
    • (2005) J Exp Med , vol.201 , pp. 1793-1803
    • Ruprecht, C.R.1    Gattorno, M.2    Ferlito, F.3
  • 63
    • 12144289938 scopus 로고    scopus 로고
    • Epitope-specific immunotherapy induces immune deviation of proinflammatory T cells in rheumatoid arthritis
    • Prakken BJ, Samodal R, Le TD, et al. Epitope-specific immunotherapy induces immune deviation of proinflammatory T cells in rheumatoid arthritis. Proc Natl Acad Sci U S A 2004; 101:4228-4233.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 4228-4233
    • Prakken, B.J.1    Samodal, R.2    Le, T.D.3
  • 64
    • 4444300314 scopus 로고    scopus 로고
    • CD4(+)CD25(+) regulatory T cells in rheumatoid arthritis: Differences in the presence, phenotype, and function between peripheral blood and synovial fluid
    • van Amelsfort JM, Jacobs KM, Bijlsma JW, et al. CD4(+)CD25(+) regulatory T cells in rheumatoid arthritis: differences in the presence, phenotype, and function between peripheral blood and synovial fluid. Arthritis Rheum 2004; 50:2775-2785.
    • (2004) Arthritis Rheum , vol.50 , pp. 2775-2785
    • van Amelsfort, J.M.1    Jacobs, K.M.2    Bijlsma, J.W.3
  • 65
    • 0037436119 scopus 로고    scopus 로고
    • Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells
    • Pasare C, Medzhitov R. Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells. Science 2003; 299:1033-1036.
    • (2003) Science , vol.299 , pp. 1033-1036
    • Pasare, C.1    Medzhitov, R.2
  • 66
    • 33646487278 scopus 로고    scopus 로고
    • R cells, in particular how immune suppression is circumvented during effective immune responses, and possibly during autoimmunity.
    • R cells, in particular how immune suppression is circumvented during effective immune responses, and possibly during autoimmunity.
  • 67
    • 8444245925 scopus 로고    scopus 로고
    • Toll-dependent control mechanisms of CD4 T cell activation
    • Pasare C, Medzhitov R. Toll-dependent control mechanisms of CD4 T cell activation. Immunity 2004; 21:733-741.
    • (2004) Immunity , vol.21 , pp. 733-741
    • Pasare, C.1    Medzhitov, R.2
  • 68
    • 33646577466 scopus 로고    scopus 로고
    • R cells.
    • R cells.
  • 69
    • 33744921639 scopus 로고    scopus 로고
    • IL-1 beta breaks tolerance through expansion of CD25+ effector T cells
    • O'Sullivan BJ, Thomas HE, Pai S, et al. IL-1 beta breaks tolerance through expansion of CD25+ effector T cells. J Immunol 2006; 176:7278-7287.
    • (2006) J Immunol , vol.176 , pp. 7278-7287
    • O'Sullivan, B.J.1    Thomas, H.E.2    Pai, S.3
  • 70
    • 33646370647 scopus 로고    scopus 로고
    • TNF downmodulates the function of human CD4+CD25hi T-regulatory cells
    • Valencia X, Stephens G, Goldbach-Mansky R, et al. TNF downmodulates the function of human CD4+CD25hi T-regulatory cells. Blood 2006; 108:253-261.
    • (2006) Blood , vol.108 , pp. 253-261
    • Valencia, X.1    Stephens, G.2    Goldbach-Mansky, R.3
  • 71
    • 0242574700 scopus 로고    scopus 로고
    • Treatment of rheumatoid arthritis by selective inhibition of T-cell activation with fusion protein CTLA4Ig
    • Kremer JM, Westhovens R, Leon M, et al. Treatment of rheumatoid arthritis by selective inhibition of T-cell activation with fusion protein CTLA4Ig. N Engl J Med 2003; 349:1907-1915.
    • (2003) N Engl J Med , vol.349 , pp. 1907-1915
    • Kremer, J.M.1    Westhovens, R.2    Leon, M.3
  • 73
    • 27644449311 scopus 로고    scopus 로고
    • The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs
    • Allan SE, Passerini L, Bacchetta R, et al. The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs. J Clin Invest 2005; 115:3276-3284.
    • (2005) J Clin Invest , vol.115 , pp. 3276-3284
    • Allan, S.E.1    Passerini, L.2    Bacchetta, R.3
  • 74
    • 0037018104 scopus 로고    scopus 로고
    • In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines
    • Barrat FJ, Cua DJ, Boonstra A, et al. In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines. J Exp Med 2004; 195:603-616.
    • (2004) J Exp Med , vol.195 , pp. 603-616
    • Barrat, F.J.1    Cua, D.J.2    Boonstra, A.3
  • 75
    • 0347895101 scopus 로고    scopus 로고
    • Activation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype
    • Kemper C, Chan AC, Green JM, et al. Activation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype. Nature 2003; 421:388-392.
    • (2003) Nature , vol.421 , pp. 388-392
    • Kemper, C.1    Chan, A.C.2    Green, J.M.3
  • 76
    • 0035339884 scopus 로고    scopus 로고
    • IFN-alpha and IL-10 induce the differentiation of human type 1 T regulatory cells
    • Levings MK, Sangregorio R, Galbiati F, et al. IFN-alpha and IL-10 induce the differentiation of human type 1 T regulatory cells. J Immunol 2001; 166:5530-5539.
    • (2001) J Immunol , vol.166 , pp. 5530-5539
    • Levings, M.K.1    Sangregorio, R.2    Galbiati, F.3
  • 77
    • 33748504567 scopus 로고    scopus 로고
    • Immature dendritic cells suppress collagen-induced arthritis by in vivo expansion of CD49b+ regulatory T cells
    • Charbonnier LM, van Duivenvoorde LM, Apparailly F, et al. Immature dendritic cells suppress collagen-induced arthritis by in vivo expansion of CD49b+ regulatory T cells. J Immunol 2006; 177:3806-3813.
    • (2006) J Immunol , vol.177 , pp. 3806-3813
    • Charbonnier, L.M.1    van Duivenvoorde, L.M.2    Apparailly, F.3
  • 78
    • 12844274909 scopus 로고    scopus 로고
    • Differentiation of Tr1 cells by immature dendritic cells requires IL-10 but not CD25+CD4+ Tr cells
    • Levings MK, Gregori S, Tresoldi E, et al. Differentiation of Tr1 cells by immature dendritic cells requires IL-10 but not CD25+CD4+ Tr cells. Blood 2005; 105:1162-1169.
    • (2005) Blood , vol.105 , pp. 1162-1169
    • Levings, M.K.1    Gregori, S.2    Tresoldi, E.3
  • 79
    • 0034613767 scopus 로고    scopus 로고
    • Induction of interleukin 10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells
    • Jonuleit H, Schmitt E, Schuler G, et al. Induction of interleukin 10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells. J Exp Med 2000; 192:1213-1222.
    • (2000) J Exp Med , vol.192 , pp. 1213-1222
    • Jonuleit, H.1    Schmitt, E.2    Schuler, G.3
  • 80
    • 10344229958 scopus 로고    scopus 로고
    • Functional regulatory immune responses against human cartilage glycoprotein-39 in health vs. proinflammatory responses in rheumatoid arthritis
    • van Bilsen JH, van Dongen H, Lard LR, et al. Functional regulatory immune responses against human cartilage glycoprotein-39 in health vs. proinflammatory responses in rheumatoid arthritis. Proc Natl Acad Sci U S A 2004; 101:17180-17185.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 17180-17185
    • van Bilsen, J.H.1    van Dongen, H.2    Lard, L.R.3
  • 81
    • 6344278853 scopus 로고    scopus 로고
    • An elevated level of IL-10- and TGFbetasecreting T cells, B cells and macrophages in the synovial membrane of patients with reactive arthritis compared to rheumatoid arthritis
    • Appel H, Neure L, Kuhne M, et al. An elevated level of IL-10- and TGFbetasecreting T cells, B cells and macrophages in the synovial membrane of patients with reactive arthritis compared to rheumatoid arthritis. Clin Rheumatol 2004; 23:435-440.
    • (2004) Clin Rheumatol , vol.23 , pp. 435-440
    • Appel, H.1    Neure, L.2    Kuhne, M.3
  • 82
    • 0041731822 scopus 로고    scopus 로고
    • Heat shock protein 60 and adjuvant arthritis: A model for T cell regulation in human arthritis
    • Prakken BJ, Roord S, Ronaghy A, et al. Heat shock protein 60 and adjuvant arthritis: a model for T cell regulation in human arthritis. Springer Semin Immunopathol 2003; 25:47-63.
    • (2003) Springer Semin Immunopathol , vol.25 , pp. 47-63
    • Prakken, B.J.1    Roord, S.2    Ronaghy, A.3
  • 83
    • 33745817772 scopus 로고    scopus 로고
    • R cells to produce IL-10 which blocks TNFα and IFN-γ production from CD4 lymphocytes.
    • R cells to produce IL-10 which blocks TNFα and IFN-γ production from CD4 lymphocytes.
  • 84
    • 21844457408 scopus 로고    scopus 로고
    • Tolerogenic immune responses to novel T-cell epitopes from heat-shock protein 60 in juvenile idiopathic arthritis
    • Kamphuis S, Kuis W, de Jager W, et al. Tolerogenic immune responses to novel T-cell epitopes from heat-shock protein 60 in juvenile idiopathic arthritis. Lancet 2005; 366:50-56.
    • (2005) Lancet , vol.366 , pp. 50-56
    • Kamphuis, S.1    Kuis, W.2    de Jager, W.3
  • 85
    • 0037198420 scopus 로고    scopus 로고
    • Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus
    • Herold KC, Hagopian W, Auger JA, et al. Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus. N Engl J Med 2002; 346:1692-1698.
    • (2002) N Engl J Med , vol.346 , pp. 1692-1698
    • Herold, K.C.1    Hagopian, W.2    Auger, J.A.3
  • 86
    • 0037314237 scopus 로고    scopus 로고
    • Activation of human T cells by FcR nonbinding anti-CD3 mAb, hOKT3gamma1(Ala-Ala)
    • Herold KC, Burton JB, Francois F, et al. Activation of human T cells by FcR nonbinding anti-CD3 mAb, hOKT3gamma1(Ala-Ala). J Clin Invest 2003; 111:409-418.
    • (2003) J Clin Invest , vol.111 , pp. 409-418
    • Herold, K.C.1    Burton, J.B.2    Francois, F.3
  • 87
    • 33645525544 scopus 로고    scopus 로고
    • CD4+ regulatory T cell responses induced by T cell vaccination in patients with multiple sclerosis
    • Hong J, Zang YC, Nie H, Zhang JZ. CD4+ regulatory T cell responses induced by T cell vaccination in patients with multiple sclerosis. Proc Natl Acad Sci U S A 2006; 103:5024-5029.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 5024-5029
    • Hong, J.1    Zang, Y.C.2    Nie, H.3    Zhang, J.Z.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.