The anti-epileptic drug levetiracetam reverses the inhibition by negative allosteric modulators of neuronal GABA- and glycine-gated currents

British Journal of Pharmacology

Volumn 136, Issue 5, 2002, Pages 659-672

  Rigo, J M ^a   Hans, G ^a   Nguyen, L ^a   Rocher, V ^a   Belachew, S ^a   Malgrange, B ^a   Leprince, P ^a   Moonen, G ^a   Selak, I ^b   Matagne, A ^b   Klitgaard, H ^b  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b UCB PHARMA   (Belgium)

Author keywords

Anti epileptic drugs; Glycine receptor; Inhibition reversal; Levetiracetam; Sound susceptible mice; Whole cell patch clamp; Zinc; carbolines

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; CARBAMAZEPINE; CLONAZEPAM; ETHOSUXIMIDE; ETIRACETAM; FLUMAZENIL; GLYCINE RECEPTOR; N METHYL BETA CARBOLINE 3 CARBOXAMIDE; PHENOBARBITAL; PHENYTOIN; VALPROIC ACID; ZINC; ANTICONVULSIVE AGENT; BENZODIAZEPINE RECEPTOR AFFECTING AGENT; DRUG DERIVATIVE; PIRACETAM;

ALLOSTERISM; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; EMBRYO; FEMALE; GRANULE CELL; HIPPOCAMPUS; MOUSE; NEUROTRANSMISSION; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; SPINAL CORD NERVE CELL; TONIC SEIZURE; ANIMAL; CELL CULTURE; CHANNEL GATING; CYTOLOGY; NERVE CELL; NERVE CELL INHIBITION; NEWBORN; PHYSIOLOGY;

ALLOSTERIC REGULATION; ANIMAL; ANIMALS, NEWBORN; ANTICONVULSANTS; CELLS, CULTURED; EMBRYO; FEMALE; GABA MODULATORS; ION CHANNEL GATING; MICE; NEURAL INHIBITION; NEURONS; PIRACETAM; RATS; RECEPTORS, GABA-A; RECEPTORS, GLYCINE; SUPPORT, NON-U.S. GOV'T; ANIMALS;

EID: 0035987775     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704766     Document Type: Article

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