On the action of the anti-absence drug ethosuximide in the rat and cat thalamus

Journal of Neuroscience

Volumn 18, Issue 13, 1998, Pages 4842-4853

  Leresche, Nathalie ^b   Parri, H Rheinallt ^a   Erdemli, Gül ^a   Guyon, Alice ^b   Turner, Jonathan P ^a,d   Williams, Stephen R ^a,e   Asprodini, Eftihia ^a,c   Crunelli, Vincenzo ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b CNRS   (France)

^c UNIVERSITY OF THESSALY   (Greece)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

^e Australian National University   (Australia)

Author keywords

Absence epilepsy; Burst firing; Ca2+ currents; Ethosuxirnide; K+ currents; Na+ currents; Thalamus; Tonic firing

Indexed keywords

CADMIUM; CALCIUM ION; ETHOSUXIMIDE; MAGNESIUM; POTASSIUM ION; SODIUM ION;

ABSENCE; ACTION POTENTIAL; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM CURRENT; CAT; CONTROLLED STUDY; DRUG MECHANISM; LATERAL GENICULATE NUCLEUS; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; RAT; SODIUM CURRENT; THALAMUS;

EID: 0032125478     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.18-13-04842.1998     Document Type: Article

References (57)

1. Avoli M, Gloor P, Kostopoulas G, Naquet R (1990) Generalized epilepsy: neurobiological approaches. Boston: Birkhäuser.
2. Avanzini G, Vergnes M, Spreafico R, Marescaux C (1993) Calcium-dependent regulation of genetically determined spike and waves by the reticular thalamic nucleus of rats. Epilepsia 34:1-7.
3. Bradley WG, Daroff RB, Fenichel GM, Marsden CD (1996) Neurology in clinical practice - principles of diagnosis and management. Boston: Butterworth-Heinemann.
4. Brown TR, Dreifuss FE, Dyken PR, Goode DJ, Penry JR, Porter RJ, White BG, White PT (1975) Ethosuximide in the treatment of absence (petit mal) seizures. Neurology 25:515-524.
5. Budde T, Mager R, Pape H-C (1992) Different types of potassium outward current in relay neurons acutely dissociated from the rat lateral geniculate nucleus. Eur J Neurosci 4:708-722.
6. Coulter DA, Huguenard JR, Prince DA (1989a) Calcium currents in rat thalamocortical relay neurones: kinetic properties of the transient, low-threshold current. J Physiol (Lond) 414:587-604.
7. Coulter DA, Huguenard JR, Prince DA (1989b) Specific petit mal anti-convulsants reduce calcium currents in thalamic neurons. Neurosci Lett 98:74-78.
8. Coulter DA, Huguenard JR, Prince DA (1989c) Characterization of ethosuximide reduction of low-threshold calcium current in thalamic neurons. Ann Neurol 25:582-593.
9. Coulter DA, Huguenard JR, Prince DA (1990a) Differential effects of petit mal anticonvulsants and convulsants on thalamic neurones: calcium current reduction. Br J Pharmacol 100:800-806.
10. Coulter DA, Huguenard JR, Prince DA (1990b) Cellular actions of petit mal anticonvulsants: implication of thalamic low-threshold calcium current in generation of spike-wave discharge. In: Generalized epilepsy (Avoli M, Gloor P, Kostopoulos G, Naquet R, eds), pp 425-435. Boston: Birkhäuser.
11. 2+ potentials in cells of the cat and rat lateral geniculate nucleus. J Physiol (Lond) 413:543-561.
12. Crunelli V, Asprodini E, Guyon A, Turner JP, Vergnes A, Williams SR, Leresche N (1995) On the action of ethosuximide in the rat and cat thalamus. Soc Neurosci Abstr 21:104.
13. Deschênes M, Paradis M, Roy JP, Steriade M (1984) Electrophysiology of neurons of the lateral thalamic nuclei in cat: resting properties and burst discharges. J Neurophysiol 51:1196-1219.
14. + currents in rat thalamocortical neurones in vitro. J Physiol (Lond) 501:25P.
15. Fohlmeister JF, Adelman WJ, Brennan JJ (1984) Excitable channel currents and gating times in the presence of anticonvulsants ethosuximide and valproate. J Pharmacol Exp Ther 230:75-81.
16. Gloor P, Fariello G (1988) Generalized epilepsy: some of its cellular mechanisms differ from those of focal epilepsy. Trends Neurosci 11:63-68.
17. B receptor types of voltage-activated calcium currents in rat thalamocortical neurones. J Physiol (Lond) 485:29-42.
18. Guyon A, Vergnes M, Leresche N (1993) Thalamic low threshold calcium current in a genetic model of absence epilepsy. NeuroReport 4:1231-1234.
19. Hernandez-Cruz A, Pape H-C (1989) Identification of low calcium currents in acutely dissociated neurons from the rat lateral geniculate nucleus. J Neurophysiol 61:1270-1283.
20. 2+ current in rat clonal (GH3) pituitary cells. J Neurophysiol 68:213-232.
21. Huguenard JR, Prince DA (1991) Slow inactivation of a TEA-sensitive K current in acutely isolated rat thalamic relay neurons. J Neurophysiol 66:1316-1328.
22. 2+-dependent burst firing in GABAergic neurons of rat thalamic reticular nucleus. J Neurosci 12:3804-3817.
23. Huguenard JR, Prince DA (1994) Intrathalamic rhythmicity studied in vitro: nominal T-current modulation causes robust antioscillatory effects. J Neurosci 14:5485-5502.
24. Huguenard JR, Coulter DA, Prince DA (1991) A fast transient potassium current in thalamic relay neurons: kinetics of activation and inactivation. J Neurophysiol 66:1304-1315.
25. Inoue M, Duysens J, Vossen JMH, Coenen AML (1993) Thalamic multiple-unit activity underlying spike-wave discharges in anesthetized rats. Brain Res 612:35-40.
26. Jahnsen H, Llinás RR (1984) Ionic basis for the electroresponsiveness and oscillatory properties of guinea-pig thalamic neurones in vitro. J Physiol (Lond) 349:227-247.
27. Kostyuk PG, Molokanova EA, Pronchuk NF, Savchenko AN, Verkhratsky AN (1992) Different action of ethosuximide on low- and high-threshold calcium currents in rat sensory neurons. Neuroscience 51:755-758.
28. B receptors. J Physiol (Lond) 502:91-104.
29. Leresche N, Jassik-Gerschenfeld D, Haby M, Soltesz I, Crunelli V (1990) Pacemaker-like and other types of spontaneous membrane potential oscillations of thalamocortical cells. Neurosci Lett 113:72-77.
30. Leresche N, Lightowler S, Soltesz I, Jassik-Gerschenfeld D, Crunelli V (1991) Low-frequency oscillatory activities intrinsic to rat and cat thalamocortical cells. J Physiol (Lond) 441:155-174.
31. Malafosse A, Genton P, Hirsch E, Marescaux C, Broglin D, Bernasconi R (1994) Idiopathic generalized epilepsies. London: Libbey.
32. Marescaux C, Vergnes M, Depaulis A (1992) Genetic absence epilepsy in rats from Strasbourg - a review. J Neural Transm [Suppl] 35:37-69.
33. McCormick DA (1991) Functional properties of a slowly inactivating potassium current in guinea pig dorsal lateral geniculate relay neurons. J Neurophysiol 66:1176-1189.
34. McCormick DA, Bal T (1997) Sleep and arousal: thalamocortical mechanisms. Annu Rev Neurosci 20:185-215.
35. McLean MJ, MacDonald RL (1986) Sodium valproate, but not ethosuximide, produces use- and voltage-dependent limitation of high frequency repetitive firing of action potentials of mouse central neurons in cell culture. J Pharmacol Exp Ther 237:1001-1011.
36. McNamara JO (1995) Drugs effective in the therapy of the epilepsies. In: The pharmacological basis of therapeutics (Hardman JG, Goodman Gilman A, Limbird LE, eds), pp 461-486. New York: McGraw-Hill.
37. Niedermeyer E (1996) Primary (idiopathic) generalized epilepsy and underlying mechanisms. Clin Electroencephalogr 27:1-21.
38. Parri HR, Crunelli V (1998) Sodium current in rat and cat thalamocortical neurons: role of a non-inactivating component in tonic and burst firing. J Neurosci 18:854-867.
39. Pfrieger FW, Veselovsky NS, Gottmann K, Lux HD (1992) Pharmacological characterization of calcium currents and synaptic transmission between thalamic neurons in vitro. J Neurosci 12:4347-4357.
40. Pirchio M, Turner JP, Williams SR, Asprodini E, Crunelli V (1997) Postnatal development of membrane properties and δ oscillations in thalamocortical neurons of the cat dorsal lateral geniculate nucleus. J Neurosci 17:5428-5444.
41. Rogawski MA, Porter RJ (1990) Antiepileptic drugs: pharmacological mechanisms and clinical efficacy with consideration of promising developmental stage compounds. Pharmacol Rev 42:223-286.
42. Roger J, Bureau M, Ferrer-Vidal LO, Daurella LO, Saltarelli A, Genton P (1994) Clinical and electroencephalographic characteristics of idiopathic generalized epilepsies. In: Idiopathic generalized epilepsies: clinical, experimental and genetic aspects (Malafosse A, Genton P, Hirsch E, Marescaux C, Broglin D, Bernasconi R, eds), pp 7-18. London: Libbey.
43. Sayer RJ, Brown AM, Schwindt PC, Crill WE (1993) Calcium currents in acutely isolated human neocortical neurons. J Neurophysiol 69:1596-1606.
44. Selzer ME, Dichter MA (1992) Cellular pathophysiology and pharmacology of epilepsy. In: Diseases of the nervous system - clinical neurobiology (Asbury AK, McKhann GM, McDonald WI, eds), pp 916-935. Philadelphia: Saunders.
45. Sherwin AL (1989) Ethosuximide. Clinical use. In: Antiepileptic drugs (Levy R, Matteson R, Meldrum, Penry JK, Dreifuss FE, eds), pp 685-689. New York: Raven.
46. Snead III CO (1995) Basic mechanisms of generalized absence seizures. Ann Neurol 37:146-157.
47. Steriade M, Contreras D (1995) Relations between cortical and thalamic cellular events during transition from sleep patterns to paroxysmal activity. J Neurosci 15:623-642.
48. Steriade M, Curró Dossi R, Nuñez A (1991) Network modulation of a slow intrinsic oscillation of cat thalamocortical neurons implicated in sleep δ waves: cortically induced synchronization and brainstem cholinergic suppression. J Neurosci 11:3200-3217.
49. Suzuki S, Rogawski MA (1989) T-type calcium channels mediate the transition between tonic and phasic firing in thalamic neurons. Proc Natl Acad Sci USA 86:7228-7232.
50. Thompson SM, Wong RS (1991) Development of calcium current subtypes in isolated rat hippocampal pyramidal cells. J Physiol (Lond) 439:671-689.
51. Tsakiridou E, Bertollini L, de Curtis M, Avanzini G, Pape H-C (1995) Selective increase in T-type calcium conductance of reticular thalamic neurons in a rat model of absence epilepsy. J Neurosci 15:3110-3117.
52. Turner JP, Anderson CM, Williams SR, Crunelli V (1997) Morphology and membrane properties of neurones in the cat ventrobasal thalamus in vitro. J Physiol (Lond) 505:707-726.
53. Upton N (1994) Mechanisms of action of new antiepileptic drugs: rational design and serendipitous findings. Trends Pharmacol Sci 15:456-463.
54. Williams DA (1953) A study of thalamic and cortical rhythms in petit mal. Brain 76:56-69.
55. Williams SR, Turner JP, Anderson CM, Crunelli V (1996) Electrophysiological and morphological properties of interneurones in the rat dorsal lateral geniculate nucleus in vitro. J Physiol (Lond) 490:129-147.
56. T produces input signal amplification and bistability in thalamocortical neurones. J Physiol (Lond) 505:689-705.
57. Williams SR, Turner JP, Hughes SW, Crunelli V (1997b) On the nature of anomalous rectification in thalamocortical neurones of the ventro-basal thalamus in vitro. J Physiol (Lond) 505:727-747.