Mechanisms of T-type calcium channel blockade by zonisamide

Seizure

Volumn 5, Issue 2, 1996, Pages 115-119

  Kito, Masao ^a   Maehara, Mitsuo ^b   Watanabe, Kazuyoshi ^c  

^a Minami Seikyo Hospital   (Japan)

^b CHUBU NATIONAL HOSPITAL   (Japan)

^c NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Absence seizure; Calcium channel currents; Human neuroblastoma cell line; Whole cell clamp recording; Zonisamide

Indexed keywords

ANTICONVULSIVE AGENT; CALCIUM CHANNEL; ZONISAMIDE;

ARTICLE; CALCIUM CURRENT; CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ELECTRIC POTENTIAL; EPILEPTIC DISCHARGE; HUMAN; HUMAN CELL; KINETICS; MEMBRANE DEPOLARIZATION; NEUROBLASTOMA CELL; PRIORITY JOURNAL; SEIZURE;

EID: 0030035708     PISSN: 10591311     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1059-1311(96)80104-X     Document Type: Article

References (18)

1. Seino, M., Miyazaki, H. and Ito, T. Zonisamide. In: (Eds F. Pisani, E. Perruca, G. Avanzini, A. Richens), New Antiepileptic Drugs. Epilepsy Research (Suppl. 3), Amsterdam, Elsevier, 1991: 169-174.
2. Rock, D.M., Macdonald, R.L. and Taylor, C.P. Blockade of sustained repetitive action potentials in cultured spinal cord neurons by zonisamide (AD 810, CI 912), a novel anticonvulsant. Epilepsy Research 1989; 3: 138-143.
3. Schauf, D.L. Zonisamide enhances slow sodium inactivation in Myxicola. Brain Research 1987; 413: 185-188.
4. Suzuki, S., Kawakami, K., Nishimura, S. et al. Zonisamide blocks T-type calcium channel in cultured neurons of rat cerebral cortex. Epilepsy Research 1992; 12: 21-27.
5. Kito, M., Maehara, M. and Watanabe, K. Antiepileptic drugs-calcium current interaction in cultured human neuroblastoma cells. Seizure 1994; 3: 141-149.
6. Miyake, S., Shimo, Y. and Kitamura, T. Characteristics of continuous and functional cell line NB-1, derived from a human neuroblastoma. Autonomic Nervous System 1973; 10: 115-120.
7. Hamil, O.P., Marty, A., Neher, E., Sackmann, B. and Sigworth, F.J. Improved patch clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflüger's Archiv: European Journal of Physiology 1984; 391: 85-100.
8. Fox, A.P., Nowycky, M.C. and Tsien, R.W. Kinetic and pharmacological properties distinguishing three types of calcium currents in chick sensory neurons. Journal of Physiology (Lond.) 1987; 394: 149-172.
9. Rogawski, M. and Porter, R.J. Antiepileptic drugs: pharmacological mechanisms and clinical efficacy with consideration of promising developmental stage compounds. Pharmacological Reviews 1990; 42: 223-286.
10. Nowycky, M.C., Fox, A.P. and Tsien, R.W. Three types of neuronal calcium channel with different calcium agonist sensitivity. Nature (Lond.) 1985; 316: 440-443.
11. Kasai, H., Aosaki, T. and Fukuda, J., Presynaptic Ca-antagonist ω-conotoxin irreversibly blocks N-type Ca-channels in chick sensory neurons. Neuroscience Research 1987; 4: 228-235.
12. Nowyczky, M.C., Fox, A.P. and Tsien, R.W. Long-opening mode of gating of neuronal calcium channels and its promotion by the dihydropyridine calcium agonist Bay K 8644. Proceedings of the National Academy of Sciences of The United States of America 1985; 82: 2178-2182.
13. Kito, M., Maehara, M. and Watanabe, K. Three types of Voltage-dependent calcium currents in cultures human neuroblastoma cells. Nagoya Journal of Medical Science 1995; 58: 29-33.
14. Miller, R.J. Multiple calcium channels and neuronal function. Science 1987; 235: 46-52.
15. Suzuki, S. and Rogawski, M.A. T-type calcium channels mediate the transition between tonic and phasic firing in thalamic neurons. Proceedings of the National Academy of Sciences of The United States of America 1989; 86: 7228-7232.
16. Twombly, D.A., Yoshii, M. and Narahashi, T. Mechanisms of calcium channel block by phenytoin. Journal of Pharmacology and Experimental Therapeutics 1989; 246: 189-195.
17. Kelly, K.M., Gross, R.A. and Macdonald, R.L. Valproic acid selectively reduces the low-threshold (T) calcium current in rat nodose neurons. Neuroscience Letters 1990; 116: 233-238.
18. Coulter, D.A., Huguenard, J.R. and Prince, D.A. Characterization of ethosuximide reduction of low-threshold calcium current in thalamic neurons. Annals of Neurology 1989; 25: 582-593.