A review of mechanisms of acrylamide carcinogenicity

Carcinogenesis

Volumn 28, Issue 3, 2007, Pages 519-528

  Besaratinia, Ahmad ^a   Pfeifer, Gerd P ^a  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACRYLAMIDE;

BREAST CANCER; BREAST TUMOR; CANCER RISK; CARCINOGENESIS; CARCINOGENICITY; CENTRAL NERVOUS SYSTEM TUMOR; DNA ADDUCT; FOOD COMPOSITION; FOOD INTAKE; GENOTOXICITY; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LUNG ADENOMA; MALIGNANT NEOPLASTIC DISEASE; MESOTHELIOMA; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; REVIEW; RODENT; SKIN CARCINOMA; THYROID ADENOMA; THYROID CARCINOMA; TOXICOKINETICS; UTERUS CARCINOMA;

ACRYLAMIDE; ANIMALS; CARCINOGENS; DIET; DISEASE MODELS, ANIMAL; DNA ADDUCTS; FOOD ANALYSIS; FOOD HANDLING; HUMANS; MICE; NEOPLASMS; RATS;

EID: 34047156621     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgm006     Document Type: Review

References (96)

1. Dearfield,K.L. et al. (1988) Acrylamide: Its metabolism, developmental and reproductive effects, genotoxicity, and carcinogenicity. Mutat. Res., 195, 45-77.
2. Dearfield,K.L. et al. (1995) Acrylamide: A review of its genotoxicity and an assessment of heritable genetic risk. Mutat. Res., 330, 71-99.
3. McCollister,D.D. et al. (1964) Toxicology of acrylamide. Toxicol. Appl. Pharmacol., 103, 172-181.
4. Friedman,M. (2003) Chemistry, biochemistry, and safety of acrylamide. A review. J. Agr. Food Chem., 51, 4504-4526.
5. Collins,J.J. et al. (1989) Mortality patterns among workers exposed to acrylamide. J. Occup. Med., 31, 614-617.
6. Granath,F. et al. (2001) Cancer risk from exposure to occupational acrylamide. Occup. Environ. Med., 58, 608-609.
7. Marsh,G.M. et al. (1999) Mortality patterns among workers exposed to acrylamide: 1994 follow up. Occup. Environ. Med., 56, 181-190.
8. Reynolds,T. (2002) Acrylamide and cancer: Tunnel leak in Sweden prompted studies. J. Natl Cancer Inst., 94, 876-878.
9. Tornqvist,M. et al. (2000) Leakage of Acrylamides from a Tunnel Construction Work: Exposure Monitoring and Health Effects to Humans and Animals.MSfor European ALARANetwork workshop, Antwerp, Belgium, pp. 1-8.
10. Godin,A.C. et al. (2002) Acrylamide and N-methylolacrylamide poisoning in a herd of Charolais crossbreed cattle. Vet. Rec., 151, 724-728.
11. Hagmar,L. et al. (2001) Health effects of occupational exposure to acrylamide using hemoglobin adducts as biomarkers of internal dose. Scand. J. Work Environ. Health, 27, 219-226.
12. Bergmark,E. (1997) Hemoglobin adducts of acrylamide and acrylonitrile in laboratory workers, smokers and nonsmokers. Chem. Res. Toxicol., 10, 78-84.
13. Tareke,E. et al. (2000) Acrylamide: A cooking carcinogen? Chem. Res. Toxicol., 13, 517-522.
14. Tareke,E. et al. (2002) Analysis of acrylamide, a carcinogen formed in heated foodstuffs. J. Agric. Food Chem., 50, 4998-5006.
15. Stadler,R.H. et al. (2002) Acrylamide from Maillard reaction products. Nature, 419, 449-450.
16. Mottram,D.S. et al. (2002) Acrylamide is formed in the Maillard reaction. Nature, 419, 448-449.
17. Mucci,L.A. et al. (2003) Dietary acrylamide and cancer of the large bowel, kidney, and bladder: Absence of an association in a population-based study in Sweden. Br. J. Cancer, 88, 84-89.
18. Pelucchi,C. et al. (2003) Fried potatoes and human cancer. Int. J. Cancer, 105, 558-560.
19. Besaratinia,A. et al. (2005) DNA adduction and mutagenic properties of acrylamide. Mutat. Res., 580, 31-40.
20. Sumner,S.C. et al. (1999) Role of cytochrome P450 2E1 in the metabolism of acrylamide and acrylonitrile in mice. Chem. Res. Toxicol., 12, 1110-1116.
21. Srivastava,S. et al. (1986) Effect of single and repeated doses of acrylamide and bis-acrylamide on glutathione-S-transferase and dopamine receptors in rat brain. Brain Res., 371, 319-323.
22. Abate,C. et al. (1990) Redox regulation of fos and jun DNA-binding activity in vitro. Science, 249, 1157-1161.
23. Banerjee,S. et al. (1986) In vitro transformation of C3H/10T1/2 and NIH/ 3T3 cells by acrylonitrile and acrylamide. Cancer Lett., 32, 293-304.
24. Schulze-Osthoff,K. et al. (1995) Redox signalling by transcription factors NF-kappa B and AP-1 in lymphocytes. Biochem. Pharmacol., 50, 735-741.
25. Tsuda,H. et al. (1993) Acrylamide; induction of DNA damage, chromosomal aberrations and cell transformation without gene mutations. Mutagenesis, 8, 23-29.
26. Agrawal,A.K. et al. (1981) Neurotransmitter receptors in brain regions of acrylamide-treated rats. I: Effects of a single exposure to acrylamide. Pharmacol. Biochem. Behav., 14, 527-731.
27. Agrawal,A.K. et al. (1981) The effects of acrylamide treatment upon the dopamine receptor. Toxicol. Appl. Pharmacol., 58, 89-99.
28. Ali,S.F. et al. (1983) Effect of acrylamide on neurotransmitter metabolism and neuropeptide levels in several brain regions and upon circulating hormones. Arch. Toxicol., 52, 35-43.
29. Bolt,H.M. (2003) Genotoxicity - threshold or not? Introduction of cases of industrial chemicals. Toxicol. Lett., 140-141, 43-51.
30. European Commission, European Chemicals Bureau Institute for Health and Consumer Protection. (2002) European Union Risk Assessment Report Acrylmaide. Office for Official Publications of the European Communities, Luxembourg, UK.
31. Tyl,R.W. et al. (2003) Effects of acrylamide on rodent reproductive performance. Reprod. Toxicol., 17, 1-13.
32. Rice,J.M. (2005) The carcinogenicity of acrylamide. Mutat Res., 580, 3-20.
33. Sorgel,F. et al. (2002) Acrylamide: Increased concentrations in homemade food and first evidence of its variable absorption from food, variable metabolism and placental and breast milk transfer in humans. Chemotherapy, 48, 267-274.
34. Fuhr,U. et al. (2006) Toxicokinetics of acrylamide in humans after ingestion of a defined dose in a test meal to improve risk assessment for acrylamide carcinogenicity. Cancer Epidemiol. Biomarkers Prev., 15, 266-271.
35. Boettcher,M.I. et al. (2006) Excretion of mercapturic acids of acrylamide and glycidamide in human urine after single oral administration of deuterium-labelled acrylamide. Arch. Toxicol., 80, 55-61.
36. Fennell,T.R. et al. (2005) Metabolism and hemoglobin adduct formation of acrylamide in humans. Toxicol. Sci., 85, 447-459.
37. Schettgen,T. et al. (2004) Trans-placental exposure of neonates to acrylamide - a pilot study. Int. Arch. Occup. Environ. Health, 77, 213-216.
38. Sumner,S.C. et al. (1997) Urinary metabolites from F344 rats and B6C3F1 mice coadministered acrylamide and acrylonitrile for 1 or 5 days. Chem. Res. Toxicol., 10, 1152-1160.
39. Paulsson,B. et al. (2001) The multiplicative model for cancer risk assessment: Applicability to acrylamide. Carcinogenesis, 22, 817-819.
40. Doerge,D.R. et al. (2005) Toxicokinetics of acrylamide and glycidamide in B6C3F1 mice. Toxicol. Appl. Pharmacol., 202, 258-267.
41. Gamboa da Costa,G. et al. (2003) DNA adduct formation from acrylamide via conversion to glycidamide in adult and neonatal mice. Chem. Res. Toxicol., 16, 1328-1337.
42. Fu,P.P. et al. (2000) Metabolic activation capacity of neonatal mice in relation to the neonatal mouse tumorigenicity bioassay. Drug Metab. Rev., 32, 241-266.
43. Solomon,J.J. et al. (1985) Direct alkylation of 2′-deoxynucleosides and DNA following in vitro reaction with acrylamide. Cancer Res., 45, 3465-3470.
44. Segerback,D. et al. (1995) Formation of N-7-(2-carbamoyl-2-hydroxyethyl) guanine in DNA of the mouse and the rat following intraperitoneal administration of [14C]acrylamide. Carcinogenesis, 16, 1161-1165.
45. Hashimoto,K. et al. (1985) Mutagenicity of acrylamide and its analogues in Salmonella typhimurium. Mutat. Res., 158, 129-133.
46. Ghanayem,B.I. et al. (2005) Comparison of germ cell mutagenicity in male CYP2E1-null and wild-type mice treated with acrylamide: Evidence supporting a glycidamide-mediated effect. Biol. Reprod., 72, 157-163.
47. Paulsson,B. et al. (2002) Hemoglobin adducts and micronucleus frequencies in mouse and rat after acrylamide or N-methylolacrylamide treatment. Mutat. Res., 516, 101-111.
48. Schmid,T.E. et al. (1999) Detection of aneuploidy by multicolor FISH in mouse sperm after in vivo treatment with acrylamide, colchicine, diazepam or thiabendazole. Mutagenesis, 14, 173-179.
49. Manjanatha,M.G. et al. (2006) Genotoxicity of acrylamide and its metabolite glycidamide administered in drinking water to male and female Big Blue mice. Environ. Mol. Mutagen., 47, 6-17.
50. Russell,L.B. et al. (1991) Induction of specific-locus mutations in male germ cells of the mouse by acrylamide monomer. Mutat. Res., 262, 101-107.
51. Neuhauser-Klaus,A. et al. (1989) Mutagenic and teratogenic effects of acrylamide in the mammalian spot test. Mutat. Res., 226, 157-162.
52. Hoorn,A.J. et al. (1993) Detection of chemical mutagens using Muta mouse: A transgenic mouse model. Mutagenesis, 8, 7-10.
53. Adler,I.D. et al. (2000) 1-Aminobenzotriazole inhibits acrylamide-induced dominant lethal effects in spermatids of male mice. Mutagenesis, 15, 133-136.
54. Ghanayem,B.I. et al. (2005) Absence of acrylamide-induced genotoxicity in CYP2E1-null mice: Evidence consistent with a glycidamide-mediated effect. Mutat. Res., 578, 284-297.
55. Besaratinia,A. et al. (2006) Investigating human cancer etiology by DNA lesion footprinting and mutagenicity analysis. Carcinogenesis, 27, 1526-1537.
56. Bull,R.J. et al. (1984) Carcinogenic effects of acrylamide in Sencar and A/J mice. Cancer Res., 44, 107-111.
57. Bull,R.J. et al. (1984) Carcinogenic activity of acrylamide in the skin and lung of Swiss-ICR mice. Cancer Lett., 24, 209-212.
58. Koizumi,A. et al. (1993) Energy restriction that inhibits cellular proliferation by torpor can decrease susceptibility to spontaneous and asbestos-induced lung tumors in A/J mice. Lab. Invest., 68, 728-739.
59. Shimkin,M.B. et al. (1975) Lung tumors in mice: Application to carcinogenesis bioassay. Adv. Cancer Res., 21, 1-58.
60. Stoner,G.D. et al. (1982) Strain A mouse lung tumor bioassay. J. Am. Coll. Toxicol., 1, 145-169.
61. Derelanko,M.J. et al. (2001) Carcinogenesis. In Derelanko,M.J. and Hollinger, M.A. (eds.) Handbook of ToxicologyCRC Press, New York, NY, pp. 627-646.
62. Li,E.E. et al. (1994) Relationships of DNA adduct formation, K-ras activating mutations and tumorigenic activities of 6-nitrochrysene and its metabolites in the lungs of CD-1 mice. Carcinogenesis, 15, 1377-1385.
63. Manenti,G. et al. (2003) Outbred CD-1 mice carry the susceptibility allele at the pulmonary adenoma susceptibility 1 (Pas1) locus. Carcinogenesis, 24, 1143-1148.
64. Koskinen,M. et al. (2000) Specific DNA adducts induced by some monosubstituted epoxides in vitro and in vivo. Chem. Biol. Interact., 129, 209-229.
65. Loeb,L.A. et al. (1986) Mutagenesis by apurinic/apyrimidinic sites. Annu. Rev. Genet., 20, 201-230.
66. Glaab,W.E. et al. (1999) Specificity of mutations induced by methyl methanesulfonate in mismatch repair-deficient human cancer cell lines. Mutat. Res., 427, 67-78.
67. Haracska,L. et al. (2001) Roles of yeast DNA polymerases delta and zeta and of Rev1 in the bypass of abasic sites. Genes Dev., 15, 945-954.
68. Zhao,B. et al. (2004) Role of DNA polymerase eta in the bypass of abasic sites in yeast cells. Nucleic Acids Res., 32, 3984-3994.
69. Besaratinia,A. et al. (2004) Genotoxicity of acrylamide and glycidamide. J. Natl Cancer Inst., 96, 1023-1029.
70. Besaratinia,A. et al. (2003)Weak yet distinct mutagenicity of acrylamide in mammalian cells. J. Natl Cancer Inst., 95, 889-896.
71. Lambert,I.B. et al. (2005) Detailed review of transgenic rodent mutation assays. Mutat. Res., 590, 1-280.
72. Tritscher,A.M. (2004) Human health risk assessment of processing-related compounds in food. Toxicol. Lett., 149, 177-186.
73. Jagerstad,M. et al. (2005) Genotoxicity of heat-processed foods. Mutat. Res., 574, 156-172.
74. World Health Organization. (2005) Summary Report of the Sixty-Fourth Meeting of the Joint FAO/WHO Expert Committee on Food Additive (JECFA). Rome, Italy. The ILSI Press International Life Sciences Institute, Washington DC. pp. 1-47.
75. Hagmar,L. et al. (2003) Inconclusive results from an epidemiological study on dietary acrylamide and cancer. Br. J. Cancer, 89, 774-776.
76. Mucci,L.A. et al. (2006) Prospective study of dietary acrylamide and risk of colorectal cancer among women. Int. J. Cancer, 118, 169-173.
77. Mucci,L.A. et al. (2004) Dietary acrylamide and risk of renal cell cancer. Int. J. Cancer, 109, 774-776.
78. Pelucchi,C. et al. (2006) Dietary acrylamide and human cancer. Int. J. Cancer, 118, 467-471.
79. Erdreich,L.S. et al. (2004) Epidemiologic evidence for assessing the carcinogenicity of acrylamide. Regul. Toxicol. Pharmacol., 39, 150-157.
80. Mucci,L.A. et al. (2005) The role of epidemiology in understanding the relationship between dietary acrylamide and cancer risk in humans. Adv. Exp. Med. Biol., 561, 39-47.
81. Petersen,B.J. et al. (2005) Exposure to acrylamide: Placing exposure in context. Adv. Exp. Med. Biol., 561, 63-76.
82. Felsot,A.S. (2002) Acrylamide Angst: Another Annoying Distraction about Food Safety Agrichemical and Environmental News: A Monthly Report on Environmental and Pesticide Related Issues Washington State University, Washington, DC.
83. Johnson,K.A. et al. (1986) Chronic toxicity and oncogenicity study on acrylamide incorporated in the drinking water of Fischer 344 rats. Toxicol. Appl. Pharmacol., 85, 154-168.
84. Robinson,M. et al. (1986) A combined carcinogen bioassay utilizing both the lung adenoma and skin papilloma protocols. Environ. Health Perspect., 68, 141-145.
85. World Health Organization Guidelines for Drinking-Water Quality WHO, Geneva, Switzerland.
86. US Environmental Protection Agency Assessment of Health Risks from Exposure to Acrylamide US EPA Office of Toxic Substances, Washington, DC.
87. International Agency for Research on Cancer Acrylamide IRAC Press, Lyon.
88. Smith,C.J. et al. (2001) "IARC group 2B carcinogens" reported in cigarette mainstream smoke. Food Chem. Toxicol., 39, 183-205.
89. Anway,M.D. et al. (2005) Epigenetic transgenerational actions of endocrine disruptors and male fertility. Science, 308, 1466-1469.
90. Feinberg,A.P. et al. (2004) The history of cancer epigenetics. Nat. Rev. Cancer, 4, 143-153.
91. Hutt,J.A. et al. (2005) Life-span inhalation exposure to mainstream cigarette smoke induces lung cancer in B6C3F1 mice through genetic and epigenetic pathways. Carcinogenesis, 26, 1999-2009.
92. Lee,Y.W. et al. (1995) Carcinogenic nickel silences gene expression by chromatin condensation and DNA methylation: A new model for epigenetic carcinogens. Mol. Cell Biol., 15, 2547-2557.
93. Mass,M.J. et al. (1997) Arsenic alters cytosine methylation patterns of the promoter of the tumor suppressor gene p53 in human lung cells: A model for a mechanism of carcinogenesis. Mutat. Res., 386, 263-277.
94. Ray,S.S. et al. (2004) Dioxin-induced immortalization of normal human keratinocytes and silencing of p53 and p16INK4a. J. Biol. Chem., 279, 27187-27193.
95. Song,S. et al. (2005) Induction of cyclooxygenase-2 by benzo[a]pyrene diol epoxide through inhibition of retinoic acid receptor-beta 2 expression. Oncogene, 24, 8268-8276.
96. Ushijima,T. et al. (2005) Aberrant methylations in cancer cells: Where do they come from? Cancer Sci., 96, 206-211.