Genotoxicity - Threshold or not? Introduction of cases of industrial chemicals

Toxicology Letters

Volumn 140-141, Issue , 2003, Pages 43-51

  Bolt, Hermann M ^a  

^a LEIBNIZ RESEARCH CENTRE FOR WORKING ENVIRONMENT AND HUMAN FACTORS   (Germany)

Author keywords

Acrylamide; Dose response; Formaldehyde; Genotoxicity; Threshold effects; Trichloroethylene; Vinyl acetate acrylonitrile

Indexed keywords

ACRYLAMIDE; ACRYLONITRILE; CARCINOGEN; FORMALDEHYDE; INDUSTRIAL CHEMICAL; TRICHLOROETHYLENE; VINYL ACETATE;

CANCER RISK; CARCINOGENESIS; CARCINOGENICITY; CONFERENCE PAPER; CONTROLLED STUDY; GENOTOXICITY; HUMAN; PRIORITY JOURNAL; RISK ASSESSMENT;

EID: 0037432670     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(02)00495-2     Document Type: Conference Paper

References (55)

1. Adler D., Andrae U., Kreis P., Neumann H.G., Thier R., Wild D. Recommendations for the categorization of germ cell mutagens. Int. Arch. Occup. Environ. Health. 73:2000;428-432.
2. AGS, 2001. Ankündigung von Luftgrenzwerten für Trichlorethylen und Dieselmotoremissionen. Bekanntmachung des BMA vom 2. November 2001, Bundesarbeitsblatt 12/2001, 62. Available from http://www.baua.de/info/index.htm .
3. BGVV, 2002. BGVV-Expertengespräch zum Vorkommen von Acrylamid in Lebensmitteln. BGVV Pressedienst 13/2002, 15.5.2002. Bundesinstitut für gesundheitlichen verbraucherschutz und Veterinärmedizin, Berlin/Germany.
4. Blair A., Stewart P.A., Zaebst D., Pottern L., Zey J., Bloom T., Miller B., Ward E., Lubin J. Mortality study of industrial workers exposed to acrylonitrile. Scand. J. Work Environ. Health. 24:(Suppl. 2):1998;25-41.
5. BMJFG, 1984. Formaldehyd. Ein gemeinsamer Bericht des Bundesgesundheitsamtes, der Bundesanstalt für Arbeitsschutz und des Umweltbundesamtes. Kohlhammer, Stuttgart.
6. Bogdanffy M.S. Vinyl acetate-induced intracellular acidification: implications for risk assessment. Toxicol. Sci. 66:2002;320-326.
7. Bolt H.M. Experimental toxicology of formaldehyde. J. Cancer Res. Clin. Oncol. 113:1987;305-309.
8. Bolt H.M., Gelbke H.P., Kimmerle G., Laib R.J., Neumann H.G., Norpoth K.H., Pott F., Steinhoff D., Wardenbach P. Stoffe mit begründetem Verdacht auf krebserzeugendes Potential (Abschnitt III, Gruppe B der MAK-Werte-Liste): Probleme und Lösungsmöglichkeiten. Arbeitsmed. Sozialmed. Präventivmed. 23:1988;139-144.
9. Brauch H., Weirich G., Hornauer M.A., Störkel S., Wöhl T., Brüning T. Trichloroethylene exposure and specific somatic mutations in patients with renal cell carcinoma. J. Natl. Cancer Inst. 91:1999;854-861.
10. Brüning T., Bolt H.M. Renal toxicity and carcinogenicity of trichloroethylene: key results, mechanisms, and controversies. Crit. Rev. Toxicol. 30:2000;253-285.
11. Brüning T., Vamvakas S., Makropoulos V., Birner G. Acute intoxication with trichloroethylene: clinical symptoms, toxicokinetics, metabolism and development of biochemical parameters for renal damage. Toxicol. Sci. 41:1998;157-165.
12. Brüning T., Mann H., Melzer H., Sundberg A.G.M., Bolt H.M. Pathological excretion patterns of urinary proteins in renal cell cancer patients exposed to trichloroethylene. Occup. Med. 49:1999;1-7.
13. Casanova-Schmitz M., Heck H.D'A. Metabolism of formaldehyde in the rat nasal mucosa in vivo. Toxicol. Appl. Pharmacol. 70:1983;239-253.
14. 14C-formaldehyde. Toxicol. Appl. Pharmacol. 76:1984;26-44.
15. Casanova M., Deyo D.F., Heck H.D'A. Covalent binding of inhaled formaldehyde to DNA in the nasal mucosa of Fischer 344 rats: analysis of formaldehyde and DNA by high-performance liquid chromatography and provisional pharmacokinetic interpretation. Fundam. Appl. Toxicol. 12:1989;397-417.
16. Casanova M., Morgan K.T., Gross E.A., Moss O.R., Heck H.D'A. DNA-protein cross-links and cell replication at specific sites in the nose of F344 rats exposed subchronically to formaldehyde. Fundam. Appl. Toxicol. 23:1994;525-536.
17. Chapman, R., Landsiedel, R., Williams, S., ten Berge, W., 2002. Recent toxicological and epidemiological findings: An overview in relation to the current review of the occupational exposure limit for acrylonitrile. Submitted to SCOEL by the CEFIC ACN Toxicology Committee, Luxembourg, 2002.
18. Collins J.J., Swaen G.M.H., Marsh G.M., Utidjian H.M.D., Caporossi J.C., Lucas L.J. Mortality patterns among workers exposed to acrylamide. J. Occup. Med. 31:1989;614-617.
19. Collins J.J., Strother D.E. CNS tumors and exposure to acrylonitrile: inconsistency between experimental and epidemiology results. Neuro-Oncol. 1:1999;221-230.
20. Crump Group, 1999. Consideration of the potency classification of acrylamide based on the incidence of tunica vaginalis mesotheliomas (TVMs) in male Fischer 344 rats. Prepared by The K.S. Crump Group, Inc., 602 East Georgia, Ruston, LA 71270.
21. Crump Group, 1999. Mechanism of acrylonitrile induction of benign mammary fibroadenomas in the aging female Fischer 344 rat: relevance to human health risk assessment. Prepared by The K.S. Crump Group, Inc., 602 East Georgia, Ruston, LA 71270.
22. Crump Group, 2000. The biological role of acrylamide-induced thyroid follicular cell tumors in the aging F344 rat to human health outcomes. Prepared by The K.S. Crump Group, Inc., 602 East Georgia, Ruston, LA 71270.
23. Doolittle D.J., Furlong J.W., Butterworth B.E. Assessment of chemically induced DNA repair in primary cultures of human bronchial epithelial cells. Toxicol. Appl. Pharmacol. 79:1985;28-38.
24. Grafstrom R.C., Fornace A., Harris C.C. Repair of DNA damage caused by formaldehyde in human cells. Cancer Res. 44:1984;4323-4327.
25. Henschler D., Vamvakas S., Lammert M., Dekant W., Kraus B., Thomas B., Ulm K. Increased incidence of renal cell tumors in a cohort of cardbord workers exposed to trichloroethylene. Arch. Toxicol. 69:1995;291-299.
26. IARC, 1994. Acrylamide. In: IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, vol. 60. IARC, Lyon/France, pp. 389-433.
27. IARC, 1995. Trichloroethylene. In: IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, vol. 63, IARC, Lyon/France, pp. 75-158.
28. IARC, 1999. Acrylonitrile. In: IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, vol. 71. IARC, Lyon/France.
29. Imbus H.R. A review of regulatory risk assessment with formaldehyde as an example. Regul. Toxicol. Pharmacol. 8:1988;356-366.
30. Kamendoulis L.M., Jiang J., Zhang H., de Feijter-Rupp H., Trosko J.E., Klaunig J.E. The effect of acrylonitrile on gap junctional intercellular communication in rat astrocytes. Cell Biol. Toxicol. 15:1999;173-183.
31. Kerns W.D., Pavkov K.L., Donofio D.J., Gralla E.J., Swenberg J.A. Carcinogenicity of formaldehyde in rats and mice after long-term inhalation exposure. Cancer Res. 43:1983;4382-4392.
32. Kreiger R.A., Garry V.F. Formaldehyde-induced cytotoxicity and sister-chromatid exchanges in human lymphocyte cultures. Mutat. Res. 120:1983;51-55.
33. Lam C.W., Casanova M., Heck H.D'A. Depletion of nasal mucosal glutathione by acrolein and enhancement of formaldehyde-induced DNA-protein cross-linking by simultaneous exposure to acrolein. Arch. Toxicol. 58:1985;67-71.
34. Lutz W.K. Quantitative evaluation of DNA binding data for risk estimation and for classification of direct and indirect carcinogens. J. Cancer Res. Clin. Oncol. 112:1986;85-91.
35. Ma T.H., Harris M.M. Review of the genotoxicity of formaldehyde. Mutat. Res. 196:1988;37-59.
36. Mensing T., Welge P., Voss B., Fels L.M., Fricke H.H., Brüning T., Wilhelm M. Renal toxicity after chronic inhalation exposure of rats to trichloroethylene. Toxicol. Lett. 128:2002;243-247.
37. Morgan K.T. A brief review of formaldehyde carcinogenesis in relation to rat nasal pathology and human risk assessment. Toxicol. Pathol. 25:1997;291-307.
38. Neumann H.G., Vamvakas S., Thielmann H.W., Gelbke H.P., Filser J.G., Reuter U., Greim H., Kappus H., Norpoth K.H., Wardenbach P., Wichmann H.E. Changes in the classification of carcinogenic chemicals in the work area. Int. Arch. Occup. Environ. Health. 71:1998;566-574.
39. Peter H., Schwarz M., Mathiasch B., Appel K.E., Bolt H.M. A note on synthesis and reactivity towards DNA of glycidonitrile, the epoxide of acrylonitrile. Carcinogenesis. 4:1983;235-237.
40. Quast J.F., Schwetz D.J., Balmer M.F., Gushow T.S., Park C.N., McKenna M.J. A Two Year Toxicity and Oncogenicity Study with Acrylonitrile Following Inhalation Exposure of Rats. 1980;DOW Toxicology Research Laboratory, Midland, MI.
41. Sakurai H. Carcinogenicity and other health effects of acrylonitrile with reference to occupational exposure limit. Ind. Health. 38:2000;165-180.
42. Schiestl R.H., Aubrecht J., Khogali F., Carls N. Carcinogens induce reversion of the mouse pink-eyed unstable mutation. Proc. Natl. Acad. Sci. 94:1997;4576-4581.
43. Seeley M.R., Tonner-Navarro L.E., Beck B.D., Deskin R., Feron V.J., Johanson G., Bolt H.M. Procedures for health risk assessment in Europe. Regul. Toxicol. Pharmacol. 34:2001;153-169.
44. Sickles D.W., Brady S.T., Testino A., Friedman M.A., Wrenn R.W. Direct effect of the neurotoxicant acrylamide an kinesin-based microtubule motility. J. Neurosci. Res. 46:1996;7-17.
45. Sobel W., Bond G.G., Parson T.W., Brenner F.E. Acrylamide cohort mortality study. Br. J. Ind. Med. 43:1986;785-788.
46. Squire R.A., Cameron L.L. An analysis of potential carcinogenic risk from formaldehyde. Regul. Toxicol. Pharmacol. 4:1984;107-129.
47. Stone J.D., Peterson A.P., Eyer J., Sickles D.W. Neurofilaments are non-essential elements of toxicant-induced reductions in fast axonal transport: pulse labeling in CNS neurons. Neutotoxicology. 21:2000;447-457.
48. Swenberg J.A., Kerns W.D., Mitchell R.E., Gralla E.J., Pavkov K.L. Induction of squameous cell carcinomas of the rat nasal cavity by inhalation exposure to formaldehyde vapor. Cancer Res. 40:1980;3398-3402.
49. Swenberg J.A., Barrow C.S., Boreiko C.D., Heck H.D'A., Levine R.J., Morgan K.T., Starr T.B. Non-linear biological responses to formaldehyde and their implications for carcinogenic risk assessment. Carcinogenesis. 4:1983;945-952.
50. Thier R., Lewalter J., Kempkes M., Selinski S., Brüning T., Bolt H.M. Haemoglobin adducts of acrylonitrile and ethylene oxide in acrylonitrile workers, dependent on polymorphisms of the glutathione transferases GSTT1 and GSTM1. Arch. Toxicol. 73:1999;197-202.
51. Thier R., Lewalter J., Bolt H.M. Species differences in acrylonitrile metabolism and toxicity between experimental animals and humans based on observations in human accidental poisonings. Arch. Toxicol. 74:2000;184-189.
52. Thier R., Lewalter J., Selinski S., Bolt H.M. Possible impact of human CYP2E1 polymorphism on the metabolism of acrylonitrile. Toxicol. Lett. 128:2002;249-255.
53. Vamvakas S., Brüning T., Thomasson B., Lammert M., Baumüller A., Bolt H.M., Dekant W., Birner G., Henschler D., Ulm K. Renal cell cancer correlated with occupational exposure to trichloroethylene. J. Cancer Res. Clin. Oncol. 124:1998;374-382.
54. Weiss N.L. Cancer in relation to occupational exposure to trichloroethylene. Occup. Environ. Med. 53:1996;1-5.
55. Whysner J., Ross P.M., Conaway C.C., Verna L.K., Williams G.M. Evaluation of possible genotoxic mechanisms for acrylonitrile tumorigenicity. Regul. Toxicol. Pharmacol. 27:1998;217-239.