Effects of acrylamide on rodent reproductive performance

Reproductive Toxicology

Volumn 17, Issue 1, 2003, Pages 1-13

  Tyl, Rochelle W ^a   Friedman, Marvin A ^b  

^a RTI INTERNATIONAL   (United States)

^b RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

Acrylamide; Clastogenicity; Dominant lethality; Endocrine related tumors; Glycidamide; Male reproductive toxicity; Mutagenicity; Neurotoxicity; Rodents

Indexed keywords

ACRYLAMIDE; DNA; DOPAMINE RECEPTOR; DYNEIN ADENOSINE TRIPHOSPHATASE; KINESIN; PROTAMINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; CELL TRANSPORT; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA BINDING; DOSE RESPONSE; ENDOCRINE TUMOR; FEMALE; GENE MUTATION; MALE; MALE GENITAL SYSTEM; MORPHOLOGY; MUSCLE WEAKNESS; MUTAGENICITY; NEUROLOGIC DISEASE; NEUROTOXICITY; NEWBORN; NONHUMAN; PARESIS; PERIPHERAL NEUROPATHY; PRENATAL DEVELOPMENT; PROTEIN BINDING; REPRODUCTIVE TOXICITY; REVIEW; SPERMATOZOON MOTILITY;

ACRYLAMIDE; ANIMALS; ANIMALS, INBRED STRAINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRINKING; FEMALE; GENES, DOMINANT; GENES, LETHAL; HAND STRENGTH; MALE; MICE; MUTAGENS; NERVOUS SYSTEM DISEASES; PREGNANCY; RATS; REPRODUCTION; RODENTIA; SPERMATOZOA; WATER SUPPLY;

RODENTIA;

EID: 0037222075     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0890-6238(02)00078-3     Document Type: Review

References (50)

1. IARC. Acrylonitrile, acrylic and modacrylic fibers, and acrylonitrile butadiene-styrene and styrene-acrylonitrile copolymers. In: Some monomers, plastics, and synthetic elastomers and Acrolein; 1979, p. 19.
2. Spencer PS, Schaumburg HH. Industrial neuropathies. Neurotoxicology 1977;427.
3. Damjanov I, Friedman MA. Mesotheliomas of the tunica vaginalis testis of Fischer 344 (F344) rats treated with acrylamide. In Vivo 1998;12:495-502.
4. Crump KS. Mechanism of acrylamide induction of benign mammary fibroadenomas in the aging female Fischer 344 rat: relevance to human health risk assessment. Ruston, LA: The K.S. Crump Group; 1999, p. 1-33.
5. Johnson KA, Gorzinski SJ, Bodner KM, Campbell RA, Wolf CH, Friedman MA, et al. Chronic toxicity and oncogenicity study on acrylamide incorporated in the drinking water of Fischer 344 rats. Toxicol Appl Pharmacol 1986;85:154-68.
6. Friedman MA, Dulak L, Stedham MA. A lifetime oncogenicity study in rats with acrylamide. Fundam Appl Toxicol 1995;25:95-105.
7. Crump KS. Consideration of the potency classification of acrylamide based on the incidence of tunica vaginalis mesotheliomas (TVMs) in male Fischer 344 rats. Ruston, LA: The K.S. Crump Group; 1999, p. 1-30.
8. Bull RJ, Robinson M, Stober JA. Carcinogenic activity of acrylamide in the skin and lung of Swiss-ICR mice. Cancer Lett 1984;24:209-12.
9. Bull RJ, Robinson M, Laurie RD, Stoner GD, Greisiger E, Meier JR, et al. Carcinogenic effects of acrylamide in Sencar and A/J mice. Cancer Res 1984;44:7-11.
10. Robinson M, Bull RJ, Knutsen GL, Shields RP, Stober J. A combined carcinogen bioassay utilizing both the lung adenoma and skin papilloma protocols. Environ Health Perspect 1986;68:141-5.
11. Dearfield K, Douglas L, George R, Ehling UH, Moore MM, Sega GA, et al. Acrylamide: a review of its genotoxicity and an assessment of heritable genetic risk. Mutat Res 1995;330:71-99.
12. Tyl RW. Combined two-generation reproduction study and dominant lethal assay in Fischer 344 rats administered acrylamide in the drinking water. Bushy Run Research Center, Export, PA. Final report to the Acrylamide Producers Association/SOCMA, dated November 6, 1987.
13. Tyl RW, Marr MC, Myers CB, Ross WP, Friedman MA. Relationship between acrylamide reproductive and neurotoxicity in male rats. Reprod Toxicol 2000;14:147-57.
14. Tyl RW, Friedman MA, Losco PE, Fisher LC, Johnson KA, Strother DE, et al. Rat two-generation reproduction and dominant lethal study of acrylamide in drinking water. Reprod Toxicol 2000;14:385-401.
15. Chapin RE, Fail PA, George JD, Grizzle TB, Heindel JJ, Harry GJ, et al. The reproductive and neural toxicities of acrylamide and three analogues in Swiss mice, evaluated using the continuous breeding protocol. Fundam Appl Toxicol 1995;27:9-24.
16. Chapin RE, Sloan RA, Haseman JK. The relationships among reproductive endpoints in Swiss mice using the reproductive assessment by continuous breeding database. Fundam Appl Toxicol 1997;38:129-42.
17. Zenick H, Hope E, Smith MK. Reproductive toxicity associated with acrylamide treatment in male and female rats. J Toxicol Environ Health 1986;17:457-72.
18. Sakamoto J, Hashimoto K. Reproductive toxicity of acrylamide and related compounds in mice - effects on fertility and sperm morphology. Arch Toxicol 1986;59:201-5.
19. Shelby MD, Cain TK, Hughes LA, Bradeen PW, Generoso WM. Dominant lethal effects of acrylamide in male mice. Mutat Res 1986;173:35-40.
20. Smith MK, Zenik H, Preston RJ, George EL, Cong RE. Dominant lethal effects of subchronic acrylamide administered in the male Long-Evans rat. Mutat Res 1986;173:273-7.
21. Adler ID, Baumgartner A, Gonda H, Friedman MA. 1-Aminobenzotriazole inhibits acrylamide-induced dominant lethal effects in spermatids of male mice. Mutagenesis 2000;15:133-6.
22. 13C nuclear magnetic resonance spectroscopy. Chem Res Toxicol 1992;5:81-9.
23. Hashimoto K, Tanii H. Mutagenicity of acrylamide and its analogues in Salmonella typhimurium. Mutat Res 1985;158:129-33.
24. Calleman CJ. The metabolism and pharmacokinetics of acrylamide: implications for mechanisms of toxicity and human risk estimation. Drug Metab Rev 1996;28:527-90.
25. Sega GA, Alcota RP, Tancongco CP, Brimer PA. Acrylamide binding to the DNA and protamine of spermiogenic stages in the mouse and its relationship to genetic damage. Mutat Res 1989;216:221-30.
26. Costa LG, Deng H, Gregotti C, Manzo L, Faustman EM, Bergmark E, et al. Comparative studies on the neuro and reproductive toxicity of acrylamide and its epoxide metabolite glycidamide in the liver. Neurotoxicology 1992;13:219-24.
27. Generoso WM, Sega GA, Lockhardt AM, Hughes LA, Cain KT, Cacheiro NLA, et al. Dominant lethal mutation, heritable translocations, and unscheduled DNA synthesis induced in male mouse germ cells by glycidamide, a metabolite of acrylamide. Mutat Res 1996;371:175-83.
28. Sega GA. Adducts in sperm protamine and DNA versus mutation frequency. Prog Clin Biol Res 1991;372:521-30.
29. Field EA, Price CJ, Sleet RB, Marr MC, Schwetz BA, Morrissey RE. Developmental toxicity evaluation of acrylamide in rats and mice. Fundam Appl Toxicol 1990;14:502-12.
30. Sleet RB, Field EA, Price CJ, Marr MC, Morrissey RE, Schwetz BA. Teratologic evaluation of acrylamide (CAS No. 79-06-1) administered to Sprague-Dawley (CD) rats on gestational days 6 through 20. National Toxicology Program Final Study Report, NTP/NIEHS Contract No. N01-ES-55080, National Technical Information Service (NTIS) Accession No. PB89-164669/AS, November 28, 1988.
31. Price CJ, Sleet RB, Field EA, Marr MC, Morrissey RE, Schwetz BA. Teratologic evaluation of acrylamide (CAS No. 79-06-1) administered to CD-1 mice on gestational days 6 through 17. National Toxicology Program Final Study Report, NTP/NIEHS Contract No. N01-ES-55080, National Technical Information Service (NTIS) Accession No. PB89-140008/AS, October 7, 1988.
32. Husain R, Dixit R, Das M, Seth PK. Neurotoxicity of acrylamide in developing rat brain: changes in the levels of brain biogenic amines and activities of monoamine oxidase and acetylcholine esterase. Ind Health 1987;25:19-28.
33. Friedman MA, Tyl RW, Marr MC, Myers CB, Gerling FS, Ross WP. Effects of lactational administration of acrylamide on rat dams and offspring. Reprod Toxicol 1999;13:511-20.
34. Sublet VH, Zenick H, Smith MK. Factors associated with reduced fertility and implantation rates in females mated to acrylamide treated rats. Toxicology 1989;55:53-67.
35. Working PK, Bentley KS, Hurtt ME, Mohr KL. Comparison of the dominant lethal effects of acrylonitrile and acrylamide in F344 rats. Mutagenesis 1987;2:215-20.
36. Shiraishi Y. Chromosome aberrations induced by monomeric acrylamide in bone marrow and germ cells of mice. Mutat Res 1978;57:313-24.
37. Hashimoto K, Sakamoto J, Tanii H. Neurotoxicity of acrylamide and related compounds and their effects on male gonads in mice. Arch Toxicol 1981;47:179-89.
38. Adler ID. Clastogenic effects of acrylamide in different germ-cell stages of male mice. In: Banbury Report 34: Biology of mammalian germ cell mutagenesis. Cold Spring Harbor Laboratory, Cold Spring Harbor Press; 1990, p. 115-30.
39. Robb GW, Amann RP, Killian GJ. Daily sperm production and epididymal sperm reserves of pubertal and adult rats. J Reprod Fertil 1978;54:103-7.
40. Robaire B, Hermo L. Efferent ducts, epididymis, and vas deferens: structure, functions, and their regulation. In: Knobil E, Neil JD, editors. The physiology of reproduction, vol. 1. New York: Raven Press; 1988, p. 999-1080 (Chapter 23).
41. Wise LD, Gordon RG, Soper KA, Duchai DM, Morrissey RE. Developmental neurotoxicity evaluation of acrylamide in SpragueDawley rats. Neurotox Teratol 1995;17(2):189-98.
42. Ali SF, Hong S, Wilson JS, Uphousle LL, Bondy SC. Effect of acrylamide on the neurotransmitter metabolism and neuropeptide levels in several brain regions and upon circulating hormones. Archiv Toxicol 1983;52:35-43.
43. Sickles D, Brady ST, Testino A, Friedman MA, Wrenn RW. Acrylamide effects on kinesin related mitotic/meiotic motor proteins. J Neurosci Res 1996;46:7-17.
44. Sickles D. Toxic neurofilamentous axonopathies and fast anterograde axonal transport. Part IV. In vitro analysis of transport following acrylamide and 2,5-hexanedione. Toxicol Lett 1992;61:199-204.
45. Adler ID, Zouth R, Schmid E. Perturbation of cell division by acrylamide in vitro and in vivo. Mutat Res 1993;301:249-54.
46. Spencer PS, Shaumburg HH. A review of acrylamide neurotoxicity. Part II Experimental animal neurotoxicity and pathologic mechanisms. Can J Neurol Sci 1974;1:152-69.
47. Miller MG, Mulholland DJ, Vogl AW. Rat testis motor proteins associated with spermatid translocation (dynein) and spermatid flagella (Kinesin-II). Biol Reprod 1999;60(4):1047-56.
48. Burek JD, Albee RR, Beyer JE, Bell TJ, Carreon RN, Morden DC, et al. Subchronic toxicity of acrylamide administered to rats in the drinking water followed by up to 144 days of recovery. J Environ Pathol Toxicol 1980;4:157-82.
49. Sokal R, Rohlf SJ, editors. Biometry. San Francisco: Freeman and Company; 1969.
50. Adler ID, Reitmeir P, Schmoeller R, Schriever-Schwemmer G. Dose response for heritable translocations induced by acrylamide in spermatids of mice. Mutat Res 1994;309:285-91.