Progressive cerebellar, auditory, and esophageal dysfunction caused by targeted disruption of the frizzled-4 gene

Journal of Neuroscience

Volumn 21, Issue 13, 2001, Pages 4761-4771

  Wang, Yanshu ^a   Huso, David ^a   Cahill, Hugh ^a   Ryugo, David ^a   Nathans, Jeremy ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cerebellar degeneration; Esophagus; Frizzled 4; Progressive hearing loss; Purkinje cells; Wnt signaling

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATAXIA; AUDITORY SYSTEM; CELL PROLIFERATION; CEREBELLUM DEGENERATION; CONTROLLED STUDY; ESOPHAGUS MALFORMATION; GENE DISRUPTION; HEARING IMPAIRMENT; HYPOACUSIS; KNOCKOUT MOUSE; MOUSE; NERVE CELL DIFFERENTIATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PURKINJE CELL; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; SYNAPSE;

EID: 0035399638     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.21-13-04761.2001     Document Type: Article

References (65)

1. Frizzled and frizzled-2 function as redundant receptors for Wingless during Drosophila embryonic development
2. Frizzled and frizzled2 play a partially redundant role in wingless signaling and have similar requirements to wingless in neurogenesis
3. Differential expression of the Wnt putative receptors Frizzled during mouse somitogenesis
4. Structural and quantitative studies on the normal C3H and Lurcher mutant mouse
5. Wnt signaling: A common theme in animal development
6. A common human skin tumour is caused by activating mutations in beta-catenin
7. Wingless transduction by the Frizzled and Frizzled2 proteins of Drosophila
8. Wnt-1 signaling inhibits apoptosis by activating beta-catenin/T cell factor-mediated transcription
9. Sonic hedgehog regulates the growth and patterning of the cerebellum
10. Evidence for a mitogenic effect of Wnt-1 in the developing central nervous system
11. Role of transcription factors Brn-3.1 and Brn-3.2 in auditory and visual system development
12. Absence epilepsy in tottering mutant mice is associated with calcium channel defects
13. Hippocampus development and generation of dentate gyrus granule cells is regulated by LEF1
14. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
15. The cells and molecules that make a cerebellum
16. Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons
17. The hem of the embryonic cerebral cortex is defined by the expression of multiple Wnt genes and is compromised in Gli3-deficient mice
18. Axonal remodeling and synaptic differentiation in the cerebellum is regulated by WNT-7a signaling
19. Disruption of the nuclear hormone receptor RORalpha in staggerer mice
20. A member of the Frizzled protein family mediating axis induction by Wnt-5A
21. Insights from mouse models into the molecular basis of neurodegeneration
22. Role of staggerer gene in determining cell number in cerebellar cortex I granule cell death is an indirect consequence of staggerer gene action
23. Cerebellar cell degeneration in the leaner mutant mouse
24. Biochemical characterization of Wnt-Frizzled interactions using a soluble, biologically active vertebrate Wnt protein
25. Genes involved in deafness
26. Wnt signaling required for expansion of neural crest and CNS progenitors
27. A "direct coloring" thiocholine method for choline esterases
28. Genomics and hearing impairment
29. Use of dsRNA-mediated genetic interference to demonstrate that frizzled and frizzled 2 act in the wingless pathway
30. Signaling by wingless in Drosophila
31. A novel mammalian wnt gene, WNT8B, shows brain-restricted expression in early development, with sharply delimited expression boundaries in the developing forebrain
32. A local Wnt-3a signal is required for development of the mammalian hippocampus
33. WNT-7a induces axonal remodeling and increases synapsin I levels in cerebellar neurons
34. The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain
35. Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC
36. Purkinje cell degeneration, a new neurological mutation in the mouse
37. Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome
38. Motility disorders of the esophagus
39. Mouse Wnt genes exhibit discrete domains of expression in the early embryonic CNS and limb buds
40. Evidence for developmentally programmed transdifferentiation in mouse esophageal muscle
41. Anatomy, anomalies, and physiology of the esophagus: Applied anatomy and anomalies
42. Spermatid-specific expression of protamine 1 in transgenic mice
43. Wnt-3, a gene activated by proviral insertion in mouse mammary tumors, is homologous to int-1/Wnt-1 and is normally expressed in mouse embryos and adult brain
44. Pathway specificity by the bifunctional receptor frizzled is determined by affinity for wingless
45. Regional expression of the Wnt-3 gene in the developing mouse forebrain in relationship to diencephalic neuromeres
46. Innervation of the esophagus in mice that lack MASH1
47. AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1
48. Sevier-Munger method for neural tissues
49. Expression of Xfz3, a Xenopus frizzled family member, is restricted to the early nervous system
50. Wnt-1-dependent regulation of local E-cadherin and alpha N-catenin expression in the embryonic mouse brain
51. Local control of granule cell generation by cerebellar Purkinje cells
52. Role of staggerer gene in determining cell number in cerebellar cortex: Granule cell death and persistence of the external granule cell layer in young mouse chimeras
53. Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development
54. Mutation in transcription factor POU4F3 associated with inherited progressive hearing loss in humans
55. A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled
56. Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog
57. Interaction of granule, Purkinje, and inferior olivary neurons in lurcher chimeric mice: Granule cell death
58. Two novel Xenopus frizzled genes expressed in developing heart and brain
59. Essential role of POU-domain factor Brn-3c in auditory and vestibular hair cell development
60. Requirement for Brn-3c in maturation and survival, but not in fate determination of inner hair cells
61. Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis
62. Neurodegeneration in Lurcher mice caused by mutation in delta-2 glutamate receptor gene