Expression of LDL receptor-related protein 5 (LRP5) as a novel marker for disease progression in high-grade osteosarcoma

International Journal of Cancer

Volumn 109, Issue 1, 2004, Pages 106-111

  Hoang, Bang H ^a,c   Kubo, Tadahiko ^a,d   Healey, John H ^a   Sowers, Rebecca ^b   Mazza, BethAnne ^b   Yang, Rui ^b   Huvos, Andrew G ^b   Meyers, Paul A ^b   Gorlick, Richard ^b  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

Author keywords

Low density lipoprotein receptor related protein; Metastasis; Osteosarcoma; Survival; Wnt

Indexed keywords

BETA CATENIN; COMPLEMENTARY DNA; CYTOSKELETON PROTEIN; GENOMIC DNA; ISOPROTEIN; LIPOPROTEIN RECEPTOR RELATED PROTEIN 5; LOW DENSITY LIPOPROTEIN RECEPTOR; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 5; MESSENGER RNA; TRANSACTIVATOR PROTEIN; UNCLASSIFIED DRUG; WNT PROTEIN;

ADOLESCENT; ADULT; AGED; ARTICLE; BIOSYNTHESIS; BONE METASTASIS; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CARTILAGE CELL; CELL DIVISION; CELL LINEAGE; CHILD; CLINICAL ARTICLE; DISEASE COURSE; DNA SEQUENCE; EXON; FEMALE; GENETIC MARKER; HISTOLOGY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; INFANT; LUNG METASTASIS; MALE; METABOLISM; METASTASIS; MUTATION; NUCLEOTIDE SEQUENCE; OSTEOSARCOMA; PATHOLOGY; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TIME; TREATMENT OUTCOME; TUMOR CELL LINE;

ADOLESCENT; ADULT; AGED; BETA CATENIN; CELL DIVISION; CELL LINE, TUMOR; CELL LINEAGE; CHILD; CHILD, PRESCHOOL; CHONDROCYTES; CYTOSKELETAL PROTEINS; DISEASE PROGRESSION; EXONS; FEMALE; GENETIC MARKERS; HUMANS; IMMUNOHISTOCHEMISTRY; INFANT; LDL-RECEPTOR RELATED PROTEINS; MALE; MIDDLE AGED; MUTATION; NEOPLASM METASTASIS; OSTEOSARCOMA; PROTEIN ISOFORMS; RECEPTORS, LDL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS, DNA; SIGNAL TRANSDUCTION; TIME FACTORS; TRANS-ACTIVATORS; TREATMENT OUTCOME;

EID: 0742287878     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.11677     Document Type: Article

References (32)

1. Meyers PA, Heller G, Healey J, Huvos A, Lane J, Marcove R, Applewhite A, Vlamis V, Rosen G. Chemotherapy for nonmetastatic osteogenic sarcoma: the Memorial Sloan-Kettering experience. J Clin Oncol 1992;10:5-15.
2. Rosen G, Caparros B, Huvos AG, Kosloff C, Nirenberg A, Cacavio A, Marcove RC, Lane JM, Mehta B, Urban C. Preoperative chemotherapy for osteogenic sarcoma: selection of postoperative adjuvant chemotherapy based on the response of the primary tumor to preoperative chemotherapy. Cancer 1982;49:1221-30.
3. Onda M, Matsuda S, Higaki S, Iijima T, Fukushima J, Yokokura A, Kojima T, Horiuchi H, Kurokawa T, Yamamoto T. ErbB-2 expression is correlated with poor prognosis for patients with osteosarcoma. Cancer 1996;77:71-8.
4. Kloen P, Gebhardt MC, Perez-Atayde A, Rosenberg AE, Springfield DS, Gold LI, Mankin HJ. Expression of transforming growth factor-beta (TGF-beta) isoforms in osteosarcomas: TGF-beta3 is related to disease progression. Cancer 1997;80:2230-9.
5. Gamberi G, Benassi MS, Bohling T, Ragazzini P, Molendini L, Sollazzo MR, Pompetti F, Merli M, Maganoli G, Balladelli A, Picci P. C-myc and c-fos in human osteosarcoma: prognostic value of mRNA and protein expression. Oncology 1998;55:556-63.
6. Gorlick R, Huvos AG, Heller G, Aledo A, Beardsley GP, Healey JH, Meyers PA. Expression of HER2/erbB-2 correlates with survival in osteosarcoma. J Clin Oncol 1999;17:2781-88.
7. Morris CD, Gorlick R, Huvos G, Heller G, Meyers PA, Healey JH. Human epidermal growth factor receptor 2 as a prognostic indicator in osteogenic sarcoma. Clin Orthop 2001;382:59-65.
8. Nusse R, Varmus HE. Wnt genes. Cell 1992;69:1073-87.
9. Moon RT, Brown JD, Torres M. WNTs modulate cell fate and behavior during vertebrate development. Trends Genet 1997;13:157-62.
10. Bhanot P, Brink M, Samos CH, Hsieh JC, Wang Y, Macke JP, Andrew D, Nathans J, Nusse R. A new member of the frizzled family from Drosophila functions as a Wingless receptor. Nature 1996;382:225-30.
11. He TC, Sparks AB, Rago C, Hermeking H, Zawel L, da Costa LT, Morin PJ, Vogelstein B, Kinzler KW. Identification of c-MYC as a target of the APC pathway. Science 1998;281:1509-12.
12. Crawford HC, Fingleton BM, Rudolph-Owen LA, Goss KJ, Rubinfeld B, Polakis P, Martisian LM. The metalloproteinase matrilysin is a target of beta-catenin transactivation in intestinal tumors. Oncogene 1999;18:2883-91.
13. Tetsu O, McCormick F. Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 1999;398:422-6.
14. Guo W, Gorlick R, Ladanyi M, Meyers PA, Huvos AG, Bertino JR, Healy HR. Expression of bone morphogenetic proteins and receptors in sarcomas. Clin Orthop 1999;365:175-83.
15. Chan SD, Karpf DB, Fowlkes ME, Hooks M, Bradley MS, Vuong V, Bambino T, Liu MY, Arnaud CD, Strewler GJ, et al. Two homologs of the Drosophila polarity gene frizzled (fz) are widely expressed in mammalian tissues. J Biol Chem 1992;267:25202-7.
16. Monaghan H, Bubb VJ, Sirimujalin R, Millward-Sadler SJ, Salter DM. Adenomatous polyposis coli (APC), beta-catenin, and cadherin are expressed in human bone and cartilage. Histopathology 2001;39:611-9.
17. Haydon RC, Deyrup A, Ishikawa A, Heck R, Jiang W, Zhou L, Feng T, King D, Cheng H, Breyer B, Peabody T, Simon MA, Montag AG, He TC. Cytoplasmic and/or nuclear accumulation of the beta-catenin protein is a frequent event in human osteosarcoma. Int J Cancer 2002;102:338-42.
18. Iwao K, Miyoshi Y, Nawa G, Yoshikawa H, Ochi T, Nakamura Y. Frequent beta-catenin abnormalities in bone and soft-tissue tumors. Jpn J Cancer Res 1999;90:205-9.
19. Saito T, Oda Y, Sakamoto A, Kawaguchi K, Tanaka K, Matsuda S, Tamiya S, Iwamoto Y, Tsuneyoshi M. APC mutations in synovial sarcoma. J Pathol 2002;196:445-9.
20. Tamai K, Semenov M, Kato Y, Spokony R, Liu C, Katsuyama Y, Hess F, Sain-Jeannet JP, He X. LDL-receptor-related proteins in Wnt signal transduction. Nature 2000;407:530-5.
21. Mao J, Wang J, Liu B, Pan W, Farr GH 3rd, Flynn C, et al. Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway. Mol Cell 2001;7:801-9.
22. Gong Y, Slee RB, Fukai N, Rawadi G, Roman-Roman S, Reginato AM, Wang H, Cundy T, Glorieux FH, Lev D, Zacharin M, Oxle K, et al. LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell 2001;107:513-23.
23. Kato M, Patel MS, Levasseur R, Lobov I, Chang BH, Glass DA 2nd, Harmann C, Li L, Hwang TH, Brayton CF, Lang RA, Karsenty G, et al. Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor. J Cell Biol 2002;157:303-14.
24. Boyden LM, Mao J, Belsky J, Mitzner L, Farhi A, Mitnick MA, Wu D, Isogna K, Lifton RP. High bone density due to a mutation in LDL-receptor-related protein 5. N Engl J Med 2002;346:1513-21.
25. Dong Y, Lathrop W, Weaver D, Qiu Q, Cini J, Bertolini D, Tamburini PP. Molecular cloning and characterization of LR3, a novel LDL receptor family protein with mitogenic activity. Biochem Biophys Res Commun 1998;251:784-90.
26. Kirikoshi H, Sekihara H, Katoh M. Expression profiles of 10 members of Frizzled gene family in human gastric cancer. Int J Oncol 2001;19:767-71.
27. Polakis P. Wnt signaling and cancer. Genes Dev 2000;14:1837-51.
28. Kirikoshi H, Sekihara H, Katoh M. Up-regulation of Frizzled-7 (FZD7) in human gastric cancer. Int J Oncol 2001;19:111-5.
29. Terasaki H, Saitoh T, Shiokawa K, Katoh M. Frizzled-10, up-regulated in primary colorectal cancer, is a positive regulator of the WNT - beta-catenin - TCF signaling pathway. Int J Mol Med 2002;9:107-12.
30. Tsuji T, Nozaki I, Miyazaki M, Sakaguchi M, Pu H, Hamazaki Y, et al. Antiproliferative activity of REIC/Dkk-3 and its significant down-regulation in nonsmall-cell lung carcinomas. Biochem Biophys Res Commun 2001;289:257-63.
31. Kobayashi K, Ouchida M, Tsuji T, Hanafusa H, Miyazaki M, Namba M, et al. Reduced expression of the REIC/Dkk-3 gene by promoter-hypermethylation in human tumor cells. Gene 2002;282:151-8.
32. Takahashi M, Tsunoda T, Seiki M, Nakamura Y, Furukawa Y. Identification of membrane-type matrix metalloproteinase-1 as a target of the beta-catenin/ Tcf4 complex in human colorectal cancers. Oncogene 2002;21:5861-7.