-
1
-
-
0035418621
-
Constitutive expression of hypoxia-inducible factor-1alpha renders pancreatic cancer cells resistant to apoptosis induced by hypoxia and nutrient deprivation
-
Akakura N, Kobayashi M, Horiuchi I, Suzuki A, Wang J, Chen J et al. (2001). Constitutive expression of hypoxia-inducible factor-1alpha renders pancreatic cancer cells resistant to apoptosis induced by hypoxia and nutrient deprivation. Cancer Res 61: 6548-6554.
-
(2001)
Cancer Res
, vol.61
, pp. 6548-6554
-
-
Akakura, N.1
Kobayashi, M.2
Horiuchi, I.3
Suzuki, A.4
Wang, J.5
Chen, J.6
-
2
-
-
0035933726
-
Hypoxia induces the activation of the phosphatidylinositol 3-kinase/Akt cell survival pathway in PC12 cells: Protective role in apoptosis
-
Alvarez-Tejado M, Naranjo-Suarez S, Jimenez C, Carrera AC, Landazuri MO, Del Peso L. (2001). Hypoxia induces the activation of the phosphatidylinositol 3-kinase/Akt cell survival pathway in PC12 cells: protective role in apoptosis. J Biol Chem 276: 22368-22374.
-
(2001)
J Biol Chem
, vol.276
, pp. 22368-22374
-
-
Alvarez-Tejado, M.1
Naranjo-Suarez, S.2
Jimenez, C.3
Carrera, A.C.4
Landazuri, M.O.5
Del Peso, L.6
-
3
-
-
0032568150
-
-
An GW, Kanekal Meera, Simon MC, Maltepe E, Blagosklonny MV, Neckers ML. (1998). Stabilization of wild-type p53by hypoxia-inducible factor 1alpha. Nature 392: 405-408.
-
An GW, Kanekal Meera, Simon MC, Maltepe E, Blagosklonny MV, Neckers ML. (1998). Stabilization of wild-type p53by hypoxia-inducible factor 1alpha. Nature 392: 405-408.
-
-
-
-
4
-
-
13444283313
-
Ras inhibition in glioblastoma down-regulates hypoxia-inducible factor-1alpha, causing glycolysis shutdown and cell death
-
Blum R, Hirsch J-J, Amariglio N, Rechavi G, Kloog Y. (2005). Ras inhibition in glioblastoma down-regulates hypoxia-inducible factor-1alpha, causing glycolysis shutdown and cell death. Cancer Res 65: 3999.
-
(2005)
Cancer Res
, vol.65
, pp. 3999
-
-
Blum, R.1
Hirsch, J.-J.2
Amariglio, N.3
Rechavi, G.4
Kloog, Y.5
-
5
-
-
0034255036
-
Expression of the gene encoding the proapoptotic Nip3protein is induced by hypoxia
-
Bruick RK. (2000). Expression of the gene encoding the proapoptotic Nip3protein is induced by hypoxia. Proc Natl Acad Sci 97: 9082-9087.
-
(2000)
Proc Natl Acad Sci
, vol.97
, pp. 9082-9087
-
-
Bruick, R.K.1
-
6
-
-
0032581277
-
Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
-
Carmeliet P, Dor Y, Herbert JM, Fukumura D, Brusselmans K, Dewerchin M et al. (1998). Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature 394: 485-490.
-
(1998)
Nature
, vol.394
, pp. 485-490
-
-
Carmeliet, P.1
Dor, Y.2
Herbert, J.M.3
Fukumura, D.4
Brusselmans, K.5
Dewerchin, M.6
-
7
-
-
0344608877
-
Dominant-negative hypoxia-inducible factor-1 alpha reduces tumorigenicity of pancreatic cancer cells through the suppression of glucose metabolism
-
Chen J, Zhao S, Nakada K, Kuge Y, Tamaki N, Okada F et al. (2003). Dominant-negative hypoxia-inducible factor-1 alpha reduces tumorigenicity of pancreatic cancer cells through the suppression of glucose metabolism. Am J Pathal 162: 1283-1291.
-
(2003)
Am J Pathal
, vol.162
, pp. 1283-1291
-
-
Chen, J.1
Zhao, S.2
Nakada, K.3
Kuge, Y.4
Tamaki, N.5
Okada, F.6
-
8
-
-
0033062014
-
Rhabdomyosarcoma: An overview
-
Dagher R, Hellman L. (1999). Rhabdomyosarcoma: an overview. Oncologist 4: 34-44.
-
(1999)
Oncologist
, vol.4
, pp. 34-44
-
-
Dagher, R.1
Hellman, L.2
-
9
-
-
0032476059
-
Hypoxia regulates beta-enolase and pyruvate kinase-M promoters by modulating Sp1/Sp3 binding to a conserved GC element
-
Discher DJ, Bishopric NH, Wu X, Peterson CA, Webster KA. (1998). Hypoxia regulates beta-enolase and pyruvate kinase-M promoters by modulating Sp1/Sp3 binding to a conserved GC element. J Biol Chem 273: 26087-26093.
-
(1998)
J Biol Chem
, vol.273
, pp. 26087-26093
-
-
Discher, D.J.1
Bishopric, N.H.2
Wu, X.3
Peterson, C.A.4
Webster, K.A.5
-
10
-
-
0042845994
-
Apoptosis-resistance of hypoxic cells: Multiple factors involved and a role for IAP-2
-
Dong Z, Wang JZ, Yu F, Venkatachalam MA. (2003). Apoptosis-resistance of hypoxic cells: multiple factors involved and a role for IAP-2. Am J Pathol 163: 663-671.
-
(2003)
Am J Pathol
, vol.163
, pp. 663-671
-
-
Dong, Z.1
Wang, J.Z.2
Yu, F.3
Venkatachalam, M.A.4
-
11
-
-
12144287046
-
Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance
-
Erler JT, Cawthorne CJ, Williams KJ, Koritzinsky M, Wouters BG, Wilson C et al. (2004). Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance. Mol Cell Biol, 2875-2879.
-
(2004)
Mol Cell Biol
, pp. 2875-2879
-
-
Erler, J.T.1
Cawthorne, C.J.2
Williams, K.J.3
Koritzinsky, M.4
Wouters, B.G.5
Wilson, C.6
-
12
-
-
0030752603
-
The CD95 (APO-1/Fas) system mediates drug-induced apoptosis in neuroblastoma cells
-
Fulda S, Sieverts H, Friesen C, Herr I, Debatin KM. (1997). The CD95 (APO-1/Fas) system mediates drug-induced apoptosis in neuroblastoma cells. Cancer Res 57: 3823-3829.
-
(1997)
Cancer Res
, vol.57
, pp. 3823-3829
-
-
Fulda, S.1
Sieverts, H.2
Friesen, C.3
Herr, I.4
Debatin, K.M.5
-
13
-
-
15744395153
-
Adenovirus-mediated p53gene therapy in pediatric soft-tissue sarcoma cell lines: Sensitization to cisplatin and doxorubicin
-
Ganjavi H, Gee M, Narendran A, Freedman HM, Malkin D. (2005). Adenovirus-mediated p53gene therapy in pediatric soft-tissue sarcoma cell lines: sensitization to cisplatin and doxorubicin. Cancer Gene Ther 12: 397-406.
-
(2005)
Cancer Gene Ther
, vol.12
, pp. 397-406
-
-
Ganjavi, H.1
Gee, M.2
Narendran, A.3
Freedman, H.M.4
Malkin, D.5
-
14
-
-
8144228566
-
Why do cancers have high aerobic glycolysis?
-
Gatenby RA, Gillies RJ. (2004). Why do cancers have high aerobic glycolysis? Nat Rev Cancer 11: 891-899.
-
(2004)
Nat Rev Cancer
, vol.11
, pp. 891-899
-
-
Gatenby, R.A.1
Gillies, R.J.2
-
15
-
-
0035030534
-
Hypoxia induces the expression of the pro-apoptotic gene BNIP3
-
Guo K, Searfoss G, Krolikowski D, Pagnoni M, Franks C, Clark K et al. (2001). Hypoxia induces the expression of the pro-apoptotic gene BNIP3. Cell Death Differ 8: 367-376.
-
(2001)
Cell Death Differ
, vol.8
, pp. 367-376
-
-
Guo, K.1
Searfoss, G.2
Krolikowski, D.3
Pagnoni, M.4
Franks, C.5
Clark, K.6
-
16
-
-
0036359548
-
Hypoxia - a key regulatory factor in tumour growth
-
Harris AL. (2002). Hypoxia - a key regulatory factor in tumour growth. Nat Rev Cancer 2: 38-47.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 38-47
-
-
Harris, A.L.1
-
17
-
-
0034751813
-
Mechanism, origin, and evolution of anoxia tolerance in animals
-
Hochachka PW, Lutz PL. (2001). Mechanism, origin, and evolution of anoxia tolerance in animals. Comp Biochem Physiol 130B: 435-459.
-
(2001)
Comp Biochem Physiol
, vol.130 B
, pp. 435-459
-
-
Hochachka, P.W.1
Lutz, P.L.2
-
18
-
-
18744375998
-
Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation
-
Jeong JW, Bae MK, Ahn MY, Kim SH, Sohn TK, Bae MH et al. (2002). Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation. Cell 111: 709-720.
-
(2002)
Cell
, vol.111
, pp. 709-720
-
-
Jeong, J.W.1
Bae, M.K.2
Ahn, M.Y.3
Kim, S.H.4
Sohn, T.K.5
Bae, M.H.6
-
19
-
-
0028049621
-
Apoptosis is regulated by the rate of glucose transport in an interleukin 3 dependent cell line
-
Kan O, Baldwin SA, Whetton AD. (1994). Apoptosis is regulated by the rate of glucose transport in an interleukin 3 dependent cell line. J Exp Med 180: 917-923.
-
(1994)
J Exp Med
, vol.180
, pp. 917-923
-
-
Kan, O.1
Baldwin, S.A.2
Whetton, A.D.3
-
20
-
-
0346655211
-
BH3-only protein Noxa is a mediator of hypoxic cell death induced by hypoxia-inducible factor 1alpha
-
Kim JY, Ahn HJ, Ryu JH, Suk K, Park JH. (2004a). BH3-only protein Noxa is a mediator of hypoxic cell death induced by hypoxia-inducible factor 1alpha. J Exp Med, 113-123.
-
(2004)
J Exp Med
, pp. 113-123
-
-
Kim, J.Y.1
Ahn, H.J.2
Ryu, J.H.3
Suk, K.4
Park, J.H.5
-
21
-
-
3042665524
-
Hypoxia inhibits tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by blocking Bax translocation
-
Kim M, Park SY, Pai HS, Kim TH, Billiar TR, Seol DW. (2004b). Hypoxia inhibits tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by blocking Bax translocation. Cancer Res 64: 4078-4081.
-
(2004)
Cancer Res
, vol.64
, pp. 4078-4081
-
-
Kim, M.1
Park, S.Y.2
Pai, H.S.3
Kim, T.H.4
Billiar, T.R.5
Seol, D.W.6
-
22
-
-
0034079959
-
GLUT-1 reduces hypoxia-induced apoptosis and JNK pathway activation
-
Lin Z, Weinberg JM, Malhotra R, Merritt SE, Holzman LB, Brosius III FC. (2000). GLUT-1 reduces hypoxia-induced apoptosis and JNK pathway activation. Am J of Physiol Endocrinol Metab 278: 958-966.
-
(2000)
Am J of Physiol Endocrinol Metab
, vol.278
, pp. 958-966
-
-
Lin, Z.1
Weinberg, J.M.2
Malhotra, R.3
Merritt, S.E.4
Holzman, L.B.5
Brosius III, F.C.6
-
24
-
-
0035887011
-
FIH-1: A novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity
-
Mahon PC, Hirota K, Semenza GL. (2001). FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev 15: 2675-2686.
-
(2001)
Genes Dev
, vol.15
, pp. 2675-2686
-
-
Mahon, P.C.1
Hirota, K.2
Semenza, G.L.3
-
25
-
-
0035900767
-
Glucose catabolism in cancer cells: Identification and characterization of a marked activation response of the type II hexokinase gene to hypoxic conditions
-
Mathupala SP, Rempel A, Pedersen PL. (2001). Glucose catabolism in cancer cells: identification and characterization of a marked activation response of the type II hexokinase gene to hypoxic conditions. J Biol Chem 276: 43407-43412.
-
(2001)
J Biol Chem
, vol.276
, pp. 43407-43412
-
-
Mathupala, S.P.1
Rempel, A.2
Pedersen, P.L.3
-
26
-
-
0027772521
-
Growth factors, mitogens, oncogenes and the regulation of glucose transport
-
Merrall NW, Plevin R, Gould GW. (1993). Growth factors, mitogens, oncogenes and the regulation of glucose transport. Cell Signal 5: 667-675.
-
(1993)
Cell Signal
, vol.5
, pp. 667-675
-
-
Merrall, N.W.1
Plevin, R.2
Gould, G.W.3
-
27
-
-
0034647742
-
Role of hypoxia-inducible factor-1 in transcriptional activation of ceruloplasmin by iron deficiency
-
Mukopadhyay CK, Mazumder B, Fox PL. (2000). Role of hypoxia-inducible factor-1 in transcriptional activation of ceruloplasmin by iron deficiency. J Biol Chem 275: 21048-21054.
-
(2000)
J Biol Chem
, vol.275
, pp. 21048-21054
-
-
Mukopadhyay, C.K.1
Mazumder, B.2
Fox, P.L.3
-
28
-
-
0033559578
-
Activation of metallothionein gene expression by hypoxia involves metal response elements and metal transcription factor-1
-
Murphy BJ, Andrews GK, Bittel D, Discher DJ, McCue J, Green CJ et al. (1999). Activation of metallothionein gene expression by hypoxia involves metal response elements and metal transcription factor-1. Cancer Res 59: 1315-1322.
-
(1999)
Cancer Res
, vol.59
, pp. 1315-1322
-
-
Murphy, B.J.1
Andrews, G.K.2
Bittel, D.3
Discher, D.J.4
McCue, J.5
Green, C.J.6
-
31
-
-
0036083168
-
Hypoxia inhibition of apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)
-
Park SY, Billar TR, Seol DW. (2002). Hypoxia inhibition of apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Biochem Biophys Res Commun 291: 150-153.
-
(2002)
Biochem Biophys Res Commun
, vol.291
, pp. 150-153
-
-
Park, S.Y.1
Billar, T.R.2
Seol, D.W.3
-
32
-
-
1842861767
-
Hypoxia and CoCl2 protect HepG2 cells against serum deprivation- and t-BHP-induced apoptosis: A possible anti-apoptotic role for HIF-1
-
Piret JP, Lecocq C, Toffoli S, Ninane N, Raes M, Michiels C. (2004). Hypoxia and CoCl2 protect HepG2 cells against serum deprivation- and t-BHP-induced apoptosis: a possible anti-apoptotic role for HIF-1. Exp Cell Res 295: 340-349.
-
(2004)
Exp Cell Res
, vol.295
, pp. 340-349
-
-
Piret, J.P.1
Lecocq, C.2
Toffoli, S.3
Ninane, N.4
Raes, M.5
Michiels, C.6
-
33
-
-
0036515618
-
Cell metabolism in the regulation of programmed cell death
-
Plas DR, Thompson CB. (2002). Cell metabolism in the regulation of programmed cell death. Trends Endocrinol Metab 13: 74-78.
-
(2002)
Trends Endocrinol Metab
, vol.13
, pp. 74-78
-
-
Plas, D.R.1
Thompson, C.B.2
-
34
-
-
0033984094
-
BNIP3heterodimerizes with Bcl-2/Bcl-X(L) and induces cell death independent of a Bcl-2 homology 3 (BH3) domain at both mitochondrial and nonmitochondrial sites
-
Ray R, Chen G, Vande Velde C, Cizeau J, Park JH, Reed JC et al. (2000). BNIP3heterodimerizes with Bcl-2/Bcl-X(L) and induces cell death independent of a Bcl-2 homology 3 (BH3) domain at both mitochondrial and nonmitochondrial sites. J Biol Chem 275: 1439-1448.
-
(2000)
J Biol Chem
, vol.275
, pp. 1439-1448
-
-
Ray, R.1
Chen, G.2
Vande Velde, C.3
Cizeau, J.4
Park, J.H.5
Reed, J.C.6
-
35
-
-
18644366801
-
Hypoxia-inducible factor-1alpha and the glycolytic phenotype in tumors
-
Robey IF, Lien AD, Welsh SJ, Baggett BK, Gillies RJ. (2005). Hypoxia-inducible factor-1alpha and the glycolytic phenotype in tumors. Neoplasia 7: 324-330.
-
(2005)
Neoplasia
, vol.7
, pp. 324-330
-
-
Robey, I.F.1
Lien, A.D.2
Welsh, S.J.3
Baggett, B.K.4
Gillies, R.J.5
-
36
-
-
23844540031
-
Mechanism of HIF-1alpha-dependent suppression of hypoxia-induced apoptosis in squamous cell carcinoma cells
-
Sasabe E, Tatemoto Y, Li D, Yamamoto T, Osaki T. (2005). Mechanism of HIF-1alpha-dependent suppression of hypoxia-induced apoptosis in squamous cell carcinoma cells. Cancer Sci 96: 394-402.
-
(2005)
Cancer Sci
, vol.96
, pp. 394-402
-
-
Sasabe, E.1
Tatemoto, Y.2
Li, D.3
Yamamoto, T.4
Osaki, T.5
-
37
-
-
0024380087
-
A rapid detection of octamer binding proteins with mini-extracts, prepared from a small number of cells
-
Schreiber E, Matthias P, Muller MM, Schaffner W. (1989). A rapid detection of octamer binding proteins with mini-extracts, prepared from a small number of cells. Nucleic Acids Res 17: 6419.
-
(1989)
Nucleic Acids Res
, vol.17
, pp. 6419
-
-
Schreiber, E.1
Matthias, P.2
Muller, M.M.3
Schaffner, W.4
-
38
-
-
0034531766
-
HIF-1: Using two hands to flip the angiogenic switch
-
Semenza GL. (2000). HIF-1: using two hands to flip the angiogenic switch. Cancer Metast Rev 19: 59-65.
-
(2000)
Cancer Metast Rev
, vol.19
, pp. 59-65
-
-
Semenza, G.L.1
-
39
-
-
0035812772
-
HIF-1, O(2), and the 3 PHDs: How animal cells signal hypoxia to the nucleus
-
Semenza GL. (2001). HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus. Cell 107: 1-3.
-
(2001)
Cell
, vol.107
, pp. 1-3
-
-
Semenza, G.L.1
-
40
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
Semenza GL. (2003). Targeting HIF-1 for cancer therapy. Nat Rev Cancer 3: 721-732.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 721-732
-
-
Semenza, G.L.1
-
41
-
-
0034464872
-
Hypoxia, HIF-1, and the pathophysiology of common human diseases
-
Semenza GL, Agani F, Feldser D. (2000). Hypoxia, HIF-1, and the pathophysiology of common human diseases. Adv Exp Med Biol 475: 123-130.
-
(2000)
Adv Exp Med Biol
, vol.475
, pp. 123-130
-
-
Semenza, G.L.1
Agani, F.2
Feldser, D.3
-
42
-
-
0028068606
-
Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1
-
Semenza GL, Roth PH, Fang HM, Wang GL. (1994). Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1. J Biol Chem 269: 23757-23763.
-
(1994)
J Biol Chem
, vol.269
, pp. 23757-23763
-
-
Semenza, G.L.1
Roth, P.H.2
Fang, H.M.3
Wang, G.L.4
-
43
-
-
0035884701
-
-
Sowter HM, Ratcliffe PJ, Watson P, Greenberg AH, Harris AL. (2001). Cancer Res 61: 6669-6673.
-
(2001)
Cancer Res
, vol.61
, pp. 6669-6673
-
-
Sowter, H.M.1
Ratcliffe, P.J.2
Watson, P.3
Greenberg, A.H.4
Harris, A.L.5
-
44
-
-
0141988698
-
HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors
-
Sowter HM, Raval RR, Moore JW, Ratcliffe PJ, Harris AL. (2003). HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors. Cancer Res 63: 6130-6142.
-
(2003)
Cancer Res
, vol.63
, pp. 6130-6142
-
-
Sowter, H.M.1
Raval, R.R.2
Moore, J.W.3
Ratcliffe, P.J.4
Harris, A.L.5
-
45
-
-
0034464436
-
A glycolytic pathway to apoptosis of hypoxic cardiac myocytes. Molecular pathways of increased acid production
-
Webster KA, Discher DJ, Hernandez OM, Yamashita K, Bishopric NH. (2000). A glycolytic pathway to apoptosis of hypoxic cardiac myocytes. Molecular pathways of increased acid production. Adv Exp Med Biol 475: 161-175.
-
(2000)
Adv Exp Med Biol
, vol.475
, pp. 161-175
-
-
Webster, K.A.1
Discher, D.J.2
Hernandez, O.M.3
Yamashita, K.4
Bishopric, N.H.5
-
46
-
-
0034502408
-
Ewing sarcoma family of tumors
-
West DC. (2000). Ewing sarcoma family of tumors. Curr Opin Oncol 12: 323-329.
-
(2000)
Curr Opin Oncol
, vol.12
, pp. 323-329
-
-
West, D.C.1
-
47
-
-
4143076004
-
Treatment with siRNA and antisense oligonucleotides targeted to HIF-1alpha induced apoptosis in human tongue squamous cell carcinomas
-
Zhang Q, Zhang ZF, Rao JY, Sato JD, Brown J, Messadi DV et al. (2004). Treatment with siRNA and antisense oligonucleotides targeted to HIF-1alpha induced apoptosis in human tongue squamous cell carcinomas. Int J Cancer 111: 849-857.
-
(2004)
Int J Cancer
, vol.111
, pp. 849-857
-
-
Zhang, Q.1
Zhang, Z.F.2
Rao, J.Y.3
Sato, J.D.4
Brown, J.5
Messadi, D.V.6
-
48
-
-
0033571682
-
Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastase
-
Zhong H, De Marzo AM, Laughner E, Lim M. (1999). Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastase. Cancer Res 59: 5830-5835.
-
(1999)
Cancer Res
, vol.59
, pp. 5830-5835
-
-
Zhong, H.1
De Marzo, A.M.2
Laughner, E.3
Lim, M.4
|