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Volumn 26, Issue 14, 2007, Pages 2027-2038

Role of hypoxia inducible factor-1 alpha in modulation of apoptosis resistance

Author keywords

Apoptosis; Ewing sarcoma; Hif 1 ; Hypoxia; Rhabdomyosarcoma

Indexed keywords

E1B PROTEIN; FRUCTOSE BISPHOSPHATE ALDOLASE; GLUCOSE; GLUCOSE TRANSPORTER 1; GLYCOLYTIC ENZYME; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INHIBITOR OF APOPTOSIS PROTEIN 2; PROTEIN BCL 2; PROTEIN P53;

EID: 34047105144     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/sj.onc.1210008     Document Type: Article
Times cited : (150)

References (48)
  • 1
    • 0035418621 scopus 로고    scopus 로고
    • Constitutive expression of hypoxia-inducible factor-1alpha renders pancreatic cancer cells resistant to apoptosis induced by hypoxia and nutrient deprivation
    • Akakura N, Kobayashi M, Horiuchi I, Suzuki A, Wang J, Chen J et al. (2001). Constitutive expression of hypoxia-inducible factor-1alpha renders pancreatic cancer cells resistant to apoptosis induced by hypoxia and nutrient deprivation. Cancer Res 61: 6548-6554.
    • (2001) Cancer Res , vol.61 , pp. 6548-6554
    • Akakura, N.1    Kobayashi, M.2    Horiuchi, I.3    Suzuki, A.4    Wang, J.5    Chen, J.6
  • 2
    • 0035933726 scopus 로고    scopus 로고
    • Hypoxia induces the activation of the phosphatidylinositol 3-kinase/Akt cell survival pathway in PC12 cells: Protective role in apoptosis
    • Alvarez-Tejado M, Naranjo-Suarez S, Jimenez C, Carrera AC, Landazuri MO, Del Peso L. (2001). Hypoxia induces the activation of the phosphatidylinositol 3-kinase/Akt cell survival pathway in PC12 cells: protective role in apoptosis. J Biol Chem 276: 22368-22374.
    • (2001) J Biol Chem , vol.276 , pp. 22368-22374
    • Alvarez-Tejado, M.1    Naranjo-Suarez, S.2    Jimenez, C.3    Carrera, A.C.4    Landazuri, M.O.5    Del Peso, L.6
  • 3
    • 0032568150 scopus 로고    scopus 로고
    • An GW, Kanekal Meera, Simon MC, Maltepe E, Blagosklonny MV, Neckers ML. (1998). Stabilization of wild-type p53by hypoxia-inducible factor 1alpha. Nature 392: 405-408.
    • An GW, Kanekal Meera, Simon MC, Maltepe E, Blagosklonny MV, Neckers ML. (1998). Stabilization of wild-type p53by hypoxia-inducible factor 1alpha. Nature 392: 405-408.
  • 4
    • 13444283313 scopus 로고    scopus 로고
    • Ras inhibition in glioblastoma down-regulates hypoxia-inducible factor-1alpha, causing glycolysis shutdown and cell death
    • Blum R, Hirsch J-J, Amariglio N, Rechavi G, Kloog Y. (2005). Ras inhibition in glioblastoma down-regulates hypoxia-inducible factor-1alpha, causing glycolysis shutdown and cell death. Cancer Res 65: 3999.
    • (2005) Cancer Res , vol.65 , pp. 3999
    • Blum, R.1    Hirsch, J.-J.2    Amariglio, N.3    Rechavi, G.4    Kloog, Y.5
  • 5
    • 0034255036 scopus 로고    scopus 로고
    • Expression of the gene encoding the proapoptotic Nip3protein is induced by hypoxia
    • Bruick RK. (2000). Expression of the gene encoding the proapoptotic Nip3protein is induced by hypoxia. Proc Natl Acad Sci 97: 9082-9087.
    • (2000) Proc Natl Acad Sci , vol.97 , pp. 9082-9087
    • Bruick, R.K.1
  • 6
    • 0032581277 scopus 로고    scopus 로고
    • Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
    • Carmeliet P, Dor Y, Herbert JM, Fukumura D, Brusselmans K, Dewerchin M et al. (1998). Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature 394: 485-490.
    • (1998) Nature , vol.394 , pp. 485-490
    • Carmeliet, P.1    Dor, Y.2    Herbert, J.M.3    Fukumura, D.4    Brusselmans, K.5    Dewerchin, M.6
  • 7
    • 0344608877 scopus 로고    scopus 로고
    • Dominant-negative hypoxia-inducible factor-1 alpha reduces tumorigenicity of pancreatic cancer cells through the suppression of glucose metabolism
    • Chen J, Zhao S, Nakada K, Kuge Y, Tamaki N, Okada F et al. (2003). Dominant-negative hypoxia-inducible factor-1 alpha reduces tumorigenicity of pancreatic cancer cells through the suppression of glucose metabolism. Am J Pathal 162: 1283-1291.
    • (2003) Am J Pathal , vol.162 , pp. 1283-1291
    • Chen, J.1    Zhao, S.2    Nakada, K.3    Kuge, Y.4    Tamaki, N.5    Okada, F.6
  • 8
    • 0033062014 scopus 로고    scopus 로고
    • Rhabdomyosarcoma: An overview
    • Dagher R, Hellman L. (1999). Rhabdomyosarcoma: an overview. Oncologist 4: 34-44.
    • (1999) Oncologist , vol.4 , pp. 34-44
    • Dagher, R.1    Hellman, L.2
  • 9
    • 0032476059 scopus 로고    scopus 로고
    • Hypoxia regulates beta-enolase and pyruvate kinase-M promoters by modulating Sp1/Sp3 binding to a conserved GC element
    • Discher DJ, Bishopric NH, Wu X, Peterson CA, Webster KA. (1998). Hypoxia regulates beta-enolase and pyruvate kinase-M promoters by modulating Sp1/Sp3 binding to a conserved GC element. J Biol Chem 273: 26087-26093.
    • (1998) J Biol Chem , vol.273 , pp. 26087-26093
    • Discher, D.J.1    Bishopric, N.H.2    Wu, X.3    Peterson, C.A.4    Webster, K.A.5
  • 10
    • 0042845994 scopus 로고    scopus 로고
    • Apoptosis-resistance of hypoxic cells: Multiple factors involved and a role for IAP-2
    • Dong Z, Wang JZ, Yu F, Venkatachalam MA. (2003). Apoptosis-resistance of hypoxic cells: multiple factors involved and a role for IAP-2. Am J Pathol 163: 663-671.
    • (2003) Am J Pathol , vol.163 , pp. 663-671
    • Dong, Z.1    Wang, J.Z.2    Yu, F.3    Venkatachalam, M.A.4
  • 11
    • 12144287046 scopus 로고    scopus 로고
    • Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance
    • Erler JT, Cawthorne CJ, Williams KJ, Koritzinsky M, Wouters BG, Wilson C et al. (2004). Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance. Mol Cell Biol, 2875-2879.
    • (2004) Mol Cell Biol , pp. 2875-2879
    • Erler, J.T.1    Cawthorne, C.J.2    Williams, K.J.3    Koritzinsky, M.4    Wouters, B.G.5    Wilson, C.6
  • 12
    • 0030752603 scopus 로고    scopus 로고
    • The CD95 (APO-1/Fas) system mediates drug-induced apoptosis in neuroblastoma cells
    • Fulda S, Sieverts H, Friesen C, Herr I, Debatin KM. (1997). The CD95 (APO-1/Fas) system mediates drug-induced apoptosis in neuroblastoma cells. Cancer Res 57: 3823-3829.
    • (1997) Cancer Res , vol.57 , pp. 3823-3829
    • Fulda, S.1    Sieverts, H.2    Friesen, C.3    Herr, I.4    Debatin, K.M.5
  • 13
    • 15744395153 scopus 로고    scopus 로고
    • Adenovirus-mediated p53gene therapy in pediatric soft-tissue sarcoma cell lines: Sensitization to cisplatin and doxorubicin
    • Ganjavi H, Gee M, Narendran A, Freedman HM, Malkin D. (2005). Adenovirus-mediated p53gene therapy in pediatric soft-tissue sarcoma cell lines: sensitization to cisplatin and doxorubicin. Cancer Gene Ther 12: 397-406.
    • (2005) Cancer Gene Ther , vol.12 , pp. 397-406
    • Ganjavi, H.1    Gee, M.2    Narendran, A.3    Freedman, H.M.4    Malkin, D.5
  • 14
    • 8144228566 scopus 로고    scopus 로고
    • Why do cancers have high aerobic glycolysis?
    • Gatenby RA, Gillies RJ. (2004). Why do cancers have high aerobic glycolysis? Nat Rev Cancer 11: 891-899.
    • (2004) Nat Rev Cancer , vol.11 , pp. 891-899
    • Gatenby, R.A.1    Gillies, R.J.2
  • 16
    • 0036359548 scopus 로고    scopus 로고
    • Hypoxia - a key regulatory factor in tumour growth
    • Harris AL. (2002). Hypoxia - a key regulatory factor in tumour growth. Nat Rev Cancer 2: 38-47.
    • (2002) Nat Rev Cancer , vol.2 , pp. 38-47
    • Harris, A.L.1
  • 17
    • 0034751813 scopus 로고    scopus 로고
    • Mechanism, origin, and evolution of anoxia tolerance in animals
    • Hochachka PW, Lutz PL. (2001). Mechanism, origin, and evolution of anoxia tolerance in animals. Comp Biochem Physiol 130B: 435-459.
    • (2001) Comp Biochem Physiol , vol.130 B , pp. 435-459
    • Hochachka, P.W.1    Lutz, P.L.2
  • 18
    • 18744375998 scopus 로고    scopus 로고
    • Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation
    • Jeong JW, Bae MK, Ahn MY, Kim SH, Sohn TK, Bae MH et al. (2002). Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation. Cell 111: 709-720.
    • (2002) Cell , vol.111 , pp. 709-720
    • Jeong, J.W.1    Bae, M.K.2    Ahn, M.Y.3    Kim, S.H.4    Sohn, T.K.5    Bae, M.H.6
  • 19
    • 0028049621 scopus 로고
    • Apoptosis is regulated by the rate of glucose transport in an interleukin 3 dependent cell line
    • Kan O, Baldwin SA, Whetton AD. (1994). Apoptosis is regulated by the rate of glucose transport in an interleukin 3 dependent cell line. J Exp Med 180: 917-923.
    • (1994) J Exp Med , vol.180 , pp. 917-923
    • Kan, O.1    Baldwin, S.A.2    Whetton, A.D.3
  • 20
    • 0346655211 scopus 로고    scopus 로고
    • BH3-only protein Noxa is a mediator of hypoxic cell death induced by hypoxia-inducible factor 1alpha
    • Kim JY, Ahn HJ, Ryu JH, Suk K, Park JH. (2004a). BH3-only protein Noxa is a mediator of hypoxic cell death induced by hypoxia-inducible factor 1alpha. J Exp Med, 113-123.
    • (2004) J Exp Med , pp. 113-123
    • Kim, J.Y.1    Ahn, H.J.2    Ryu, J.H.3    Suk, K.4    Park, J.H.5
  • 21
    • 3042665524 scopus 로고    scopus 로고
    • Hypoxia inhibits tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by blocking Bax translocation
    • Kim M, Park SY, Pai HS, Kim TH, Billiar TR, Seol DW. (2004b). Hypoxia inhibits tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by blocking Bax translocation. Cancer Res 64: 4078-4081.
    • (2004) Cancer Res , vol.64 , pp. 4078-4081
    • Kim, M.1    Park, S.Y.2    Pai, H.S.3    Kim, T.H.4    Billiar, T.R.5    Seol, D.W.6
  • 24
    • 0035887011 scopus 로고    scopus 로고
    • FIH-1: A novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity
    • Mahon PC, Hirota K, Semenza GL. (2001). FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev 15: 2675-2686.
    • (2001) Genes Dev , vol.15 , pp. 2675-2686
    • Mahon, P.C.1    Hirota, K.2    Semenza, G.L.3
  • 25
    • 0035900767 scopus 로고    scopus 로고
    • Glucose catabolism in cancer cells: Identification and characterization of a marked activation response of the type II hexokinase gene to hypoxic conditions
    • Mathupala SP, Rempel A, Pedersen PL. (2001). Glucose catabolism in cancer cells: identification and characterization of a marked activation response of the type II hexokinase gene to hypoxic conditions. J Biol Chem 276: 43407-43412.
    • (2001) J Biol Chem , vol.276 , pp. 43407-43412
    • Mathupala, S.P.1    Rempel, A.2    Pedersen, P.L.3
  • 26
    • 0027772521 scopus 로고
    • Growth factors, mitogens, oncogenes and the regulation of glucose transport
    • Merrall NW, Plevin R, Gould GW. (1993). Growth factors, mitogens, oncogenes and the regulation of glucose transport. Cell Signal 5: 667-675.
    • (1993) Cell Signal , vol.5 , pp. 667-675
    • Merrall, N.W.1    Plevin, R.2    Gould, G.W.3
  • 27
    • 0034647742 scopus 로고    scopus 로고
    • Role of hypoxia-inducible factor-1 in transcriptional activation of ceruloplasmin by iron deficiency
    • Mukopadhyay CK, Mazumder B, Fox PL. (2000). Role of hypoxia-inducible factor-1 in transcriptional activation of ceruloplasmin by iron deficiency. J Biol Chem 275: 21048-21054.
    • (2000) J Biol Chem , vol.275 , pp. 21048-21054
    • Mukopadhyay, C.K.1    Mazumder, B.2    Fox, P.L.3
  • 28
    • 0033559578 scopus 로고    scopus 로고
    • Activation of metallothionein gene expression by hypoxia involves metal response elements and metal transcription factor-1
    • Murphy BJ, Andrews GK, Bittel D, Discher DJ, McCue J, Green CJ et al. (1999). Activation of metallothionein gene expression by hypoxia involves metal response elements and metal transcription factor-1. Cancer Res 59: 1315-1322.
    • (1999) Cancer Res , vol.59 , pp. 1315-1322
    • Murphy, B.J.1    Andrews, G.K.2    Bittel, D.3    Discher, D.J.4    McCue, J.5    Green, C.J.6
  • 31
    • 0036083168 scopus 로고    scopus 로고
    • Hypoxia inhibition of apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)
    • Park SY, Billar TR, Seol DW. (2002). Hypoxia inhibition of apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Biochem Biophys Res Commun 291: 150-153.
    • (2002) Biochem Biophys Res Commun , vol.291 , pp. 150-153
    • Park, S.Y.1    Billar, T.R.2    Seol, D.W.3
  • 32
    • 1842861767 scopus 로고    scopus 로고
    • Hypoxia and CoCl2 protect HepG2 cells against serum deprivation- and t-BHP-induced apoptosis: A possible anti-apoptotic role for HIF-1
    • Piret JP, Lecocq C, Toffoli S, Ninane N, Raes M, Michiels C. (2004). Hypoxia and CoCl2 protect HepG2 cells against serum deprivation- and t-BHP-induced apoptosis: a possible anti-apoptotic role for HIF-1. Exp Cell Res 295: 340-349.
    • (2004) Exp Cell Res , vol.295 , pp. 340-349
    • Piret, J.P.1    Lecocq, C.2    Toffoli, S.3    Ninane, N.4    Raes, M.5    Michiels, C.6
  • 33
    • 0036515618 scopus 로고    scopus 로고
    • Cell metabolism in the regulation of programmed cell death
    • Plas DR, Thompson CB. (2002). Cell metabolism in the regulation of programmed cell death. Trends Endocrinol Metab 13: 74-78.
    • (2002) Trends Endocrinol Metab , vol.13 , pp. 74-78
    • Plas, D.R.1    Thompson, C.B.2
  • 34
    • 0033984094 scopus 로고    scopus 로고
    • BNIP3heterodimerizes with Bcl-2/Bcl-X(L) and induces cell death independent of a Bcl-2 homology 3 (BH3) domain at both mitochondrial and nonmitochondrial sites
    • Ray R, Chen G, Vande Velde C, Cizeau J, Park JH, Reed JC et al. (2000). BNIP3heterodimerizes with Bcl-2/Bcl-X(L) and induces cell death independent of a Bcl-2 homology 3 (BH3) domain at both mitochondrial and nonmitochondrial sites. J Biol Chem 275: 1439-1448.
    • (2000) J Biol Chem , vol.275 , pp. 1439-1448
    • Ray, R.1    Chen, G.2    Vande Velde, C.3    Cizeau, J.4    Park, J.H.5    Reed, J.C.6
  • 35
    • 18644366801 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1alpha and the glycolytic phenotype in tumors
    • Robey IF, Lien AD, Welsh SJ, Baggett BK, Gillies RJ. (2005). Hypoxia-inducible factor-1alpha and the glycolytic phenotype in tumors. Neoplasia 7: 324-330.
    • (2005) Neoplasia , vol.7 , pp. 324-330
    • Robey, I.F.1    Lien, A.D.2    Welsh, S.J.3    Baggett, B.K.4    Gillies, R.J.5
  • 36
    • 23844540031 scopus 로고    scopus 로고
    • Mechanism of HIF-1alpha-dependent suppression of hypoxia-induced apoptosis in squamous cell carcinoma cells
    • Sasabe E, Tatemoto Y, Li D, Yamamoto T, Osaki T. (2005). Mechanism of HIF-1alpha-dependent suppression of hypoxia-induced apoptosis in squamous cell carcinoma cells. Cancer Sci 96: 394-402.
    • (2005) Cancer Sci , vol.96 , pp. 394-402
    • Sasabe, E.1    Tatemoto, Y.2    Li, D.3    Yamamoto, T.4    Osaki, T.5
  • 37
    • 0024380087 scopus 로고
    • A rapid detection of octamer binding proteins with mini-extracts, prepared from a small number of cells
    • Schreiber E, Matthias P, Muller MM, Schaffner W. (1989). A rapid detection of octamer binding proteins with mini-extracts, prepared from a small number of cells. Nucleic Acids Res 17: 6419.
    • (1989) Nucleic Acids Res , vol.17 , pp. 6419
    • Schreiber, E.1    Matthias, P.2    Muller, M.M.3    Schaffner, W.4
  • 38
    • 0034531766 scopus 로고    scopus 로고
    • HIF-1: Using two hands to flip the angiogenic switch
    • Semenza GL. (2000). HIF-1: using two hands to flip the angiogenic switch. Cancer Metast Rev 19: 59-65.
    • (2000) Cancer Metast Rev , vol.19 , pp. 59-65
    • Semenza, G.L.1
  • 39
    • 0035812772 scopus 로고    scopus 로고
    • HIF-1, O(2), and the 3 PHDs: How animal cells signal hypoxia to the nucleus
    • Semenza GL. (2001). HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus. Cell 107: 1-3.
    • (2001) Cell , vol.107 , pp. 1-3
    • Semenza, G.L.1
  • 40
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • Semenza GL. (2003). Targeting HIF-1 for cancer therapy. Nat Rev Cancer 3: 721-732.
    • (2003) Nat Rev Cancer , vol.3 , pp. 721-732
    • Semenza, G.L.1
  • 41
    • 0034464872 scopus 로고    scopus 로고
    • Hypoxia, HIF-1, and the pathophysiology of common human diseases
    • Semenza GL, Agani F, Feldser D. (2000). Hypoxia, HIF-1, and the pathophysiology of common human diseases. Adv Exp Med Biol 475: 123-130.
    • (2000) Adv Exp Med Biol , vol.475 , pp. 123-130
    • Semenza, G.L.1    Agani, F.2    Feldser, D.3
  • 42
    • 0028068606 scopus 로고
    • Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1
    • Semenza GL, Roth PH, Fang HM, Wang GL. (1994). Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1. J Biol Chem 269: 23757-23763.
    • (1994) J Biol Chem , vol.269 , pp. 23757-23763
    • Semenza, G.L.1    Roth, P.H.2    Fang, H.M.3    Wang, G.L.4
  • 44
    • 0141988698 scopus 로고    scopus 로고
    • HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors
    • Sowter HM, Raval RR, Moore JW, Ratcliffe PJ, Harris AL. (2003). HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors. Cancer Res 63: 6130-6142.
    • (2003) Cancer Res , vol.63 , pp. 6130-6142
    • Sowter, H.M.1    Raval, R.R.2    Moore, J.W.3    Ratcliffe, P.J.4    Harris, A.L.5
  • 45
    • 0034464436 scopus 로고    scopus 로고
    • A glycolytic pathway to apoptosis of hypoxic cardiac myocytes. Molecular pathways of increased acid production
    • Webster KA, Discher DJ, Hernandez OM, Yamashita K, Bishopric NH. (2000). A glycolytic pathway to apoptosis of hypoxic cardiac myocytes. Molecular pathways of increased acid production. Adv Exp Med Biol 475: 161-175.
    • (2000) Adv Exp Med Biol , vol.475 , pp. 161-175
    • Webster, K.A.1    Discher, D.J.2    Hernandez, O.M.3    Yamashita, K.4    Bishopric, N.H.5
  • 46
    • 0034502408 scopus 로고    scopus 로고
    • Ewing sarcoma family of tumors
    • West DC. (2000). Ewing sarcoma family of tumors. Curr Opin Oncol 12: 323-329.
    • (2000) Curr Opin Oncol , vol.12 , pp. 323-329
    • West, D.C.1
  • 47
    • 4143076004 scopus 로고    scopus 로고
    • Treatment with siRNA and antisense oligonucleotides targeted to HIF-1alpha induced apoptosis in human tongue squamous cell carcinomas
    • Zhang Q, Zhang ZF, Rao JY, Sato JD, Brown J, Messadi DV et al. (2004). Treatment with siRNA and antisense oligonucleotides targeted to HIF-1alpha induced apoptosis in human tongue squamous cell carcinomas. Int J Cancer 111: 849-857.
    • (2004) Int J Cancer , vol.111 , pp. 849-857
    • Zhang, Q.1    Zhang, Z.F.2    Rao, J.Y.3    Sato, J.D.4    Brown, J.5    Messadi, D.V.6
  • 48
    • 0033571682 scopus 로고    scopus 로고
    • Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastase
    • Zhong H, De Marzo AM, Laughner E, Lim M. (1999). Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastase. Cancer Res 59: 5830-5835.
    • (1999) Cancer Res , vol.59 , pp. 5830-5835
    • Zhong, H.1    De Marzo, A.M.2    Laughner, E.3    Lim, M.4


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