-
1
-
-
10744227590
-
Human CD4+ CD25+ regulatory T cells control T-cell responses to human immunodeficiency virus and cytomegalovirus antigens
-
Aandahl E.M., Michaelsson J., Moretto W.J., Hecht F.M., and Nixon D.F. Human CD4+ CD25+ regulatory T cells control T-cell responses to human immunodeficiency virus and cytomegalovirus antigens. J. Virol. 78 (2004) 2454-2459
-
(2004)
J. Virol.
, vol.78
, pp. 2454-2459
-
-
Aandahl, E.M.1
Michaelsson, J.2
Moretto, W.J.3
Hecht, F.M.4
Nixon, D.F.5
-
2
-
-
33947723195
-
-
Ontario HIV Treatment Network Research Conference, Toronto, Ontario, Canada
-
Abdkader K., Al-Hetheel A., Sant N., Angel J.B., Kumar A., Diaz-Mitoma F., and Kryworuchko M. Disruption of cytokine signaling in T cells from HIV+ pateints: Role in pathogenesis. Ontario HIV Treatment Network Research Conference, Toronto, Ontario, Canada (2005)
-
(2005)
Disruption of cytokine signaling in T cells from HIV+ pateints: Role in pathogenesis
-
-
Abdkader, K.1
Al-Hetheel, A.2
Sant, N.3
Angel, J.B.4
Kumar, A.5
Diaz-Mitoma, F.6
Kryworuchko, M.7
-
3
-
-
0036839102
-
Homeostasis of peripheral CD4+ T cells: IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers
-
Almeida A.R., Legrand N., Papiernik M., and Freitas A.A. Homeostasis of peripheral CD4+ T cells: IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers. J. Immunol. 169 (2002) 4850-4860
-
(2002)
J. Immunol.
, vol.169
, pp. 4850-4860
-
-
Almeida, A.R.1
Legrand, N.2
Papiernik, M.3
Freitas, A.A.4
-
4
-
-
2942560498
-
NK cells and polymorphonuclear neutrophils are both critical for IL-2-induced pulmonary vascular leak syndrome
-
Assier E., Jullien V., Lefort J., Moreau J.L., Di Santo J.P., Vargaftig B.B., Lapa e Silva J.R., and Theze J. NK cells and polymorphonuclear neutrophils are both critical for IL-2-induced pulmonary vascular leak syndrome. J. Immunol. 172 (2004) 7661-7668
-
(2004)
J. Immunol.
, vol.172
, pp. 7661-7668
-
-
Assier, E.1
Jullien, V.2
Lefort, J.3
Moreau, J.L.4
Di Santo, J.P.5
Vargaftig, B.B.6
Lapa e Silva, J.R.7
Theze, J.8
-
5
-
-
31744432271
-
Constitutive expression of IL-2Rbeta chain and its effects on IL-2-induced vascular leak syndrome
-
Assier E., Jullien V., Lefort J., Moreau J.L., Vargaftig B.B., Lapa e Silva J.R., and Theze J. Constitutive expression of IL-2Rbeta chain and its effects on IL-2-induced vascular leak syndrome. Cytokine 32 (2005) 280-286
-
(2005)
Cytokine
, vol.32
, pp. 280-286
-
-
Assier, E.1
Jullien, V.2
Lefort, J.3
Moreau, J.L.4
Vargaftig, B.B.5
Lapa e Silva, J.R.6
Theze, J.7
-
6
-
-
0036276002
-
Interleukin-2: Clinical applications
-
Atkins M.B. Interleukin-2: Clinical applications. Semin. Oncol. 29 (2002) 12-17
-
(2002)
Semin. Oncol.
, vol.29
, pp. 12-17
-
-
Atkins, M.B.1
-
7
-
-
0035399828
-
Unstimulated human CD4 lymphocytes express a cytoplasmic immature form of the common cytokine receptor gamma-chain
-
Bani L., Kryworuchko M., Pasquier V., Salamero J., and Thèze J. Unstimulated human CD4 lymphocytes express a cytoplasmic immature form of the common cytokine receptor gamma-chain. J. Immunol. 167 (2001) 344-349
-
(2001)
J. Immunol.
, vol.167
, pp. 344-349
-
-
Bani, L.1
Kryworuchko, M.2
Pasquier, V.3
Salamero, J.4
Thèze, J.5
-
8
-
-
0022446998
-
Stimulation of oligodendroglial proliferation and maturation by interleukin-2
-
Benveniste E.N., and Merrill J.E. Stimulation of oligodendroglial proliferation and maturation by interleukin-2. Nature 321 (1986) 610-613
-
(1986)
Nature
, vol.321
, pp. 610-613
-
-
Benveniste, E.N.1
Merrill, J.E.2
-
9
-
-
0036785617
-
Lymphoadenopathy in IL-2-deficient mice: Further characterization and overexpression of the antiapoptotic molecule cellular FLIP
-
Chastagner P., Reddy J., and Theze J. Lymphoadenopathy in IL-2-deficient mice: Further characterization and overexpression of the antiapoptotic molecule cellular FLIP. J. Immunol. 169 (2002) 3644-3651
-
(2002)
J. Immunol.
, vol.169
, pp. 3644-3651
-
-
Chastagner, P.1
Reddy, J.2
Theze, J.3
-
10
-
-
0037022629
-
Enhanced signaling through the IL-2 receptor in CD8+ T cells regulated by antigen recognition results in preferential proliferation and expansion of responding CD8+ T cells rather than promotion of cell death
-
Cheng L.E., Ohlen C., Nelson B.H., and Greenberg P.D. Enhanced signaling through the IL-2 receptor in CD8+ T cells regulated by antigen recognition results in preferential proliferation and expansion of responding CD8+ T cells rather than promotion of cell death. Proc. Natl. Acad. Sci. USA 99 (2002) 3001-3006
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 3001-3006
-
-
Cheng, L.E.1
Ohlen, C.2
Nelson, B.H.3
Greenberg, P.D.4
-
11
-
-
0027446129
-
Relationship between IL-2 receptor expression and proliferative responses in lymphocytes from HIV-1 seropositive homosexual men
-
Chopra R.K., Raj N.B., Scally J.P., Donnenberg A.D., Adler W.H., Saah A.J., and Margolick J.B. Relationship between IL-2 receptor expression and proliferative responses in lymphocytes from HIV-1 seropositive homosexual men. Clin. Exp. Immunol. 91 (1993) 18-24
-
(1993)
Clin. Exp. Immunol.
, vol.91
, pp. 18-24
-
-
Chopra, R.K.1
Raj, N.B.2
Scally, J.P.3
Donnenberg, A.D.4
Adler, W.H.5
Saah, A.J.6
Margolick, J.B.7
-
12
-
-
0004781509
-
Immunologic and virologic effects of subcutaneous interleukin 2 in combination with antiretroviral therapy: A randomized controlled trial
-
Davey Jr. R.T., Murphy R.L., Graziano F.M., Boswell S.L., Pavia A.T., Cancio M., Nadler J.P., Chaitt D.G., Dewar R.L., Sahner D.K., Duliege A.M., Capra W.B., et al. Immunologic and virologic effects of subcutaneous interleukin 2 in combination with antiretroviral therapy: A randomized controlled trial. J. Am. Med. Assoc. 284 (2000) 183-189
-
(2000)
J. Am. Med. Assoc.
, vol.284
, pp. 183-189
-
-
Davey Jr., R.T.1
Murphy, R.L.2
Graziano, F.M.3
Boswell, S.L.4
Pavia, A.T.5
Cancio, M.6
Nadler, J.P.7
Chaitt, D.G.8
Dewar, R.L.9
Sahner, D.K.10
Duliege, A.M.11
Capra, W.B.12
-
13
-
-
17944400837
-
Further analysis of interleukin-2 receptor subunit expression on the different human peripheral blood mononuclear cell subsets
-
David D., Bani L., Moreau J.L., Demaison C., Sun K., Salvucci O., Nakarai T., de Montalembert M., Chouaib S., Joussemet M., Ritz J., and Theze J. Further analysis of interleukin-2 receptor subunit expression on the different human peripheral blood mononuclear cell subsets. Blood 91 (1998) 165-172
-
(1998)
Blood
, vol.91
, pp. 165-172
-
-
David, D.1
Bani, L.2
Moreau, J.L.3
Demaison, C.4
Sun, K.5
Salvucci, O.6
Nakarai, T.7
de Montalembert, M.8
Chouaib, S.9
Joussemet, M.10
Ritz, J.11
Theze, J.12
-
14
-
-
13144252233
-
Regulatory dysfunction of the interleukin-2 receptor during HIV infection and the impact of triple combination therapy
-
David D., Bani L., Moreau J.L., Treilhou M.P., Nakarai T., Joussemet M., Ritz J., Dupont B., Pialoux G., and Thèze J. Regulatory dysfunction of the interleukin-2 receptor during HIV infection and the impact of triple combination therapy. Proc. Natl. Acad. Sci. USA 95 (1998) 11348-11353
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 11348-11353
-
-
David, D.1
Bani, L.2
Moreau, J.L.3
Treilhou, M.P.4
Nakarai, T.5
Joussemet, M.6
Ritz, J.7
Dupont, B.8
Pialoux, G.9
Thèze, J.10
-
15
-
-
0035282639
-
Rapid effect of interleukin-2 therapy in human immunodeficiency virus-infected patients whose CD4 cell counts increase only slightly in response to combined antiretroviral treatment
-
David D., Nait-Ighil L., Dupont B., Maral J., Gachot B., and Theze J. Rapid effect of interleukin-2 therapy in human immunodeficiency virus-infected patients whose CD4 cell counts increase only slightly in response to combined antiretroviral treatment. J. Infect. Dis. 183 (2001) 730-735
-
(2001)
J. Infect. Dis.
, vol.183
, pp. 730-735
-
-
David, D.1
Nait-Ighil, L.2
Dupont, B.3
Maral, J.4
Gachot, B.5
Theze, J.6
-
16
-
-
0037165877
-
Involvement of Bcl-2 and IL-2R in HIV-positive patients whose CD4 cell counts fail to increase rapidly with highly active antiretroviral therapy
-
David D., Keller H., Nait-Ighil L., Treilhou M.P., Joussemet M., Dupont B., Gachot B., Maral J., and Theze J. Involvement of Bcl-2 and IL-2R in HIV-positive patients whose CD4 cell counts fail to increase rapidly with highly active antiretroviral therapy. AIDS 16 (2002) 1093-1101
-
(2002)
AIDS
, vol.16
, pp. 1093-1101
-
-
David, D.1
Keller, H.2
Nait-Ighil, L.3
Treilhou, M.P.4
Joussemet, M.5
Dupont, B.6
Gachot, B.7
Maral, J.8
Theze, J.9
-
17
-
-
27544446622
-
Development and function of agonist-induced CD25+ Foxp3+ regulatory T cells in the absence of interleukin 2 signaling
-
D'Cruz L.M., and Klein L. Development and function of agonist-induced CD25+ Foxp3+ regulatory T cells in the absence of interleukin 2 signaling. Nat. Immunol. 6 (2005) 1152-1159
-
(2005)
Nat. Immunol.
, vol.6
, pp. 1152-1159
-
-
D'Cruz, L.M.1
Klein, L.2
-
18
-
-
0021101080
-
Molecular cloning of human interleukin 2 cDNA and its expression in E. coli
-
Devos R., Plaetinck G., Cheroutre H., Simons G., Degrave W., Tavernier J., Remaut E., and Fiers W. Molecular cloning of human interleukin 2 cDNA and its expression in E. coli. Nucleic Acids Res. 11 (1983) 4307-4323
-
(1983)
Nucleic Acids Res.
, vol.11
, pp. 4307-4323
-
-
Devos, R.1
Plaetinck, G.2
Cheroutre, H.3
Simons, G.4
Degrave, W.5
Tavernier, J.6
Remaut, E.7
Fiers, W.8
-
20
-
-
0036604208
-
Essential role for IL-2 in the regulation of antiviral extralymphoid CD8 T cell responses
-
D'Souza W.N., Schluns K.S., Masopust D., and Lefrancois L. Essential role for IL-2 in the regulation of antiviral extralymphoid CD8 T cell responses. J. Immunol. 168 (2002) 5566-5572
-
(2002)
J. Immunol.
, vol.168
, pp. 5566-5572
-
-
D'Souza, W.N.1
Schluns, K.S.2
Masopust, D.3
Lefrancois, L.4
-
21
-
-
0034614890
-
The first alpha helix of interleukin (IL)-2 folds as a homotetramer, acts as an agonist of the IL-2 receptor beta chain, and induces lymphokine-activated killer cells
-
Eckenberg R., Rose T., Moreau J.L., Weil R., Gesbert F., Dubois S., Tello D., Bossus M., Gras H., Tartar A., Bertoglio J., Chouaib S., et al. The first alpha helix of interleukin (IL)-2 folds as a homotetramer, acts as an agonist of the IL-2 receptor beta chain, and induces lymphokine-activated killer cells. J. Exp. Med. 191 (2000) 529-540
-
(2000)
J. Exp. Med.
, vol.191
, pp. 529-540
-
-
Eckenberg, R.1
Rose, T.2
Moreau, J.L.3
Weil, R.4
Gesbert, F.5
Dubois, S.6
Tello, D.7
Bossus, M.8
Gras, H.9
Tartar, A.10
Bertoglio, J.11
Chouaib, S.12
-
22
-
-
0036006813
-
Alternate signalling pathways from the interleukin-2 receptor
-
Ellery J.M., and Nicholls P.J. Alternate signalling pathways from the interleukin-2 receptor. Cytokine Growth Factor Rev. 13 (2002) 27-40
-
(2002)
Cytokine Growth Factor Rev.
, vol.13
, pp. 27-40
-
-
Ellery, J.M.1
Nicholls, P.J.2
-
23
-
-
0028798833
-
Interleukin-2 and human monocyte activation
-
Espinoza-Delgado I., Bosco M.C., Musso T., Gusella G.L., Longo D.L., and Varesio L. Interleukin-2 and human monocyte activation. J. Leukoc. Biol. 57 (1995) 13-19
-
(1995)
J. Leukoc. Biol.
, vol.57
, pp. 13-19
-
-
Espinoza-Delgado, I.1
Bosco, M.C.2
Musso, T.3
Gusella, G.L.4
Longo, D.L.5
Varesio, L.6
-
25
-
-
1842581892
-
Regulation of T lymphocyte metabolism
-
Frauwirth K.A., and Thompson C.B. Regulation of T lymphocyte metabolism. J. Immunol. 172 (2004) 4661-4665
-
(2004)
J. Immunol.
, vol.172
, pp. 4661-4665
-
-
Frauwirth, K.A.1
Thompson, C.B.2
-
26
-
-
0032538799
-
Functional dissection of the cytoplasmic subregions of the IL-2 receptor betac chain in primary lymphocyte populations
-
Fujii H., Ogasawara K., Otsuka H., Suzuki M., Yamamura K., Yokochi T., Miyazaki T., Suzuki H., Mak T.W., Taki S., and Taniguchi T. Functional dissection of the cytoplasmic subregions of the IL-2 receptor betac chain in primary lymphocyte populations. EMBO J. 17 (1998) 6551-6557
-
(1998)
EMBO J.
, vol.17
, pp. 6551-6557
-
-
Fujii, H.1
Ogasawara, K.2
Otsuka, H.3
Suzuki, M.4
Yamamura, K.5
Yokochi, T.6
Miyazaki, T.7
Suzuki, H.8
Mak, T.W.9
Taki, S.10
Taniguchi, T.11
-
27
-
-
0030198558
-
Expression of the immunoglobulin J chain in a murine B lymphoma is driven by autocrine production of interleukin 2
-
Gaffen S.L., Wang S., and Koshland M.E. Expression of the immunoglobulin J chain in a murine B lymphoma is driven by autocrine production of interleukin 2. Cytokine 8 (1996) 513-524
-
(1996)
Cytokine
, vol.8
, pp. 513-524
-
-
Gaffen, S.L.1
Wang, S.2
Koshland, M.E.3
-
28
-
-
0031694552
-
Recent advances in the understanding of interleukin-2 signal transduction
-
Gesbert F., Delespine-Carmagnat M., and Bertoglio J. Recent advances in the understanding of interleukin-2 signal transduction. J. Clin. Immunol. 18 (1998) 307-320
-
(1998)
J. Clin. Immunol.
, vol.18
, pp. 307-320
-
-
Gesbert, F.1
Delespine-Carmagnat, M.2
Bertoglio, J.3
-
29
-
-
23844460275
-
IL-2 responsiveness of CD4 and CD8 lymphocytes: Further investigations with human IL-2Rbeta transgenic mice
-
Gesbert F., Moreau J.L., and Theze J. IL-2 responsiveness of CD4 and CD8 lymphocytes: Further investigations with human IL-2Rbeta transgenic mice. Int. Immunol. 17 (2005) 1093-1102
-
(2005)
Int. Immunol.
, vol.17
, pp. 1093-1102
-
-
Gesbert, F.1
Moreau, J.L.2
Theze, J.3
-
30
-
-
0018174365
-
T cell growth factor: Parameters of production and a quantitative microassay for activity
-
Gillis S., Ferm M.M., Ou W., and Smith K.A. T cell growth factor: Parameters of production and a quantitative microassay for activity. J Immunol. 120 (1978) 2027-2032
-
(1978)
J Immunol.
, vol.120
, pp. 2027-2032
-
-
Gillis, S.1
Ferm, M.M.2
Ou, W.3
Smith, K.A.4
-
31
-
-
0342820096
-
Intermediate affinity interleukin-2 receptor mediates survival via a phosphatidylinositol 3-kinase-dependent pathway
-
Gonzalez-Garcia A., Merida I., Martinez A.C., and Carrera A.C. Intermediate affinity interleukin-2 receptor mediates survival via a phosphatidylinositol 3-kinase-dependent pathway. J. Biol. Chem. 272 (1997) 10220-10226
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 10220-10226
-
-
Gonzalez-Garcia, A.1
Merida, I.2
Martinez, A.C.3
Carrera, A.C.4
-
32
-
-
0035554678
-
Inducible IL-2 production by dendritic cells revealed by global gene expression analysis
-
Granucci F., Vizzardelli C., Pavelka N., Feau S., Persico M., Virzi E., Rescigno M., Moro G., and Ricciardi-Castagnoli P. Inducible IL-2 production by dendritic cells revealed by global gene expression analysis. Nat. Immunol. 2 (2001) 882-888
-
(2001)
Nat. Immunol.
, vol.2
, pp. 882-888
-
-
Granucci, F.1
Vizzardelli, C.2
Pavelka, N.3
Feau, S.4
Persico, M.5
Virzi, E.6
Rescigno, M.7
Moro, G.8
Ricciardi-Castagnoli, P.9
-
34
-
-
0021367361
-
Interleukin-2 production and response to exogenous interleukin-2 in a patient with the acquired immune deficiency syndrome (AIDS)
-
Hauser G.J., Bino T., Rosenberg H., Zakuth V., Geller E., and Spirer Z. Interleukin-2 production and response to exogenous interleukin-2 in a patient with the acquired immune deficiency syndrome (AIDS). Clin. Exp. Immunol. 56 (1984) 14-17
-
(1984)
Clin. Exp. Immunol.
, vol.56
, pp. 14-17
-
-
Hauser, G.J.1
Bino, T.2
Rosenberg, H.3
Zakuth, V.4
Geller, E.5
Spirer, Z.6
-
35
-
-
0031965469
-
A natural immunological adjuvant enhances T cell clonal expansion through a CD28-dependent, interleukin (IL)-2-independent mechanism
-
Khoruts A., Mondino A., Pape K.A., Reiner S.L., and Jenkins M.K. A natural immunological adjuvant enhances T cell clonal expansion through a CD28-dependent, interleukin (IL)-2-independent mechanism. J. Exp. Med. 187 (1998) 225-236
-
(1998)
J. Exp. Med.
, vol.187
, pp. 225-236
-
-
Khoruts, A.1
Mondino, A.2
Pape, K.A.3
Reiner, S.L.4
Jenkins, M.K.5
-
36
-
-
3543098686
-
CD25(+)CD4(+) regulatory T cells from the peripheral blood of asymptomatic HIV-infected individuals regulate CD4(+) and CD8(+) HIV-specific T cell immune responses in vitro and are associated with favorable clinical markers of disease status
-
Kinter A.L., Hennessey M., Bell A., Kern S., Lin Y., Daucher M., Planta M., McGlaughlin M., Jackson R., Ziegler S.F., and Fauci A.S. CD25(+)CD4(+) regulatory T cells from the peripheral blood of asymptomatic HIV-infected individuals regulate CD4(+) and CD8(+) HIV-specific T cell immune responses in vitro and are associated with favorable clinical markers of disease status. J. Exp. Med. 200 (2004) 331-343
-
(2004)
J. Exp. Med.
, vol.200
, pp. 331-343
-
-
Kinter, A.L.1
Hennessey, M.2
Bell, A.3
Kern, S.4
Lin, Y.5
Daucher, M.6
Planta, M.7
McGlaughlin, M.8
Jackson, R.9
Ziegler, S.F.10
Fauci, A.S.11
-
37
-
-
0029118133
-
Normal clonal expansion but impaired Fas-mediated cell death and anergy induction in interleukin-2-deficient mice
-
Kneitz B., Herrmann T., Yonehara S., and Schimpl A. Normal clonal expansion but impaired Fas-mediated cell death and anergy induction in interleukin-2-deficient mice. Eur. J. Immunol. 25 (1995) 2572-2577
-
(1995)
Eur. J. Immunol.
, vol.25
, pp. 2572-2577
-
-
Kneitz, B.1
Herrmann, T.2
Yonehara, S.3
Schimpl, A.4
-
38
-
-
0013610170
-
Controlled trial of interleukin-2 infusions in patients infected with the human immunodeficiency virus
-
Kovacs J.A., Vogel S., Albert J.M., Falloon J., Davey Jr. R.T., Walker R.E., Polis M.A., Spooner K., Metcalf J.A., Baseler M., Fyfe G., and Lane H.C. Controlled trial of interleukin-2 infusions in patients infected with the human immunodeficiency virus. N. Engl. J. Med. 335 (1996) 1350-1356
-
(1996)
N. Engl. J. Med.
, vol.335
, pp. 1350-1356
-
-
Kovacs, J.A.1
Vogel, S.2
Albert, J.M.3
Falloon, J.4
Davey Jr., R.T.5
Walker, R.E.6
Polis, M.A.7
Spooner, K.8
Metcalf, J.A.9
Baseler, M.10
Fyfe, G.11
Lane, H.C.12
-
39
-
-
0037374815
-
The role of PI3K in immune cells
-
Koyasu S. The role of PI3K in immune cells. Nat. Immunol. 4 (2003) 313-319
-
(2003)
Nat. Immunol.
, vol.4
, pp. 313-319
-
-
Koyasu, S.1
-
40
-
-
0037340455
-
Human immunodeficiency virus-1 envelope glycoproteins and anti-CD4 antibodies inhibit Interleukin-2-induced Jak/STAT signaling in human CD4 T lymphocytes
-
Kryworuchko M., Pasquier V., and Theze J. Human immunodeficiency virus-1 envelope glycoproteins and anti-CD4 antibodies inhibit Interleukin-2-induced Jak/STAT signaling in human CD4 T lymphocytes. Clin. Exp. Immunol. 131 (2003) 422-427
-
(2003)
Clin. Exp. Immunol.
, vol.131
, pp. 422-427
-
-
Kryworuchko, M.1
Pasquier, V.2
Theze, J.3
-
41
-
-
33947719094
-
-
Fenton M.J. (Ed), Medimond, San Juan, Puerto Rico
-
Kryworuchko M., Abdkader K., Alhetheel A., Sant N., Pasquier V., Kumar A., Diaz-Mitoma F., Keller H., David D., Goujard C., Gilquin J., Viard J.-P., et al. In: Fenton M.J. (Ed). "Fifth Joint Meeting of ICS and ISICR" (2004), Medimond, San Juan, Puerto Rico
-
(2004)
"Fifth Joint Meeting of ICS and ISICR"
-
-
Kryworuchko, M.1
Abdkader, K.2
Alhetheel, A.3
Sant, N.4
Pasquier, V.5
Kumar, A.6
Diaz-Mitoma, F.7
Keller, H.8
David, D.9
Goujard, C.10
Gilquin, J.11
Viard, J.-P.12
-
42
-
-
12144290424
-
Defective IL-2-dependent STAT5 signaling in the CD8 T lymphocytes from HIV+ patients: Restoration by HAART
-
Kryworuchko M., Pasquier V., Keller H., David D., Goujard C., Gilquin J., Viard J.P., Joussemet M., Delfraissy J.-F., and Thèze J. Defective IL-2-dependent STAT5 signaling in the CD8 T lymphocytes from HIV+ patients: Restoration by HAART. AIDS 18 (2004) 421-426
-
(2004)
AIDS
, vol.18
, pp. 421-426
-
-
Kryworuchko, M.1
Pasquier, V.2
Keller, H.3
David, D.4
Goujard, C.5
Gilquin, J.6
Viard, J.P.7
Joussemet, M.8
Delfraissy, J.-F.9
Thèze, J.10
-
43
-
-
0033007321
-
Mature T lymphocyte apoptosis: Immune regulation in a dynamic and unpredictable antigenic environment
-
Lenardo M., Chan K.M., Hornung F., McFarland H., Siegel R., Wang J., and Zheng L. Mature T lymphocyte apoptosis: Immune regulation in a dynamic and unpredictable antigenic environment. Annu. Rev. Immunol. 17 (1999) 221-253
-
(1999)
Annu. Rev. Immunol.
, vol.17
, pp. 221-253
-
-
Lenardo, M.1
Chan, K.M.2
Hornung, F.3
McFarland, H.4
Siegel, R.5
Wang, J.6
Zheng, L.7
-
44
-
-
0026017971
-
Interleukin-2 programs mouse alpha beta T lymphocytes for apoptosis
-
Lenardo M.J. Interleukin-2 programs mouse alpha beta T lymphocytes for apoptosis. Nature 353 (1991) 858-861
-
(1991)
Nature
, vol.353
, pp. 858-861
-
-
Lenardo, M.J.1
-
45
-
-
0032943428
-
Mechanisms of leukocyte-mediated tissue injury induced by interleukin-2
-
Lentsch A.B., Miller F.N., and Edwards M.J. Mechanisms of leukocyte-mediated tissue injury induced by interleukin-2. Cancer Immunol. Immunother. 47 (1999) 243-248
-
(1999)
Cancer Immunol. Immunother.
, vol.47
, pp. 243-248
-
-
Lentsch, A.B.1
Miller, F.N.2
Edwards, M.J.3
-
46
-
-
0031919849
-
Jaks and STATs: Biological implications
-
Leonard W.J., and O'Shea J.J. Jaks and STATs: Biological implications. Annu. Rev. Immunol. 16 (1998) 293-322
-
(1998)
Annu. Rev. Immunol.
, vol.16
, pp. 293-322
-
-
Leonard, W.J.1
O'Shea, J.J.2
-
47
-
-
0034177560
-
Regulation of lymphoid homeostasis by IL-2 receptor signals in vivo
-
Leung D.T., Morefield S., and Willerford D.M. Regulation of lymphoid homeostasis by IL-2 receptor signals in vivo. J. Immunol. 164 (2000) 3527-3534
-
(2000)
J. Immunol.
, vol.164
, pp. 3527-3534
-
-
Leung, D.T.1
Morefield, S.2
Willerford, D.M.3
-
48
-
-
0034657396
-
The role of Stat5a and Stat5b in signaling by IL-2 family cytokines
-
Lin J.X., and Leonard W.J. The role of Stat5a and Stat5b in signaling by IL-2 family cytokines. Oncogene 19 (2000) 2566-2576
-
(2000)
Oncogene
, vol.19
, pp. 2566-2576
-
-
Lin, J.X.1
Leonard, W.J.2
-
49
-
-
0032990632
-
Activation of endothelium by immunotherapy with interleukin-2 in patients with malignant disorders
-
Locker G.J., Kapiotis S., Veitl M., Mader R.M., Stoiser B., Kofler J., Sieder A.E., Rainer H., Steger G.G., Mannhalter C., and Wagner O.F. Activation of endothelium by immunotherapy with interleukin-2 in patients with malignant disorders. Br. J. Haematol. 105 (1999) 912-919
-
(1999)
Br. J. Haematol.
, vol.105
, pp. 912-919
-
-
Locker, G.J.1
Kapiotis, S.2
Veitl, M.3
Mader, R.M.4
Stoiser, B.5
Kofler, J.6
Sieder, A.E.7
Rainer, H.8
Steger, G.G.9
Mannhalter, C.10
Wagner, O.F.11
-
50
-
-
4544241811
-
Tolerance, not immunity, crucially depends on IL-2
-
Malek T.R., and Bayer A.L. Tolerance, not immunity, crucially depends on IL-2. Nat. Rev. Immunol. 4 (2004) 665-674
-
(2004)
Nat. Rev. Immunol.
, vol.4
, pp. 665-674
-
-
Malek, T.R.1
Bayer, A.L.2
-
51
-
-
0034654319
-
Normal lymphoid homeostasis and lack of lethal autoimmunity in mice containing mature T cells with severely impaired IL-2 receptors
-
Malek T.R., Porter B.O., Codias E.K., Scibelli P., and Yu A. Normal lymphoid homeostasis and lack of lethal autoimmunity in mice containing mature T cells with severely impaired IL-2 receptors. J. Immunol. 164 (2000) 2905-2914
-
(2000)
J. Immunol.
, vol.164
, pp. 2905-2914
-
-
Malek, T.R.1
Porter, B.O.2
Codias, E.K.3
Scibelli, P.4
Yu, A.5
-
52
-
-
0036669298
-
CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2
-
Malek T.R., Yu A., Vincek V., Scibelli P., and Kong L. CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2. Immunity 17 (2002) 167-178
-
(2002)
Immunity
, vol.17
, pp. 167-178
-
-
Malek, T.R.1
Yu, A.2
Vincek, V.3
Scibelli, P.4
Kong, L.5
-
53
-
-
17444385673
-
Partial immune reconstitution following highly active antiretroviral therapy: Can adjuvant interleukin-2 fill the gap?
-
Marchetti G., Franzetti F., and Gori A. Partial immune reconstitution following highly active antiretroviral therapy: Can adjuvant interleukin-2 fill the gap?. J. Antimicrob. Chemother. 55 (2005) 401-409
-
(2005)
J. Antimicrob. Chemother.
, vol.55
, pp. 401-409
-
-
Marchetti, G.1
Franzetti, F.2
Gori, A.3
-
54
-
-
0035912232
-
The dynamics of CD4+ T-cell depletion in HIV disease
-
McCune J.M. The dynamics of CD4+ T-cell depletion in HIV disease. Nature 410 (2001) 974-979
-
(2001)
Nature
, vol.410
, pp. 974-979
-
-
McCune, J.M.1
-
55
-
-
0027405991
-
The IL-2 receptor complex: Its structure, function, and target genes
-
Minami Y., Kono T., Miyazaki T., and Taniguchi T. The IL-2 receptor complex: Its structure, function, and target genes. Annu. Rev. Immunol. 11 (1993) 245-268
-
(1993)
Annu. Rev. Immunol.
, vol.11
, pp. 245-268
-
-
Minami, Y.1
Kono, T.2
Miyazaki, T.3
Taniguchi, T.4
-
56
-
-
0029054455
-
Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation
-
Miyazaki T., Liu Z.J., Kawahara A., Minami Y., Yamada K., Tsujimoto Y., Barsoumian E.L., Permutter R.M., and Taniguchi T. Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation. Cell 81 (1995) 223-231
-
(1995)
Cell
, vol.81
, pp. 223-231
-
-
Miyazaki, T.1
Liu, Z.J.2
Kawahara, A.3
Minami, Y.4
Yamada, K.5
Tsujimoto, Y.6
Barsoumian, E.L.7
Permutter, R.M.8
Taniguchi, T.9
-
57
-
-
0036678129
-
Increased peripheral expansion of naive CD4+ T cells in vivo after IL-2 treatment of patients with HIV infection
-
Natarajan V., Lempicki R.A., Sereti I., Badralmaa Y., Adelsberger J.W., Metcalf J.A., Prieto D.A., Stevens R., Baseler M.W., Kovacs J.A., and Lane H.C. Increased peripheral expansion of naive CD4+ T cells in vivo after IL-2 treatment of patients with HIV infection. Proc. Natl. Acad. Sci. USA 99 (2002) 10712-10717
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 10712-10717
-
-
Natarajan, V.1
Lempicki, R.A.2
Sereti, I.3
Badralmaa, Y.4
Adelsberger, J.W.5
Metcalf, J.A.6
Prieto, D.A.7
Stevens, R.8
Baseler, M.W.9
Kovacs, J.A.10
Lane, H.C.11
-
58
-
-
1642321982
-
IL-2, regulatory T cells, and tolerance
-
Nelson B.H. IL-2, regulatory T cells, and tolerance. J. Immunol. 172 (2004) 3983-3988
-
(2004)
J. Immunol.
, vol.172
, pp. 3983-3988
-
-
Nelson, B.H.1
-
59
-
-
0036667391
-
Therapeutic use of interleukin-2 in HIV-infected patients
-
Pau A.K., and Tavel J.A. Therapeutic use of interleukin-2 in HIV-infected patients. Curr. Opin. Pharmacol. 2 (2002) 433-439
-
(2002)
Curr. Opin. Pharmacol.
, vol.2
, pp. 433-439
-
-
Pau, A.K.1
Tavel, J.A.2
-
60
-
-
0003101145
-
Cytokines and chemokines in HIV infection
-
Pantaleo, G., and Walker B.D. (Eds), Humana Press, Totowa, New Jersey
-
Poli G. Cytokines and chemokines in HIV infection. In: Pantaleo, G., and Walker B.D. (Eds). "Retroviral Immunology" (2001), Humana Press, Totowa, New Jersey 53-78
-
(2001)
"Retroviral Immunology"
, pp. 53-78
-
-
Poli, G.1
-
61
-
-
0033635249
-
In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability
-
Rathmell J.C., Vander Heiden M.G., Harris M.H., Frauwirth K.A., and Thompson C.B. In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability. Mol. Cell 6 (2000) 683-692
-
(2000)
Mol. Cell
, vol.6
, pp. 683-692
-
-
Rathmell, J.C.1
Vander Heiden, M.G.2
Harris, M.H.3
Frauwirth, K.A.4
Thompson, C.B.5
-
62
-
-
0026573004
-
Abnormal expression of IL-2R beta (p70)-binding polypeptide on HIV-infected patients' cells
-
Sahraoui Y., Ammar A., Lunardi-Iskandar Y., Tsapis A., Spanakis E., N'Go N., Allouche M., Bellile V.G., Jasmin C., and Georgoulias V. Abnormal expression of IL-2R beta (p70)-binding polypeptide on HIV-infected patients' cells. Cell Immunol. 139 (1992) 318-332
-
(1992)
Cell Immunol.
, vol.139
, pp. 318-332
-
-
Sahraoui, Y.1
Ammar, A.2
Lunardi-Iskandar, Y.3
Tsapis, A.4
Spanakis, E.5
N'Go, N.6
Allouche, M.7
Bellile, V.G.8
Jasmin, C.9
Georgoulias, V.10
-
63
-
-
0037105607
-
Long-term effects of intermittent interleukin 2 therapy in patients with HIV infection: Characterization of a novel subset of CD4(+)/CD25(+) T cells
-
Sereti I., Martinez-Wilson H., Metcalf J.A., Baseler M.W., Hallahan C.W., Hahn B., Hengel R.L., Davey R.T., Kovacs J.A., and Lane H.C. Long-term effects of intermittent interleukin 2 therapy in patients with HIV infection: Characterization of a novel subset of CD4(+)/CD25(+) T cells. Blood 100 (2002) 2159-2167
-
(2002)
Blood
, vol.100
, pp. 2159-2167
-
-
Sereti, I.1
Martinez-Wilson, H.2
Metcalf, J.A.3
Baseler, M.W.4
Hallahan, C.W.5
Hahn, B.6
Hengel, R.L.7
Davey, R.T.8
Kovacs, J.A.9
Lane, H.C.10
-
64
-
-
3242773778
-
IL-2-induced CD4+ T-cell expansion in HIV-infected patients is associated with long-term decreases in T-cell proliferation
-
Sereti I., Anthony K.B., Martinez-Wilson H., Lempicki R., Adelsberger J., Metcalf J.A., Hallahan C.W., Follmann D., Davey R.T., Kovacs J.A., and Lane H.C. IL-2-induced CD4+ T-cell expansion in HIV-infected patients is associated with long-term decreases in T-cell proliferation. Blood 104 (2004) 775-780
-
(2004)
Blood
, vol.104
, pp. 775-780
-
-
Sereti, I.1
Anthony, K.B.2
Martinez-Wilson, H.3
Lempicki, R.4
Adelsberger, J.5
Metcalf, J.A.6
Hallahan, C.W.7
Follmann, D.8
Davey, R.T.9
Kovacs, J.A.10
Lane, H.C.11
-
65
-
-
0030903027
-
Human immune disorder arising from mutation of the alpha chain of the interleukin-2 receptor
-
Sharfe N., Dadi H.K., Shahar M., and Roifman C.M. Human immune disorder arising from mutation of the alpha chain of the interleukin-2 receptor. Proc. Natl. Acad. Sci. USA 94 (1997) 3168-3171
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 3168-3171
-
-
Sharfe, N.1
Dadi, H.K.2
Shahar, M.3
Roifman, C.M.4
-
66
-
-
0029962080
-
The interleukin-2 receptor gamma chain: Its role in the multiple cytokine receptor complexes and T cell development in XSCID
-
Sugamura K., Asao H., Kondo M., Tanaka N., Ishii N., Ohbo K., Nakamura M., and Takeshita T. The interleukin-2 receptor gamma chain: Its role in the multiple cytokine receptor complexes and T cell development in XSCID. Annu. Rev. Immunol. 14 (1996) 179-205
-
(1996)
Annu. Rev. Immunol.
, vol.14
, pp. 179-205
-
-
Sugamura, K.1
Asao, H.2
Kondo, M.3
Tanaka, N.4
Ishii, N.5
Ohbo, K.6
Nakamura, M.7
Takeshita, T.8
-
67
-
-
0030861424
-
Normal thymic selection, superantigen-induced deletion and Fas-mediated apoptosis of T cells in IL-2 receptor beta chain-deficient mice
-
Suzuki H., Hayakawa A., Bouchard D., Nakashima I., and Mak T.W. Normal thymic selection, superantigen-induced deletion and Fas-mediated apoptosis of T cells in IL-2 receptor beta chain-deficient mice. Int. Immunol. 9 (1997) 1367-1374
-
(1997)
Int. Immunol.
, vol.9
, pp. 1367-1374
-
-
Suzuki, H.1
Hayakawa, A.2
Bouchard, D.3
Nakashima, I.4
Mak, T.W.5
-
68
-
-
0020699991
-
Structure and expression of a cloned cDNA for human interleukin-2
-
Taniguchi T., Matsui H., Fujita T., Takaoka C., Kashima N., Yoshimoto R., and Hamuro J. Structure and expression of a cloned cDNA for human interleukin-2. Nature 302 (1983) 305-310
-
(1983)
Nature
, vol.302
, pp. 305-310
-
-
Taniguchi, T.1
Matsui, H.2
Fujita, T.3
Takaoka, C.4
Kashima, N.5
Yoshimoto, R.6
Hamuro, J.7
-
69
-
-
0030272248
-
Interleukin 2 and its receptors: Recent advances and new immunological functions
-
Thèze J., Alzari P.M., and Bertoglio J. Interleukin 2 and its receptors: Recent advances and new immunological functions. Immunol. Today 17 (1996) 481-486
-
(1996)
Immunol. Today
, vol.17
, pp. 481-486
-
-
Thèze, J.1
Alzari, P.M.2
Bertoglio, J.3
-
70
-
-
0032502801
-
Homeostasis and self-tolerance in the immune system: Turning lymphocytes off
-
Van Parijs L., and Abbas A.K. Homeostasis and self-tolerance in the immune system: Turning lymphocytes off. Science 280 (1998) 243-248
-
(1998)
Science
, vol.280
, pp. 243-248
-
-
Van Parijs, L.1
Abbas, A.K.2
-
71
-
-
0031569514
-
Functional responses and apoptosis of CD25 (IL-2R alpha)-deficient T cells expressing a transgenic antigen receptor
-
Van Parijs L., Biuckians A., Ibragimov A., Alt F.W., Willerford D.M., and Abbas A.K. Functional responses and apoptosis of CD25 (IL-2R alpha)-deficient T cells expressing a transgenic antigen receptor. J. Immunol. 158 (1997) 3738-3745
-
(1997)
J. Immunol.
, vol.158
, pp. 3738-3745
-
-
Van Parijs, L.1
Biuckians, A.2
Ibragimov, A.3
Alt, F.W.4
Willerford, D.M.5
Abbas, A.K.6
-
72
-
-
0033199317
-
Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death
-
Van Parijs L., Refaeli Y., Lord J.D., Nelson B.H., Abbas A.K., and Baltimore D. Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death. Immunity 11 (1999) 281-288
-
(1999)
Immunity
, vol.11
, pp. 281-288
-
-
Van Parijs, L.1
Refaeli, Y.2
Lord, J.D.3
Nelson, B.H.4
Abbas, A.K.5
Baltimore, D.6
-
73
-
-
0028296213
-
The interleukin-2 receptor subunit expression and function on peripheral blood lymphocytes from HIV-infected and control persons
-
Vanham G., Kestens L., Vingerhoets J., Penne G., Colebunders R., Vandenbruaene M., Goeman J., Ceuppens J.L., Sugamura K., and Gigase P. The interleukin-2 receptor subunit expression and function on peripheral blood lymphocytes from HIV-infected and control persons. Clin. Immunol. Immunopathol. 71 (1994) 60-68
-
(1994)
Clin. Immunol. Immunopathol.
, vol.71
, pp. 60-68
-
-
Vanham, G.1
Kestens, L.2
Vingerhoets, J.3
Penne, G.4
Colebunders, R.5
Vandenbruaene, M.6
Goeman, J.7
Ceuppens, J.L.8
Sugamura, K.9
Gigase, P.10
-
74
-
-
0023855306
-
Murine B lymphoma cell lines release functionally active interleukin 2 after stimulation with Staphylococcus aureus
-
Walker E., Leemhuis T., and Roeder W. Murine B lymphoma cell lines release functionally active interleukin 2 after stimulation with Staphylococcus aureus. J. Immunol. 140 (1988) 859-865
-
(1988)
J. Immunol.
, vol.140
, pp. 859-865
-
-
Walker, E.1
Leemhuis, T.2
Roeder, W.3
-
75
-
-
8644280556
-
Human immunodeficiency virus-driven expansion of CD4+CD25+ regulatory T cells, which suppress HIV-specific CD4 T-cell responses in HIV-infected patients
-
Weiss L., Donkova-Petrini V., Caccavelli L., Balbo M., Carbonneil C., and Levy Y. Human immunodeficiency virus-driven expansion of CD4+CD25+ regulatory T cells, which suppress HIV-specific CD4 T-cell responses in HIV-infected patients. Blood 104 (2004) 3249-3256
-
(2004)
Blood
, vol.104
, pp. 3249-3256
-
-
Weiss, L.1
Donkova-Petrini, V.2
Caccavelli, L.3
Balbo, M.4
Carbonneil, C.5
Levy, Y.6
-
76
-
-
0028784289
-
Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment
-
Willerford D.M., Chen J., Ferry J.A., Davidson L., Ma A., and Alt F.W. Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment. Immunity 3 (1995) 521-530
-
(1995)
Immunity
, vol.3
, pp. 521-530
-
-
Willerford, D.M.1
Chen, J.2
Ferry, J.A.3
Davidson, L.4
Ma, A.5
Alt, F.W.6
-
77
-
-
0033215132
-
Regulation of T cell homeostasis by heparan sulfate-bound IL-2
-
Wrenshall L.E., and Platt J.L. Regulation of T cell homeostasis by heparan sulfate-bound IL-2. J. Immunol. 163 (1999) 3793-3800
-
(1999)
J. Immunol.
, vol.163
, pp. 3793-3800
-
-
Wrenshall, L.E.1
Platt, J.L.2
-
78
-
-
0042914703
-
Randomized study of high-dose and low-dose interleukin-2 in patients with metastatic renal cancer
-
Yang J.C., Sherry R.M., Steinberg S.M., Topalian S.L., Schwartzentruber D.J., Hwu P., Seipp C.A., Rogers-Freezer L., Morton K.E., White D.E., Liewehr D.J., Merino M.J., et al. Randomized study of high-dose and low-dose interleukin-2 in patients with metastatic renal cancer. J. Clin. Oncol. 21 (2003) 3127-3132
-
(2003)
J. Clin. Oncol.
, vol.21
, pp. 3127-3132
-
-
Yang, J.C.1
Sherry, R.M.2
Steinberg, S.M.3
Topalian, S.L.4
Schwartzentruber, D.J.5
Hwu, P.6
Seipp, C.A.7
Rogers-Freezer, L.8
Morton, K.E.9
White, D.E.10
Liewehr, D.J.11
Merino, M.J.12
-
79
-
-
30744458573
-
Lymphopenia and interleukin-2 therapy alter homeostasis of CD4+CD25+ regulatory T cells
-
Zhang H., Chua K.S., Guimond M., Kapoor V., Brown M.V., Fleisher T.A., Long L.M., Bernstein D., Hill B.J., Douek D.C., Berzofsky J.A., Carter C.S., et al. Lymphopenia and interleukin-2 therapy alter homeostasis of CD4+CD25+ regulatory T cells. Nat. Med. 11 (2005) 1238-1243
-
(2005)
Nat. Med.
, vol.11
, pp. 1238-1243
-
-
Zhang, H.1
Chua, K.S.2
Guimond, M.3
Kapoor, V.4
Brown, M.V.5
Fleisher, T.A.6
Long, L.M.7
Bernstein, D.8
Hill, B.J.9
Douek, D.C.10
Berzofsky, J.A.11
Carter, C.S.12
-
80
-
-
0034088346
-
Hierarchy of protein tyrosine kinases in interleukin-2 (IL-2) signaling: Activation of syk depends on Jak3; however, neither Syk nor Lck is required for IL-2-mediated STAT activation
-
Zhou Y.J., Magnuson K.S., Cheng T.P., Gadina M., Frucht D.M., Galon J., Candotti F., Geahlen R.L., Changelian P.S., and O'Shea J.J. Hierarchy of protein tyrosine kinases in interleukin-2 (IL-2) signaling: Activation of syk depends on Jak3; however, neither Syk nor Lck is required for IL-2-mediated STAT activation. Mol. Cell. Biol. 20 (2000) 4371-4380
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 4371-4380
-
-
Zhou, Y.J.1
Magnuson, K.S.2
Cheng, T.P.3
Gadina, M.4
Frucht, D.M.5
Galon, J.6
Candotti, F.7
Geahlen, R.L.8
Changelian, P.S.9
O'Shea, J.J.10
|