The first α helix of interleukin (IL)-2 folds as a homotetramer, acts as an agonist of the IL-2 receptor β chain, and induces lymphokine-activated killer cells

Journal of Experimental Medicine

Volumn 191, Issue 3, 2000, Pages 529-539

  Eckenberg, Ralph ^a   Rose, Thierry ^a   Moreau, Jean Louis ^a   Weil, Robert ^a   Gesbert, Franck ^b   Dubois, Sigrid ^b   Tello, Diana ^a   Bossus, Marc ^c   Gras, Hélène ^c   Tartar, André ^c   Bertoglio, Jacques ^b   Chouaïb, Salem ^b   Goldberg, Michel ^a   Jacques, Yannick ^b   Alzari, Pedro M ^a   Thèze, Jacques ^a  

^a INSTITUT PASTEUR   (France)

^b INSERM   (France)

^c INSTITUT PASTEUR DE LILLE   (France)

Author keywords

Dimeric interleukin 2 receptor chain; Interleukin 2 mimetic; Natural killer cells; Signal transduction; Synthetic hemopoietin

Indexed keywords

CD8 ANTIGEN; CYTOKINE; ERYTHROPOIETIN; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; PROTEIN P56; STAT5 PROTEIN;

ALPHA HELIX; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BETA CHAIN; CAPILLARY LEAK SYNDROME; CIRCULAR DICHROISM; IMMUNE RESPONSE; INFLAMMATION; LYMPHOKINE ACTIVATED KILLER CELL; MOUSE; NATURAL KILLER CELL; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN QUATERNARY STRUCTURE; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CD8-POSITIVE T-LYMPHOCYTES; CELL LINE; ENZYME ACTIVATION; HUMANS; INTERFERON TYPE II; INTERLEUKIN-2; KILLER CELLS, LYMPHOKINE-ACTIVATED; LYMPHOCYTE ACTIVATION; LYMPHOCYTE SPECIFIC PROTEIN TYROSINE KINASE P56(LCK); LYMPHOCYTE SUBSETS; MICE; MOLECULAR SEQUENCE DATA; MONOCYTES; PEPTIDE FRAGMENTS; PROTEIN FOLDING; RECEPTORS, INTERLEUKIN-2; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS;

EID: 0034614890     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.191.3.529     Document Type: Article

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