Molecular basis of the voltage-dependent gating of TREK-1, a mechano-sensitive K+ channel

Biochemical and Biophysical Research Communications

Volumn 292, Issue 2, 2002, Pages 339-346

  Maingret, François ^a   Honoré, Eric ^a   Lazdunski, Michel ^a   Patel, Amanda Jane ^a  

^a CNRS   (France)

Author keywords

2P domain K+ channels; Arachidonic acid; KCNK 2; Stretch; Voltage sensor

Indexed keywords

MAGNESIUM ION; POTASSIUM; POTASSIUM CHANNEL; PROTEIN; PROTEIN TREK 1; UNCLASSIFIED DRUG;

ACTION POTENTIAL; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE DEPOLARIZATION; CELL STRAIN COS1; CHANNEL GATING; CHIMERA; CONTROLLED STUDY; DEPOLARIZATION; ELECTRIC POTENTIAL; GENE DELETION; GENETIC TRANSFECTION; HUMAN; MEMBRANE STEADY POTENTIAL; MOUSE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM;

MAMMALIA;

EID: 0036297457     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2002.6674     Document Type: Article

References (33)

1. + channels
2. Inward rectifier potassium channels
3. + channel diversity in the mammalian myocardium
4. Molecular biology of voltage-dependent potassium channels
5. + channel beta subunits
6. + channels
7. + channels
8. + channels
9. Molecular and functional properties of two-pore-domain potassium channels
10. Eight potassium channel families revealed by the C. elegans genome project
11. + channel subunits via a disulfide bridge
12. + channel
13. + channel function by distinct second messengers
14. Learning to modulate transmitter release: Themes and variations in synaptic plasticity
15. + channels in Aplysia sensory neurones
16. + channels of Aplysia sensory neurones in cell-free membrane patches
17. + channels by a 12-lipoxygenase metabolite of arachidonic acid
18. + channels
19. + channels
20. Mechano- or acid stimulation, two interactive modes of activation of the TREK-1 potassium channel
21. FMRFamide and membrane stretch as activators of the Aplysia S-channel
22. Stretch activation of the Aplysia S-channel
23. Volatile general anesthetics produce hyperpolarization of Aplysia neurons by activation of a discrete population of baseline potassium channels
24. + channel
25. + channels TREK-1 and TRAAK
26. + channel activated by arachidonic acid and polyunsaturated fatty acid
27. KCNK2: Reversible conversion of a hippocampal potassium leak into a voltage-dependent channel
28. + channel
29. Cloning, localisation and functional expression of the human orthologue of the TREK-1 potassium channel
30. Voltage-induced membrane movement
31. Voltage- and tension-dependent lipid mobility in the outer hair cell plasma membrane
32. Voltage-induced membrane displacement in patch pipettes activates mechanosensitive channels