The lipid-activated two-pore domain K+ channel TREK-1 is resistant to hypoxia: Implication for ischaemic neuroprotection

Journal of Physiology

Volumn 562, Issue 1, 2005, Pages 213-222

  Buckler, Keith J ^a   Honore E ^b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONIC ACID; LIPID; LYSOPHOSPHOLIPID; PICRIC ACID; POTASSIUM CHANNEL; SODIUM CHLORIDE; UNSATURATED FATTY ACID; VOLTAGE GATED POTASSIUM CHANNEL; MESSENGER RNA; POLYUNSATURATED FATTY ACID; TANDEM PORE DOMAIN POTASSIUM CHANNEL; TREK 1 PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; ARTIFACT; BASEMENT MEMBRANE; BRAIN HYPOXIA; BRAIN ISCHEMIA; BRAIN OXYGEN TENSION; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVATION; EXPERIMENTAL DESIGN; GAS; HUMAN; HUMAN CELL; MECHANOTRANSDUCTION; NEUROPROTECTION; NUCLEOTIDE SEQUENCE; PH MEASUREMENT; POTASSIUM CHANNEL TREK 1; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; ELECTROPHYSIOLOGY; HYPOXIA; PH; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN STRUCTURE;

ANIMALS; ARACHIDONIC ACID; CELL LINE; ELECTROPHYSIOLOGY; HUMANS; HYPOXIA-ISCHEMIA, BRAIN; ISCHEMIC PRECONDITIONING; LIPIDS; MEMBRANE POTENTIALS; MICE; PATCH-CLAMP TECHNIQUES; PICRATES; POTASSIUM CHANNELS, TANDEM PORE DOMAIN; RNA, MESSENGER; SOLUTIONS; TRANSFECTION;

EID: 13444274758     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.2004.077503     Document Type: Article

References (27)

1. Blondeau N, Lauritzen I, Widmann C, Lazdunski M & Heurteaux C (2002a). A potent protective role of lysophospholipids against global cerebral ischemia and glutamate excitotoxicity in neuronal cultures. J Cereb Blood Flow Metab 22, 821-834.
2. Blondeau N, Widmann C, Lazdunski M & Heurteaux C (2002b . Polyunsaturated fatty acids induce ischemic and epileptic tolerance. Neuroscience 109, 231-241.
3. + channels TREK-1 and TRAAK. Mol Pharmacol 57, 906-912.
4. + channel. EMBO J 15, 6854-6862.
5. + channel activated by arachidonic acid and polyunsaturated fatty acid. EMBO J 17, 3297-3308.
6. Goldstein SA, Bockenhauer D, O'Kelly I & Zilberberg N (2001). Potassium leak channels and the KCNK family of two-P-domain subunits. Nat Rev Neurosci 2, 175-184.
7. + channels are a novel target for the anesthetic gases xenon, nitrous oxide, and cyclopropane. Mol Pharmacol 65, 443-452.
8. Han J, Gnatenco C, Sladek CD & Kim D (2003). Background and tandem-pore potassium channels in magnocellular neurosecretory cells of the rat supraoptic nucleus. J Physiol 546, 625-639.
9. + channel involved in neuroprotection and general anesthesia. EMBO J 23, 2684-2695.
10. + channel TREK-1. EMBO J 21, 2968-2976.
11. Kemp PJ, Searle GJ, Hartness ME, Lewis A, Miller P, Williams S et al. (2003). Acute oxygen sensing in cellular models: relevance to the physiology of pulmonary neuroepithelial and carotid bodies. Anat Rec 270A, 41-50.
12. Kim D & Clapham DE (1989). Potassium channels in cardiac cells activated by arachidonic acid and phospholipids. Science 244, 1174-1176.
13. + channels in cultured rat neuronal cells. J Physiol 484, 643-660.
14. Lang-Lazdunski L, Blondeau N, Jarretou G, Lazdunski M & Heurteaux C (2003). Linolenic acid prevents neuronal cell death and paraplegia after transient spinal cord ischemia in rats. J Vasc Surg 38, 564-575.
15. Lauritzen I, Blondeau N, Heurteaux C, Widmann C, Romey G & Lazdunski M (2000). Poly-unsaturated fatty acids are potent neuroprotectors. EMBO J 19, 1784-1793.
16. Lesage F & Lazdunski M (2000). Molecular and functional properties of two-pore-domain potassium channels. Am J Physiol Renal Physiol 279, F793-F801.
17. + channel. Biochem Biophys Res Commun 285, 1290-1294.
18. Lopez Barneo J, Pardal R & Ortega Saenz P (2001). Cellular mechanism of oxygen sensing. Annu Rev Physiol 63, 259-287.
19. + channel. Biochem Biophys Res Commun 292, 339-346.
20. + channel. EMBO J 19, 2483-2491.
21. Maingret F, Patel AJ, Lesage F, Lazdunski M & Honore E (1999). Mechano- or acid stimulation, two interactive modes of activation of the TREK-1 potassium channel. J Biol Chem 274, 26691-26696.
22. + channels TREK-1 and TRAAK. J Biol Chem 275, 10128-10133.
23. + channels in central neuroprotection. J Physiol 548, 31-37.
24. Miller P, Peers C & Kemp PJ (2004). Polymodal regulation of hTREK1 by pH, arachidonic acid, and hypoxia: physiological impact in acidosis and alkalosis. Am J Physiol Cell Physiol 286, C272-C282.
25. + channels. Trends Neurosci 24, 339-346.
26. + channel. EMBO J 17, 4283-4290.
27. + channels. Curr Opin Cell Biol 13, 422-428.