Blockade of the tumor necrosis factor-related apoptosis inducing ligand death receptor DR5 prevents β-amyloid neurotoxicity

Neuropsychopharmacology

Volumn 32, Issue 4, 2007, Pages 872-880

  Uberti, Daniela ^a   Ferrari Toninelli, Giulia ^a   Bonini, Sara Anna ^a   Sarnico, Ilenia ^a   Benarese, Marina ^a   Pizzi, Marina ^a   Benussi, Luisa ^b   Ghidoni, Roberta ^b   Binetti, Giuliano ^b   Spano, PierFranco ^a   Facchetti, Fabio ^a   Memo, Maurizio ^a  

^a UNIVERSITY OF BRESCIA   (Italy)

^b IRCCS ISTITUTO CENTRO SAN GIOVANNI DI DIO FATEBENEFRATELLI   (Italy)

Author keywords

amyloid; Alzheimer's disease; Apoptosis; DR5 receptor; p53; TRAIL

Indexed keywords

AMYLOID BETA PROTEIN; DEATH RECEPTOR 5; PIFITHRIN ALPHA; PROTEIN INHIBITOR; PROTEIN P53;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN SLICE; CELL DEATH; CELL LEVEL; CELL LINE; CELL PROTECTION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOSE RESPONSE; EMBRYO; HUMAN; HUMAN CELL; MOUSE; NERVE CELL; NEUROTOXICITY; NONHUMAN; PATHOPHYSIOLOGY; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR BLOCKING; RECEPTOR UPREGULATION;

AGED; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; APOPTOSIS; CELL SURVIVAL; CELLS, CULTURED; CEREBRAL CORTEX; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYO; FEMALE; GENE EXPRESSION REGULATION; HUMANS; MICE; MICE, INBRED C57BL; NEUROBLASTOMA; NEURONS; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; TNF-RELATED APOPTOSIS-INDUCING LIGAND;

EID: 33947262115     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.npp.1301185     Document Type: Article

References (58)

1. Almog N, Rotter V (1997). Involvement of p53 in cell differentiation and development. Biochim Biophys Acta 1333: F1-F27.
2. Cantarella G, Uberti D, Carsana T, Lombardo G, Bernardini R, Memo M (2003). Neutralization of TRAIL death pathway protects human neuronal cell line from beta-amyloid toxicity. Cell Death Differ 10: 134-141.
3. Copani A, Uberti D, Sortino MA, Bruno V, Nicoletti F, Memo M (2001). Activation of cell-cycle-associated proteins in neuronal death: a mandatory or dispensable path? Trends Neurosci 24: 25-31.
4. Cotman CW, Pike CJ, Copani A (1992). Beta amyloid neurotoxicity: a discussion of in vitro findings. Neurobiol Aging 13: 587-590.
5. Crumrine RC, Thomas AL, Morgan PF (1994). Attenuation of p53 expression protects against focal ischemic damage in transgenic mice. J Cereb Blood Flow Metab 14: 887-891.
6. Culmsee C, Zhu X, Yu QS, Chan SL, Camandola S, Guo Z et al (2001). A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide. J Neurochem 77: 220-228.
7. Degli-Esposti MA, Dougall WC, Smolak PJ, Waugh JY, Smith CA, Goodwin RG (1997). The novel receptor TRAIL-R4 induces NF-kappaB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain. Immunity 7: 813-820.
8. Deng Y, Wu X (2000). Peg3/Pw1 promotes p53 mediated apoptosis by inducing Bax translocation from cytosol to mitochondria. Proc Natl Acad Sci 97: 12050-12055.
9. Dewachter I, Van Dorpe J, Smeijers L, Gilis M, Kuiperi C, Laenen I et al (2000). Aging increased amyloid peptide and caused amyloid plaques in brain of old APP/V717I transgenic mice by a different mechanism than mutant presenilin1. J Neurosci 20: 6452-6458.
10. Dorr J, Bechmann I, Waiczies S, Aktas O, Walczak H, Krammer PH et al (2002). Lack of tumor necrosis factor-related apoptosis-inducing ligand but presence of its receptors in the human brain. J Neurosci 22: 1-5.
11. Ekinci FJ, Linsley M, Shea TB (2000). Beta amyloid-induced calcium influx induces apoptosis in culture by oxidative stress rather than tau phosphorylation. Mol Brain Res 76: 389-395.
12. Emery JG, McDonnell P, Burke MB, Deen KC, Lyn S, Silverman C et al (1998). Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL. J Biol Chem 273: 14363-14367.
13. Geula C, Wu CK, Saroff D, Lorenzo A, Yuan M, Yankner BA (1998). Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity. Nat Med 4: 827-831.
14. Gray CW, Patel AJ (1995). Neurodegeneration mediated by glutamate and beta-amyloid peptide: a comparison and possible interaction. Brain Res 691: 169-179.
15. Green DR (1998). Apoptotic pathway: the road to ruin. Cell 94: 695-698.
16. Haas C, Scholossmacher MC, Hung AY, Vigo-Pelfrey C, Mellon A, Ostaszewski BL et al (1992). Amyloid beta-peptide is produced by cultured cells during normal metabolism. Nature 359: 149-153.
17. Helpern JA, Lee SP, Falangola MF, Dyakin VV, Bogart A, Ardekani B et al (2004). MRI assessment of neuropathology in a transgenic mouse model of Alzheimer's disease. Magn Reson Med 51: 794-798.
18. Heppner FL, Gandy S, McLaurin J (2004). Current concepts and future prospects for Alzheimer disease vaccines. Alzheimer Dis Assoc Disord 18: 38-43.
19. Ichikawa K, Liu W, Zhao L, Wang Z, Liu D, Ohtsuka T et al (2001). Tumoricidal activity of a novel anti-human DR5 monoclonal antibody without hepatocyte cytotoxicity. Nat Med 7: 954-960.
20. Inamura N, Araki T, Enokido Y, Nishio C, Aizawa S, Hatanaka H (2000). Role of p53 in DNA strand break-induced apoptosis in organotypic slice culture from the mouse cerebellum. J Neurosci Res 60: 450-457.
21. Johnson MD, Xiang H, London S, Kinoshita Y, Knudson M, Mayberg M et al (1998). Evidence for involvement of Bax a nd p53, but not caspases, in radiation-induced cell death of cultured postnatal hippocampal neurons. J Neurosci Res 54: 721-733.
22. Kischkel FC, Hellbardt S, Behrmann I, Germer M, Pawlita M, Krammer PH et al (1995). Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor. EMBO J 14: 5579-5588.
23. Kowalska A (2003). Amyloid precursor protein gene mutations responsible for early-onset autosomal dominant Alzheimer's disease. Folia Neuropathol 41: 35-40.
24. LeVine III H (2004). The Amyloid Hypothesis and the clearance and degradation of Alzheimer's beta-peptide. J Alzheimers Dis 6: 303-314.
25. Lewis HD, Beher D, Smith D, Hewson L, Cookson N, Reynolds DS et al (2004). Novel aspects of accumulation dynamics and A beta composition in transgenic models of AD. Neurobiol Aging 21: 1175-1185.
26. Li P, Nijhawan D, Budihardjo I, Sirinvasula C, Wang X (1998). Cytochrome c and dATP-dependent formation of Apaf-1/caspase 9 complex initiates an apoptotic protease caspase. Cell 91: 479-489.
27. Luo X, Budihardjo I, Zou H, Slaughter C, Wang X (1998). BID, a Blc2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell 94: 481-490.
28. Martin-Villalba A, Herr I, Jeremias I, Hahne M, Brandt R, Vogel J et al (1999). CD95 (FAS-L/APO-1L) and Tumour Necrosis Factor-Related Apoptosis-Inducing Ligand mediate ischemia-induced apoptosis in neurons. J Neurosci 15: 3809-3817.
29. Matsumoto K, Akao Y, Yi H, Shamoto-Nagai M, Maruyama W, Naoi M (2006). Overexpression of amyloid precursor protein induces susceptibility to oxidative stress in human neuroblastoma SH-SY5Y cells. J Neural Transm 113: 125-135.
30. Mattson MP, Cheng B, Davis D, Bryant K, Lieberburg I, Rydel RE (1992). beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity. J Neurosci 12: 376-389.
31. Milani D, Zauli G, Rimondi E, Celeghini C, Marmiroli S, Narducci P et al (2003). Tumour necrosis factor-related apoptosis-inducing ligand sequentially activates pro-survival and proapoptotic pathways in SK-N-MC neuronal cells. J Neurochem 86: 126-135.
32. Mirra SS, Heyman A, McKell D, Sumi SM, Crain BJ, Brownlee LM et al (1991). The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathological assessment of Alzheimer's disease. Neurology 41: 479-486.
33. Misiti F, Sampaolese B, Pezzotti M, Marini S, Coletta M, Ceccarelli L et al (2005). Abeta(31-35) peptide induce apoptosis in PC 12 cells: contrast with Abeta(25-35) peptide and examination of underlying mechanisms. Neurochem Int 46: 575-583.
34. Miura Y, Misawa N, Kawano Y, Okada H, Inagaki Y, Yamamoto N et al (2003). Tumour necrosis factor-related apoptosis-inducing ligand induces neuronal death in a murine model of HIV central nervous system infection. Proc Natl Acad Sci USA 100: 2777-2782.
35. Moechars D, Lorent K, Van Leuven F (1999). Premature death in transgenic mice that overexpress a mutant amyloid precursor protein is preceded by severe neurodegeneration and apoptosis. Neuroscience 91: 819-830.
36. Mori H, Takio K, Ogawara M, Selkoe DJ (1992). Mass spectometry of purified amyloid beta protein in Alzheimer's disease. J Biol Chem 267: 17082-17086.
37. Nitsch R, Bechmann I, Deisz RA, Haas D, Lehmann TN, Wendling U et al (2000). Human brain-cell death induced by tumournecrosis-factor-related apoptosis-inducing ligand (TRAIL). Lancet 356: 827-828.
38. Oster-Granite ML, McPhie DL, Greenan J, Neve RL (1996). Age-dependent neuronal and synaptic degeneration in mice transgenic for the C terminus of the amyloid precursor protein. J Neurosci 16: 6732-6741.
39. Pan G, Ni J, Wei Y, Yu G, Gentz R, Dixit VM (1997b). An antagonist decoy receptor and a death domain-containing receptor for TRAIL. Science 277: 815-818.
40. Pan G, O'Rourke K, Chinnaiyan AM, Gentz R, Ebner R, Ni J et al (1997a). The receptor for the cytotoxic ligand TRAIL. Science 276: 111-113.
41. Peng QL, Buz'Zard AR, Lau BHS (2002). Pycnogenol protects neurons from amyloid beta peptide-induced apoptosis. Mol Brain Res 104: 55-65.
42. Pike CJ, Burdik D, Walencewicz AJ, Gable CG, Cotman CW (1993). Neurodegeneration induced by β-amyloid peptides in vitro: the role of peptide assembly state. J Neurosci 13: 1676-1687.
43. Pitti RM, Marsters SA, Ruppert S, Donahue CJ, Moore A, Ashkenazi A (1996). Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family. J Biol Chem 271: 12687-12690.
44. Rosales-Corral S, Tan DX, Reiter RJ, Valdivia-Velazquez M, Acosta-Martinez JP, Ortiz GG (2004). Kinetics of the neuroinflammation-oxidative stress correlation in rat brain following the injection of fibrillar amyloid beta onto the hippocampus in vivo. J Neuroimmunol 150: 20-28.
45. Ryan LA, Peng H, Erichsen DA, Huang Y, Persidsky Y, Zhou Y et al (2004). TNF-related apoptosis-inducing ligand mediates human neuronal apoptosis: link to HIV-1-associated dementia. J Neuroimmunol 148: 127-139.
46. Sakhi S, Bruce A, Sun N, Tocco G, Baudry M, Schreiber SS (1997). Induction of tumor suppressor p53 and DNA fragmentation in organotypic hippocampal cultures following excitotoxin treatment. Exp Neurol 145: 81-88.
47. Selkoe DJ (1996). Amyloid beta protein and the genetics of Alzheimer's disease. J Biol Chem 271: 18295-18298.
48. Seubert PC, Vigo-Pelfrey C, Esch F, Lee M, Dovery H, Davis D et al (1992). Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids. Nature 359: 325-327.
49. Sheridan JP, Marsters S, Pitti RM, Gurney A, Skubatch M, Baldwin D et al (1997). Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors. Science 277: 818-821.
50. Tamagno E, Parola M, Gulglielmotto M, Santoro G, Bardini P, Marra L et al (2003). Multiple signaling events in amyloid beta induced oxidative stress-dependent neuronal apoptosis. Free Radical Biol Med 35: 45-58.
51. Uberti D, Belloni M, Grilli M, Spano P, Memo M (1998). Induction of tumour-suppressor phosphoprotein p53 in the apoptosis of cultured rat cerebellar neurones triggered by excitatory amino acids. Eur J Neurosci 10: 246-254.
52. Uberti D, Cantarella G, Facchetti F, Cafici A, Grasso G, Bernardini R et al (2004). TRAIL is expressed in the brain cells of Alzheimer's disease patients. Neuroreport 15: 579-581.
53. Walczak H, Degli-Esposti MA, Johnson RS, Smolak PJ, Waugh JY, Boiani N et al (1997). TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL. EMBO J 16: 5386-5397.
54. Weiss JH, Pike CJ, Cotman CW (1994). Ca2+ channel blockers attenuate beta-amyloid peptide toxicity to cortical neurons in culture. J Neurochem 62: 372-375.
55. Wu GS, Burns TF, McDonald III ER, Jiang W, Meng R, Krantz ID et al (1997). KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene. Nat Genet 17: 141-143.
56. Wu GS, Burns TF, Zhan Y, Alnemri ES, El-Deiry S (1999). Molecular cloning and functional analysis of the mouse homologue of the KILLER/DR5 tumour necrosis factor-related apoptosis -inducing ligand (TRAIL) death receptor. Cancer Res 59: 2770-2775.
57. Yankner BA, Dawes LR, Fisher S, Villa-Komaroff L, Oster-Granite ML, Neve RL (1989). Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease. Science 245: 417-420.
58. 2+ release from intracellular stores. Neurobiol Dis 15: 269-278.