메뉴 건너뛰기




Volumn 25, Issue 9, 2004, Pages 1175-1185

Novel aspects of accumulation dynamics and Aβ composition in transgenic models of AD

Author keywords

amyloid; amyloid precursor protein; amyloid precursor protein containing the Swedish mutation; APP; APPswe; A ; AD; Alzheimer's disease; FAD; familial Alzheimer's disease; GFAP; glial fibrillary acidic protein

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; PRESENILIN 1;

EID: 4143106673     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2003.12.009     Document Type: Article
Times cited : (22)

References (37)
  • 1
    • 0033026550 scopus 로고    scopus 로고
    • Proteolytic fragments of Alzheimer's disease-associated presenilin 1 are present in synaptic organelles and growth cone membranes of rat brain
    • Beher D., Elle C., Underwood J., Davis J.B., Ward R., Karran E., et al. Proteolytic fragments of Alzheimer's disease-associated presenilin 1 are present in synaptic organelles and growth cone membranes of rat brain. J. Neurochem. 72(4):1999;1564-1573
    • (1999) J. Neurochem. , vol.72 , Issue.4 , pp. 1564-1573
    • Beher, D.1    Elle, C.2    Underwood, J.3    Davis, J.B.4    Ward, R.5    Karran, E.6
  • 2
    • 0036322138 scopus 로고    scopus 로고
    • Generation of C-terminally truncated amyloid-beta peptides is dependent on gamma-secretase activity
    • Beher D., Wrigley J.D., Owens A.P., Shearman M.S. Generation of C-terminally truncated amyloid-beta peptides is dependent on gamma-secretase activity. J. Neurochem. 82(3):2002;563-575
    • (2002) J. Neurochem. , vol.82 , Issue.3 , pp. 563-575
    • Beher, D.1    Wrigley, J.D.2    Owens, A.P.3    Shearman, M.S.4
  • 3
    • 0030833055 scopus 로고    scopus 로고
    • Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins
    • Borchelt D.R., Ratovitski T., van Lare J., Lee M.K., Gonzales V., Jenkins N.A., et al. Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins. Neuron. 19(4):1997;939-945
    • (1997) Neuron , vol.19 , Issue.4 , pp. 939-945
    • Borchelt, D.R.1    Ratovitski, T.2    Van Lare, J.3    Lee, M.K.4    Gonzales, V.5    Jenkins, N.A.6
  • 4
    • 0030293676 scopus 로고    scopus 로고
    • Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo
    • Borchelt D.R., Thinakaran G., Eckman C.B., Lee M.K., Davenport F., Ratovitsky T., et al. Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo. Neuron. 17(5):1996;1005-1013
    • (1996) Neuron , vol.17 , Issue.5 , pp. 1005-1013
    • Borchelt, D.R.1    Thinakaran, G.2    Eckman, C.B.3    Lee, M.K.4    Davenport, F.5    Ratovitsky, T.6
  • 5
    • 0035102386 scopus 로고    scopus 로고
    • Augmented senile plaque load in aged female beta-amyloid precursor protein-transgenic mice
    • Callahan M.J., Lipinski W.J., Bian F., Durham R.A., Pack A., Walker L.C. Augmented senile plaque load in aged female beta-amyloid precursor protein-transgenic mice. Am. J. Pathol. 158(3):2001;1173-1177
    • (2001) Am. J. Pathol. , vol.158 , Issue.3 , pp. 1173-1177
    • Callahan, M.J.1    Lipinski, W.J.2    Bian, F.3    Durham, R.A.4    Pack, A.5    Walker, L.C.6
  • 6
    • 0035877756 scopus 로고    scopus 로고
    • Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695
    • Chishti M.A., Yang D.S., Janus C., Phinney A.L., Horne P., Pearson J., et al. Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695. J. Biol. Chem. 276(24):2001;21562-21570
    • (2001) J. Biol. Chem. , vol.276 , Issue.24 , pp. 21562-21570
    • Chishti, M.A.1    Yang, D.S.2    Janus, C.3    Phinney, A.L.4    Horne, P.5    Pearson, J.6
  • 7
    • 0035116442 scopus 로고    scopus 로고
    • Growth arrest of individual senile plaques in a model of Alzheimer's disease observed by in vivo multiphoton microscopy
    • Christie R.H., Bacskai B.J., Zipfel W.R., Williams R.M., Kajdasz S.T., Webb W.W., et al. Growth arrest of individual senile plaques in a model of Alzheimer's disease observed by in vivo multiphoton microscopy. J. Neurosci. 21(3):2001;858-864
    • (2001) J. Neurosci. , vol.21 , Issue.3 , pp. 858-864
    • Christie, R.H.1    Bacskai, B.J.2    Zipfel, W.R.3    Williams, R.M.4    Kajdasz, S.T.5    Webb, W.W.6
  • 8
    • 16944362157 scopus 로고    scopus 로고
    • Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice
    • Citron M., Westaway D., Xia W., Carlson G., Diehl T., Levesque G., et al. Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice. Nat. Med. 3(1):1997;67-72
    • (1997) Nat. Med. , vol.3 , Issue.1 , pp. 67-72
    • Citron, M.1    Westaway, D.2    Xia, W.3    Carlson, G.4    Diehl, T.5    Levesque, G.6
  • 9
    • 0034668139 scopus 로고    scopus 로고
    • Quantitation of amyloid-beta peptides in biological milieu using a novel homogeneous time-resolved fluorescence (HTRF) assay
    • Clarke E.E., Shearman M.S. Quantitation of amyloid-beta peptides in biological milieu using a novel homogeneous time-resolved fluorescence (HTRF) assay. J. Neurosci. Methods. 102(1):2000;61-68
    • (2000) J. Neurosci. Methods , vol.102 , Issue.1 , pp. 61-68
    • Clarke, E.E.1    Shearman, M.S.2
  • 10
    • 0034654282 scopus 로고    scopus 로고
    • Presenilin 2 expression in neuronal cells: Induction during differentiation of embryonic carcinoma cells
    • Culvenor J.G., Evin G., Cooney M.A., Wardan H., Sharples R.A., Maher F., et al. Presenilin 2 expression in neuronal cells: induction during differentiation of embryonic carcinoma cells. Exp. Cell Res. 255(2):2000;192-206
    • (2000) Exp. Cell Res. , vol.255 , Issue.2 , pp. 192-206
    • Culvenor, J.G.1    Evin, G.2    Cooney, M.A.3    Wardan, H.4    Sharples, R.A.5    Maher, F.6
  • 11
    • 16044366039 scopus 로고    scopus 로고
    • Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1
    • Duff K., Eckman C., Zehr C., Yu X., Prada C.M., Perez-tur J., et al. Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1. Nature. 383(6602):1996;710-713
    • (1996) Nature , vol.383 , Issue.6602 , pp. 710-713
    • Duff, K.1    Eckman, C.2    Zehr, C.3    Yu, X.4    Prada, C.M.5    Perez-Tur, J.6
  • 12
    • 0035399822 scopus 로고    scopus 로고
    • Age-related impairment of synaptic transmission but normal long-term potentiation in transgenic mice that overexpress the human APP695SWE mutant form of amyloid precursor protein
    • Fitzjohn S.M., Morton R.A., Kuenzi F., Rosahl T.W., Shearman M., Lewis H., et al. Age-related impairment of synaptic transmission but normal long-term potentiation in transgenic mice that overexpress the human APP695SWE mutant form of amyloid precursor protein. J. Neurosci. 21(13):2001;4691-4698
    • (2001) J. Neurosci. , vol.21 , Issue.13 , pp. 4691-4698
    • Fitzjohn, S.M.1    Morton, R.A.2    Kuenzi, F.3    Rosahl, T.W.4    Shearman, M.5    Lewis, H.6
  • 13
    • 0029949755 scopus 로고    scopus 로고
    • APP transgenesis: Approaches toward the development of animal models for Alzheimer disease neuropathology
    • Greenberg B.D., Savage M.J., Howland D.S., Ali S.M., Siedlak S.L., Perry G., et al. APP transgenesis: approaches toward the development of animal models for Alzheimer disease neuropathology. Neurobiol. Aging. 17(2):1996;153-171
    • (1996) Neurobiol. Aging , vol.17 , Issue.2 , pp. 153-171
    • Greenberg, B.D.1    Savage, M.J.2    Howland, D.S.3    Ali, S.M.4    Siedlak, S.L.5    Perry, G.6
  • 14
    • 0025899041 scopus 로고
    • Amyloid deposition as the central event in the aetiology of Alzheimer's disease
    • Hardy J., Allsop D. Amyloid deposition as the central event in the aetiology of Alzheimer's disease. Trends Pharmacol. Sci. 12(10):1991;383-388
    • (1991) Trends Pharmacol. Sci. , vol.12 , Issue.10 , pp. 383-388
    • Hardy, J.1    Allsop, D.2
  • 15
    • 0031914718 scopus 로고    scopus 로고
    • Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes
    • Holcomb L., Gordon M.N., McGowan E., Yu X., Benkovic S., Jantzen P., et al. Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes. Nat. Med. 4(1):1998;97-100
    • (1998) Nat. Med. , vol.4 , Issue.1 , pp. 97-100
    • Holcomb, L.1    Gordon, M.N.2    McGowan, E.3    Yu, X.4    Benkovic, S.5    Jantzen, P.6
  • 16
    • 0029742199 scopus 로고    scopus 로고
    • Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice
    • Hsiao K., Chapman P., Nilsen S., Eckman C., Harigaya Y., Younkin S., et al. Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science. 274(5284):1996;99-102
    • (1996) Science , vol.274 , Issue.5284 , pp. 99-102
    • Hsiao, K.1    Chapman, P.2    Nilsen, S.3    Eckman, C.4    Harigaya, Y.5    Younkin, S.6
  • 17
    • 0029661424 scopus 로고    scopus 로고
    • Analysis of heterogeneous A4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive Western blot assay
    • Ida N., Hartmann T., Pantel J., Schroder J., Zerfass R., Forstl H., et al. Analysis of heterogeneous A4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive Western blot assay. J. Biol. Chem. 271(37):1996;22908-22914
    • (1996) J. Biol. Chem. , vol.271 , Issue.37 , pp. 22908-22914
    • Ida, N.1    Hartmann, T.2    Pantel, J.3    Schroder, J.4    Zerfass, R.5    Forstl, H.6
  • 18
    • 0028169925 scopus 로고
    • Visualization of a beta 42(43) and a beta 40 in senile plaques with end-specific a beta monoclonals: Evidence that an initially deposited species is a beta 42(43)
    • Iwatsubo T., Odaka A., Suzuki N., Mizusawa H., Nukina N., Ihara Y. Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43). Neuron. 13(1):1994;45-53
    • (1994) Neuron , vol.13 , Issue.1 , pp. 45-53
    • Iwatsubo, T.1    Odaka, A.2    Suzuki, N.3    Mizusawa, H.4    Nukina, N.5    Ihara, Y.6
  • 19
    • 0027258525 scopus 로고
    • The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: Implications for the pathogenesis of Alzheimer's disease
    • Jarrett J.T., Berger E.P., Lansbury P.T. Jr. The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease. Biochemistry. 32(18):1993;4693-4697
    • (1993) Biochemistry , vol.32 , Issue.18 , pp. 4693-4697
    • Jarrett, J.T.1    Berger, E.P.2    Lansbury Jr., P.T.3
  • 20
    • 0031020909 scopus 로고    scopus 로고
    • Amyloid precursor protein processing and a beta42 deposition in a transgenic mouse model of Alzheimer disease
    • Johnson-Wood K., Lee M., Motter R., Hu K., Gordon G., Barbour R., et al. Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease. Proc. Natl. Acad. Sci. U.S.A. 94(4):1997;1550-1555
    • (1997) Proc. Natl. Acad. Sci. U.S.A. , vol.94 , Issue.4 , pp. 1550-1555
    • Johnson-Wood, K.1    Lee, M.2    Motter, R.3    Hu, K.4    Gordon, G.5    Barbour, R.6
  • 21
    • 0037154117 scopus 로고    scopus 로고
    • APP transgenic mice Tg2576 accumulate Abeta peptides that are distinct from the chemically modified and insoluble peptides deposited in Alzheimer's disease senile plaques
    • Kalback W., Watson M.D., Kokjohn T.A., Kuo Y.M., Weiss N., Luehrs D.C., et al. APP transgenic mice Tg2576 accumulate Abeta peptides that are distinct from the chemically modified and insoluble peptides deposited in Alzheimer's disease senile plaques. Biochemistry. 41(3):2002;922-928
    • (2002) Biochemistry , vol.41 , Issue.3 , pp. 922-928
    • Kalback, W.1    Watson, M.D.2    Kokjohn, T.A.3    Kuo, Y.M.4    Weiss, N.5    Luehrs, D.C.6
  • 22
    • 0035863055 scopus 로고    scopus 로고
    • Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease
    • Kawarabayashi T., Younkin L.H., Saido T.C., Shoji M., Ashe K.H., Younkin S.G. Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease. J. Neurosci. 21(2):2001;372-381
    • (2001) J. Neurosci. , vol.21 , Issue.2 , pp. 372-381
    • Kawarabayashi, T.1    Younkin, L.H.2    Saido, T.C.3    Shoji, M.4    Ashe, K.H.5    Younkin, S.G.6
  • 23
    • 0023916455 scopus 로고    scopus 로고
    • Production and characterization of monoclonal antibodies reactive to synthetic cerebrovascular amyloid peptide
    • Kim K.S., Miller D.L., Sapienza V.J., Chen C.M.J., Bai C., Grundke-Iqbal I., et al. Production and characterization of monoclonal antibodies reactive to synthetic cerebrovascular amyloid peptide. Neurosci. Res. Commun. 2:1998;121-130
    • (1998) Neurosci. Res. Commun. , vol.2 , pp. 121-130
    • Kim, K.S.1    Miller, D.L.2    Sapienza, V.J.3    Chen, C.M.J.4    Bai, C.5    Grundke-Iqbal, I.6
  • 25
    • 0035918312 scopus 로고    scopus 로고
    • Comparative analysis of amyloid-beta chemical structure and amyloid plaque morphology of transgenic mouse and Alzheimer's disease brains
    • Kuo Y.M., Kokjohn T.A., Beach T.G., Sue L.I., Brune D., Lopez J.C., et al. Comparative analysis of amyloid-beta chemical structure and amyloid plaque morphology of transgenic mouse and Alzheimer's disease brains. J. Biol. Chem. 276(16):2001;12991-12998
    • (2001) J. Biol. Chem. , vol.276 , Issue.16 , pp. 12991-12998
    • Kuo, Y.M.1    Kokjohn, T.A.2    Beach, T.G.3    Sue, L.I.4    Brune, D.5    Lopez, J.C.6
  • 26
    • 0346101885 scopus 로고    scopus 로고
    • Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death
    • Leissring MA, Farris W, Chang AY, Walsh DM, Wu X, Sun X, Frosch MP, Selkoe DJ. Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death. Neuron 2003;40(6):1087-93.
    • (2003) Neuron , vol.40 , Issue.6 , pp. 1087-1093
    • Leissring, M.A.1    Farris, W.2    Chang, A.Y.3    Walsh, D.M.4    Wu, X.5    Sun, X.6    Frosch, M.P.7    Selkoe, D.J.8
  • 27
    • 17944382037 scopus 로고    scopus 로고
    • Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP
    • Lewis J., Dickson D.W., Lin W.L., Chisholm L., Corral A., Jones G., et al. Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP. Science. 293(5534):2001;1487-1491
    • (2001) Science , vol.293 , Issue.5534 , pp. 1487-1491
    • Lewis, J.1    Dickson, D.W.2    Lin, W.L.3    Chisholm, L.4    Corral, A.5    Jones, G.6
  • 28
    • 0032886415 scopus 로고    scopus 로고
    • Amyloid phenotype characterization of transgenic mice overexpressing both mutant amyloid precursor protein and mutant presenilin 1 transgenes
    • McGowan E., Sanders S., Iwatsubo T., Takeuchi A., Saido T., Zehr C., et al. Amyloid phenotype characterization of transgenic mice overexpressing both mutant amyloid precursor protein and mutant presenilin 1 transgenes. Neurobiol. Dis. 6(4):1999;231-244
    • (1999) Neurobiol. Dis. , vol.6 , Issue.4 , pp. 231-244
    • McGowan, E.1    Sanders, S.2    Iwatsubo, T.3    Takeuchi, A.4    Saido, T.5    Zehr, C.6
  • 29
    • 0042697305 scopus 로고    scopus 로고
    • Triple-transgenic model of Alzheimer's disease with plaques and tangles: Intracellular Abeta and synaptic dysfunction
    • Oddo S., Caccamo A., Shepherd J.D., Murphy M.P., Golde T.E., Kayed R., et al. Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron. 39(3):2003;409-421
    • (2003) Neuron , vol.39 , Issue.3 , pp. 409-421
    • Oddo, S.1    Caccamo, A.2    Shepherd, J.D.3    Murphy, M.P.4    Golde, T.E.5    Kayed, R.6
  • 30
    • 0032032847 scopus 로고    scopus 로고
    • Mutant human presenilin 1 protects presenilin 1 null mouse against embryonic lethality and elevates Abeta1-42/43 expression
    • Qian S., Jiang P., Guan X.M., Singh G., Trumbauer M.E., Yu H., et al. Mutant human presenilin 1 protects presenilin 1 null mouse against embryonic lethality and elevates Abeta1-42/43 expression. Neuron. 20(3):1998;611-617
    • (1998) Neuron , vol.20 , Issue.3 , pp. 611-617
    • Qian, S.1    Jiang, P.2    Guan, X.M.3    Singh, G.4    Trumbauer, M.E.5    Yu, H.6
  • 31
    • 16044373524 scopus 로고    scopus 로고
    • Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
    • Scheuner D., Eckman C., Jensen M., Song X., Citron M., Suzuki N., et al. Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat. Med. 2(8):1996;864-870
    • (1996) Nat. Med. , vol.2 , Issue.8 , pp. 864-870
    • Scheuner, D.1    Eckman, C.2    Jensen, M.3    Song, X.4    Citron, M.5    Suzuki, N.6
  • 32
    • 0033046817 scopus 로고    scopus 로고
    • Transgenic animals relevant to Alzheimer's disease
    • Seabrook G.R., Rosahl T.W. Transgenic animals relevant to Alzheimer's disease. Neuropharmacology. 38(1):1999;1-17
    • (1999) Neuropharmacology , vol.38 , Issue.1 , pp. 1-17
    • Seabrook, G.R.1    Rosahl, T.W.2
  • 33
    • 0031661940 scopus 로고    scopus 로고
    • Transgenic mouse models of Alzheimer's disease
    • Sirinathsinghji D.J. Transgenic mouse models of Alzheimer's disease. Biochem. Soc. Trans. 26(3):1998;504-508
    • (1998) Biochem. Soc. Trans. , vol.26 , Issue.3 , pp. 504-508
    • Sirinathsinghji, D.J.1
  • 34
    • 15844425969 scopus 로고    scopus 로고
    • Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo
    • Thinakaran G., Borchelt D.R., Lee M.K., Slunt H.H., Spitzer L., Kim G., et al. Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo. Neuron. 17(1):1996;181-190
    • (1996) Neuron , vol.17 , Issue.1 , pp. 181-190
    • Thinakaran, G.1    Borchelt, D.R.2    Lee, M.K.3    Slunt, H.H.4    Spitzer, L.5    Kim, G.6
  • 35
    • 0033595706 scopus 로고    scopus 로고
    • Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
    • Vassar R., Bennett B.D., Babu-Khan S., Kahn S., Mendiaz E.A., Denis P., et al. Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science. 286(5440):1999;735-741
    • (1999) Science , vol.286 , Issue.5440 , pp. 735-741
    • Vassar, R.1    Bennett, B.D.2    Babu-Khan, S.3    Kahn, S.4    Mendiaz, E.A.5    Denis, P.6
  • 36
    • 0034736182 scopus 로고    scopus 로고
    • Quantitative histological analysis of amyloid deposition in Alzheimer's double transgenic mouse brain
    • Wengenack T.M., Whelan S., Curran G.L., Duff K.E., Poduslo J.F. Quantitative histological analysis of amyloid deposition in Alzheimer's double transgenic mouse brain. Neuroscience. 101(4):2000;939-944
    • (2000) Neuroscience , vol.101 , Issue.4 , pp. 939-944
    • Wengenack, T.M.1    Whelan, S.2    Curran, G.L.3    Duff, K.E.4    Poduslo, J.F.5
  • 37
    • 0030848729 scopus 로고    scopus 로고
    • Increased susceptibility to ischemic brain damage in transgenic mice overexpressing the amyloid precursor protein
    • Zhang F., Eckman C., Younkin S., Hsiao K.K., Iadecola C. Increased susceptibility to ischemic brain damage in transgenic mice overexpressing the amyloid precursor protein. J. Neurosci. 17(20):1997;7655-7661
    • (1997) J. Neurosci. , vol.17 , Issue.20 , pp. 7655-7661
    • Zhang, F.1    Eckman, C.2    Younkin, S.3    Hsiao, K.K.4    Iadecola, C.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.