-
1
-
-
0033026550
-
Proteolytic fragments of Alzheimer's disease-associated presenilin 1 are present in synaptic organelles and growth cone membranes of rat brain
-
Beher D., Elle C., Underwood J., Davis J.B., Ward R., Karran E., et al. Proteolytic fragments of Alzheimer's disease-associated presenilin 1 are present in synaptic organelles and growth cone membranes of rat brain. J. Neurochem. 72(4):1999;1564-1573
-
(1999)
J. Neurochem.
, vol.72
, Issue.4
, pp. 1564-1573
-
-
Beher, D.1
Elle, C.2
Underwood, J.3
Davis, J.B.4
Ward, R.5
Karran, E.6
-
2
-
-
0036322138
-
Generation of C-terminally truncated amyloid-beta peptides is dependent on gamma-secretase activity
-
Beher D., Wrigley J.D., Owens A.P., Shearman M.S. Generation of C-terminally truncated amyloid-beta peptides is dependent on gamma-secretase activity. J. Neurochem. 82(3):2002;563-575
-
(2002)
J. Neurochem.
, vol.82
, Issue.3
, pp. 563-575
-
-
Beher, D.1
Wrigley, J.D.2
Owens, A.P.3
Shearman, M.S.4
-
3
-
-
0030833055
-
Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins
-
Borchelt D.R., Ratovitski T., van Lare J., Lee M.K., Gonzales V., Jenkins N.A., et al. Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins. Neuron. 19(4):1997;939-945
-
(1997)
Neuron
, vol.19
, Issue.4
, pp. 939-945
-
-
Borchelt, D.R.1
Ratovitski, T.2
Van Lare, J.3
Lee, M.K.4
Gonzales, V.5
Jenkins, N.A.6
-
4
-
-
0030293676
-
Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo
-
Borchelt D.R., Thinakaran G., Eckman C.B., Lee M.K., Davenport F., Ratovitsky T., et al. Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo. Neuron. 17(5):1996;1005-1013
-
(1996)
Neuron
, vol.17
, Issue.5
, pp. 1005-1013
-
-
Borchelt, D.R.1
Thinakaran, G.2
Eckman, C.B.3
Lee, M.K.4
Davenport, F.5
Ratovitsky, T.6
-
5
-
-
0035102386
-
Augmented senile plaque load in aged female beta-amyloid precursor protein-transgenic mice
-
Callahan M.J., Lipinski W.J., Bian F., Durham R.A., Pack A., Walker L.C. Augmented senile plaque load in aged female beta-amyloid precursor protein-transgenic mice. Am. J. Pathol. 158(3):2001;1173-1177
-
(2001)
Am. J. Pathol.
, vol.158
, Issue.3
, pp. 1173-1177
-
-
Callahan, M.J.1
Lipinski, W.J.2
Bian, F.3
Durham, R.A.4
Pack, A.5
Walker, L.C.6
-
6
-
-
0035877756
-
Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695
-
Chishti M.A., Yang D.S., Janus C., Phinney A.L., Horne P., Pearson J., et al. Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695. J. Biol. Chem. 276(24):2001;21562-21570
-
(2001)
J. Biol. Chem.
, vol.276
, Issue.24
, pp. 21562-21570
-
-
Chishti, M.A.1
Yang, D.S.2
Janus, C.3
Phinney, A.L.4
Horne, P.5
Pearson, J.6
-
7
-
-
0035116442
-
Growth arrest of individual senile plaques in a model of Alzheimer's disease observed by in vivo multiphoton microscopy
-
Christie R.H., Bacskai B.J., Zipfel W.R., Williams R.M., Kajdasz S.T., Webb W.W., et al. Growth arrest of individual senile plaques in a model of Alzheimer's disease observed by in vivo multiphoton microscopy. J. Neurosci. 21(3):2001;858-864
-
(2001)
J. Neurosci.
, vol.21
, Issue.3
, pp. 858-864
-
-
Christie, R.H.1
Bacskai, B.J.2
Zipfel, W.R.3
Williams, R.M.4
Kajdasz, S.T.5
Webb, W.W.6
-
8
-
-
16944362157
-
Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice
-
Citron M., Westaway D., Xia W., Carlson G., Diehl T., Levesque G., et al. Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice. Nat. Med. 3(1):1997;67-72
-
(1997)
Nat. Med.
, vol.3
, Issue.1
, pp. 67-72
-
-
Citron, M.1
Westaway, D.2
Xia, W.3
Carlson, G.4
Diehl, T.5
Levesque, G.6
-
9
-
-
0034668139
-
Quantitation of amyloid-beta peptides in biological milieu using a novel homogeneous time-resolved fluorescence (HTRF) assay
-
Clarke E.E., Shearman M.S. Quantitation of amyloid-beta peptides in biological milieu using a novel homogeneous time-resolved fluorescence (HTRF) assay. J. Neurosci. Methods. 102(1):2000;61-68
-
(2000)
J. Neurosci. Methods
, vol.102
, Issue.1
, pp. 61-68
-
-
Clarke, E.E.1
Shearman, M.S.2
-
10
-
-
0034654282
-
Presenilin 2 expression in neuronal cells: Induction during differentiation of embryonic carcinoma cells
-
Culvenor J.G., Evin G., Cooney M.A., Wardan H., Sharples R.A., Maher F., et al. Presenilin 2 expression in neuronal cells: induction during differentiation of embryonic carcinoma cells. Exp. Cell Res. 255(2):2000;192-206
-
(2000)
Exp. Cell Res.
, vol.255
, Issue.2
, pp. 192-206
-
-
Culvenor, J.G.1
Evin, G.2
Cooney, M.A.3
Wardan, H.4
Sharples, R.A.5
Maher, F.6
-
11
-
-
16044366039
-
Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1
-
Duff K., Eckman C., Zehr C., Yu X., Prada C.M., Perez-tur J., et al. Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1. Nature. 383(6602):1996;710-713
-
(1996)
Nature
, vol.383
, Issue.6602
, pp. 710-713
-
-
Duff, K.1
Eckman, C.2
Zehr, C.3
Yu, X.4
Prada, C.M.5
Perez-Tur, J.6
-
12
-
-
0035399822
-
Age-related impairment of synaptic transmission but normal long-term potentiation in transgenic mice that overexpress the human APP695SWE mutant form of amyloid precursor protein
-
Fitzjohn S.M., Morton R.A., Kuenzi F., Rosahl T.W., Shearman M., Lewis H., et al. Age-related impairment of synaptic transmission but normal long-term potentiation in transgenic mice that overexpress the human APP695SWE mutant form of amyloid precursor protein. J. Neurosci. 21(13):2001;4691-4698
-
(2001)
J. Neurosci.
, vol.21
, Issue.13
, pp. 4691-4698
-
-
Fitzjohn, S.M.1
Morton, R.A.2
Kuenzi, F.3
Rosahl, T.W.4
Shearman, M.5
Lewis, H.6
-
13
-
-
0029949755
-
APP transgenesis: Approaches toward the development of animal models for Alzheimer disease neuropathology
-
Greenberg B.D., Savage M.J., Howland D.S., Ali S.M., Siedlak S.L., Perry G., et al. APP transgenesis: approaches toward the development of animal models for Alzheimer disease neuropathology. Neurobiol. Aging. 17(2):1996;153-171
-
(1996)
Neurobiol. Aging
, vol.17
, Issue.2
, pp. 153-171
-
-
Greenberg, B.D.1
Savage, M.J.2
Howland, D.S.3
Ali, S.M.4
Siedlak, S.L.5
Perry, G.6
-
14
-
-
0025899041
-
Amyloid deposition as the central event in the aetiology of Alzheimer's disease
-
Hardy J., Allsop D. Amyloid deposition as the central event in the aetiology of Alzheimer's disease. Trends Pharmacol. Sci. 12(10):1991;383-388
-
(1991)
Trends Pharmacol. Sci.
, vol.12
, Issue.10
, pp. 383-388
-
-
Hardy, J.1
Allsop, D.2
-
15
-
-
0031914718
-
Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes
-
Holcomb L., Gordon M.N., McGowan E., Yu X., Benkovic S., Jantzen P., et al. Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes. Nat. Med. 4(1):1998;97-100
-
(1998)
Nat. Med.
, vol.4
, Issue.1
, pp. 97-100
-
-
Holcomb, L.1
Gordon, M.N.2
McGowan, E.3
Yu, X.4
Benkovic, S.5
Jantzen, P.6
-
16
-
-
0029742199
-
Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice
-
Hsiao K., Chapman P., Nilsen S., Eckman C., Harigaya Y., Younkin S., et al. Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science. 274(5284):1996;99-102
-
(1996)
Science
, vol.274
, Issue.5284
, pp. 99-102
-
-
Hsiao, K.1
Chapman, P.2
Nilsen, S.3
Eckman, C.4
Harigaya, Y.5
Younkin, S.6
-
17
-
-
0029661424
-
Analysis of heterogeneous A4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive Western blot assay
-
Ida N., Hartmann T., Pantel J., Schroder J., Zerfass R., Forstl H., et al. Analysis of heterogeneous A4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive Western blot assay. J. Biol. Chem. 271(37):1996;22908-22914
-
(1996)
J. Biol. Chem.
, vol.271
, Issue.37
, pp. 22908-22914
-
-
Ida, N.1
Hartmann, T.2
Pantel, J.3
Schroder, J.4
Zerfass, R.5
Forstl, H.6
-
18
-
-
0028169925
-
Visualization of a beta 42(43) and a beta 40 in senile plaques with end-specific a beta monoclonals: Evidence that an initially deposited species is a beta 42(43)
-
Iwatsubo T., Odaka A., Suzuki N., Mizusawa H., Nukina N., Ihara Y. Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43). Neuron. 13(1):1994;45-53
-
(1994)
Neuron
, vol.13
, Issue.1
, pp. 45-53
-
-
Iwatsubo, T.1
Odaka, A.2
Suzuki, N.3
Mizusawa, H.4
Nukina, N.5
Ihara, Y.6
-
19
-
-
0027258525
-
The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: Implications for the pathogenesis of Alzheimer's disease
-
Jarrett J.T., Berger E.P., Lansbury P.T. Jr. The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease. Biochemistry. 32(18):1993;4693-4697
-
(1993)
Biochemistry
, vol.32
, Issue.18
, pp. 4693-4697
-
-
Jarrett, J.T.1
Berger, E.P.2
Lansbury Jr., P.T.3
-
20
-
-
0031020909
-
Amyloid precursor protein processing and a beta42 deposition in a transgenic mouse model of Alzheimer disease
-
Johnson-Wood K., Lee M., Motter R., Hu K., Gordon G., Barbour R., et al. Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease. Proc. Natl. Acad. Sci. U.S.A. 94(4):1997;1550-1555
-
(1997)
Proc. Natl. Acad. Sci. U.S.A.
, vol.94
, Issue.4
, pp. 1550-1555
-
-
Johnson-Wood, K.1
Lee, M.2
Motter, R.3
Hu, K.4
Gordon, G.5
Barbour, R.6
-
21
-
-
0037154117
-
APP transgenic mice Tg2576 accumulate Abeta peptides that are distinct from the chemically modified and insoluble peptides deposited in Alzheimer's disease senile plaques
-
Kalback W., Watson M.D., Kokjohn T.A., Kuo Y.M., Weiss N., Luehrs D.C., et al. APP transgenic mice Tg2576 accumulate Abeta peptides that are distinct from the chemically modified and insoluble peptides deposited in Alzheimer's disease senile plaques. Biochemistry. 41(3):2002;922-928
-
(2002)
Biochemistry
, vol.41
, Issue.3
, pp. 922-928
-
-
Kalback, W.1
Watson, M.D.2
Kokjohn, T.A.3
Kuo, Y.M.4
Weiss, N.5
Luehrs, D.C.6
-
22
-
-
0035863055
-
Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease
-
Kawarabayashi T., Younkin L.H., Saido T.C., Shoji M., Ashe K.H., Younkin S.G. Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease. J. Neurosci. 21(2):2001;372-381
-
(2001)
J. Neurosci.
, vol.21
, Issue.2
, pp. 372-381
-
-
Kawarabayashi, T.1
Younkin, L.H.2
Saido, T.C.3
Shoji, M.4
Ashe, K.H.5
Younkin, S.G.6
-
23
-
-
0023916455
-
Production and characterization of monoclonal antibodies reactive to synthetic cerebrovascular amyloid peptide
-
Kim K.S., Miller D.L., Sapienza V.J., Chen C.M.J., Bai C., Grundke-Iqbal I., et al. Production and characterization of monoclonal antibodies reactive to synthetic cerebrovascular amyloid peptide. Neurosci. Res. Commun. 2:1998;121-130
-
(1998)
Neurosci. Res. Commun.
, vol.2
, pp. 121-130
-
-
Kim, K.S.1
Miller, D.L.2
Sapienza, V.J.3
Chen, C.M.J.4
Bai, C.5
Grundke-Iqbal, I.6
-
24
-
-
0033590975
-
High levels of circulating Abeta42 are sequestered by plasma proteins in Alzheimer's disease
-
Kuo Y.M., Emmerling M.R., Lampert H.C., Hempelman S.R., Kokjohn T.A., Woods A.S., et al. High levels of circulating Abeta42 are sequestered by plasma proteins in Alzheimer's disease. Biochem. Biophys. Res. Commun. 257(3):1999;787-791
-
(1999)
Biochem. Biophys. Res. Commun.
, vol.257
, Issue.3
, pp. 787-791
-
-
Kuo, Y.M.1
Emmerling, M.R.2
Lampert, H.C.3
Hempelman, S.R.4
Kokjohn, T.A.5
Woods, A.S.6
-
25
-
-
0035918312
-
Comparative analysis of amyloid-beta chemical structure and amyloid plaque morphology of transgenic mouse and Alzheimer's disease brains
-
Kuo Y.M., Kokjohn T.A., Beach T.G., Sue L.I., Brune D., Lopez J.C., et al. Comparative analysis of amyloid-beta chemical structure and amyloid plaque morphology of transgenic mouse and Alzheimer's disease brains. J. Biol. Chem. 276(16):2001;12991-12998
-
(2001)
J. Biol. Chem.
, vol.276
, Issue.16
, pp. 12991-12998
-
-
Kuo, Y.M.1
Kokjohn, T.A.2
Beach, T.G.3
Sue, L.I.4
Brune, D.5
Lopez, J.C.6
-
26
-
-
0346101885
-
Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death
-
Leissring MA, Farris W, Chang AY, Walsh DM, Wu X, Sun X, Frosch MP, Selkoe DJ. Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death. Neuron 2003;40(6):1087-93.
-
(2003)
Neuron
, vol.40
, Issue.6
, pp. 1087-1093
-
-
Leissring, M.A.1
Farris, W.2
Chang, A.Y.3
Walsh, D.M.4
Wu, X.5
Sun, X.6
Frosch, M.P.7
Selkoe, D.J.8
-
27
-
-
17944382037
-
Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP
-
Lewis J., Dickson D.W., Lin W.L., Chisholm L., Corral A., Jones G., et al. Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP. Science. 293(5534):2001;1487-1491
-
(2001)
Science
, vol.293
, Issue.5534
, pp. 1487-1491
-
-
Lewis, J.1
Dickson, D.W.2
Lin, W.L.3
Chisholm, L.4
Corral, A.5
Jones, G.6
-
28
-
-
0032886415
-
Amyloid phenotype characterization of transgenic mice overexpressing both mutant amyloid precursor protein and mutant presenilin 1 transgenes
-
McGowan E., Sanders S., Iwatsubo T., Takeuchi A., Saido T., Zehr C., et al. Amyloid phenotype characterization of transgenic mice overexpressing both mutant amyloid precursor protein and mutant presenilin 1 transgenes. Neurobiol. Dis. 6(4):1999;231-244
-
(1999)
Neurobiol. Dis.
, vol.6
, Issue.4
, pp. 231-244
-
-
McGowan, E.1
Sanders, S.2
Iwatsubo, T.3
Takeuchi, A.4
Saido, T.5
Zehr, C.6
-
29
-
-
0042697305
-
Triple-transgenic model of Alzheimer's disease with plaques and tangles: Intracellular Abeta and synaptic dysfunction
-
Oddo S., Caccamo A., Shepherd J.D., Murphy M.P., Golde T.E., Kayed R., et al. Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron. 39(3):2003;409-421
-
(2003)
Neuron
, vol.39
, Issue.3
, pp. 409-421
-
-
Oddo, S.1
Caccamo, A.2
Shepherd, J.D.3
Murphy, M.P.4
Golde, T.E.5
Kayed, R.6
-
30
-
-
0032032847
-
Mutant human presenilin 1 protects presenilin 1 null mouse against embryonic lethality and elevates Abeta1-42/43 expression
-
Qian S., Jiang P., Guan X.M., Singh G., Trumbauer M.E., Yu H., et al. Mutant human presenilin 1 protects presenilin 1 null mouse against embryonic lethality and elevates Abeta1-42/43 expression. Neuron. 20(3):1998;611-617
-
(1998)
Neuron
, vol.20
, Issue.3
, pp. 611-617
-
-
Qian, S.1
Jiang, P.2
Guan, X.M.3
Singh, G.4
Trumbauer, M.E.5
Yu, H.6
-
31
-
-
16044373524
-
Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
-
Scheuner D., Eckman C., Jensen M., Song X., Citron M., Suzuki N., et al. Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat. Med. 2(8):1996;864-870
-
(1996)
Nat. Med.
, vol.2
, Issue.8
, pp. 864-870
-
-
Scheuner, D.1
Eckman, C.2
Jensen, M.3
Song, X.4
Citron, M.5
Suzuki, N.6
-
32
-
-
0033046817
-
Transgenic animals relevant to Alzheimer's disease
-
Seabrook G.R., Rosahl T.W. Transgenic animals relevant to Alzheimer's disease. Neuropharmacology. 38(1):1999;1-17
-
(1999)
Neuropharmacology
, vol.38
, Issue.1
, pp. 1-17
-
-
Seabrook, G.R.1
Rosahl, T.W.2
-
33
-
-
0031661940
-
Transgenic mouse models of Alzheimer's disease
-
Sirinathsinghji D.J. Transgenic mouse models of Alzheimer's disease. Biochem. Soc. Trans. 26(3):1998;504-508
-
(1998)
Biochem. Soc. Trans.
, vol.26
, Issue.3
, pp. 504-508
-
-
Sirinathsinghji, D.J.1
-
34
-
-
15844425969
-
Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo
-
Thinakaran G., Borchelt D.R., Lee M.K., Slunt H.H., Spitzer L., Kim G., et al. Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo. Neuron. 17(1):1996;181-190
-
(1996)
Neuron
, vol.17
, Issue.1
, pp. 181-190
-
-
Thinakaran, G.1
Borchelt, D.R.2
Lee, M.K.3
Slunt, H.H.4
Spitzer, L.5
Kim, G.6
-
35
-
-
0033595706
-
Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
-
Vassar R., Bennett B.D., Babu-Khan S., Kahn S., Mendiaz E.A., Denis P., et al. Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science. 286(5440):1999;735-741
-
(1999)
Science
, vol.286
, Issue.5440
, pp. 735-741
-
-
Vassar, R.1
Bennett, B.D.2
Babu-Khan, S.3
Kahn, S.4
Mendiaz, E.A.5
Denis, P.6
-
36
-
-
0034736182
-
Quantitative histological analysis of amyloid deposition in Alzheimer's double transgenic mouse brain
-
Wengenack T.M., Whelan S., Curran G.L., Duff K.E., Poduslo J.F. Quantitative histological analysis of amyloid deposition in Alzheimer's double transgenic mouse brain. Neuroscience. 101(4):2000;939-944
-
(2000)
Neuroscience
, vol.101
, Issue.4
, pp. 939-944
-
-
Wengenack, T.M.1
Whelan, S.2
Curran, G.L.3
Duff, K.E.4
Poduslo, J.F.5
-
37
-
-
0030848729
-
Increased susceptibility to ischemic brain damage in transgenic mice overexpressing the amyloid precursor protein
-
Zhang F., Eckman C., Younkin S., Hsiao K.K., Iadecola C. Increased susceptibility to ischemic brain damage in transgenic mice overexpressing the amyloid precursor protein. J. Neurosci. 17(20):1997;7655-7661
-
(1997)
J. Neurosci.
, vol.17
, Issue.20
, pp. 7655-7661
-
-
Zhang, F.1
Eckman, C.2
Younkin, S.3
Hsiao, K.K.4
Iadecola, C.5
|