The inhibition of 5-enolpyruvylshikimate-3-phosphate synthase as a model for development of novel antimicrobials

Current Drug Targets

Volumn 8, Issue 3, 2007, Pages 445-457

  Marques, Maurício Ribeiro ^a   Pereira, José Henrique ^a   Oliveira, Jaim S ^b   Basso, Luiz Augusto ^c   de Azevedo Jr , Walter Filgueira ^b,c   Santos, Diógenes Santiago ^b,c   Palma, Mário Sérgio ^a  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^b FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^c PONTIFICAL CATHOLIC UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Active site; Domain; Enzyme catalysis; Enzyme kinetics; EPSP synthase; Glyphosate; Inhibitor; Structural determination

Indexed keywords

3 PHOSPHOSHIKIMATE 1 CARBOXYVINYLTRANSFERASE; 3 PHOSPHOSHIKIMATE 1 CARBOXYVINYLTRANSFERASE INHIBITOR; ANTIFUNGAL AGENT; ANTIINFECTIVE AGENT; ANTIPARASITIC AGENT; FOSFOMYCIN; GLYPHOSATE; SHIKIMIC ACID; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; BACTERIAL GENE; BACTERIAL STRAIN; CARBOXY TERMINAL SEQUENCE; CATALYSIS; DRUG DESIGN; DRUG MECHANISM; DRUG RESEARCH; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME BINDING; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME MODIFICATION; ENZYME STRUCTURE; GENE STRUCTURE; GENETIC CODE; HUMAN; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DOCKING; NONHUMAN; OPPORTUNISTIC INFECTION; PARASITOSIS; PROTEIN DOMAIN; PROTEIN TARGETING; REVIEW; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

3-PHOSPHOSHIKIMATE 1-CARBOXYVINYLTRANSFERASE; ANIMALS; ANTI-INFECTIVE AGENTS; DRUGS, INVESTIGATIONAL; ENZYME INHIBITORS; HUMANS; MODELS, CHEMICAL;

EID: 33847694649     PISSN: 13894501     EISSN: None     Source Type: Journal    
DOI: 10.2174/138945007780058951     Document Type: Review

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