Novel targets for the future development of antibacterial agents

Journal of Applied Microbiology Symposium Supplement

Volumn 92, Issue 1, 2002, Pages

  McDevitt, D ^a   Payne, David J ^a   Holmes, D J ^a   Rosenberg, M ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 PHOSPHOSHIKIMATE 1 CARBOXYVINYLTRANSFERASE; 4 AMINOBENZOIC ACID; AMINO ACID TRANSFER RNA LIGASE; ANTIINFECTIVE AGENT; AROMATIC AMINO ACID; BACTERIAL PROTEIN; BENZODIAZEPINE; CERULENIN; CHORISMIC ACID; DIAZABORINE; ENTERCHELIN; FTSZ PROTEIN; IMIDAZOLE DERIVATIVE; ISOPRENOID; PROTEIN FTSA; PROTEIN MURA1; PROTEIN MURA2; THIOLACTOMYCIN; TRICLOSAN; UBIQUINONE; UNCLASSIFIED DRUG; VITAMIN K GROUP;

AMINO ACID SYNTHESIS; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; BACTERIAL GENOME; BACTERIAL GROWTH; BIOSYNTHESIS; CELL DIVISION; CELL WALL; CONFERENCE PAPER; DNA SEQUENCE; DRUG TARGETING; FATTY ACID SYNTHESIS; HUMAN; NONHUMAN; PATHOGENICITY; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN PROTEIN INTERACTION; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION; TECHNOLOGY; ANIMAL; BACTERIUM; DRUG DESIGN; DRUG EFFECT; GENETICS; GENOMICS; METABOLISM; REVIEW; SYNTHESIS;

ANTI-BACTERIAL AGENTS; BACTERIAL INFECTIONS; DRUG DESIGN; HUMANS; ANIMALS; BACTERIA; GENOME, BACTERIAL; GENOMICS;

BACTERIA (MICROORGANISMS);

EID: 0036090929     PISSN: 02674440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (23)

1. Use of genomics to identify bacterial undecaprenyl pyrophosphate synthetase: Cloning, expression, and characterization of the essential uppS gene
2. A genome-based approach for the identification of essential bacterial genes
3. Gram positive resistance: Challenge for the development of new antibiotics
4. New drugs for superbugs
5. Two active forms of UDP-N-acetylglucosamine enolpyruvyl transferase in Gram-positive bacteria
6. Characterization of Streptococcus pneumoniae 5-enolpyruvylshikimate-3-phosphate synthase and its activation by monovalent cations
7. 1,4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI)
8. Analysis of a second bacteriophage hyaluronidase gene from Streptococcus pyogenes: Evidence for a third hyaluronidase involved in extracellular enzymatic activity
9. Initial sequencing and analysis of the human genome
10. Regulated antisense RNA eliminates alpha-toxin virulence in Staphylococcus aureus infection
11. Epidemiological trends in nosocomial and community-acquired infections due to antibiotic resistant Gram-positive bacteria
12. Role in cell permeability of an essential two component system in Staphylococcus aureus
13. Regulation of fatty acid biosynthesis in Escherichia coli
14. Bacterial fatty acid biosynthesis: A genomics driven target for antibacterial drug discovery
15. Bacterial pathogens isolated from patients with blood stream infection: Frequency of occurrence and antimicrobial susceptibility patterns
16. Inhibitors of bacterial enoyl acyl carrier protein reductase (FabI): 2,9-Disubstituted 1,2,3,4-tetrahydropyrido[3,4-b]indoles as potential antibacterial agents
17. Hospital-acquired infections: Diseases with increasingly limited therapies
18. A genomic analysis of two-component signal transduction in Streptococcus pneumoniae
19. The sequence of the human genome
20. Identification, evolution and essentiality of the mevalonate pathway for isopretentyl diphosphate biosynthesis in Gram positive cocci
21. Essentiality, expression and characterisation of the Class II 3-hydroxy-3-methylglutaryl coenzyme A reductase of Staphylococcus aureus
22. A hydrophobic residue at the extreme C-terminus of FtsZ is critical for the FtsA-FtsZ interaction in Staphylococcus aureus
23. Regulated gene expression in Staphylococcus aureus for identifying conditional lethal phenotypes and antibiotic mode of action