Substrate and inhibitor-induced conformational changes in the structurally related enzymes UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) and 5-enolpyruvylshikimate 3-phosphate synthase (EPSPS)

Biochemistry

Volumn 38, Issue 28, 1999, Pages 8864-8878

  Krekel, Florian ^a   Oecking, Claudia ^b   Amrhein, Nikolaus ^a   Macheroux, Peter ^a  

^a ETH ZURICH   (Switzerland)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

3 PHOSPHOSHIKIMATE 1 CARBOXYVINYLTRANSFERASE; FOSFOMYCIN; TRANSFERASE; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE N ACETYLGLUCOSAMINE; URIDINE DIPHOSPHATE N ACETYLGLUCOSAMINE ENOLPYRUVYL TRANSFERASE;

ARTICLE; CONFORMATIONAL TRANSITION; ENTEROBACTER CLOACAE; ENZYME CONFORMATION; ENZYME DEGRADATION; ENZYME MECHANISM; ENZYME PURIFICATION; ENZYME STABILITY; ENZYME SUBSTRATE; ESCHERICHIA COLI; PRIORITY JOURNAL;

3-PHOSPHOSHIKIMATE 1-CARBOXYVINYLTRANSFERASE; ALKYL AND ARYL TRANSFERASES; ANTIBODIES, MONOCLONAL; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME INHIBITORS; ESCHERICHIA COLI; HYDROLYSIS; MODELS, MOLECULAR; PEPTIDE FRAGMENTS; PRECIPITIN TESTS; PROTEIN CONFORMATION; SHIKIMIC ACID; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SUBSTRATE SPECIFICITY; TRYPSIN;

ENTEROBACTER CLOACAE; ESCHERICHIA COLI;

EID: 0033551439     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi990412o     Document Type: Article

References (37)

1. Walsh, C. T., Benson, T. E., Kim, D. H., and Lees, W. J. (1996) Curr. Biol. 3, 83-91.
2. Stallings, W. C., Abdel-Meguid, S. S., Lim, L. W., Shieh, H.-S., Dayringer, H. E., Leimgruber, N. K., Stegeman, R. A., Anderson, K. S., Sikorski, J. A., Padgette, S. R., and Kishore, G. M. (1991) Proc. Natl. Acad. Sci. U.S.A. 88, 5046-5050.
3. Schönbrunn, E., Sack, S., Eschenburg, S., Perrakis, A., Krekel, F., Amrhein, N., and Mandelkow, E. (1996) Structure 4, 1065-1075.
4. Bugg, T. D. H., and Walsh, C. T. (1992) Nat. Prod. Rep. 199-215.
5. Schmid, J., and Amrhein, N. (1999) in Plant Amino Acids: Biochemistry and Biotechnology (Singh, B. K., Ed.) pp 147-169, M. Dekker, Inc., New York.
6. Steinrücken, H. C., and Amrhein, N. (1984) Eur. J. Biochem. 143, 351-357.
7. Kahan, F. M., Kahan, J. S., Cassidy, P. J., and Kropp, H. (1974) Ann. NY Acad. Sci. 235, 364-385.
8. Wanke, C., and Amrhein, N. (1993) Eur. J. Biochem. 218, 861-870.
9. Marquardt, J. L., Brown, E. D., Lane, W. S., Haley, T. M., Ichikawa, Y., Wong, C.-H., and Walsh, C. T. (1994) Biochemistry 33, 10646-10651.
10. Skarzynski, T., Mistry, A., Wonacott, A., Hutchinson, S. E., Kelly, V. A., and Duncan, K. (1996) Structure 4, 1465-1474.
11. Sikorski, J. A., and Gruys, K. J. (1997) Acc. Chem. Res. 30, 2-8.
12. Gruys, K. J., Walker, M. C., and Sikorski, J. A. (1992) Biochemistry 31, 5534-5544.
13. Ream, J. E., Yuen, H. K., Frazier, R. B., and Sikorski, J. A. (1992) Biochemistry 31, 5528-5534.
14. Schönbrunn, E., Svergun, D. I., Amrhein, N., and Koch, M. H. J. (1998) Eur. J. Biochem. 253, 406-412.
15. Skarzynski, T., Kim, D. H., Lees, W. J., Walsh, C. T., and Duncan, K. (1998) Biochemistry 37, 2572-2577.
16. della-Cioppa, G., and Kishore, G. M. (1988) EMBO J. 7, 1299-1305.
17. Anderson, K. S., Sikorski, J. A., and Johnson, K. A. (1988) Biochemistry 27, 1604-1610.
18. Studelska, D. R., Klug, C. A., Beusen, D. D., McDowell, L. M., and Schaefer, J. (1996) J. Am. Chem. Soc. 118, 5476-5477.
19. Shuttleworth, W. A., Pohl, M. E., Helms, G. L., Jakeman, D. L., and Evans, J. N. S. (1999) Biochemistry 38, 296-302.
20. Stepanek, F. (1990) Ph.D. Thesis, Ruhr-Universität Bochum, Germany.
21. Bradford, M. M. (1976) Anal. Biochem 72, 248-254.
22. Laemmli, U. K. (1970) Nature (London) 227, 680-685.
23. Brown, E. D., Marquardt, J. L., Lee, J. P., Walsh, C. T., and Anderson, K. S. (1994) Biochemistry 33, 10638-10645.
24. Krekel, F. (1998) Ph.D. Thesis, Eidgenössische Technische Hochschule Zürich, Switzerland.
25. Lanzetta, P. A., Alvarez, L. J., Remack, P. S., and Candia, O. A. (1979) Anal. Biochem. 100, 95-97.
26. Rogers, S. G., Brand, L. A., Holder, S. B., Sharps, E. S., and Brackin, M. J. (1983) Appl. Environ. Microbiol. 46, 37-43.
27. Ramilo, C., Appleyard, R. J., Wanke, C., Krekel, F., Amrhein, N., and Evans, J. N. S. (1994) Biochemistry 33, 15071-15079.
28. Franz, J. E., Mao, K. M., and Sikorski, J. A. (1997) Glyphosate: A unique global herbicide, Vol. 189, American Chemical Society, Washington DC.
29. Pagette, S. R., Re, D. B., Gasser, C. S., Eichholtz, D. A., Frazier, R. B., Hironaka, C. M., Levine, E. B., Shah, D. M., Fraley, R. T., and Kishore, G. M. (1991) J. Biol. Chem. 266, 22364-22369.
30. Sost, D., and Amrhein, N. (1990) Arch. Biochem. Biophys. 282, 433-436.
31. Stalker, D. M., Hiatt, W. R., and Comai, L. (1985) J. Biol. Chem. 260, 4724-4728.
32. Comai, L., Sen, L., and Stalker, D. M. (1983) Science 221, 370-371.
33. Huynh, K. Q. (1993) Biochem. J. 290, 525-530.
34. Shuttleworth, W. A., and Evans, J. N. (1994) Biochemistry 33, 7062-7068.
35. Shuttleworth, W. A., and Evans, J. N. (1996) Arch. Biochem. Biophys. 334, 37-42.
36. Guex, N., and Peitsch, M. C. (1997) Electrophoresis 18, 2714-2723.
37. Jones, T. A., Zou, J. Y., Cowan, S. W., and Kjeldgaard. (1991) Acta Crystallogr., Sect. A 47, 110-119.