Amphipathic benzoic acid derivatives: Synthesis and binding in the hydrophobic tunnel of the zinc deacetylase LpxC

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 7, 2007, Pages 2617-2623

  Shin, Hyunshun ^a   Gennadios, Heather A ^b   Whittington, Douglas A ^b   Christianson, David W ^b  

^a UNIVERSITY OF SAN FRANCISCO   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Enzyme inhibitor complex; Hydrophobic tunnel; Lipid A biosynthesis; Zinc enzyme

Indexed keywords

2 [4 (HEPTYLOXY)PHENYL]ACETIC ACID; 3 (HEPTYLOXY)BENZOIC ACID; 3 CHLORO 4 (HEPTYLOXY)BENZOIC ACID; 4 (HEPTYLOXY) 3 HYDROXYBENZOIC ACID; 4 (HEPTYLOXY) 3 METHOXYBENZOIC ACID; 4 (HEPTYLOXY) 3 NITROBENZOIC ACID; 4 (OCT 1 ENYL)BENZOIC ACID; ANTIBIOTIC AGENT; BENZOIC ACID DERIVATIVE; ENZYME; GLUCOSAMINE; HYDROXAMIC ACID; LIPID A; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE [3 O (3 HYDROXYMYRISTOYL)] N ACETYLGLUCOSAMINE DEACETYLASE; ZINC ION;

ARTICLE; BINDING AFFINITY; COMPARATIVE STUDY; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG BINDING; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME SPECIFICITY; ENZYME SUBSTRATE; GRAM NEGATIVE BACTERIUM; HYDROPHOBICITY; LIGAND BINDING; METAL BINDING; NONHUMAN; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

AMIDOHYDROLASES; BENZOIC ACIDS; CRYSTALLOGRAPHY, X-RAY; HYDROLYSIS; INDICATORS AND REAGENTS; LIGANDS; MODELS, MOLECULAR; PROTEIN BINDING; SUBSTRATE SPECIFICITY;

NEGIBACTERIA;

EID: 33847654341     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.01.044     Document Type: Article

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