Inhibition of the antibacterial target UDP-(3-O-acyl)-N-acetylglucosamine deacetylase (LpxC): Isoxazoline zinc amidase inhibitors bearing diverse metal binding groups

Journal of Medicinal Chemistry

Volumn 45, Issue 19, 2002, Pages 4359-4370

  Pirrung, Michael C ^a   Tumey, L Nathan ^a   Raetz, Christian R H ^b   Jackman, Jane E ^b   Snehalatha, Karnem ^b   McClerren, Amanda L ^b   Fierke, Carol A ^c   Gantt, Stephanie L ^c   Rusche, Kristin M ^c  

^a DUKE UNIVERSITY   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 (4 METHOXYPHENYL) 4,5 DIHYDROISOXAZOLE 5 CARBOXYLIC ACID HYDROXYAMIDE; AMIDASE; ANTIINFECTIVE AGENT; ENZYME INHIBITOR; HYDROXAMIC ACID; ISOXAZOLINE ZINC AMIDASE INHIBITOR; L 159692; LIPID A; OXAZOLINE DERIVATIVE; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE (3 O ACYL) N ACETYLGLUCOSAMINE DEACETYLASE;

ANTIBACTERIAL ACTIVITY; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG POTENCY; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME MECHANISM; GRAM NEGATIVE BACTERIUM; LIPOGENESIS; METAL BINDING; MOLECULAR STABILITY; NONHUMAN; TIME;

AMIDOHYDROLASES; ANTI-BACTERIAL AGENTS; COLONY COUNT, MICROBIAL; ENZYME INHIBITORS; ESCHERICHIA COLI; HYDROXAMIC ACIDS; INHIBITORY CONCENTRATION 50; ISOXAZOLES; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; STRUCTURE-ACTIVITY RELATIONSHIP; ZINC;

EID: 0037068502     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020183v     Document Type: Article

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