Binding of uridine 5′-diphosphate in the "basic patch" of the zinc deacetylase LpxC and implications for substrate binding

Biochemistry

Volumn 45, Issue 51, 2006, Pages 15216-15223

  Gennadios, Heather A ^a   Christianson, David W ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SUBSTRATE BINDING; X RAY CRYSTAL STRUCTURE; ZINC DEACETYLASE; ZINC METALLOENZYME;

BIOSYNTHESIS; CHEMICAL BONDS; CRYSTAL STRUCTURE; HYDROGEN BONDS; PHOSPHATES; SUBSTRATES; X RAY ANALYSIS; ZINC COMPOUNDS;

ENZYMES;

CARBONYL DERIVATIVE; LIPID A; METALLOPROTEIN; PYROPHOSPHATE; RIBOSE; SOLVENT; UNCLASSIFIED DRUG; URACIL; URIDINE DIPHOSPHATE; WATER; ZINC DEACETYLASE LPXC; ZINC ION;

AQUIFEX AEOLICUS; ARTICLE; COMPLEX FORMATION; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME MECHANISM; ENZYME SUBSTRATE COMPLEX; GRAM NEGATIVE BACTERIUM; GRAM NEGATIVE INFECTION; HYDROGEN BOND; LIPOGENESIS; MOLECULAR INTERACTION; MOLECULAR RECOGNITION; NONHUMAN; OUTER MEMBRANE; PRIORITY JOURNAL;

AMIDOHYDROLASES; BACTERIAL PROTEINS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DIPHOSPHATES; SUBSTRATE SPECIFICITY; URIDINE DIPHOSPHATE; ZINC FINGERS;

AQUIFEX AEOLICUS; BACTERIA (MICROORGANISMS); NEGIBACTERIA;

EID: 33845951202     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0619021     Document Type: Article

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