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Volumn 29, Issue 4, 2007, Pages 193-201

Genetically engineered human neural stem cells for brain repair in neurological diseases

Author keywords

Brain tumor; Cell therapy; F3 human NSCs; Human neural stem cell; Huntington disease; Lysosomal storage disease; Parkinson disease; Stroke

Indexed keywords

RETROVIRUS VECTOR;

EID: 33847120763     PISSN: 03877604     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.braindev.2006.07.012     Document Type: Review
Times cited : (87)

References (86)
  • 1
    • 0030894092 scopus 로고    scopus 로고
    • Stem cells in the central nervous system
    • McKay R.G. Stem cells in the central nervous system. Science 276 (1997) 66-71
    • (1997) Science , vol.276 , pp. 66-71
    • McKay, R.G.1
  • 2
    • 0034712047 scopus 로고    scopus 로고
    • Mammalian neural stem cells
    • Gage F.H. Mammalian neural stem cells. Science 287 (2000) 1433-1438
    • (2000) Science , vol.287 , pp. 1433-1438
    • Gage, F.H.1
  • 3
    • 0035499887 scopus 로고    scopus 로고
    • The development of neural stem cells
    • Temple S. The development of neural stem cells. Nature 414 (2001) 112-117
    • (2001) Nature , vol.414 , pp. 112-117
    • Temple, S.1
  • 4
    • 0036308853 scopus 로고    scopus 로고
    • Large scale sources of neural stem cells
    • Gottlieb D.I. Large scale sources of neural stem cells. Annu Rev Neurosci 25 (2002) 381-407
    • (2002) Annu Rev Neurosci , vol.25 , pp. 381-407
    • Gottlieb, D.I.1
  • 5
    • 0028032236 scopus 로고
    • Grafting immortalized neurons to the CNS
    • Snyder E.Y. Grafting immortalized neurons to the CNS. Curr Opin Neurobiol 4 (1994) 742-751
    • (1994) Curr Opin Neurobiol , vol.4 , pp. 742-751
    • Snyder, E.Y.1
  • 6
    • 0029983762 scopus 로고    scopus 로고
    • Clonal and population analyses demonstrate that an EGF-responsive mammalian embryonic precursor is a stem cell
    • Raynolds B.A., and Weiss S. Clonal and population analyses demonstrate that an EGF-responsive mammalian embryonic precursor is a stem cell. Dev Biol 175 (1996) 1-13
    • (1996) Dev Biol , vol.175 , pp. 1-13
    • Raynolds, B.A.1    Weiss, S.2
  • 7
    • 0030079438 scopus 로고    scopus 로고
    • Physiological relevance and functional potential of central nervous system-derived cell lines
    • Whittemore S.R., and Snyder E.Y. Physiological relevance and functional potential of central nervous system-derived cell lines. Mol Neurobiol 12 (1996) 13-38
    • (1996) Mol Neurobiol , vol.12 , pp. 13-38
    • Whittemore, S.R.1    Snyder, E.Y.2
  • 8
    • 0030838238 scopus 로고    scopus 로고
    • Immortalized neural progenitor cells for CNS gene transfer and repair
    • Martinez-Serrano A., and Bjorklund A. Immortalized neural progenitor cells for CNS gene transfer and repair. Trends Neurosci 20 (1997) 530-538
    • (1997) Trends Neurosci , vol.20 , pp. 530-538
    • Martinez-Serrano, A.1    Bjorklund, A.2
  • 10
    • 0030273384 scopus 로고    scopus 로고
    • Neuronal progenitors as tools for cell replacement in the nervous system
    • Brustle O., and McKay R.G. Neuronal progenitors as tools for cell replacement in the nervous system. Curr Opin Neurobiol 6 (1996) 688-695
    • (1996) Curr Opin Neurobiol , vol.6 , pp. 688-695
    • Brustle, O.1    McKay, R.G.2
  • 11
    • 0029240724 scopus 로고
    • Neuroepithelial progenitor cells explanted from human fetal brain proliferate and differentiate in vitro
    • Buc-Caron M.H. Neuroepithelial progenitor cells explanted from human fetal brain proliferate and differentiate in vitro. Neurobiol Dis 2 (1995) 37-47
    • (1995) Neurobiol Dis , vol.2 , pp. 37-47
    • Buc-Caron, M.H.1
  • 13
    • 0031771599 scopus 로고    scopus 로고
    • Engraftable human neural stem cells respond to developmental clues, replace neurons, and express foreign genes
    • Flax J.D., Aurora S., Yang C., Simonin C., Wills A.M., Billinghurst L.L., et al. Engraftable human neural stem cells respond to developmental clues, replace neurons, and express foreign genes. Nat Biotech 16 (1998) 1033-1039
    • (1998) Nat Biotech , vol.16 , pp. 1033-1039
    • Flax, J.D.1    Aurora, S.2    Yang, C.3    Simonin, C.4    Wills, A.M.5    Billinghurst, L.L.6
  • 14
    • 0031006419 scopus 로고    scopus 로고
    • Bipotent progenitor cell lines from the human CNS
    • Sah D.W., Ray J., and Gage F. Bipotent progenitor cell lines from the human CNS. Nat Biotech 15 (1997) 574-580
    • (1997) Nat Biotech , vol.15 , pp. 574-580
    • Sah, D.W.1    Ray, J.2    Gage, F.3
  • 15
    • 0034008662 scopus 로고    scopus 로고
    • Establishment and properties of a growth factor-dependent, perpetual neural stem cell line from the human CNS
    • Villa A., Snyder E.Y., Vescovi A., and Martinez A. Establishment and properties of a growth factor-dependent, perpetual neural stem cell line from the human CNS. Exp Neurol 161 (2000) 67-84
    • (2000) Exp Neurol , vol.161 , pp. 67-84
    • Villa, A.1    Snyder, E.Y.2    Vescovi, A.3    Martinez, A.4
  • 16
    • 4644224829 scopus 로고    scopus 로고
    • Human neural stem cells genetically modified for brain repair in neurological diseases
    • Kim S.U. Human neural stem cells genetically modified for brain repair in neurological diseases. Neuropathology 24 (2004) 159-171
    • (2004) Neuropathology , vol.24 , pp. 159-171
    • Kim, S.U.1
  • 17
    • 0026535505 scopus 로고
    • Generation of neurons and astrocytes from isolated cells from the adult mammalian central nervous system
    • Raynolds B.A., and Weiss S. Generation of neurons and astrocytes from isolated cells from the adult mammalian central nervous system. Science 255 (1992) 1707-1710
    • (1992) Science , vol.255 , pp. 1707-1710
    • Raynolds, B.A.1    Weiss, S.2
  • 19
    • 0026501444 scopus 로고
    • Multipotent neural cell lines can engraft and participate in development of mouse cerebellum
    • Snyder E.Y., Deitcher D.L., and Walsh C. Multipotent neural cell lines can engraft and participate in development of mouse cerebellum. Cell 68 (1992) 33-51
    • (1992) Cell , vol.68 , pp. 33-51
    • Snyder, E.Y.1    Deitcher, D.L.2    Walsh, C.3
  • 20
    • 0029981428 scopus 로고    scopus 로고
    • Differentiation of the immortalized adult neuronal progenitor cell line HC2S2 into neurons by regulatable suppression of the v-myc oncogene
    • Hoshimaru M., Ray J., Sah D.W., and Gage F.H. Differentiation of the immortalized adult neuronal progenitor cell line HC2S2 into neurons by regulatable suppression of the v-myc oncogene. Proc Natl Acad Sci USA 93 (1996) 1518-1523
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 1518-1523
    • Hoshimaru, M.1    Ray, J.2    Sah, D.W.3    Gage, F.H.4
  • 21
    • 0025833294 scopus 로고
    • Region-specific differentiation of the hippocampal stem cell line HiB5 upon implantation into the developing mammalian brain
    • Renfranz P.J., Cunningham M., and McKay R. Region-specific differentiation of the hippocampal stem cell line HiB5 upon implantation into the developing mammalian brain. Cell 66 (1991) 713-729
    • (1991) Cell , vol.66 , pp. 713-729
    • Renfranz, P.J.1    Cunningham, M.2    McKay, R.3
  • 22
    • 0037036895 scopus 로고    scopus 로고
    • Human neural stem cells: Electrophysiological properties of voltage-gated ion channels
    • Cho T., Bae J., Choi H.B., Kim S.S., McLarnon J.G., Suh H., et al. Human neural stem cells: Electrophysiological properties of voltage-gated ion channels. Neuroreport 13 (2002) 1447-1452
    • (2002) Neuroreport , vol.13 , pp. 1447-1452
    • Cho, T.1    Bae, J.2    Choi, H.B.3    Kim, S.S.4    McLarnon, J.G.5    Suh, H.6
  • 23
    • 0242432424 scopus 로고    scopus 로고
    • Adenosine triphosphate induces proliferation of human neural stem cells: Role of calcium and p70 ribosomal protein S6 kinase
    • Ryu J.K., Choi H.B., Hatori K., Heisel R.L., Pelech S.L., McLarnon J.G., et al. Adenosine triphosphate induces proliferation of human neural stem cells: Role of calcium and p70 ribosomal protein S6 kinase. J Neurosci Res 72 (2003) 352-362
    • (2003) J Neurosci Res , vol.72 , pp. 352-362
    • Ryu, J.K.1    Choi, H.B.2    Hatori, K.3    Heisel, R.L.4    Pelech, S.L.5    McLarnon, J.G.6
  • 24
    • 0037986476 scopus 로고    scopus 로고
    • Human neural stem cells can migrate, differentiate and integrate after intravenous transplantation in adult rats with transient forebrain ischemia
    • Chu K., Kim M.H., Jeong S.W., Kim S.U., and Yoon B.W. Human neural stem cells can migrate, differentiate and integrate after intravenous transplantation in adult rats with transient forebrain ischemia. Neurosci Lett 343 (2003) 129-133
    • (2003) Neurosci Lett , vol.343 , pp. 129-133
    • Chu, K.1    Kim, M.H.2    Jeong, S.W.3    Kim, S.U.4    Yoon, B.W.5
  • 25
    • 3042773051 scopus 로고    scopus 로고
    • Human neural stem cells improve sensorymotor deficits in the adult rat brain with experimental focal ischemia
    • Chu K., Kim M., Park K.I., Jeong S.W., Park H.K., Jung K.H., et al. Human neural stem cells improve sensorymotor deficits in the adult rat brain with experimental focal ischemia. Brain Res 1016 (2004) 145-153
    • (2004) Brain Res , vol.1016 , pp. 145-153
    • Chu, K.1    Kim, M.2    Park, K.I.3    Jeong, S.W.4    Park, H.K.5    Jung, K.H.6
  • 26
    • 0042919307 scopus 로고    scopus 로고
    • Human neural stem cell transplantation promotes functional recovery in rats with experimental intracerebral hemorrhage
    • Jeong S.W., Chu K., Jung K.H., Kim S.U., Kim M., Roh J.K., et al. Human neural stem cell transplantation promotes functional recovery in rats with experimental intracerebral hemorrhage. Stroke 34 (2003) 2258-2263
    • (2003) Stroke , vol.34 , pp. 2258-2263
    • Jeong, S.W.1    Chu, K.2    Jung, K.H.3    Kim, S.U.4    Kim, M.5    Roh, J.K.6
  • 27
    • 2342562572 scopus 로고    scopus 로고
    • Proactive transplantation of human neural stem cells prevents cell death of striatal neurons in rat model of Huntington disease
    • Ryu J.K., Kim J., Cho S.J., Hatori K., Nagai A., Choi H.B., et al. Proactive transplantation of human neural stem cells prevents cell death of striatal neurons in rat model of Huntington disease. Neurobiol Dis 16 (2004) 68-77
    • (2004) Neurobiol Dis , vol.16 , pp. 68-77
    • Ryu, J.K.1    Kim, J.2    Cho, S.J.3    Hatori, K.4    Nagai, A.5    Choi, H.B.6
  • 28
    • 20144381234 scopus 로고    scopus 로고
    • Intravenous administration of human neural stem cells induces functional recovery in Huntington's disease rat model
    • Lee S.T., Chu K., Park J.E., Lee L., Kang L., Kim S.U., et al. Intravenous administration of human neural stem cells induces functional recovery in Huntington's disease rat model. Neurosci Res 52 (2005) 243-249
    • (2005) Neurosci Res , vol.52 , pp. 243-249
    • Lee, S.T.1    Chu, K.2    Park, J.E.3    Lee, L.4    Kang, L.5    Kim, S.U.6
  • 29
    • 33645512055 scopus 로고    scopus 로고
    • Brain transplantation of human neural stem cells transduced with tyrosine hydroxylase and GTP cyclohydrolase 1 provides functional improvement in animal models of Parkinson disease
    • Kim S.U., Park I.H., Kim T.H., Kim K.S., Choi H.B., Hong S.H., et al. Brain transplantation of human neural stem cells transduced with tyrosine hydroxylase and GTP cyclohydrolase 1 provides functional improvement in animal models of Parkinson disease. Neuropathology 26 (2006) 129-140
    • (2006) Neuropathology , vol.26 , pp. 129-140
    • Kim, S.U.1    Park, I.H.2    Kim, T.H.3    Kim, K.S.4    Choi, H.B.5    Hong, S.H.6
  • 30
    • 0141705207 scopus 로고    scopus 로고
    • Brain transplantation of genetically engineered human neural stem cells transduced with beta-glucuronidase globally corrects lysosomal storage and brain lesions in mucopolysaccharidosis VII mice
    • Meng X.L., Shen J.S., Ohashi T., Maeda H., Kim S.U., Eto Y., et al. Brain transplantation of genetically engineered human neural stem cells transduced with beta-glucuronidase globally corrects lysosomal storage and brain lesions in mucopolysaccharidosis VII mice. J Neurosci Res 74 (2003) 266-277
    • (2003) J Neurosci Res , vol.74 , pp. 266-277
    • Meng, X.L.1    Shen, J.S.2    Ohashi, T.3    Maeda, H.4    Kim, S.U.5    Eto, Y.6
  • 31
    • 0035102110 scopus 로고    scopus 로고
    • Neural bHLH genes control the neuronal versus glial fate decision in cortical progenitors
    • Nieto M., Schuurmans C., Britz O., and Guillemot F. Neural bHLH genes control the neuronal versus glial fate decision in cortical progenitors. Neuron 29 (2001) 401-413
    • (2001) Neuron , vol.29 , pp. 401-413
    • Nieto, M.1    Schuurmans, C.2    Britz, O.3    Guillemot, F.4
  • 32
    • 0035023474 scopus 로고    scopus 로고
    • Growth factors regulate the survival and fate of cells derived from human neurosphere
    • Caldwell M.A., He X., Wilkie N., Pollack S., Marshall G., Wafford K.A., et al. Growth factors regulate the survival and fate of cells derived from human neurosphere. Nat Biotech 19 (2001) 475-479
    • (2001) Nat Biotech , vol.19 , pp. 475-479
    • Caldwell, M.A.1    He, X.2    Wilkie, N.3    Pollack, S.4    Marshall, G.5    Wafford, K.A.6
  • 33
    • 0033152408 scopus 로고    scopus 로고
    • Generation of tyrosine hydroxylase producing neurons from precursors of the embryonic and adult forebrain
    • Daadi M.M., and Weiss S. Generation of tyrosine hydroxylase producing neurons from precursors of the embryonic and adult forebrain. J Neurosci 19 (1999) 4484-4497
    • (1999) J Neurosci , vol.19 , pp. 4484-4497
    • Daadi, M.M.1    Weiss, S.2
  • 34
    • 0035139022 scopus 로고    scopus 로고
    • Notch1 and Notch3 instructively restrict bFGF-responsive multipotent neural progenitor cells to an astroglial fate
    • Tanigaki K., Nogaki F., Takahashi J., Tashiro K., Kurooka H., Honjo T., et al. Notch1 and Notch3 instructively restrict bFGF-responsive multipotent neural progenitor cells to an astroglial fate. Neuron 29 (2001) 45-55
    • (2001) Neuron , vol.29 , pp. 45-55
    • Tanigaki, K.1    Nogaki, F.2    Takahashi, J.3    Tashiro, K.4    Kurooka, H.5    Honjo, T.6
  • 35
    • 0033767315 scopus 로고    scopus 로고
    • Sonic hedgehog-regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system
    • Lu Q.R., Yuk D., Alberta J.A., Zhu Z., Pawlitzky I., and Chan J. Sonic hedgehog-regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system. Neuron 25 (2000) 317-329
    • (2000) Neuron , vol.25 , pp. 317-329
    • Lu, Q.R.1    Yuk, D.2    Alberta, J.A.3    Zhu, Z.4    Pawlitzky, I.5    Chan, J.6
  • 36
    • 0033764232 scopus 로고    scopus 로고
    • The bHLH transcription factors Olig2 and Olig1 couple neuronal and glial subtype specification
    • Zhou Q., Wang S., and Anderson D.J. The bHLH transcription factors Olig2 and Olig1 couple neuronal and glial subtype specification. Neuron 25 (2000) 331-343
    • (2000) Neuron , vol.25 , pp. 331-343
    • Zhou, Q.1    Wang, S.2    Anderson, D.J.3
  • 38
    • 0037197831 scopus 로고    scopus 로고
    • Brain-directed gene therapy for lysosomal storage disease: going well beyond the blood-brain barrier
    • Sly W.S., and Vogler C. Brain-directed gene therapy for lysosomal storage disease: going well beyond the blood-brain barrier. Proc Natl Acad Sci USA 99 (2002) 5760-5762
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 5760-5762
    • Sly, W.S.1    Vogler, C.2
  • 39
    • 0028951119 scopus 로고
    • Neural progenitor cell engraftment corrects lysosomal storage throughout the MPS VII mouse brain
    • Snyder E.Y., Taylor R.M., and Wolfe J.H. Neural progenitor cell engraftment corrects lysosomal storage throughout the MPS VII mouse brain. Nature 374 (1995) 367-370
    • (1995) Nature , vol.374 , pp. 367-370
    • Snyder, E.Y.1    Taylor, R.M.2    Wolfe, J.H.3
  • 40
    • 0030854815 scopus 로고    scopus 로고
    • Decreased lysosomal storage in the adult MPS VII mouse brain in the vicinity of grafts of retroviral vector-corrected fibroblasts secreting high levels of beta-glucuronidase
    • Taylor R.M., and Wolfe J.H. Decreased lysosomal storage in the adult MPS VII mouse brain in the vicinity of grafts of retroviral vector-corrected fibroblasts secreting high levels of beta-glucuronidase. Nat Med 3 (1997) 771-774
    • (1997) Nat Med , vol.3 , pp. 771-774
    • Taylor, R.M.1    Wolfe, J.H.2
  • 41
    • 0034990351 scopus 로고    scopus 로고
    • Engraftment of genetically engineered amniotic epithelial cells corrects lysosomal storage in multiple areas of the brain in MPS VII mice
    • Kosuga M., Sasaki K., Tanabe A., Li X.K., Okawa H., Ogino I., et al. Engraftment of genetically engineered amniotic epithelial cells corrects lysosomal storage in multiple areas of the brain in MPS VII mice. Mol Ther 3 (2001) 139-148
    • (2001) Mol Ther , vol.3 , pp. 139-148
    • Kosuga, M.1    Sasaki, K.2    Tanabe, A.3    Li, X.K.4    Okawa, H.5    Ogino, I.6
  • 43
    • 0037099784 scopus 로고    scopus 로고
    • Caspase inhibition of Z-VAD increases the survival of grafted bone marrow cells and improves functional outcome after MCOA in rats
    • Chen J., Li Y., Wang L., Lu M., and Chopp M. Caspase inhibition of Z-VAD increases the survival of grafted bone marrow cells and improves functional outcome after MCOA in rats. J Neurol Sci 190 (2002) 17-24
    • (2002) J Neurol Sci , vol.190 , pp. 17-24
    • Chen, J.1    Li, Y.2    Wang, L.3    Lu, M.4    Chopp, M.5
  • 44
    • 0036118625 scopus 로고    scopus 로고
    • Human bone marrow stem cells exhibit neural phenotypes and ameliorate neurological deficits after grafting into the ischmica brain of rats
    • Zhao L.R., Duan W.M., Reyes M., Keene C.D., Verfaille C.M., Low W.C., et al. Human bone marrow stem cells exhibit neural phenotypes and ameliorate neurological deficits after grafting into the ischmica brain of rats. Exp Neurol 174 (2002) 11-20
    • (2002) Exp Neurol , vol.174 , pp. 11-20
    • Zhao, L.R.1    Duan, W.M.2    Reyes, M.3    Keene, C.D.4    Verfaille, C.M.5    Low, W.C.6
  • 45
    • 0025142541 scopus 로고
    • Spatial memory deficit resulting from ischemia-induced damage to the hippocampus is ameliorated by intra-hippocampal transplants of fetal hippocampal neurons
    • Onifer S.M., and Low W.C. Spatial memory deficit resulting from ischemia-induced damage to the hippocampus is ameliorated by intra-hippocampal transplants of fetal hippocampal neurons. Prog Brain Res 82 (1990) 359-366
    • (1990) Prog Brain Res , vol.82 , pp. 359-366
    • Onifer, S.M.1    Low, W.C.2
  • 46
    • 0031587271 scopus 로고    scopus 로고
    • Recovery of spatial learning by grafts of a conditionally immortalized hippocampal neuroepithelial cell line into the ischemia-lesioned hippocampus
    • Sinden J.D., Rashid-Doubell F., Kershaw T.R., Nelson A., Chadwick A., Jat P.S., et al. Recovery of spatial learning by grafts of a conditionally immortalized hippocampal neuroepithelial cell line into the ischemia-lesioned hippocampus. Neuroscience 81 (1997) 599-608
    • (1997) Neuroscience , vol.81 , pp. 599-608
    • Sinden, J.D.1    Rashid-Doubell, F.2    Kershaw, T.R.3    Nelson, A.4    Chadwick, A.5    Jat, P.S.6
  • 47
    • 0035070869 scopus 로고    scopus 로고
    • Resolution of stroke deficits following contralateral grafts of conditionally immortalized neuroepithelial stem cells
    • Veizovic T., Beech J.S., Stroemer R.P., Watson W.P., and Hodges H. Resolution of stroke deficits following contralateral grafts of conditionally immortalized neuroepithelial stem cells. Stroke 32 (2001) 1012-1019
    • (2001) Stroke , vol.32 , pp. 1012-1019
    • Veizovic, T.1    Beech, J.S.2    Stroemer, R.P.3    Watson, W.P.4    Hodges, H.5
  • 48
    • 0036715222 scopus 로고    scopus 로고
    • Effects of implantation site of stem cell grafts on behavioral recovery from stroke damage
    • Modo M., Stroemer R.P., Tang E., Patel S., and Hodges H. Effects of implantation site of stem cell grafts on behavioral recovery from stroke damage. Stroke 33 (2002) 2270-2278
    • (2002) Stroke , vol.33 , pp. 2270-2278
    • Modo, M.1    Stroemer, R.P.2    Tang, E.3    Patel, S.4    Hodges, H.5
  • 49
    • 0035167706 scopus 로고    scopus 로고
    • Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in rats
    • Chen J., Sanberg P.R., Li Y., Wang L., Lu M., Willing A.E., et al. Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in rats. Stroke 32 (2001) 2682-2688
    • (2001) Stroke , vol.32 , pp. 2682-2688
    • Chen, J.1    Sanberg, P.R.2    Li, Y.3    Wang, L.4    Lu, M.5    Willing, A.E.6
  • 50
    • 0032006347 scopus 로고    scopus 로고
    • Transplantation of cryopreserved human embryonic carcinoma-derived neurons (NT2N cells) promotes functional recovery in ischemic rats
    • Borlongan C.V., Tajima Y., Trojanowski J.Q., Lee V.M., and Sanberg P.R. Transplantation of cryopreserved human embryonic carcinoma-derived neurons (NT2N cells) promotes functional recovery in ischemic rats. Exp Neurol 149 (1998) 310-321
    • (1998) Exp Neurol , vol.149 , pp. 310-321
    • Borlongan, C.V.1    Tajima, Y.2    Trojanowski, J.Q.3    Lee, V.M.4    Sanberg, P.R.5
  • 51
    • 0032938922 scopus 로고    scopus 로고
    • Neural transplantation of human neuroteratocarcinoma neurons into ischemic rats. A quantitative dose-response analysis of cell survival and behavioral recovery
    • Saporta S., Borlongan C.V., and Sanberg P.R. Neural transplantation of human neuroteratocarcinoma neurons into ischemic rats. A quantitative dose-response analysis of cell survival and behavioral recovery. Neuroscience 91 (1999) 519-525
    • (1999) Neuroscience , vol.91 , pp. 519-525
    • Saporta, S.1    Borlongan, C.V.2    Sanberg, P.R.3
  • 53
    • 20444419744 scopus 로고    scopus 로고
    • Autologous mesenchymal stem cell transplantation in stroke patients
    • Bang O.Y., Lee J.S., Lee P.H., and Lee G. Autologous mesenchymal stem cell transplantation in stroke patients. Ann Neurol 57 (2005) 874-882
    • (2005) Ann Neurol , vol.57 , pp. 874-882
    • Bang, O.Y.1    Lee, J.S.2    Lee, P.H.3    Lee, G.4
  • 54
    • 0034008113 scopus 로고    scopus 로고
    • Intracerebral hemorrhage
    • Gebel J.M., and Broderick J.P. Intracerebral hemorrhage. Neurol Clin 18 (2000) 419-438
    • (2000) Neurol Clin , vol.18 , pp. 419-438
    • Gebel, J.M.1    Broderick, J.P.2
  • 55
    • 33847139905 scopus 로고    scopus 로고
    • Priorities for clinical research in intracerebral hemorrhage: report from a National Institute of Neurological Disorders and Stroke workshop
    • NINDS ICH Workshop Participants. Priorities for clinical research in intracerebral hemorrhage: report from a National Institute of Neurological Disorders and Stroke workshop. Stroke 36 (2005) 23-41
    • (2005) Stroke , vol.36 , pp. 23-41
    • NINDS ICH Workshop Participants1
  • 56
    • 4744367348 scopus 로고    scopus 로고
    • Human neural stem/progenitor cells, expanded in long-term neurosphere culture, promote functional recovery after focal ischemia in Mongolian gerbils
    • Ishibashi S., Sakaguchi M., Kuroiwa T., Yamasaki M., Kanemura Y., Shizuko I., et al. Human neural stem/progenitor cells, expanded in long-term neurosphere culture, promote functional recovery after focal ischemia in Mongolian gerbils. J Neurosci Res 78 (2004) 215-223
    • (2004) J Neurosci Res , vol.78 , pp. 215-223
    • Ishibashi, S.1    Sakaguchi, M.2    Kuroiwa, T.3    Yamasaki, M.4    Kanemura, Y.5    Shizuko, I.6
  • 57
    • 27744466016 scopus 로고    scopus 로고
    • Using endogenous neural stem cells to enhance recovery from ischemic brain injury
    • Leker R.R., and McKay R.D. Using endogenous neural stem cells to enhance recovery from ischemic brain injury. Curr Neurovasc Res 1 (2004) 421-427
    • (2004) Curr Neurovasc Res , vol.1 , pp. 421-427
    • Leker, R.R.1    McKay, R.D.2
  • 58
    • 0027977759 scopus 로고
    • Evidence for long-term survival and function of dopaminergic grafts in progressive Parkinson's disease
    • Lindvall O., Sawle G., and Widner H. Evidence for long-term survival and function of dopaminergic grafts in progressive Parkinson's disease. Ann Neurol 35 (1994) 172-180
    • (1994) Ann Neurol , vol.35 , pp. 172-180
    • Lindvall, O.1    Sawle, G.2    Widner, H.3
  • 59
    • 0030041034 scopus 로고    scopus 로고
    • Fetal nigral transplantation as a therapy for Parkinson's disease
    • Olanow C.W., Kordower J.H., and Freeman T. Fetal nigral transplantation as a therapy for Parkinson's disease. Trends Neurosci 19 (1996) 102-109
    • (1996) Trends Neurosci , vol.19 , pp. 102-109
    • Olanow, C.W.1    Kordower, J.H.2    Freeman, T.3
  • 60
    • 0028911848 scopus 로고    scopus 로고
    • Neuropathological evidence of graft survival and striatal reinnervations after the transplantation of fetal mesencephalic tissue in a patients with Parkinson's disease
    • Kordower J.J., Freeman T.B., and Snow B.J. Neuropathological evidence of graft survival and striatal reinnervations after the transplantation of fetal mesencephalic tissue in a patients with Parkinson's disease. N Eng J Med 2717 (1997) 1118-1124
    • (1997) N Eng J Med , vol.2717 , pp. 1118-1124
    • Kordower, J.J.1    Freeman, T.B.2    Snow, B.J.3
  • 61
    • 0025963275 scopus 로고
    • Survival and function of intrastriatally grafted primary fibroblasts genetically modified to produce L-dopa
    • Fischer L.J., Jinnah H.A., Kale L.C., Higgins G.A., and Gage F.H. Survival and function of intrastriatally grafted primary fibroblasts genetically modified to produce L-dopa. Neuron 6 (1991) 371-380
    • (1991) Neuron , vol.6 , pp. 371-380
    • Fischer, L.J.1    Jinnah, H.A.2    Kale, L.C.3    Higgins, G.A.4    Gage, F.H.5
  • 62
    • 0028559601 scopus 로고
    • Long-term behavioral recovery in parkinsonian rats by an HSV vector expressing tyrosine hydroxylase
    • During M.J., Naegele J.R., and O'Malley K.L. Long-term behavioral recovery in parkinsonian rats by an HSV vector expressing tyrosine hydroxylase. Science 266 (1994) 1399-1403
    • (1994) Science , vol.266 , pp. 1399-1403
    • During, M.J.1    Naegele, J.R.2    O'Malley, K.L.3
  • 63
    • 0029610630 scopus 로고
    • Intrastriatal implantation of fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevents degeneration of dopaminergic neurons in a rat model of Parkinson's disease
    • Levivier M., Przedborski S., Bencsis C., and Kang U.J. Intrastriatal implantation of fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevents degeneration of dopaminergic neurons in a rat model of Parkinson's disease. J Neurosci 15 (1995) 7810-7820
    • (1995) J Neurosci , vol.15 , pp. 7810-7820
    • Levivier, M.1    Przedborski, S.2    Bencsis, C.3    Kang, U.J.4
  • 64
    • 0028953328 scopus 로고
    • Basic fibroblast growth factor increases dopaminergic graft survival and function in a rat model of Parkinson's disease
    • Takayama H., Ray J., and Raymon H. Basic fibroblast growth factor increases dopaminergic graft survival and function in a rat model of Parkinson's disease. Nat Med 1 (1995) 53-58
    • (1995) Nat Med , vol.1 , pp. 53-58
    • Takayama, H.1    Ray, J.2    Raymon, H.3
  • 65
    • 0030006065 scopus 로고    scopus 로고
    • Double transduction with GTP-cyclohydrolase I and tyrosine hydroxylase is necessary for spontaneous synthesis of l-DOPA by primary fibroblasts
    • Bencsics C., Wachtel S.R., Milstein S., Hatakeyama K., Becker J.B., Kang U.J., et al. Double transduction with GTP-cyclohydrolase I and tyrosine hydroxylase is necessary for spontaneous synthesis of l-DOPA by primary fibroblasts. J Neurosci 16 (1996) 4449-4456
    • (1996) J Neurosci , vol.16 , pp. 4449-4456
    • Bencsics, C.1    Wachtel, S.R.2    Milstein, S.3    Hatakeyama, K.4    Becker, J.B.5    Kang, U.J.6
  • 66
    • 33847139502 scopus 로고    scopus 로고
    • Generation of immortalized human neural stem cells and brain transplantation in animal models of Parkinson's disease
    • Kim S.U., Lee M.A., Jin B.K., Ryu J.K., et al. Generation of immortalized human neural stem cells and brain transplantation in animal models of Parkinson's disease. Ann Neurol 40 (2000) 222
    • (2000) Ann Neurol , vol.40 , pp. 222
    • Kim, S.U.1    Lee, M.A.2    Jin, B.K.3    Ryu, J.K.4
  • 67
    • 0037110966 scopus 로고    scopus 로고
    • Overexpression of midbrain-specific transcription factor Nurr1 modifies susceptibility of neural stem cells to neurotoxins
    • Lee M.A., Lee H.S., Cho K.G., Jin B.K., Sohn S., Lee Y.S., et al. Overexpression of midbrain-specific transcription factor Nurr1 modifies susceptibility of neural stem cells to neurotoxins. Neurosci Lett 333 (2002) 74-78
    • (2002) Neurosci Lett , vol.333 , pp. 74-78
    • Lee, M.A.1    Lee, H.S.2    Cho, K.G.3    Jin, B.K.4    Sohn, S.5    Lee, Y.S.6
  • 68
    • 0000179125 scopus 로고
    • Huntington disease
    • Calne D. (Ed), W.B. Saunders, Philadelphia
    • Greenamyre J.T., and Shoulson I. Huntington disease. In: Calne D. (Ed). Neurodegenerative disease (1994), W.B. Saunders, Philadelphia 5-704
    • (1994) Neurodegenerative disease , pp. 5-704
    • Greenamyre, J.T.1    Shoulson, I.2
  • 70
    • 0034627143 scopus 로고    scopus 로고
    • Motor and cognitive improvements in patients with Huntington's disease after neural transplantation
    • Bachoud-Levi A.C., Remy P., Nguen J.P., Brugieres P., Lefaucheur J.P., Bourdet C., et al. Motor and cognitive improvements in patients with Huntington's disease after neural transplantation. Lancet 356 (2000) 1975-1979
    • (2000) Lancet , vol.356 , pp. 1975-1979
    • Bachoud-Levi, A.C.1    Remy, P.2    Nguen, J.P.3    Brugieres, P.4    Lefaucheur, J.P.5    Bourdet, C.6
  • 71
    • 0034015127 scopus 로고    scopus 로고
    • Fetal tissue transplants in animal models of Huntington's disease: The effects on damaged neuronal circuitry and behavioral deficits
    • Nakao N., and Itakura T. Fetal tissue transplants in animal models of Huntington's disease: The effects on damaged neuronal circuitry and behavioral deficits. Prog Neurobiol 61 (2000) 313-338
    • (2000) Prog Neurobiol , vol.61 , pp. 313-338
    • Nakao, N.1    Itakura, T.2
  • 73
    • 12944288307 scopus 로고    scopus 로고
    • Transplanted fetal striatum in Huntington's disease: Phenotypic development and lack of pathology
    • Freeman T.B., Cicchetti F., Hauser R.A., Deacon T.W., Li X.J., and Hersch S.M. Transplanted fetal striatum in Huntington's disease: Phenotypic development and lack of pathology. Proc Natl Acad Sci USA 97 (2000) 13877-13882
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 13877-13882
    • Freeman, T.B.1    Cicchetti, F.2    Hauser, R.A.3    Deacon, T.W.4    Li, X.J.5    Hersch, S.M.6
  • 74
    • 0034032642 scopus 로고    scopus 로고
    • Cell replacement therapies for central nervous system disorders
    • Bjorklund A., and Lindvall O. Cell replacement therapies for central nervous system disorders. Nat Neurosci 3 (2000) 537-544
    • (2000) Nat Neurosci , vol.3 , pp. 537-544
    • Bjorklund, A.1    Lindvall, O.2
  • 75
    • 0027480960 scopus 로고
    • A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
    • Huntington's Disease Collaborative Research Group. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell 72 (1993) 971-983
    • (1993) Cell , vol.72 , pp. 971-983
    • Huntington's Disease Collaborative Research Group1
  • 76
    • 0032860404 scopus 로고    scopus 로고
    • Reduced basal ganglia blood flow and volume in pre-symptomatic, gene-tested persons at-risk for Huntington's disease
    • Harris G.J., Codori A.M., Lewis R.F., Schmidt E., Bedi A., Brandt J., et al. Reduced basal ganglia blood flow and volume in pre-symptomatic, gene-tested persons at-risk for Huntington's disease. Brain 122 (1999) 1667-1678
    • (1999) Brain , vol.122 , pp. 1667-1678
    • Harris, G.J.1    Codori, A.M.2    Lewis, R.F.3    Schmidt, E.4    Bedi, A.5    Brandt, J.6
  • 77
    • 0036345704 scopus 로고    scopus 로고
    • The distribution of structural neuropathology in pre-clinical Huntington's disease
    • Thieben M.J., Duggins A.J., Good C.D., Gomes L., Mahant N., Richards F., et al. The distribution of structural neuropathology in pre-clinical Huntington's disease. Brain 125 (2002) 1815-1828
    • (2002) Brain , vol.125 , pp. 1815-1828
    • Thieben, M.J.1    Duggins, A.J.2    Good, C.D.3    Gomes, L.4    Mahant, N.5    Richards, F.6
  • 78
    • 0027433553 scopus 로고
    • Neurochemical and histologic characterization of triatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid
    • Beal M.F., Brouillet E., Jenkins B.G., Ferrante R.J., Kowall N.W., Miller J.M., et al. Neurochemical and histologic characterization of triatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid. J Neurosci 13 (1993) 4181-4192
    • (1993) J Neurosci , vol.13 , pp. 4181-4192
    • Beal, M.F.1    Brouillet, E.2    Jenkins, B.G.3    Ferrante, R.J.4    Kowall, N.W.5    Miller, J.M.6
  • 79
    • 0343983913 scopus 로고
    • 3-Nitropropionic acid, the toxic substance of Indiuofera, is a suicide inactivator of succinic dehydrogenase
    • Alston T.A., Mela L., and Bright H.J. 3-Nitropropionic acid, the toxic substance of Indiuofera, is a suicide inactivator of succinic dehydrogenase. Proc Natl Acad Sci USA 74 (1977) 3767-3771
    • (1977) Proc Natl Acad Sci USA , vol.74 , pp. 3767-3771
    • Alston, T.A.1    Mela, L.2    Bright, H.J.3
  • 80
    • 0033544840 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor-mediated protection of striatal neurons in an excitotoxic rat model of Huntington disease, as demonstrated by adenoviral gene transfer
    • Bemelmans A.P., Horellou P., Pradier L., Brunet I., Colin P., and Mallet J. Brain-derived neurotrophic factor-mediated protection of striatal neurons in an excitotoxic rat model of Huntington disease, as demonstrated by adenoviral gene transfer. Hum Gene Ther 10 (1999) 2987-2997
    • (1999) Hum Gene Ther , vol.10 , pp. 2987-2997
    • Bemelmans, A.P.1    Horellou, P.2    Pradier, L.3    Brunet, I.4    Colin, P.5    Mallet, J.6
  • 81
    • 0033789409 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor, NT-3 and NT-3/4 prevent the death of striatal projection neurons in rodent model of Huntington's disease
    • Perez-Navarro E., Canudas A.M., Akerund P., Alberch J., and Arenas E. Brain-derived neurotrophic factor, NT-3 and NT-3/4 prevent the death of striatal projection neurons in rodent model of Huntington's disease. J Neurochem 75 (2000) 2190-2199
    • (2000) J Neurochem , vol.75 , pp. 2190-2199
    • Perez-Navarro, E.1    Canudas, A.M.2    Akerund, P.3    Alberch, J.4    Arenas, E.5
  • 83
    • 0034619328 scopus 로고    scopus 로고
    • Neural stem cells display extensive tropism for pathology in adult brain: Evidence from intracranial gliomas
    • Aboody K., Brown A., Rainov N., Bower K.A., Liu S., Yang W., et al. Neural stem cells display extensive tropism for pathology in adult brain: Evidence from intracranial gliomas. Proc Natl Acad Sci USA 97 (2000) 12846-12851
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 12846-12851
    • Aboody, K.1    Brown, A.2    Rainov, N.3    Bower, K.A.4    Liu, S.5    Yang, W.6
  • 84
    • 23844542740 scopus 로고    scopus 로고
    • PEX-producing human neural stem cells inhibit tumor growth in a mouse glioma model
    • Kim S.K., Cargioli T.G., Machluf M., Yang W., Sun Y., Al-Hashem R., et al. PEX-producing human neural stem cells inhibit tumor growth in a mouse glioma model. Clin Cancer Res 11 (2005) 5965-5970
    • (2005) Clin Cancer Res , vol.11 , pp. 5965-5970
    • Kim, S.K.1    Cargioli, T.G.2    Machluf, M.3    Yang, W.4    Sun, Y.5    Al-Hashem, R.6
  • 85
    • 0035893737 scopus 로고    scopus 로고
    • Simultaneous inhibition of glioma angiogenesis, cell proliferation, and invasion by a naturally occurring fragment of human metaloproteinase-2
    • Bello L., Lucini V., Carrabba G., Giussani C., Machluf M., Pluderi M., et al. Simultaneous inhibition of glioma angiogenesis, cell proliferation, and invasion by a naturally occurring fragment of human metaloproteinase-2. Cancer Res 61 (2001) 8730-8736
    • (2001) Cancer Res , vol.61 , pp. 8730-8736
    • Bello, L.1    Lucini, V.2    Carrabba, G.3    Giussani, C.4    Machluf, M.5    Pluderi, M.6
  • 86
    • 33847097563 scopus 로고    scopus 로고
    • Human neural stem cells target human primary and metastatic cancers in animal models: Potential therapeutic applications
    • Aboody K., Garcia E., Kim S.U., et al. Human neural stem cells target human primary and metastatic cancers in animal models: Potential therapeutic applications. Proc Int Soc Stem Cell Res 2 (2004) 542
    • (2004) Proc Int Soc Stem Cell Res , vol.2 , pp. 542
    • Aboody, K.1    Garcia, E.2    Kim, S.U.3


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