Striatal transplantation in a transgenic mouse model of Huntington's disease

Experimental Neurology

Volumn 154, Issue 1, 1998, Pages 31-40

  Dunnett, S B ^a,b   Carter, R J ^b   Watts, C ^a   Torres, E M ^a   Mahal, A ^c   Mangiarini, L ^c   Bates, G ^c   Morton, A J ^b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN GRAFT; CONTROLLED STUDY; CORPUS STRIATUM; GRAFT SURVIVAL; HEMIZYGOSITY; HUNTINGTON CHOREA; LOCOMOTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSGENIC MOUSE; WEIGHT REDUCTION;

EID: 0032211289     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.1998.6926     Document Type: Article

References (38)

1. Björklund A., Campbell K., Sirinathsinghji D. J. S., Fricker R. A., Dunnett S. B. Functional capacity of striatal transplants in the rat Huntington model. Functional Neural Transplantation. 1994;Raven Press, New York. p. 157-195.
2. Björklund A., Dunnett S. B. Neural transplantation in adult rats. Dunnett S. B., Björklund A. Neural Transplantation: A Practical Approach. 1992;57-78 IRL Press, Oxford.
3. Borlongan C. V., Polgar S., Freeman T. B., Hauser R. A., Cahill D. W., Sanberg P. R. Will fetal striatal transplants correct the akinetic end-stage of Huntington's disease. Neurodegeneration. 5:1996;189-192.
4. Cha J. H. J., Kosinski C. M., Kerner J. A., Alsdorf S. A., Mangiarini L., Davies S. W., Penney J. B., Bates G. P., Young A. B. Altered brain neurotransmitter receptors in transgenic mice expressing a portion of an abnormal human Huntington disease gene. Proc. Natl. Acad. Sci. USA. 95:1998;6480-6485.
5. Davies S. W., Turmaine M., Cozens B. A., DiFiglia M., Sharp A. H., Ross C. A., Scherzinger E., Wanker E. E., Mangiarini L., Bates G. P. Formation of neuronal intranuclear inclusions (NII) underlies the neurological dysfunction in mice transgenic for the HD mutation. Cell. 90:1997;537-548.
6. DiFiglia M., Sapp E., Chase K. O., Davies S. W., Bates G. P., Vonsattel J.-P., Aronin N. Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain. Science. 277:1997;1990-1993.
7. Dunnett S. B., Björklund A. Staging and dissection of rat embryos. Dunnett S. B., Björklund A. Neural Transplantation: A Practical Approach. 1992;1-19 IRL Press, Oxford.
8. Dunnett S. B., Iversen S. D. Regulatory impairments following selective kainic acid lesions of the neostriatum. Behav. Brain Res. 1:1980;497-506.
9. Dunnett S. B., Kendall A. L., Watts C., Torres E. M. Neuronal cell transplantation for Parkinson's and Huntington's diseases. Brit. Med. Bull. 53:1997;757-776.
10. Duyao M. P., Auerbach A. B., Ryan A., Persichetti F., Barnes G. T., McNeil S. M., Ge P., Vonsattel J.-P., Gusella J. F., Joyner A. L., MacDonald M. E. Inactivation of the mouse Huntington's disease gene homologHdh. Science. 269:1995;407-410.
11. Giordano M., Hagenmeyer-Houser S. H., Sanberg P. R. Intraparenchymal fetal striatal transplants and recovery in kainic acid lesioned rats. Brain Res. 446:1988;183-188.
12. Goldberg Y. P., Kalchman M. A., Metzler M., Nasir J., Zeisler J., Graham R., Koide K., O'Kusky J. R., Sharp A. H., Ross C. A., Jirik F., Hayden M. R. Absence of disease phenotype and intergenerational stability of the CAG repeat in transgenic mice expressing the human Huntington disease transcript. Hum. Mol. Genet. 5:1996;177-185.
13. Graybiel A. M., Liu F. C., Dunnett S. B. Intrastriatal grafts derived from fetal striatal primordia. 1. Phenotypy and modular organization. J. Neurosci. 9:1989;3250-3271.
14. Helm G. A., Palmer P. E., Simmons N. E., DiPerro C., Bennett J. P. Descriptive morphology of developing fetal neostriatal allografts in the rhesus monkey: a correlated light and electron microscopic golgi study. Neuroscience. 50:1992;163-179.
15. Kopyov O. V., Jacques S., Kurth M., Philpott L. M., Lee A., Patterson M., Duma C., Lieberman A., Eagle K. S. Fetal transplantation for Huntington's disease: clinical studies. Freeman T. B., Kordower J. H. Fetal Transplantation in Neurological Disease. 1998;95-134 Humana Press, Totowa.
16. Kopyov O. V., Jacques S., Lieberman A., Duma C. M., Eagle K. S. Safety of intrastriatal neurotransplantation for Huntington's disease patients. Exp. Neurol. 119:1998;97-108.
17. Labandeira-Garcia J. L., Wictorin K., Cunningham E. T., Björklund A. Development of intrastriatal striatal grafts and their afferent innervation from the host. Neuroscience. 42:1991;407-426.
18. Lindvall O. Prospects of transplantation in human neurodegenerative diseases. Trends Neurosci. 14:1991;376-384.
19. Lindvall O. Neural transplantation: A hope for patients with Parkinson's disease. NeuroReport. 8:1997;iii-x.
20. Madrazo I., Franco-Bourland R. E., Castrejon H., Cuevas C., Ostrosky-Solis F. Fetal striatal homotransplantation for Huntington's disease: First two case reports. Neurol. Res. 17:1995;312-315.
21. Mangiarini L., Sathasivam K., Mahal A., Mott R., Seller M., Bates G. P. Instability of highly expanded CAG repeats in mice transgenic for the Huntington's disease mutation. Nature Genet. 15:1997;197-200.
22. Mangiarini L., Sathasivam K., Seller M., Cozens B., Harper A., Hetherington C., Lawton M., Trottier Y., Lehrach H., Davies S. W., Bates G. P. Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice. Cell. 87:1996;493-506.
23. Olanow C. W., Kordower J. H., Freeman T. B. Fetal nigral transplantation as a therapy for Parkinson's disease. Trends Neurosci. 19:1996;102-109.
24. Page K. J., Potter L., Aronni S., Everitt B. J., Dunnett S. B. The expression of huntingtin-associated protein (HAP1) mRNA in developing, adult and aging rat CNS: Implications for Huntington's disease neuropathology. Eur. J. Neurosci. 10:1997;1835-1845.
25. Palfi S., Nguyen J. P., Brugieres P., LeGuerinel C., Hantraye P., Rémy P., Rostaing S., Defer G. L., Césaro P., Keravel Y., Peschanski M. MRI-stereotactical approach for neural grafting in basal ganglia disorders. Exp. Neurol. 150:1998;272-281.
26. Peschanski M., Cesaro P., Hantraye P. Rationale for intrastriatal grafting of striatal neuroblasts in patients with Huntington's disease. Neuroscience. 68:1995;273-285.
27. Philpott L. M., Kopyov O. V., Lee A. J., Jacques S., Duma C. M., Caine S., Yang M., Eagle K. S. Neuropsychological functioning following fetal striatal transplantation in Huntington's chorea: Three case presentations. Cell Transplant. 6:1997;203-212.
28. Quinn N. P., Brown R., Craufurd D., Goldman S., Hodges J. R., Kieburtz K., Lindvall O., MacMillan J. C., Roos R. A. C. Core assessment programme for intracerebral transplantation in Huntington's disease (CAPIT-HD). Mov. Dis. 11:1996;143-150.
29. Ross B. D., Dubowitz D. J., Hoang T., Bluml S., Kopyov O. V., Jacques D. S. Quantitative 1H MRS of neurotransplantation in patients with Parkinson's and Huntington's disease. Radiology. 205:1997;759-759.
30. Sanberg P. R., Borlongan C. V., Wictorin K., Isacson O. Fetal tissue transplantation for Huntington's disease: Preclinical studies. Freeman T. B., Kordower J. H. Fetal Transplantation in Neurological Disease. 1998;77-93 Humana Press, Totowa.
31. Sanberg P. R., Calderon S. F., Giordano M., Tew J. M., Norman A. B. The quinolinic acid model of Huntington's disease: locomotor abnormalities. Exp. Neurol. 105:1989;45-53.
32. Sanberg P. R., Wictorin K., Isacson O. Cell Transplantation for Huntington's Disease. 1994;R. G. Landes, Austin.
33. Shannon K. M., Kordower J. H. Neural transplantation for Huntington's disease: Experimental rationale and recommendations for clinical trials. Cell Trans. 5:1996;339-352.
34. Sokal R. R., Rohlf F. J. Biometry. 1981;Freeman, New York.
35. Sramka M., Rattaj M., Molina H., Vojtassak J., Belan V., Ruzicky E. Stereotactic technique and pathophysiological mechanisms of neurotransplantation in Huntington's chorea. Stereotact. Funct. Neurosurg. 58:1992;79-83.
36. Watts C., Dunnett S. B. Effects of severity of host striatal damage on the morphological development of intrastriatal transplants in a rodent model of Huntington's disease. J. Neurosurg. 89:1998;367-374.
37. Wictorin K. Anatomy and connectivity of intrastriatal striatal transplants. Prog. Neurobiol. 38:1992;611-639.
38. Zeitlin S., Liu J. P., Chapman D. L., Papaioannou V. E., Efstratiadis A. Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue. Nature Genet. 11:1995;155-163.