Inhibition of PI3K and calcineurin suppresses chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2)-dependent responses of Th2 lymphocytes to prostaglandin D2

Biochemical Pharmacology

Volumn 73, Issue 6, 2007, Pages 843-853

  Xue, Luzheng ^a   Gyles, Shân L ^a   Barrow, Anna ^a   Pettipher, Roy ^a  

^a Oxagen Ltd   (United Kingdom)

Author keywords

Calcineurin; Chemotaxis; CRTH2; Cytokines; PI3K; Th2 lymphocytes

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2,4 DICHLOROPHENYL) 3 (1 METHYL 3 INDOLYL)MALEIMIDE; 2 MORPHOLINO 8 PHENYLCHROMONE; 5 (6 CARBOXYHEXYL) 1 (3 CYCLOHEXYL 3 HYDROXYPROPYL)HYDANTOIN; ACTIN; CALCINEURIN; CALCINEURIN INHIBITOR; CALCIUM ION; CHEMOATTRACTANT; CYCLOSPORIN A; GLYCOGEN SYNTHASE KINASE 3BETA; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; IONOMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROSTAGLANDIN D2; PROTEIN; PROTEIN CRTH2; RAMATROBAN; TACROLIMUS; TRANSCRIPTION FACTOR NFAT; UNCLASSIFIED DRUG;

ACTIN POLYMERIZATION; ARTICLE; CELL MIGRATION; CHEMOTAXIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOSKELETON; ENZYME ACTIVATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; TH2 CELL;

1-PHOSPHATIDYLINOSITOL 3-KINASE; CALCINEURIN; CELLS, CULTURED; CHEMOTAXIS, LEUKOCYTE; CHROMONES; GLYCOGEN SYNTHASE KINASE 3; HUMANS; MORPHOLINES; NFATC TRANSCRIPTION FACTORS; PHOSPHORYLATION; PROSTAGLANDIN D2; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, IMMUNOLOGIC; RECEPTORS, PROSTAGLANDIN; SIGNAL TRANSDUCTION; TH2 CELLS;

EID: 33846865609     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2006.11.021     Document Type: Article

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