-
1
-
-
0036490612
-
-
LOUIS DN, POMEROY SL, CAIRNCROSS JG: Focus on central nervous system neoplasia. Cancer Cell (2002) 1(2):125-128. • Comprehensive review on brain tumors that includes all their histological features relevant to design treatments.
-
LOUIS DN, POMEROY SL, CAIRNCROSS JG: Focus on central nervous system neoplasia. Cancer Cell (2002) 1(2):125-128. • Comprehensive review on brain tumors that includes all their histological features relevant to design treatments.
-
-
-
-
2
-
-
20044366163
-
-
STUPP R, MASON WP, VAN DEN BENT MJ et al.: Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N. Engl. J. Med. (2005) 352(10):987-996. •• First clinical trial showing significant improvement in the treatment of malignant gliomas.
-
STUPP R, MASON WP, VAN DEN BENT MJ et al.: Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N. Engl. J. Med. (2005) 352(10):987-996. •• First clinical trial showing significant improvement in the treatment of malignant gliomas.
-
-
-
-
3
-
-
0003532553
-
-
Kleihues P, Cavenee WK Eds, International Agency for Research on Cancer, Lyon, France
-
KLEIHUES P, CAVENEE WK: Pathology and Genetics of Tumors of the Nervous System. Kleihues P, Cavenee WK (Eds), International Agency for Research on Cancer, Lyon, France (1997).
-
(1997)
Pathology and Genetics of Tumors of the Nervous System
-
-
KLEIHUES, P.1
CAVENEE, W.K.2
-
4
-
-
0034473064
-
Anti-angiogenic treatment strategies for malignant brain tumors
-
KIRSCH M, SCHACKERT G, BLACK PM: Anti-angiogenic treatment strategies for malignant brain tumors. J. Neurooncol. (2000) 50(1-2):149-163.
-
(2000)
J. Neurooncol
, vol.50
, Issue.1-2
, pp. 149-163
-
-
KIRSCH, M.1
SCHACKERT, G.2
BLACK, P.M.3
-
5
-
-
0346252644
-
Novel chemotherapeutic agents for the treatment of glioblastoma multiforme
-
JENDROSSEK V, BELKA C, BAMBERG M: Novel chemotherapeutic agents for the treatment of glioblastoma multiforme. Expert Opin. Investig. Drugs (2003) 12(12):1899-1924.
-
(2003)
Expert Opin. Investig. Drugs
, vol.12
, Issue.12
, pp. 1899-1924
-
-
JENDROSSEK, V.1
BELKA, C.2
BAMBERG, M.3
-
6
-
-
2942534196
-
Recent progress in immunotherapy for malignant glioma: Treatment strategies and results from clinical trials
-
EHTESHAM M, BLACK KL, YU JS: Recent progress in immunotherapy for malignant glioma: treatment strategies and results from clinical trials. Cancer Control (2004) 11(3):192-207.
-
(2004)
Cancer Control
, vol.11
, Issue.3
, pp. 192-207
-
-
EHTESHAM, M.1
BLACK, K.L.2
YU, J.S.3
-
7
-
-
1042291304
-
Recent advances in brain tumor therapy: Local intracerebral drug delivery by polymers
-
GUERIN C, OLIVI A, WEINGART JD, LAWSON HC, BREM H: Recent advances in brain tumor therapy: local intracerebral drug delivery by polymers. Invest. New Drugs (2004) 22(1):27-37.
-
(2004)
Invest. New Drugs
, vol.22
, Issue.1
, pp. 27-37
-
-
GUERIN, C.1
OLIVI, A.2
WEINGART, J.D.3
LAWSON, H.C.4
BREM, H.5
-
8
-
-
0035057752
-
Potential of gene therapy for brain tumors
-
LAM PY, BREAKEFIELD XO: Potential of gene therapy for brain tumors. Hum. Mol. Genet. (2001) 10(7):777-787.
-
(2001)
Hum. Mol. Genet
, vol.10
, Issue.7
, pp. 777-787
-
-
LAM, P.Y.1
BREAKEFIELD, X.O.2
-
9
-
-
33749618683
-
Viral therapy for glioblastoma
-
CHIOCCA EA, AGHI M, FULCI G: Viral therapy for glioblastoma. Cancer J. (2003) 9(3):167-179.
-
(2003)
Cancer J
, vol.9
, Issue.3
, pp. 167-179
-
-
CHIOCCA, E.A.1
AGHI, M.2
FULCI, G.3
-
10
-
-
27144449641
-
Viral vectors as therapeutic agents for glioblastoma
-
AGHI M, RABKIN S: Viral vectors as therapeutic agents for glioblastoma. Curr. Opin. Mol. Ther. (2005) 7(5):419-430.
-
(2005)
Curr. Opin. Mol. Ther
, vol.7
, Issue.5
, pp. 419-430
-
-
AGHI, M.1
RABKIN, S.2
-
11
-
-
0034649787
-
Deregulation of the p14ARF/MDM2/p53 pathway is a prerequisite for human astrocytic gliomas with G1-S transition control gene abnormalities
-
ICHIMURA K, BOLIN MB, GOIKE HM, SCHMIDT EE, MOSHREF A, COLLINS VP: Deregulation of the p14ARF/MDM2/p53 pathway is a prerequisite for human astrocytic gliomas with G1-S transition control gene abnormalities. Cancer Res. (2000) 60(2):417-424.
-
(2000)
Cancer Res
, vol.60
, Issue.2
, pp. 417-424
-
-
ICHIMURA, K.1
BOLIN, M.B.2
GOIKE, H.M.3
SCHMIDT, E.E.4
MOSHREF, A.5
COLLINS, V.P.6
-
12
-
-
0034601410
-
p53 gene mutation and ink4a-arf deletion appear to be two mutually exclusive events in human glioblastoma
-
FULCI G, LABUHN M, MAIER D et al.: p53 gene mutation and ink4a-arf deletion appear to be two mutually exclusive events in human glioblastoma. Oncogene (2000) 19(33):3816-3822.
-
(2000)
Oncogene
, vol.19
, Issue.33
, pp. 3816-3822
-
-
FULCI, G.1
LABUHN, M.2
MAIER, D.3
-
13
-
-
0034032620
-
Bifidobacterium longum as a delivery system for cancer gene therapy: Selective localization and growth in hypoxic tumors
-
YAZAWA K, FUJIMORI M, AMANO J et al.: Bifidobacterium longum as a delivery system for cancer gene therapy: selective localization and growth in hypoxic tumors. Cancer Gene Ther. (2000) 7(2):269-274.
-
(2000)
Cancer Gene Ther
, vol.7
, Issue.2
, pp. 269-274
-
-
YAZAWA, K.1
FUJIMORI, M.2
AMANO, J.3
-
14
-
-
6344284114
-
Bacteriolytic therapy can generate a potent immune response against experimental tumors
-
AGRAWAL N, BETTEGOWDA C, CHEONG I et al.: Bacteriolytic therapy can generate a potent immune response against experimental tumors. Proc. Natl. Acad. Sci. USA (2004) 101(42):15172-15177.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, Issue.42
, pp. 15172-15177
-
-
AGRAWAL, N.1
BETTEGOWDA, C.2
CHEONG, I.3
-
15
-
-
31144460811
-
Bacterial gene therapy strategies
-
VASSAUX G, NITCHEU J, JEZZARD S, LEMOINE NR: Bacterial gene therapy strategies. J. Pathol. (2006) 208(2):290-298.
-
(2006)
J. Pathol
, vol.208
, Issue.2
, pp. 290-298
-
-
VASSAUX, G.1
NITCHEU, J.2
JEZZARD, S.3
LEMOINE, N.R.4
-
16
-
-
0034619328
-
Neural stem cells display extensive tropism for pathology in adult brain: Evidence from intracranial gliomas
-
ABOODY KS, BROWN A, RAINOV NG et al.: Neural stem cells display extensive tropism for pathology in adult brain: evidence from intracranial gliomas. Proc. Natl. Acad. Sci. USA (2000) 97(23):12846-12851.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, Issue.23
, pp. 12846-12851
-
-
ABOODY, K.S.1
BROWN, A.2
RAINOV, N.G.3
-
17
-
-
20144384863
-
Glioblastoma-induced attraction of endogenous neural precursor cells is associated with improved survival
-
GLASS R, SYNOWITZ M, KRONENBERG G et al.: Glioblastoma-induced attraction of endogenous neural precursor cells is associated with improved survival. J. Neurosci. (2005) 25(10):2637-2646.
-
(2005)
J. Neurosci
, vol.25
, Issue.10
, pp. 2637-2646
-
-
GLASS, R.1
SYNOWITZ, M.2
KRONENBERG, G.3
-
18
-
-
0034117480
-
Gene therapy of experimental brain tumors using neural progenitor cells
-
BENEDETTI S, PIROLA B, POLLO B et al.: Gene therapy of experimental brain tumors using neural progenitor cells. Nat. Med. (2000) 6(4):447-450.
-
(2000)
Nat. Med
, vol.6
, Issue.4
, pp. 447-450
-
-
BENEDETTI, S.1
PIROLA, B.2
POLLO, B.3
-
19
-
-
0346873982
-
Clinical gene therapy for brain tumors. Liposomal delivery of anticancer molecule to glioma
-
YOSHIDA J, MIZUNO M: Clinical gene therapy for brain tumors. Liposomal delivery of anticancer molecule to glioma. J. Neurooncol. (2003) 65(3):261-267.
-
(2003)
J. Neurooncol
, vol.65
, Issue.3
, pp. 261-267
-
-
YOSHIDA, J.1
MIZUNO, M.2
-
20
-
-
0141870056
-
-
VOGES J, RESZKA R, GOSSMANN A et al.: Imaging-guided convection-enhanced delivery and gene therapy of glioblastoma. Ann. Neurol. (2003) 54(4):479-487. • First clinical trial using a non-viral gene therapy vector in combination with novel imaging and delivery techniques; this trial provides important information about existing gene therapy limits.
-
VOGES J, RESZKA R, GOSSMANN A et al.: Imaging-guided convection-enhanced delivery and gene therapy of glioblastoma. Ann. Neurol. (2003) 54(4):479-487. • First clinical trial using a non-viral gene therapy vector in combination with novel imaging and delivery techniques; this trial provides important information about existing gene therapy limits.
-
-
-
-
21
-
-
18244378287
-
Gene therapy for malignant glioma]
-
MIZUNO M, YOSHIDA J: [Gene therapy for malignant glioma]. Nippon Rinsho (2005) 63(3):469-475.
-
(2005)
Nippon Rinsho
, vol.63
, Issue.3
, pp. 469-475
-
-
MIZUNO, M.1
YOSHIDA, J.2
-
22
-
-
0346873932
-
Clinical trials with retrovirus mediated gene therapy-what have we learned?
-
RAINOV NG, REN H: Clinical trials with retrovirus mediated gene therapy-what have we learned? J. Neurooncol. (2003) 65(3):227-236.
-
(2003)
J. Neurooncol
, vol.65
, Issue.3
, pp. 227-236
-
-
RAINOV, N.G.1
REN, H.2
-
23
-
-
0347504489
-
Clinical trials of adenoviruses in brain tumors: A review of Ad-p53 and oncolytic adenoviruses
-
VECIL GG, LANG FF: Clinical trials of adenoviruses in brain tumors: a review of Ad-p53 and oncolytic adenoviruses. J. Neurooncol. (2003) 65(3):237-246.
-
(2003)
J. Neurooncol
, vol.65
, Issue.3
, pp. 237-246
-
-
VECIL, G.G.1
LANG, F.F.2
-
24
-
-
4243175966
-
Infectious delivery of the 132 kb CDKN2A/CDKN2B genomic DNA region results in correctly spliced gene expression and growth suppression in glioma cells
-
INOUE R, MOGHADDAM KA, RANASINGHE M, SAEKI Y, CHIOCCA EA, WADE-MARTINS R: Infectious delivery of the 132 kb CDKN2A/CDKN2B genomic DNA region results in correctly spliced gene expression and growth suppression in glioma cells. Gene Ther. (2004) 11(15):1195-1204.
-
(2004)
Gene Ther
, vol.11
, Issue.15
, pp. 1195-1204
-
-
INOUE, R.1
MOGHADDAM, K.A.2
RANASINGHE, M.3
SAEKI, Y.4
CHIOCCA, E.A.5
WADE-MARTINS, R.6
-
25
-
-
27844477732
-
Herpes simplex virus amplicon delivery of a hypoxia-inducible soluble vascular endothelial growth factor receptor (sFlk-1) inhibits angiogenesis and tumor growth in pancreatic adenocarcinoma
-
REINBLATT M, PIN RH, BOWERS WJ, FEDEROFF HJ, FONG Y: Herpes simplex virus amplicon delivery of a hypoxia-inducible soluble vascular endothelial growth factor receptor (sFlk-1) inhibits angiogenesis and tumor growth in pancreatic adenocarcinoma. Ann. Surg. Oncol. (2005) 12(12):1025-1036.
-
(2005)
Ann. Surg. Oncol
, vol.12
, Issue.12
, pp. 1025-1036
-
-
REINBLATT, M.1
PIN, R.H.2
BOWERS, W.J.3
FEDEROFF, H.J.4
FONG, Y.5
-
26
-
-
27744519930
-
Herpes simplex virus 1 amplicon vector-mediated siRNA targeting epidermal growth factor receptor inhibits growth of human glioma cells in vivo
-
SAYDAM O, GLAUSER DL, HEID I et al.: Herpes simplex virus 1 amplicon vector-mediated siRNA targeting epidermal growth factor receptor inhibits growth of human glioma cells in vivo. Mol. Ther. (2005) 12(5):803-812.
-
(2005)
Mol. Ther
, vol.12
, Issue.5
, pp. 803-812
-
-
SAYDAM, O.1
GLAUSER, D.L.2
HEID, I.3
-
27
-
-
27744497012
-
Adeno-associated virus vectors: Potential applications for cancer gene therapy
-
LI C, BOWLES DE, VAN DYKE T, SAMULSKI RJ: Adeno-associated virus vectors: potential applications for cancer gene therapy. Cancer Gene Ther. (2005) 12(12):913-925.
-
(2005)
Cancer Gene Ther
, vol.12
, Issue.12
, pp. 913-925
-
-
LI, C.1
BOWLES, D.E.2
VAN DYKE, T.3
SAMULSKI, R.J.4
-
28
-
-
32644447640
-
Therapeutic protein transduction of mammalian cells and mice by nucleic acid-free lentiviral nanoparticles
-
LINK N, AUBEL C, KELM JM et al.: Therapeutic protein transduction of mammalian cells and mice by nucleic acid-free lentiviral nanoparticles. Nucleic Acids Res. (2006) 34(2):e16.
-
(2006)
Nucleic Acids Res
, vol.34
, Issue.2
-
-
LINK, N.1
AUBEL, C.2
KELM, J.M.3
-
29
-
-
0034927057
-
Replication-selective virotherapy for cancer: Biological principles, risk management and future directions
-
KIRN D, MARTUZA RL, ZWIEBEL J: Replication-selective virotherapy for cancer: biological principles, risk management and future directions. Nat. Med. (2001) 7(7):781-787.
-
(2001)
Nat. Med
, vol.7
, Issue.7
, pp. 781-787
-
-
KIRN, D.1
MARTUZA, R.L.2
ZWIEBEL, J.3
-
30
-
-
3142756540
-
Oncolytic viruses for the therapy of brain tumors and other solid malignancies: A review
-
FULCI G, CHIOCCA EA: Oncolytic viruses for the therapy of brain tumors and other solid malignancies: a review. Front. Biosci. (2003) 8:e346-e360.
-
(2003)
Front. Biosci
, vol.8
-
-
FULCI, G.1
CHIOCCA, E.A.2
-
31
-
-
27944433469
-
Oncolytic viral therapies - the clinical experience
-
AGHI M, MARTUZA RL: Oncolytic viral therapies - the clinical experience. Oncogene (2005) 24(52):7802-7816.
-
(2005)
Oncogene
, vol.24
, Issue.52
, pp. 7802-7816
-
-
AGHI, M.1
MARTUZA, R.L.2
-
32
-
-
27144483926
-
Tumor-targeted, systemic delivery of therapeutic viral vectors using hitchhiking on antigen-specific T cells
-
COLE C, QIAO J, KOTTKE T et al.: Tumor-targeted, systemic delivery of therapeutic viral vectors using hitchhiking on antigen-specific T cells. Nat. Med. (2005) 11(10):1073-1081.
-
(2005)
Nat. Med
, vol.11
, Issue.10
, pp. 1073-1081
-
-
COLE, C.1
QIAO, J.2
KOTTKE, T.3
-
33
-
-
33645468259
-
Mesenchymal progenitor cells as cellular vehicles for delivery of oncolytic adenoviruses
-
KOMAROVA S, KAWAKAMI Y, STOFF-KHALILI MA, CURIEL DT, PEREBOEVA L: Mesenchymal progenitor cells as cellular vehicles for delivery of oncolytic adenoviruses. Mol. Cancer Ther. (2006) 5(3):755-766.
-
(2006)
Mol. Cancer Ther
, vol.5
, Issue.3
, pp. 755-766
-
-
KOMAROVA, S.1
KAWAKAMI, Y.2
STOFF-KHALILI, M.A.3
CURIEL, D.T.4
PEREBOEVA, L.5
-
34
-
-
33645239282
-
Synergistic antitumor effects of immune cell-viral biotherapy
-
THORNE SH, NEGRIN RS, CONTAG CH: Synergistic antitumor effects of immune cell-viral biotherapy. Science (2006) 311(5768):1780-1784.
-
(2006)
Science
, vol.311
, Issue.5768
, pp. 1780-1784
-
-
THORNE, S.H.1
NEGRIN, R.S.2
CONTAG, C.H.3
-
35
-
-
2342641762
-
Replicative oncolytic herpes simplex viruses in combination cancer therapies
-
POST DE, FULCI G, CHIOCCA EA, VAN MEIR EG: Replicative oncolytic herpes simplex viruses in combination cancer therapies. Curr. Gene Ther. (2004) 4(1):41-51.
-
(2004)
Curr. Gene Ther
, vol.4
, Issue.1
, pp. 41-51
-
-
POST, D.E.1
FULCI, G.2
CHIOCCA, E.A.3
VAN MEIR, E.G.4
-
36
-
-
33646455930
-
Gene therapy vector design strategies for the treatment of cancer
-
DONG JY, WORARATANADHARM J: Gene therapy vector design strategies for the treatment of cancer. Future Oncol. (2005) 1(3):361-373.
-
(2005)
Future Oncol
, vol.1
, Issue.3
, pp. 361-373
-
-
DONG, J.Y.1
WORARATANADHARM, J.2
-
37
-
-
85047689435
-
Potential applications of RNA interference technology in the treatment of cancer
-
LAGE H: Potential applications of RNA interference technology in the treatment of cancer. Future Oncol. (2005) 1(1):103-113.
-
(2005)
Future Oncol
, vol.1
, Issue.1
, pp. 103-113
-
-
LAGE, H.1
-
38
-
-
0029992327
-
Human malignant brain tumor response to herpes simplex thymidine kinase (HSVtk)/ganciclovir gene therapy
-
IZQUIERDO M, MARTIN V, DE FELIPE P et al.: Human malignant brain tumor response to herpes simplex thymidine kinase (HSVtk)/ganciclovir gene therapy. Gene Ther. (1996) 3(6):491-495.
-
(1996)
Gene Ther
, vol.3
, Issue.6
, pp. 491-495
-
-
IZQUIERDO, M.1
MARTIN, V.2
DE FELIPE, P.3
-
39
-
-
0031463632
-
Therapy of malignant brain tumors by intratumoral implantation of retroviral vector-producing cells
-
RAM Z, CULVER KW, OSHIRO EM et al.: Therapy of malignant brain tumors by intratumoral implantation of retroviral vector-producing cells. Nat. Med. (1997) 3(12):1354-1361.
-
(1997)
Nat. Med
, vol.3
, Issue.12
, pp. 1354-1361
-
-
RAM, Z.1
CULVER, K.W.2
OSHIRO, E.M.3
-
40
-
-
2442767029
-
A Phase I/II study of herpes simplex virus type 1 thymidine kinase 'suicide' gene therapy for recurrent glioblastoma. Study Group on Gene Therapy for Glioblastoma
-
KLATZMANN D, VALERY CA, BENSIMON G et al.: A Phase I/II study of herpes simplex virus type 1 thymidine kinase 'suicide' gene therapy for recurrent glioblastoma. Study Group on Gene Therapy for Glioblastoma. Hum. Gene Ther. (1998) 9(17):2595-2604.
-
(1998)
Hum. Gene Ther
, vol.9
, Issue.17
, pp. 2595-2604
-
-
KLATZMANN, D.1
VALERY, C.A.2
BENSIMON, G.3
-
41
-
-
0033588816
-
A Phase 1-2 clinical trial of gene therapy for recurrent glioblastoma multiforme by tumor transduction with the herpes simplex thymidine kinase gene followed by ganciclovir. GLI328 European-Canadian Study Group
-
SHAND N, WEBER F, MARIANI L et al.: A Phase 1-2 clinical trial of gene therapy for recurrent glioblastoma multiforme by tumor transduction with the herpes simplex thymidine kinase gene followed by ganciclovir. GLI328 European-Canadian Study Group. Hum. Gene Ther. (1999) 10(14):2325-2335.
-
(1999)
Hum. Gene Ther
, vol.10
, Issue.14
, pp. 2325-2335
-
-
SHAND, N.1
WEBER, F.2
MARIANI, L.3
-
42
-
-
0033764608
-
The HSV-TK/GCV gene therapy in five cases of recurrent glioblastoma multiforme]
-
ADACHI N, KONU DL, FREI K, YONEKAWA Y: [The HSV-TK/GCV gene therapy in five cases of recurrent glioblastoma multiforme]. No Shinkei Geka (2000) 28(10):865-871.
-
(2000)
No Shinkei Geka
, vol.28
, Issue.10
, pp. 865-871
-
-
ADACHI, N.1
KONU, D.L.2
FREI, K.3
YONEKAWA, Y.4
-
43
-
-
0034095219
-
Thymidine kinase activation of ganciclovir in recurrent malignant gliomas: A gene-marking and neuropathological study
-
HARSH GR, DEISBOECK TS, LOUIS DN et al.: Thymidine kinase activation of ganciclovir in recurrent malignant gliomas: a gene-marking and neuropathological study. J. Neurosurg. (2000) 92(5):804-811.
-
(2000)
J. Neurosurg
, vol.92
, Issue.5
, pp. 804-811
-
-
HARSH, G.R.1
DEISBOECK, T.S.2
LOUIS, D.N.3
-
44
-
-
0033957146
-
Treatment of progressive or recurrent pediatric malignant supratentorial brain tumors with herpes simplex virus thymidine kinase gene vector-producer cells followed by intravenous ganciclovir administration
-
PACKER RJ, RAFFEL C, VILLABLANCA JG et al.: Treatment of progressive or recurrent pediatric malignant supratentorial brain tumors with herpes simplex virus thymidine kinase gene vector-producer cells followed by intravenous ganciclovir administration. J. Neurosurg. (2000) 92(2):249-254.
-
(2000)
J. Neurosurg
, vol.92
, Issue.2
, pp. 249-254
-
-
PACKER, R.J.1
RAFFEL, C.2
VILLABLANCA, J.G.3
-
45
-
-
0034694011
-
-
RAINOV NG: A Phase III clinical evaluation of herpes simplex virus type 1 thymidine kinase and ganciclovir gene therapy as an adjuvant to surgical resection and radiation in adults with previously untreated glioblastoma multiforme. Hum. Gene Ther. (2000) 11(17):2389-2401. •• Clinical trial that demonstrated the lack of improvement in brain tumor therapy when using retrovirus gene therapy systems; this study has pushed clinicians and researchers to study new vector systems for gene therapy.
-
RAINOV NG: A Phase III clinical evaluation of herpes simplex virus type 1 thymidine kinase and ganciclovir gene therapy as an adjuvant to surgical resection and radiation in adults with previously untreated glioblastoma multiforme. Hum. Gene Ther. (2000) 11(17):2389-2401. •• Clinical trial that demonstrated the lack of improvement in brain tumor therapy when using retrovirus gene therapy systems; this study has pushed clinicians and researchers to study new vector systems for gene therapy.
-
-
-
-
46
-
-
0033000339
-
Gene therapy of glioblastoma multiforme via combined expression of suicide and cytokine genes: A pilot study in humans
-
PALU G, CAVAGGIONI A, CALVI P et al.: Gene therapy of glioblastoma multiforme via combined expression of suicide and cytokine genes: a pilot study in humans. Gene Ther. (1999) 6(3):330-337.
-
(1999)
Gene Ther
, vol.6
, Issue.3
, pp. 330-337
-
-
PALU, G.1
CAVAGGIONI, A.2
CALVI, P.3
-
47
-
-
30644457691
-
Combined HSV-TK/IL-2 gene therapy in patients with recurrent glioblastoma multiforme: Biological and clinical results
-
COLOMBO F, BARZON L, FRANCHIN E et al.: Combined HSV-TK/IL-2 gene therapy in patients with recurrent glioblastoma multiforme: biological and clinical results. Cancer Gene Ther. (2005) 12(10):835-848.
-
(2005)
Cancer Gene Ther
, vol.12
, Issue.10
, pp. 835-848
-
-
COLOMBO, F.1
BARZON, L.2
FRANCHIN, E.3
-
48
-
-
0034329438
-
Thymidine kinase gene therapy for human malignant glioma, using replication-deficient retroviruses or adenoviruses
-
SANDMAIR AM, LOIMAS S, PURANEN P et al.: Thymidine kinase gene therapy for human malignant glioma, using replication-deficient retroviruses or adenoviruses. Hum. Gene Ther. (2000) 11(16):2197-2205.
-
(2000)
Hum. Gene Ther
, vol.11
, Issue.16
, pp. 2197-2205
-
-
SANDMAIR, A.M.1
LOIMAS, S.2
PURANEN, P.3
-
49
-
-
0034136802
-
Phase I study of adenoviral delivery of the HSV-tk gene and ganciclovir administration in patients with current malignant brain tumors
-
TRASK TW, TRASK RP, AGUILAR-CORDOVA E et al.: Phase I study of adenoviral delivery of the HSV-tk gene and ganciclovir administration in patients with current malignant brain tumors. Mol. Ther. (2000) 1(2):195-203.
-
(2000)
Mol. Ther
, vol.1
, Issue.2
, pp. 195-203
-
-
TRASK, T.W.1
TRASK, R.P.2
AGUILAR-CORDOVA, E.3
-
50
-
-
0346243603
-
Adenovirus/herpes simplex-thymidine kinase/ganciclovir complex: Preliminary results of a Phase I trial in patients with recurrent malignant gliomas
-
GERMANO IM, FABLE J, GULTEKIN SH, SILVERS A: Adenovirus/herpes simplex-thymidine kinase/ganciclovir complex: preliminary results of a Phase I trial in patients with recurrent malignant gliomas. J. Neurooncol. (2003) 65(3):279-289.
-
(2003)
J. Neurooncol
, vol.65
, Issue.3
, pp. 279-289
-
-
GERMANO, I.M.1
FABLE, J.2
GULTEKIN, S.H.3
SILVERS, A.4
-
51
-
-
85047697641
-
Phase I trial of adenovirus-mediated p53 gene therapy for recurrent glioma: Biological and clinical results
-
LANG FF, BRUNER JM, FULLER GN et al.: Phase I trial of adenovirus-mediated p53 gene therapy for recurrent glioma: biological and clinical results. J. Clin. Oncol. (2003) 21(13):2508-2518.
-
(2003)
J. Clin. Oncol
, vol.21
, Issue.13
, pp. 2508-2518
-
-
LANG, F.F.1
BRUNER, J.M.2
FULLER, G.N.3
-
52
-
-
7044235842
-
AdvHSV-tk gene therapy with intravenous ganciclovir improves survival in human malignant glioma: A randomised, controlled study
-
IMMONEN A, VAPALAHTI M, TYYNELA K et al.: AdvHSV-tk gene therapy with intravenous ganciclovir improves survival in human malignant glioma: a randomised, controlled study. Mol. Ther. (2004) 10(5):967-972.
-
(2004)
Mol. Ther
, vol.10
, Issue.5
, pp. 967-972
-
-
IMMONEN, A.1
VAPALAHTI, M.2
TYYNELA, K.3
-
53
-
-
12944315014
-
Conditionally replicating herpes simplex virus mutant, G207 for the treatment of malignant glioma: Results of a Phase I trial
-
MARKERT JM, MEDLOCK MD, RABKIN SD et al.: Conditionally replicating herpes simplex virus mutant, G207 for the treatment of malignant glioma: results of a Phase I trial. Gene Ther. (2000) 7(10):867-874.
-
(2000)
Gene Ther
, vol.7
, Issue.10
, pp. 867-874
-
-
MARKERT, J.M.1
MEDLOCK, M.D.2
RABKIN, S.D.3
-
54
-
-
12944272092
-
Toxicity evaluation of replication-competent herpes simplex virus (ICP 34.5 null mutant 1716) in patients with recurrent malignant glioma
-
RAMPLING R, CRUICKSHANK G, PAPANASTASSIOU V et al.: Toxicity evaluation of replication-competent herpes simplex virus (ICP 34.5 null mutant 1716) in patients with recurrent malignant glioma. Gene Ther. (2000) 7(10):859-866.
-
(2000)
Gene Ther
, vol.7
, Issue.10
, pp. 859-866
-
-
RAMPLING, R.1
CRUICKSHANK, G.2
PAPANASTASSIOU, V.3
-
55
-
-
7044228126
-
A Phase I open-label, dose-escalation, multi-institutional trial of injection with an E1B-attenuated adenovirus, ONYX-015, into the peritumoral region of recurrent malignant gliomas, in the adjuvant setting
-
CHIOCCA EA, ABBED KM, TATTER S et al.: A Phase I open-label, dose-escalation, multi-institutional trial of injection with an E1B-attenuated adenovirus, ONYX-015, into the peritumoral region of recurrent malignant gliomas, in the adjuvant setting. Mol. Ther. (2004) 10(5):958-966.
-
(2004)
Mol. Ther
, vol.10
, Issue.5
, pp. 958-966
-
-
CHIOCCA, E.A.1
ABBED, K.M.2
TATTER, S.3
-
56
-
-
28844468988
-
Phase I/II trial of intravenous NDV-HUJ oncolytic virus in recurrent glioblastoma multiforme
-
FREEMAN AI, ZAKAY-RONES Z, GOMORI JM et al.: Phase I/II trial of intravenous NDV-HUJ oncolytic virus in recurrent glioblastoma multiforme. Mol. Ther. (2006) 13(1):221-228.
-
(2006)
Mol. Ther
, vol.13
, Issue.1
, pp. 221-228
-
-
FREEMAN, A.I.1
ZAKAY-RONES, Z.2
GOMORI, J.M.3
-
57
-
-
17344371681
-
Beta-galactosidase gene transfer to human malignant glioma in vivo using replication-deficient retroviruses and adenoviruses
-
PUUMALAINEN AM, VAPALAHTI M, AGRAWAL RS et al.: Beta-galactosidase gene transfer to human malignant glioma in vivo using replication-deficient retroviruses and adenoviruses. Hum. Gene Ther. (1998) 9(12):1769-1774.
-
(1998)
Hum. Gene Ther
, vol.9
, Issue.12
, pp. 1769-1774
-
-
PUUMALAINEN, A.M.1
VAPALAHTI, M.2
AGRAWAL, R.S.3
-
58
-
-
12144287757
-
The combination of adenoviral HSV TK gene therapy and radiation is effective in athymic mouse glioblastoma xenografts without increasing toxic side effects
-
NESTLER U, WAKIMOTO H, SILLER-LOPEZ F et al.: The combination of adenoviral HSV TK gene therapy and radiation is effective in athymic mouse glioblastoma xenografts without increasing toxic side effects. J. Neurooncol. (2004) 67(1-2):177-188.
-
(2004)
J. Neurooncol
, vol.67
, Issue.1-2
, pp. 177-188
-
-
NESTLER, U.1
WAKIMOTO, H.2
SILLER-LOPEZ, F.3
-
59
-
-
4143091531
-
Immobilized cobalt affinity chromatography provides a novel, efficient method for herpes simplex virus type 1 gene vector purification
-
JIANG C, WECHUCK JB, GOINS WF et al.: Immobilized cobalt affinity chromatography provides a novel, efficient method for herpes simplex virus type 1 gene vector purification. J. Virol. (2004) 78(17):8994-9006.
-
(2004)
J. Virol
, vol.78
, Issue.17
, pp. 8994-9006
-
-
JIANG, C.1
WECHUCK, J.B.2
GOINS, W.F.3
-
60
-
-
33745192604
-
DNA-based methods to prepare helper virus-free herpes amplicon vectors and versatile design of amplicon vector plasmids
-
KASAI K, SAEKI Y: DNA-based methods to prepare helper virus-free herpes amplicon vectors and versatile design of amplicon vector plasmids. Curr. Gene Ther. (2006) 6(3):303-314.
-
(2006)
Curr. Gene Ther
, vol.6
, Issue.3
, pp. 303-314
-
-
KASAI, K.1
SAEKI, Y.2
-
61
-
-
25444440853
-
Surface properties, more than size, limiting convective distribution of virus-sized particles and viruses in the central nervous system
-
CHEN MY, HOFFER A, MORRISON PF et al.: Surface properties, more than size, limiting convective distribution of virus-sized particles and viruses in the central nervous system. J. Neurosurg. (2005) 103(2):311- 319.
-
(2005)
J. Neurosurg
, vol.103
, Issue.2
, pp. 311-319
-
-
CHEN, M.Y.1
HOFFER, A.2
MORRISON, P.F.3
-
62
-
-
33745479790
-
Tissue affinity of the infusate affects the distribution volume during convection-enhanced delivery into rodent brains: Implications for local drug delivery
-
SAITO R, KRAUZE MT, NOBLE CO et al.: Tissue affinity of the infusate affects the distribution volume during convection-enhanced delivery into rodent brains: implications for local drug delivery. J. Neurosci. Methods (2006) 154(1-2):225-232.
-
(2006)
J. Neurosci. Methods
, vol.154
, Issue.1-2
, pp. 225-232
-
-
SAITO, R.1
KRAUZE, M.T.2
NOBLE, C.O.3
-
63
-
-
27744517790
-
Gadolinium-loaded liposomes allow for real-time magnetic resonance imaging of convection-enhanced delivery in the primate brain
-
SAITO R, KRAUZE MT, BRINGAS JR et al.: Gadolinium-loaded liposomes allow for real-time magnetic resonance imaging of convection-enhanced delivery in the primate brain. Exp. Neurol. (2005) 196(2):381-389.
-
(2005)
Exp. Neurol
, vol.196
, Issue.2
, pp. 381-389
-
-
SAITO, R.1
KRAUZE, M.T.2
BRINGAS, J.R.3
-
64
-
-
0029318648
-
Toxicity studies and distribution dynamics of retroviral vectors following intrathecal administration of retroviral vector-producer cells
-
OSHIRO EM, VIOLA JJ, OLDFIELD EH et al.: Toxicity studies and distribution dynamics of retroviral vectors following intrathecal administration of retroviral vector-producer cells. Cancer Gene Ther. (1995) 2(2):87-95.
-
(1995)
Cancer Gene Ther
, vol.2
, Issue.2
, pp. 87-95
-
-
OSHIRO, E.M.1
VIOLA, J.J.2
OLDFIELD, E.H.3
-
65
-
-
0033839344
-
Intra-CSF administered recombinant adenovirus causes an immune response-mediated toxicity
-
DRIESSE MJ, ESANDI MC, KROS JM et al.: Intra-CSF administered recombinant adenovirus causes an immune response-mediated toxicity. Gene Ther. (2000) 7(16):1401-1409.
-
(2000)
Gene Ther
, vol.7
, Issue.16
, pp. 1401-1409
-
-
DRIESSE, M.J.1
ESANDI, M.C.2
KROS, J.M.3
-
66
-
-
0032853699
-
Immune responses to adenovirus and adeno-associated virus in humans
-
CHIRMULE N, PROPERT K, MAGOSIN S, QIAN Y, QIAN R, WILSON J: Immune responses to adenovirus and adeno-associated virus in humans. Gene Ther. (1999) 6(9):1574-1583.
-
(1999)
Gene Ther
, vol.6
, Issue.9
, pp. 1574-1583
-
-
CHIRMULE, N.1
PROPERT, K.2
MAGOSIN, S.3
QIAN, Y.4
QIAN, R.5
WILSON, J.6
-
67
-
-
0038467368
-
Effects of innate immunity on herpes simplex virus and its ability to kill tumor cells
-
WAKIMOTO H, JOHNSON PR, KNIPE DM, CHIOCCA EA: Effects of innate immunity on herpes simplex virus and its ability to kill tumor cells. Gene Ther. (2003) 10(11):983-990.
-
(2003)
Gene Ther
, vol.10
, Issue.11
, pp. 983-990
-
-
WAKIMOTO, H.1
JOHNSON, P.R.2
KNIPE, D.M.3
CHIOCCA, E.A.4
-
68
-
-
0028826147
-
Delivery of herpesvirus and adenovirus to nude rat intracerebral tumors after osmotic blood-brain barrier disruption
-
NILAVER G, MULDOON LL, KROLL RA et al.: Delivery of herpesvirus and adenovirus to nude rat intracerebral tumors after osmotic blood-brain barrier disruption. Proc. Natl. Acad. Sci. USA (1995) 92(21):9829-9833.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, Issue.21
, pp. 9829-9833
-
-
NILAVER, G.1
MULDOON, L.L.2
KROLL, R.A.3
-
69
-
-
0032609665
-
Selective delivery of herpes virus vectors to experimental brain tumors using RMP-7
-
BARNETT FH, RAINOV NG, IKEDA K et al.: Selective delivery of herpes virus vectors to experimental brain tumors using RMP-7. Cancer Gene Ther. (1999) 6(1):14-20.
-
(1999)
Cancer Gene Ther
, vol.6
, Issue.1
, pp. 14-20
-
-
BARNETT, F.H.1
RAINOV, N.G.2
IKEDA, K.3
-
70
-
-
0032551583
-
Mapping the in vivo distribution of herpes simplex virions
-
SCHELLINGERHOUT D, BOGDANOV A JR, MARECOS E, SPEAR M, BREAKEFIELD XO, WEISSLEDER R: Mapping the in vivo distribution of herpes simplex virions. Hum. Gene Ther. (1998) 9(11):1543-1549.
-
(1998)
Hum. Gene Ther
, vol.9
, Issue.11
, pp. 1543-1549
-
-
SCHELLINGERHOUT, D.1
BOGDANOV, A.J.2
MARECOS, E.3
SPEAR, M.4
BREAKEFIELD, X.O.5
WEISSLEDER, R.6
-
71
-
-
0033759311
-
Quantitation of HSV mass distribution in a rodent brain tumor model
-
SCHELLINGERHOUT D, RAINOV NG, BREAKEFIELD XO, WEISSLEDER R: Quantitation of HSV mass distribution in a rodent brain tumor model. Gene Ther. (2000) 7(19):1648-1655.
-
(2000)
Gene Ther
, vol.7
, Issue.19
, pp. 1648-1655
-
-
SCHELLINGERHOUT, D.1
RAINOV, N.G.2
BREAKEFIELD, X.O.3
WEISSLEDER, R.4
-
72
-
-
0032814773
-
-
IKEDA K, ICHIKAWA T, WAKIMOTO H et al.: Oncolytic virus therapy of multiple tumors in the brain requires suppression of innate and elicited antiviral responses. Nat. Med. (1999) 5(8):881-887. •• Preclinical study applying oncolytic viruses in combination with immunosuppressive chemotherapeutic agents; this study has showed for the first time that host innate immune responses may be detrimental for viral therapy, and presented a therapeutic strategy that strongly increases the efficacy of oncolytic viruses.
-
IKEDA K, ICHIKAWA T, WAKIMOTO H et al.: Oncolytic virus therapy of multiple tumors in the brain requires suppression of innate and elicited antiviral responses. Nat. Med. (1999) 5(8):881-887. •• Preclinical study applying oncolytic viruses in combination with immunosuppressive chemotherapeutic agents; this study has showed for the first time that host innate immune responses may be detrimental for viral therapy, and presented a therapeutic strategy that strongly increases the efficacy of oncolytic viruses.
-
-
-
-
73
-
-
0033997183
-
Complement depletion facilitates the infection of multiple brain tumors by an intravascular, replication-conditional herpes simplex virus mutant
-
IKEDA K, WAKIMOTO H, ICHIKAWA T et al.: Complement depletion facilitates the infection of multiple brain tumors by an intravascular, replication-conditional herpes simplex virus mutant. J. Virol. (2000) 74(10):4765-4775.
-
(2000)
J. Virol
, vol.74
, Issue.10
, pp. 4765-4775
-
-
IKEDA, K.1
WAKIMOTO, H.2
ICHIKAWA, T.3
-
74
-
-
0036199737
-
The complement response against an oncolytic virus is species-specific in its activation pathways
-
WAKIMOTO H, IKEDA K, ABE T et al.: The complement response against an oncolytic virus is species-specific in its activation pathways. Mol. Ther. (2002) 5(3):275-282.
-
(2002)
Mol. Ther
, vol.5
, Issue.3
, pp. 275-282
-
-
WAKIMOTO, H.1
IKEDA, K.2
ABE, T.3
-
75
-
-
0035266284
-
Protease pretreatment increases the efficacy of adenovirus-mediated gene therapy for the treatment of an experimental glioblastoma model
-
KURIYAMA N, KURIYAMA H, JULIN CM, LAMBORN KR, ISRAEL MA: Protease pretreatment increases the efficacy of adenovirus-mediated gene therapy for the treatment of an experimental glioblastoma model. Cancer Res. (2001) 61(5):1805-1809.
-
(2001)
Cancer Res
, vol.61
, Issue.5
, pp. 1805-1809
-
-
KURIYAMA, N.1
KURIYAMA, H.2
JULIN, C.M.3
LAMBORN, K.R.4
ISRAEL, M.A.5
-
76
-
-
33645066093
-
Degradation of fibrillar collagen in a human melanoma xenograft improves the efficacy of an oncolytic herpes simplex virus vector
-
MCKEE TD, GRANDI P, MOK W et al.: Degradation of fibrillar collagen in a human melanoma xenograft improves the efficacy of an oncolytic herpes simplex virus vector. Cancer Res. (2006) 66(5):2509-2513.
-
(2006)
Cancer Res
, vol.66
, Issue.5
, pp. 2509-2513
-
-
MCKEE, T.D.1
GRANDI, P.2
MOK, W.3
-
77
-
-
22644438234
-
The case for immunosuppression in clinical gene transfer
-
LOWENSTEIN PR: The case for immunosuppression in clinical gene transfer. Mol. Ther. (2005) 12(2):185-186.
-
(2005)
Mol. Ther
, vol.12
, Issue.2
, pp. 185-186
-
-
LOWENSTEIN, P.R.1
-
78
-
-
33644547005
-
-
FRIEDMAN A, TIAN JP, FULCI G, CHIOCCA EA, WANG J: Glioma virotherapy: effects of innate immune suppression and increased viral replication capacity. Cancer Res. (2006) 66(4):2314-2319. • A mathematical model describing the interaction between oncolytic viruses, the host immune system and immunosuppressive drugs; this model has predicted the outcome of preclinical research that has followed.
-
FRIEDMAN A, TIAN JP, FULCI G, CHIOCCA EA, WANG J: Glioma virotherapy: effects of innate immune suppression and increased viral replication capacity. Cancer Res. (2006) 66(4):2314-2319. • A mathematical model describing the interaction between oncolytic viruses, the host immune system and immunosuppressive drugs; this model has predicted the outcome of preclinical research that has followed.
-
-
-
-
79
-
-
0742271990
-
Altered expression of antiviral cytokine mRNAs associated with cyclophosphamide's enhancement of viral oncolysis
-
WAKIMOTO H, FULCI G, TYMINSKI E, CHIOCCA EA: Altered expression of antiviral cytokine mRNAs associated with cyclophosphamide's enhancement of viral oncolysis. Gene Ther. (2004) 11(2):214-223.
-
(2004)
Gene Ther
, vol.11
, Issue.2
, pp. 214-223
-
-
WAKIMOTO, H.1
FULCI, G.2
TYMINSKI, E.3
CHIOCCA, E.A.4
-
80
-
-
33748088164
-
Cyclophosphamide enhances glioma virotherapy by inhibiting innate immune responses
-
FULCI G, BREYMANN L, GIANNI D et al.: Cyclophosphamide enhances glioma virotherapy by inhibiting innate immune responses. Proc. Natl. Acad. Sci. USA (2006) 103(34):12873-12878.
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, Issue.34
, pp. 12873-12878
-
-
FULCI, G.1
BREYMANN, L.2
GIANNI, D.3
-
81
-
-
33751005823
-
Cyclophosphamide increases transgene expression mediated by an oncolytic adenovirus in glioma-bearing mice monitored by bioluminescence imaging
-
In Press
-
LAMFERS ML, FULCI G, GIANNI D et al.: Cyclophosphamide increases transgene expression mediated by an oncolytic adenovirus in glioma-bearing mice monitored by bioluminescence imaging. Mol. Ther. (2006) (In Press).
-
(2006)
Mol. Ther
-
-
LAMFERS, M.L.1
FULCI, G.2
GIANNI, D.3
-
82
-
-
0035114089
-
Efficient oncolysis by a replicating adenovirus (ad) in vivo is critically dependent on tumor expression of primary ad receptors
-
DOUGLAS JT, KIM M, SUMEREL LA, CAREY DE, CURIEL DT: Efficient oncolysis by a replicating adenovirus (ad) in vivo is critically dependent on tumor expression of primary ad receptors. Cancer Res. (2001) 61(3):813-817.
-
(2001)
Cancer Res
, vol.61
, Issue.3
, pp. 813-817
-
-
DOUGLAS, J.T.1
KIM, M.2
SUMEREL, L.A.3
CAREY, D.E.4
CURIEL, D.T.5
-
83
-
-
0032835001
-
Selective gene delivery to head and neck cancer cells via an integrin targeted adenoviral vector
-
KASONO K, BLACKWELL JL, DOUGLAS JT et al.: Selective gene delivery to head and neck cancer cells via an integrin targeted adenoviral vector. Clin. Cancer Res. (1999) 5(9):2571-2579.
-
(1999)
Clin. Cancer Res
, vol.5
, Issue.9
, pp. 2571-2579
-
-
KASONO, K.1
BLACKWELL, J.L.2
DOUGLAS, J.T.3
-
84
-
-
17444385274
-
Characterization of a recombinant herpes simplex virus 1 designed to enter cells via the IL13Ralpha2 receptor of malignant glioma cells
-
ZHOU G, ROIZMAN B: Characterization of a recombinant herpes simplex virus 1 designed to enter cells via the IL13Ralpha2 receptor of malignant glioma cells. J. Virol. (2005) 79(9):5272-5277.
-
(2005)
J. Virol
, vol.79
, Issue.9
, pp. 5272-5277
-
-
ZHOU, G.1
ROIZMAN, B.2
-
85
-
-
0032865620
-
B-myb promoter retargeting of herpes simplex virus gamma34.5 gene-mediated virulence toward tumor and cycling cells
-
CHUNG R, SAEKI Y, CHIOCCA EA: B-myb promoter retargeting of herpes simplex virus gamma34.5 gene-mediated virulence toward tumor and cycling cells. J. Virol. (1999) 73(9):7556-7564.
-
(1999)
J. Virol
, vol.73
, Issue.9
, pp. 7556-7564
-
-
CHUNG, R.1
SAEKI, Y.2
CHIOCCA, E.A.3
-
86
-
-
0036212495
-
-
NAKAMURA H, KASUYA H, MULLEN JT et al.: Regulation of herpes simplex virus gamma(1)34.5 expression and oncolysis of diffuse liver metastases by Myb34.5. J. Clin. Invest. (2002) 109(7):871-882.
-
NAKAMURA H, KASUYA H, MULLEN JT et al.: Regulation of herpes simplex virus gamma(1)34.5 expression and oncolysis of diffuse liver metastases by Myb34.5. J. Clin. Invest. (2002) 109(7):871-882.
-
-
-
-
87
-
-
1942442146
-
Selectivity of an oncolytic herpes simplex virus for cells expressing the DF3/MUC1 antigen
-
KASUYA H, PAWLIK TM, MULLEN JT et al.: Selectivity of an oncolytic herpes simplex virus for cells expressing the DF3/MUC1 antigen. Cancer Res. (2004) 64(7):2561-2567.
-
(2004)
Cancer Res
, vol.64
, Issue.7
, pp. 2561-2567
-
-
KASUYA, H.1
PAWLIK, T.M.2
MULLEN, J.T.3
-
88
-
-
16844366956
-
An oncolytic HSV-1 mutant expressing ICP34.5 under control of a nestin promoter increases survival of animals even when symptomatic from a brain tumor
-
KAMBARA H, OKANO H, CHIOCCA EA, SAEKI Y: An oncolytic HSV-1 mutant expressing ICP34.5 under control of a nestin promoter increases survival of animals even when symptomatic from a brain tumor. Cancer Res. (2005) 65(7):2832-2839.
-
(2005)
Cancer Res
, vol.65
, Issue.7
, pp. 2832-2839
-
-
KAMBARA, H.1
OKANO, H.2
CHIOCCA, E.A.3
SAEKI, Y.4
-
89
-
-
29944447647
-
Enhanced therapeutic efficacy of G207 for the treatment of glioma through Musashi1 promoter retargeting of gamma34.5-mediated virulence
-
KANAI R, TOMITA H, SHINODA A et al.: Enhanced therapeutic efficacy of G207 for the treatment of glioma through Musashi1 promoter retargeting of gamma34.5-mediated virulence. Gene Ther. (2006) 13(2):106-116.
-
(2006)
Gene Ther
, vol.13
, Issue.2
, pp. 106-116
-
-
KANAI, R.1
TOMITA, H.2
SHINODA, A.3
-
90
-
-
0035036952
-
A herpes simplex virus Type 1 gamma34.5 second-site suppressor mutant that exhibits enhanced growth in cultured glioblastoma cells is severely attenuated in animals
-
MOHR I, STERNBERG D, WARD S, LEIB D, MULVEY M, GLUZMAN Y: A herpes simplex virus Type 1 gamma34.5 second-site suppressor mutant that exhibits enhanced growth in cultured glioblastoma cells is severely attenuated in animals. J. Virol. (2001) 75(11):5189-5196.
-
(2001)
J. Virol
, vol.75
, Issue.11
, pp. 5189-5196
-
-
MOHR, I.1
STERNBERG, D.2
WARD, S.3
LEIB, D.4
MULVEY, M.5
GLUZMAN, Y.6
-
91
-
-
0035933088
-
-
TODO T, MARTUZA RL, RABKIN SD, JOHNSON PA: Oncolytic herpes simplex virus vector with enhanced MHC class I presentation and tumor cell killing. Proc. Natl. Acad. Sci. USA (2001) 98(11):6396-6401. • Engineering of a very promising oncolytic virus for brain tumors; although it has not been tested in clinical trials, preclinical research has demonstrated that this virus has significantly increased both safety and replication capacity when used for brain tumors.
-
TODO T, MARTUZA RL, RABKIN SD, JOHNSON PA: Oncolytic herpes simplex virus vector with enhanced MHC class I presentation and tumor cell killing. Proc. Natl. Acad. Sci. USA (2001) 98(11):6396-6401. • Engineering of a very promising oncolytic virus for brain tumors; although it has not been tested in clinical trials, preclinical research has demonstrated that this virus has significantly increased both safety and replication capacity when used for brain tumors.
-
-
-
-
92
-
-
27944471015
-
Development of transcriptionally regulated oncolytic adenoviruses
-
KO D, HAWKINS L, YU DC: Development of transcriptionally regulated oncolytic adenoviruses. Oncogene (2005) 24(52):7763-7774.
-
(2005)
Oncogene
, vol.24
, Issue.52
, pp. 7763-7774
-
-
KO, D.1
HAWKINS, L.2
YU, D.C.3
-
93
-
-
0344188096
-
-
BISCHOFF JR, KIRN DH, WILLIAMS A et al.: An adenovirus mutant that replicates selectively in p53-deficient human tumor cells. Science (1996) 274(5286):373-376. •• Describes the first oncolytic virus targeting a specific genetic/molecular feature of cancer cells; even though further research has found that the selectivity of this virus for cancer cells is more complex than what was described here, it has opened a new field of research.
-
BISCHOFF JR, KIRN DH, WILLIAMS A et al.: An adenovirus mutant that replicates selectively in p53-deficient human tumor cells. Science (1996) 274(5286):373-376. •• Describes the first oncolytic virus targeting a specific genetic/molecular feature of cancer cells; even though further research has found that the selectivity of this virus for cancer cells is more complex than what was described here, it has opened a new field of research.
-
-
-
-
94
-
-
0034610723
-
A mutant oncolytic adenovirus targeting the Rb pathway produces anti-glioma effect in vivo
-
FUEYO J, GOMEZ-MANZANO C, ALEMANY R et al.: A mutant oncolytic adenovirus targeting the Rb pathway produces anti-glioma effect in vivo. Oncogene (2000) 19(1):2-12.
-
(2000)
Oncogene
, vol.19
, Issue.1
, pp. 2-12
-
-
FUEYO, J.1
GOMEZ-MANZANO, C.2
ALEMANY, R.3
-
95
-
-
11144356850
-
A novel E1A-E1B mutant adenovirus induces glioma regression in vivo
-
GOMEZ-MANZANO C, BALAGUE C, ALEMANY R et al.: A novel E1A-E1B mutant adenovirus induces glioma regression in vivo. Oncogene (2004) 23(10):1821-1828.
-
(2004)
Oncogene
, vol.23
, Issue.10
, pp. 1821-1828
-
-
GOMEZ-MANZANO, C.1
BALAGUE, C.2
ALEMANY, R.3
-
96
-
-
0034910459
-
Oncogenes in Ras signalling pathway dictate host-cell permissiveness to herpes simplex virus 1
-
FARASSATI F, YANG AD, LEE PW: Oncogenes in Ras signalling pathway dictate host-cell permissiveness to herpes simplex virus 1. Nat. Cell Biol. (2001) 3(8):745-750.
-
(2001)
Nat. Cell Biol
, vol.3
, Issue.8
, pp. 745-750
-
-
FARASSATI, F.1
YANG, A.D.2
LEE, P.W.3
-
97
-
-
33746210173
-
Serial passage through human glioma xenografts selects for a deltagamma134.5 herpes simplex virus type 1 mutant that exhibits decreased neurotoxicity and prolongs survival of mice with experimental brain tumors
-
SHAH AC, PRICE KH, PARKER JN et al.: Serial passage through human glioma xenografts selects for a deltagamma134.5 herpes simplex virus type 1 mutant that exhibits decreased neurotoxicity and prolongs survival of mice with experimental brain tumors. J. Virol. (2006) 80(15):7308-7315.
-
(2006)
J. Virol
, vol.80
, Issue.15
, pp. 7308-7315
-
-
SHAH, A.C.1
PRICE, K.H.2
PARKER, J.N.3
-
98
-
-
0028034286
-
Long-term survival of rats harboring brain neoplasms treated with ganciclovir and a herpes simplex virus vector that retains an intact thymidine kinase gene
-
BOVIATSIS EJ, PARK JS, SENA-ESTEVES M et al.: Long-term survival of rats harboring brain neoplasms treated with ganciclovir and a herpes simplex virus vector that retains an intact thymidine kinase gene. Cancer Res. (1994) 54(22):5745-5751.
-
(1994)
Cancer Res
, vol.54
, Issue.22
, pp. 5745-5751
-
-
BOVIATSIS, E.J.1
PARK, J.S.2
SENA-ESTEVES, M.3
-
99
-
-
0031947191
-
An oncolytic viral mutant that delivers the CYP2B1 transgene and augments cyclophosphamide chemotherapy
-
CHASE M, CHUNG RY, CHIOCCA EA: An oncolytic viral mutant that delivers the CYP2B1 transgene and augments cyclophosphamide chemotherapy. Nat. Biotechnol. (1998) 16(5):444-448.
-
(1998)
Nat. Biotechnol
, vol.16
, Issue.5
, pp. 444-448
-
-
CHASE, M.1
CHUNG, R.Y.2
CHIOCCA, E.A.3
-
100
-
-
23044450359
-
Brain tumor oncolysis with replication-conditional herpes simplex virus type 1 expressing the prodrug-activating genes, CYP2B1 and secreted human intestinal carboxylesterase, in combination with cyclophosphamide and irinotecan
-
TYMINSKI E, LEROY S, TERADA K et al.: Brain tumor oncolysis with replication-conditional herpes simplex virus type 1 expressing the prodrug-activating genes, CYP2B1 and secreted human intestinal carboxylesterase, in combination with cyclophosphamide and irinotecan. Cancer Res. (2005) 65(15):6850-6857.
-
(2005)
Cancer Res
, vol.65
, Issue.15
, pp. 6850-6857
-
-
TYMINSKI, E.1
LEROY, S.2
TERADA, K.3
-
101
-
-
30344448580
-
Effect of chemotherapy-induced DNA repair on oncolytic herpes simplex viral replication
-
AGHI M, RABKIN S, MARTUZA RL: Effect of chemotherapy-induced DNA repair on oncolytic herpes simplex viral replication. J. Natl Cancer Inst. (2006) 98(1):38-50.
-
(2006)
J. Natl Cancer Inst
, vol.98
, Issue.1
, pp. 38-50
-
-
AGHI, M.1
RABKIN, S.2
MARTUZA, R.L.3
-
102
-
-
0034760178
-
-
LAMPSON LA: New animal models to probe brain tumor biology, therapy, and immunotherapy: advantages and remaining concerns. J. Neurooncol. (2001) 53(3):275-287. • Comprehensive review on animal models for brain tumor preclinical research; this review clearly shows the difficulty in translating gene therapy preclinical data from the available animal models to humans.
-
LAMPSON LA: New animal models to probe brain tumor biology, therapy, and immunotherapy: advantages and remaining concerns. J. Neurooncol. (2001) 53(3):275-287. • Comprehensive review on animal models for brain tumor preclinical research; this review clearly shows the difficulty in translating gene therapy preclinical data from the available animal models to humans.
-
-
-
-
103
-
-
0021183267
-
Transgenic mice harboring SV40 T-antigen genes develop characteristic brain tumors
-
BRINSTER RL, CHEN HY, MESSING A, VAN DYKE T, LEVINE AJ, PALMITER RD: Transgenic mice harboring SV40 T-antigen genes develop characteristic brain tumors. Cell (1984) 37(2):367-379.
-
(1984)
Cell
, vol.37
, Issue.2
, pp. 367-379
-
-
BRINSTER, R.L.1
CHEN, H.Y.2
MESSING, A.3
VAN DYKE, T.4
LEVINE, A.J.5
PALMITER, R.D.6
-
104
-
-
0034753859
-
A mouse model for medulloblastoma and basal cell nevus syndrome
-
CORCORAN RB, SCOTT MP: A mouse model for medulloblastoma and basal cell nevus syndrome. J. Neurooncol. (2001) 53(3):307-318.
-
(2001)
J. Neurooncol
, vol.53
, Issue.3
, pp. 307-318
-
-
CORCORAN, R.B.1
SCOTT, M.P.2
-
105
-
-
0034762880
-
Modeling gliomagenesis with somatic cell gene transfer using retroviral vectors
-
UHRBOM L, HOLLAND EC: Modeling gliomagenesis with somatic cell gene transfer using retroviral vectors. J. Neurooncol. (2001) 53(3):297-305.
-
(2001)
J. Neurooncol
, vol.53
, Issue.3
, pp. 297-305
-
-
UHRBOM, L.1
HOLLAND, E.C.2
-
106
-
-
0034758466
-
Mouse astrocytoma models: Embryonic stem cell mediated transgenesis
-
DING H, GUHA A: Mouse astrocytoma models: embryonic stem cell mediated transgenesis. J. Neurooncol. (2001) 53(3):289-296.
-
(2001)
J. Neurooncol
, vol.53
, Issue.3
, pp. 289-296
-
-
DING, H.1
GUHA, A.2
-
107
-
-
0023831370
-
Cerebral astrocytomas: Histopathologic correlation of MR and CT contrast enhancement with stereotactic biopsy
-
EARNEST FT, KELLY PJ, SCHEITHAUER BW et al.: Cerebral astrocytomas: histopathologic correlation of MR and CT contrast enhancement with stereotactic biopsy. Radiology (1988) 166(3):823-827.
-
(1988)
Radiology
, vol.166
, Issue.3
, pp. 823-827
-
-
EARNEST, F.T.1
KELLY, P.J.2
SCHEITHAUER, B.W.3
-
109
-
-
0034798179
-
PET as a potential tool for imaging molecular mechanisms of oncology in man
-
PRICE P: PET as a potential tool for imaging molecular mechanisms of oncology in man. Trends Mol. Med. (2001) 7(10):442-446.
-
(2001)
Trends Mol. Med
, vol.7
, Issue.10
, pp. 442-446
-
-
PRICE, P.1
-
110
-
-
0042433500
-
-
JACOBS AH, DITTMAR C, WINKELER A, GARLIP G, HEISS WD: Molecular imaging of gliomas. Mol. Imaging (2002) 1(4):309-335. • Comprehensive review on molecular imaging of gliomas; it clearly shows how gene therapy has impacted the development of this field.
-
JACOBS AH, DITTMAR C, WINKELER A, GARLIP G, HEISS WD: Molecular imaging of gliomas. Mol. Imaging (2002) 1(4):309-335. • Comprehensive review on molecular imaging of gliomas; it clearly shows how gene therapy has impacted the development of this field.
-
-
-
-
111
-
-
0034114693
-
Expression and activity of human Na+/I- symporter in human glioma cells by adenovirus-mediated gene delivery
-
CHO JY, XING S, LIU X et al.: Expression and activity of human Na+/I- symporter in human glioma cells by adenovirus-mediated gene delivery. Gene Ther. (2000) 7(9):740-749.
-
(2000)
Gene Ther
, vol.7
, Issue.9
, pp. 740-749
-
-
CHO, J.Y.1
XING, S.2
LIU, X.3
-
112
-
-
0034234255
-
Adenovirus-mediated transfer of the thyroid sodium/iodide symporter gene into tumors for a targeted radiotherapy
-
BOLAND A, RICARD M, OPOLON P et al.: Adenovirus-mediated transfer of the thyroid sodium/iodide symporter gene into tumors for a targeted radiotherapy. Cancer Res. (2000) 60(13):3484-3492.
-
(2000)
Cancer Res
, vol.60
, Issue.13
, pp. 3484-3492
-
-
BOLAND, A.1
RICARD, M.2
OPOLON, P.3
-
113
-
-
0035300468
-
Positron emission tomography-based imaging of transgene expression mediated by replication-conditional, oncolytic herpes simplex virus type 1 mutant vectors in vivo
-
JACOBS A, TJUVAJEV JG, DUBROVIN M et al.: Positron emission tomography-based imaging of transgene expression mediated by replication-conditional, oncolytic herpes simplex virus type 1 mutant vectors in vivo. Cancer Res. (2001) 61(7):2983-2995.
-
(2001)
Cancer Res
, vol.61
, Issue.7
, pp. 2983-2995
-
-
JACOBS, A.1
TJUVAJEV, J.G.2
DUBROVIN, M.3
-
114
-
-
0002179495
-
Molecular imaging of gene expression and efficacy following adenoviral-mediated brain tumor gene therapy
-
REHEMTULLA A, HALL DE, STEGMAN LD et al.: Molecular imaging of gene expression and efficacy following adenoviral-mediated brain tumor gene therapy. Mol. Imaging (2002) 1(1):43-55.
-
(2002)
Mol. Imaging
, vol.1
, Issue.1
, pp. 43-55
-
-
REHEMTULLA, A.1
HALL, D.E.2
STEGMAN, L.D.3
-
115
-
-
0034834151
-
MR imaging and single-photon emission CT findings after gene therapy for human glioblastoma
-
FLOETH FW, AULICH A, LANGEN KJ, BURGER KJ, BOCK WJ, WEBER F: MR imaging and single-photon emission CT findings after gene therapy for human glioblastoma. Am. J. Neuroradiol. (2001) 22(8):1517-1527.
-
(2001)
Am. J. Neuroradiol
, vol.22
, Issue.8
, pp. 1517-1527
-
-
FLOETH, F.W.1
AULICH, A.2
LANGEN, K.J.3
BURGER, K.J.4
BOCK, W.J.5
WEBER, F.6
-
116
-
-
28844454649
-
A cDNA-microarray analysis of camptothecin resistance in glioblastoma cell lines
-
MORANDI E, ZINGARETTI C, CHIOZZOTTO D et al.: A cDNA-microarray analysis of camptothecin resistance in glioblastoma cell lines. Cancer Lett. (2006) 231(1):74-86.
-
(2006)
Cancer Lett
, vol.231
, Issue.1
, pp. 74-86
-
-
MORANDI, E.1
ZINGARETTI, C.2
CHIOZZOTTO, D.3
-
117
-
-
33746096585
-
Innate immune functions of microglia isolated from human glioma patients
-
HUSSAIN SF, YANG D, SUKI D, GRIMM E, HEIMBERGER AB: Innate immune functions of microglia isolated from human glioma patients. J. Transl. Med. (2006) 4:15.
-
(2006)
J. Transl. Med
, vol.4
, pp. 15
-
-
HUSSAIN, S.F.1
YANG, D.2
SUKI, D.3
GRIMM, E.4
HEIMBERGER, A.B.5
-
118
-
-
31044433663
-
Macrophages: Obligate partners for tumor cell migration, invasion, and metastasis
-
CONDEELIS J, POLLARD JW: Macrophages: obligate partners for tumor cell migration, invasion, and metastasis. Cell (2006) 124(2):263-266.
-
(2006)
Cell
, vol.124
, Issue.2
, pp. 263-266
-
-
CONDEELIS, J.1
POLLARD, J.W.2
|