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Volumn 6, Issue 3, 1999, Pages 330-337

Gene therapy of glioblastoma multiforme via combined expression of suicide and cytokine genes: A pilot study in humans

Author keywords

Brain tumours; Gene therapy; Glioblastoma multiforme; Interleukin 2; Retroviral bicistronic vector; Thymidine kinase

Indexed keywords

CYTOKINE; INTERLEUKIN 2; THYMIDINE KINASE;

EID: 0033000339     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3300805     Document Type: Article
Times cited : (124)

References (28)
  • 1
    • 0027548077 scopus 로고
    • Clinical protocol: Gene therapy for the treatment of brain tumors using intra-tumoral transduction with the thymidine kinase gene and intravenous ganciclovir
    • Oldfield EH et al. Clinical protocol: gene therapy for the treatment of brain tumors using intra-tumoral transduction with the thymidine kinase gene and intravenous ganciclovir. Hum Gene Ther 1993; 4: 39-69.
    • (1993) Hum Gene Ther , vol.4 , pp. 39-69
    • Oldfield, E.H.1
  • 2
    • 0029913138 scopus 로고    scopus 로고
    • Gap junctions play a role in the 'bystander effect' of the herpes simplex virus thymidine kinase/ganciclovir system in vitro
    • Elshami AA et al. Gap junctions play a role in the 'bystander effect' of the herpes simplex virus thymidine kinase/ganciclovir system in vitro. Gene Therapy 1996; 3: 85-92.
    • (1996) Gene Therapy , vol.3 , pp. 85-92
    • Elshami, A.A.1
  • 3
    • 0029997766 scopus 로고    scopus 로고
    • Herpes simplex virus thymidine kinase/ ganciclovir-mediated apoptotic death of bystander cells
    • Hamel W et al. Herpes simplex virus thymidine kinase/ ganciclovir-mediated apoptotic death of bystander cells. Cancer Res 1996; 56: 2697-2701.
    • (1996) Cancer Res , vol.56 , pp. 2697-2701
    • Hamel, W.1
  • 4
    • 17344372848 scopus 로고    scopus 로고
    • Biosafety monitoring of patients receiving intracerebral injections of murine retroviral vector producer cells
    • Long Z et al. Biosafety monitoring of patients receiving intracerebral injections of murine retroviral vector producer cells. Hum Gene Ther 1998; 9: 1165-1172.
    • (1998) Hum Gene Ther , vol.9 , pp. 1165-1172
    • Long, Z.1
  • 5
    • 0002391815 scopus 로고
    • The clinical evaluation of chemotherapeutic agents in cancer
    • McLeod CM (ed). Columbia University Press: New York
    • Karnofsky DA, Burchenal JH. The clinical evaluation of chemotherapeutic agents in cancer. In: McLeod CM (ed). Evaluation of Chemotherapeutic Agents. Columbia University Press: New York, 1945, pp 191-205.
    • (1945) Evaluation of Chemotherapeutic Agents , pp. 191-205
    • Karnofsky, D.A.1    Burchenal, J.H.2
  • 6
    • 0025077386 scopus 로고
    • Multimarker immunohistochemical staining of calgranulins, chloroacetate esterase, and s100 for simultaneous demonstration of inflammatory cells on paraffin sections
    • Chilosi M et al. Multimarker immunohistochemical staining of calgranulins, chloroacetate esterase, and S100 for simultaneous demonstration of inflammatory cells on paraffin sections. J Histochem Cytochem 1990; 38: 1669-1675.
    • (1990) J Histochem Cytochem , vol.38 , pp. 1669-1675
    • Chilosi, M.1
  • 7
    • 0030917683 scopus 로고    scopus 로고
    • Generation of an anti-tumour immune response in a non-immunogenic tumour: HSVtk killing in vivo stimulates a mononuclear cell infiltrate and a Th1-like profile of intratumoural cytokine expression
    • Vile RG et al. Generation of an anti-tumour immune response in a non-immunogenic tumour: HSVtk killing in vivo stimulates a mononuclear cell infiltrate and a Th1-like profile of intratumoural cytokine expression. Int J Cancer 1997; 71: 267-274.
    • (1997) Int J Cancer , vol.71 , pp. 267-274
    • Vile, R.G.1
  • 8
    • 0031825184 scopus 로고    scopus 로고
    • Production and characterization of a bicistronic moloney-based retroviral vector expressing human interleukin 2 and herpes simplex virus thymidine kinase for gene therapy of cancer
    • Pizzato M et al. Production and characterization of a bicistronic Moloney-based retroviral vector expressing human interleukin 2 and herpes simplex virus thymidine kinase for gene therapy of cancer. Gene Therapy 1998; 5: 1003-1007.
    • (1998) Gene Therapy , vol.5 , pp. 1003-1007
    • Pizzato, M.1
  • 9
    • 0024510754 scopus 로고
    • Intratumoral LAK cell and interleukin 2 therapy of human gliomas
    • Barba D et al. Intratumoral LAK cell and interleukin 2 therapy of human gliomas. J Neurosurg 1989; 70: 175-182.
    • (1989) J Neurosurg , vol.70 , pp. 175-182
    • Barba, D.1
  • 10
    • 0031454617 scopus 로고    scopus 로고
    • Endostatin: An endogenous inhibitor of angiogenesis and rumor growth
    • O'Reilly MS et al. Endostatin: an endogenous inhibitor of angiogenesis and rumor growth. Cell 1997; 88: 277-285.
    • (1997) Cell , vol.88 , pp. 277-285
    • O'Reilly, M.S.1
  • 11
    • 0027787053 scopus 로고
    • In vitro evidence that metabolic cooperation is responsible for the bystander effect observed with HSVtk retroviral gene therapy
    • Bi WL et al. In vitro evidence that metabolic cooperation is responsible for the bystander effect observed with HSVtk retroviral gene therapy. Hum Gene Ther 1993; 4: 725-731.
    • (1993) Hum Gene Ther , vol.4 , pp. 725-731
    • Bi, W.L.1
  • 12
    • 0031463632 scopus 로고    scopus 로고
    • Therapy of malignant brain tumors by intratumoral implantation of retroviral vector-producing cells
    • Ram Z et al. Therapy of malignant brain tumors by intratumoral implantation of retroviral vector-producing cells. Nature Med 1997; 3: 1354-1361.
    • (1997) Nature Med , vol.3 , pp. 1354-1361
    • Ram, Z.1
  • 13
    • 0028907313 scopus 로고
    • RG-2 glioma growth attenuation and severe brain edema caused by local production of interleukin-2 and interferon-gamma
    • Tjuvajev J et al. RG-2 glioma growth attenuation and severe brain edema caused by local production of interleukin-2 and interferon-gamma. Cancer Res 1995; 55: 1902-1910.
    • (1995) Cancer Res , vol.55 , pp. 1902-1910
    • Tjuvajev, J.1
  • 14
    • 0027483695 scopus 로고
    • The 'bystander effect': Tumor regression when a fraction of the tumor mass is genetically modified
    • Freeman SM et al. The 'bystander effect': tumor regression when a fraction of the tumor mass is genetically modified. Cancer Res 1993; 53: 5274-5283.
    • (1993) Cancer Res , vol.53 , pp. 5274-5283
    • Freeman, S.M.1
  • 15
    • 0029997766 scopus 로고    scopus 로고
    • Herpes simplex virus thymidine kinase/ganciclovir-mediated apoptotic death of bystander cells
    • Hamel W, Magnelli L, Chiarugi VP, Isreal MA. Herpes simplex virus thymidine kinase/ganciclovir-mediated apoptotic death of bystander cells. Cancer Res 1996; 56: 2697-2702.
    • (1996) Cancer Res , vol.56 , pp. 2697-2702
    • Hamel, W.1    Magnelli, L.2    Chiarugi, V.P.3    Isreal, M.A.4
  • 16
    • 0029074452 scopus 로고
    • The role of cytokines in mediating the bystander effect using HSV-tk xenogeneic cells
    • Freeman SM et al. The role of cytokines in mediating the bystander effect using HSV-tk xenogeneic cells. Cancer Lett 1995; 92: 167-174.
    • (1995) Cancer Lett , vol.92 , pp. 167-174
    • Freeman, S.M.1
  • 17
    • 0030100158 scopus 로고    scopus 로고
    • Prodrug-activated gene therapy: Involvement of an immunological component in the 'bystander effect'
    • Gagandeep S et al. Prodrug-activated gene therapy: involvement of an immunological component in the 'bystander effect'. Cancer Gene Ther 1996; 3: 83-88.
    • (1996) Cancer Gene Ther , vol.3 , pp. 83-88
    • Gagandeep, S.1
  • 18
    • 0031085078 scopus 로고    scopus 로고
    • Herpes simplex virus thymidine kinase/ ganciclovir-mediated killing of tumor cell induces tumor-specific cytotoxic T cells in mice
    • Yamamoto S et al. Herpes simplex virus thymidine kinase/ ganciclovir-mediated killing of tumor cell induces tumor-specific cytotoxic T cells in mice. Cancer Gene Ther 1997; 4: 91-96.
    • (1997) Cancer Gene Ther , vol.4 , pp. 91-96
    • Yamamoto, S.1
  • 19
    • 9544258381 scopus 로고    scopus 로고
    • Analysis of IL-2 receptor expression and of the biological effects of IL-2 gene transfection in small-cell lung cancer
    • Meazza R et al. Analysis of IL-2 receptor expression and of the biological effects of IL-2 gene transfection in small-cell lung cancer. Br J Cancer 1996; 74: 788-795.
    • (1996) Br J Cancer , vol.74 , pp. 788-795
    • Meazza, R.1
  • 20
    • 13344261952 scopus 로고    scopus 로고
    • T-cell mediated rejection of gene-modified HIV-specific cytotoxic T lymphocytes in HIV-infected patients
    • Riddell SR et al. T-cell mediated rejection of gene-modified HIV-specific cytotoxic T lymphocytes in HIV-infected patients. Nature Med 1996; 2: 216-223.
    • (1996) Nature Med , vol.2 , pp. 216-223
    • Riddell, S.R.1
  • 21
    • 0029844091 scopus 로고    scopus 로고
    • Immunotherapy 1: Cyclosine gene transfer strategies
    • Colombo MP, Forni G. Immunotherapy 1: cyclosine gene transfer strategies. Cancer Metastasis Rev 1996; 15: 317-328.
    • (1996) Cancer Metastasis Rev , vol.15 , pp. 317-328
    • Colombo, M.P.1    Forni, G.2
  • 22
    • 0031613280 scopus 로고    scopus 로고
    • Characterization and tumorigenicity of human neuroblastoma cells transfected with the IL-2 gene
    • Corrias MV et al. Characterization and tumorigenicity of human neuroblastoma cells transfected with the IL-2 gene. Cancer Gene Ther 1998; 5: 38-44.
    • (1998) Cancer Gene Ther , vol.5 , pp. 38-44
    • Corrias, M.V.1
  • 23
    • 0028839609 scopus 로고
    • High-titer packaging cells producing recombinant retroviruses resistant to human serum
    • Cosset FL et al. High-titer packaging cells producing recombinant retroviruses resistant to human serum. J Virol 1995; 69: 7430-7436.
    • (1995) J Virol , vol.69 , pp. 7430-7436
    • Cosset, F.L.1
  • 24
    • 0001171494 scopus 로고
    • Summary of results and conclusions of the gene therapy of malignant brain tumors: Clinical study
    • Ram Z et al. Summary of results and conclusions of the gene therapy of malignant brain tumors: clinical study. J Neurosurg 1995; 82: 343A.
    • (1995) J Neurosurg , vol.82
    • Ram, Z.1
  • 25
    • 0019406057 scopus 로고
    • Characterization of the reverse transcriptase from a new retrovirus (HTLV) produced by a human cutaneous T-cell lymphoma cell line
    • Rho HM et al. Characterization of the reverse transcriptase from a new retrovirus (HTLV) produced by a human cutaneous T-cell lymphoma cell line. Virology 1981; 112: 355-360.
    • (1981) Virology , vol.112 , pp. 355-360
    • Rho, H.M.1
  • 26
    • 0023277545 scopus 로고
    • Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
    • Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987; 162: 156-159.
    • (1987) Anal Biochem , vol.162 , pp. 156-159
    • Chomczynski, P.1    Sacchi, N.2
  • 27
    • 0027773169 scopus 로고
    • A single protocol to detect transcripts of various types and expression levels in neural tissue and cultured cells: In situ hybridization using digoxigenin-labelled cRNA probes
    • Schaeren-Wiemers N, Gerfin-Moser A. A single protocol to detect transcripts of various types and expression levels in neural tissue and cultured cells: in situ hybridization using digoxigenin-labelled cRNA probes. Histochemistry 1993; 100: 431-440.
    • (1993) Histochemistry , vol.100 , pp. 431-440
    • Schaeren-Wiemers, N.1    Gerfin-Moser, A.2
  • 28
    • 10544225750 scopus 로고    scopus 로고
    • p21/WAF1 cyclin-kinase inhibitor expression in non-Hodgkin's lymphomas: A potential marker of p53 tumor-suppressor gene function
    • Chilosi M et al. p21/WAF1 cyclin-kinase inhibitor expression in non-Hodgkin's lymphomas: a potential marker of p53 tumor-suppressor gene function. Blood 1996; 88: 4012-4020.
    • (1996) Blood , vol.88 , pp. 4012-4020
    • Chilosi, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.