The HSV-TK/GCV gene therapy in five cases of recurrent glioblastoma multiforme

Neurological Surgery

Volumn 28, Issue 10, 2000, Pages 865-871

  Adachi, N ^a   Konu, D ^a   Frei, K ^a   Yonekawa, Y ^a  

^a YAMAGUCHI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Ganciclovir; Gene therapy; Glioblastoma multiforme; Herpes simplex virus thymidine kinase

Indexed keywords

GADOLINIUM PENTETATE; GANCICLOVIR; THYMIDINE KINASE; VIRUS VECTOR;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; FEMALE; FOLLOW UP; GENE THERAPY; GLIOBLASTOMA; HERPES SIMPLEX VIRUS; HUMAN; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; TUMOR RECURRENCE;

ADULT; AGED; ANTIVIRAL AGENTS; CENTRAL NERVOUS SYSTEM NEOPLASMS; FEMALE; GANCICLOVIR; GENE THERAPY; GENETIC VECTORS; GLIOBLASTOMA; HUMANS; MALE; MIDDLE AGED; SIMPLEXVIRUS; THYMIDINE KINASE;

EID: 0033764608     PISSN: 03012603     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. HSV-TK/ganciclovir gene therapy in relapsed glioblastoma multiformeresults of an international multicentre study
2. The HSV-TK/ganciclovir gene therapy for brain tumor
3. Reoperation in the treatment of recurrent intracranial malignant gliomas
4. In vitro evidence that metabolic cooperation is responsible for the bystander effect observed with HSV-tk retroviral gene therapy
5. Long-term survival of rats harboring brain neoplasms treated with ganciclovir and a herpes simplex virus vector that retains an intact thymidine kinase gene
6. Effect of herpes simplex virus thymidine kinase expression levels on ganciclovirmediated cytotoxicity and the 'bystander effect'
7. In vivo gene transfer with retroviral vector-produced cells for the treatment of experimental brain tumors
8. The value of reoperation for recurrent glioblastoma
9. Reoperation for recurrent glioblastoma and anaplastic astrocytoma
10. Fate and structure of Dna microinjectioed into mouse TK-L cells
11. Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: Paradigm for a prospective cancer control strategy
12. Curability of tumors bearing herpes thymidine kinase genes transferred by retroviral vectors
13. Gene therapy for the treatment of brain tumors using intra-tumoral transduction with the thymidine kinase gene and intravenous ganciclovir
14. Intravenous carboplatin for recurrent gliomas
15. Survival in patients with recurrent glioma as a measure of treatment efficacy: Prognostic factors following nitrosourea chemotherapy
16. Toxity studies of retroviral-mediated gene transfer for the treatment of brain tumors
17. Summary of results and conclusions of the gene therapy of malignant brain tumors: Clinical study
18. Therapy of malignant brain tumors by intratumoral implantation of retroviral vector-producing cells
19. Genetic prodrug activation therapy
20. A phase 1-2 clinical trial of gene therapy for recurrent glioblastoma multiforme by tumor transduction with the herpes simplex thymidine kinase gene followed by ganciclovir
21. Gene therapy of malignant brain tumors: A rat glioma line bearing the herpes simplex virus type 1 thymidine kinase gene and wild type retrovirus kills other tumor cells
22. Herpes simplex virus thymidine kinase gene therapy for rat melignant brain tumors
23. Cellular and molecular neurosurgery: Pathways from concept to reality-part I
24. Cellular and molecular neurosurgery: Pathways from concept to reality-part II