Adenovirus/herpes simplex-thymidine kinase/ganciclovir complex: Preliminary results of a phase I trial in patients with recurrent malignant gliomas

Journal of Neuro-Oncology

Volumn 65, Issue 3, 2003, Pages 279-289

  Germano, Isabelle M ^a   Fable, Jennifer ^a   Gultekin, S Humayun ^a   Silvers, Adam ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Adenovirus vector; Anaplastic astrocytoma; Gangciclovir; Gene therapy; Glioblastoma; Thymidine kinase

Indexed keywords

ADENOVIRUS VECTOR; GANCICLOVIR; THYMIDINE KINASE;

ADULT; AGED; ANEMIA; ARTICLE; BONE MARROW TOXICITY; BRAIN EDEMA; BRAIN TOXICITY; BRAIN VENTRICULITIS; CANCER RADIOTHERAPY; CANCER SIZE; CANCER SURGERY; CANCER SURVIVAL; CLINICAL ARTICLE; CLINICAL TRIAL; COHORT ANALYSIS; COMPUTER ASSISTED SURGERY; DOSE RESPONSE; DRUG EFFECT; DRUG SAFETY; DRUG TOXICITY; ENCEPHALITIS; FEMALE; GENE TRANSFER; GLIOBLASTOMA; HERPES SIMPLEX VIRUS; HISTOPATHOLOGY; HUMAN; KIDNEY FAILURE; LIVER FAILURE; MALE; MAXIMUM TOLERATED DOSE; NEUROTOXICITY; NEUTROPHILIA; NUCLEAR MAGNETIC RESONANCE IMAGING; PHASE 1 CLINICAL TRIAL; POLYMERASE CHAIN REACTION; PROGNOSIS; QUALITY OF LIFE; RECURRENT CANCER; SURVIVAL TIME; SYSTEMIC DISEASE; THROMBOCYTOPENIA; TISSUE; VIRAL GENE THERAPY; VIRUS SHEDDING;

ADENOVIRIDAE; ADULT; AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BRAIN NEOPLASMS; COMBINED MODALITY THERAPY; FEMALE; GANCICLOVIR; GENE THERAPY; GENETIC VECTORS; GLIOBLASTOMA; HUMANS; INJECTIONS, INTRALESIONAL; MALE; MIDDLE AGED; SIMPLEXVIRUS; SURVIVAL ANALYSIS; THYMIDINE KINASE; TREATMENT OUTCOME;

EID: 0346243603     PISSN: 0167594X     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:NEON.0000003657.95085.56     Document Type: Article

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